The network for 'formation of anatomical boundary' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

formation of anatomical boundary

The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

Drosophila melanogaster
Name Description Probability Func Analog Organism
HLHmdelta E(spl) region transcript mdelta 0.999
wg wingless 0.994
E(spl) Enhancer of split 0.989
robo roundabout 0.989
Tom Twin of m4 0.986
HLHm7 E(spl) region transcript m7 0.985
Dl Delta 0.984
Su(H) Suppressor of Hairless 0.961
HLHmbeta E(spl) region transcript mbeta 0.956
HLHmgamma E(spl) region transcript mgamma 0.952
stan starry night 0.948
malpha E(spl) region transcript malpha 0.938
Ser Serrate 0.892
hh hedgehog 0.883
Mad Mothers against dpp 0.882
m4 E(spl) region transcript m4 0.877
HLHm5 E(spl) region transcript m5 0.849
en engrailed 0.846
ci cubitus interruptus 0.831
sca scabrous 0.814
ds dachsous 0.767
NetB Netrin-B 0.556
lea leak 0.496
bowl brother of odd with entrails limited 0.467
eya eyes absent 0.380
hth homothorax 0.377
comm commissureless 0.374
ac achaete 0.369
ptc patched 0.344
ara araucan 0.338
Moe Moesin 0.335
fj four-jointed 0.324
spi spitz 0.323
Rac1 CG2248 gene product from transcript CG2248-RA 0.323
H Hairless 0.299
unc-5 CG8166 gene product from transcript CG8166-RA 0.294
ato atonal 0.290
aop anterior open 0.288
Ptp69D Protein tyrosine phosphatase 69D 0.282
Nedd4 CG42279 gene product from transcript CG42279-RJ 0.267
eg eagle 0.258
BobA Brother of Bearded A 0.241
CG9772 CG9772 gene product from transcript CG9772-RB 0.239
gcm glial cells missing 0.239
wb wing blister 0.229
nub nubbin 0.226
ase asense 0.224
if inflated 0.218
not non-stop 0.212
eyg eyegone 0.206
HLHm3 E(spl) region transcript m3 0.200
tkv thickveins 0.196
Wnt4 Wnt oncogene analog 4 0.192
bin biniou 0.191
fng fringe 0.188
B-H2 BarH2 0.181
zfh2 Zn finger homeodomain 2 0.166
m2 E(spl) region transcript m2 0.156
mirr mirror 0.144
Notum CG13076 gene product from transcript CG13076-RB 0.141
so sine oculis 0.138
nau nautilus 0.134
klu klumpfuss 0.128
dpp decapentaplegic 0.128
htl heartless 0.128
sd scalloped 0.126
phyl phyllopod 0.123
bib big brain 0.121
Fas2 Fasciclin 2 0.120
Pk61C Protein kinase 61C 0.113
al aristaless 0.111
LanB1 CG7123 gene product from transcript CG7123-RA 0.111
vg vestigial 0.108
Spc105R Spc105-related 0.108
bi bifid 0.107
ex expanded 0.104
kuz kuzbanian 0.098
Nrt Neurotactin 0.095
Cdc42 CG12530 gene product from transcript CG12530-RA 0.094
sv shaven 0.094
chic chickadee 0.094
mam mastermind 0.092
Akt1 CG4006 gene product from transcript CG4006-RA 0.090
twi twist 0.089
Tollo CG6890 gene product from transcript CG6890-RA 0.089
ro rough 0.084
sns sticks and stones 0.082
pan pangolin 0.082
amos absent MD neurons and olfactory sensilla 0.082
slou slouch 0.079
ham hamlet 0.078
hipk homeodomain interacting protein kinase 0.078
dsh dishevelled 0.077
abd-A abdominal A 0.074
spdo sanpodo 0.074
fra frazzled 0.073
m6 E(spl) region transcript m6 0.072
Egfr Epidermal growth factor receptor 0.072
tup tailup 0.071
vav CG7893 gene product from transcript CG7893-RB 0.071
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cam-1 Protein CAM-1 0.047
ten-1 Protein TEN-1 0.029
sel-8 Protein SEL-8 0.026
unc-73 Protein UNC-73 0.025
elt-6 Protein ELT-6 0.023
igcm-3 Protein IGCM-3 0.019
cgef-1 Protein CGEF-1 0.019
kal-1 Protein KAL-1 0.019
faah-1 Protein FAAH-1 0.018
pha-4 Protein PHA-4 0.018
flt-1 Protein FLT-1 0.017
ced-10 Protein CED-10 0.017
lin-12 Protein LIN-12 0.017
cnd-1 Protein CND-1 0.016
mig-23 Protein MIG-23 0.015
tag-123 Protein TAG-123 0.015
mlt-10 Protein MLT-10 0.015
cfz-2 Protein CFZ-2 0.015
ptc-1 Protein PTC-1 0.015
nhr-67 Protein NHR-67 0.015
egl-18 Protein EGL-18 0.015
bli-1 Protein BLI-1 0.014
ref-2 Protein REF-2 0.014
CELE_ZK1025.3 Protein ZK1025.3 0.014
T08B1.4 Protein T08B1.4 0.014
C05C9.1 Protein C05C9.1 0.014
nhr-25 Protein NHR-25 0.013
skn-1 Protein SKN-1 0.013
csnk-1 Protein CSNK-1 0.013
CELE_Y46G5A.29 Protein Y46G5A.29 0.013
smp-1 Protein SMP-1 0.013
gap-2 Protein GAP-2 0.013
F41E6.9 Protein F41E6.9 0.012
F43D9.1 Protein F43D9.1 0.012
sqt-1 Protein SQT-1 0.012
unc-86 Protein UNC-86 0.012
egl-46 Protein EGL-46 0.012
T16G1.2 Protein T16G1.2 0.012
lag-2 Protein LAG-2 0.012
gpb-1 Protein GPB-1 0.012
C30H6.5 Protein C30H6.5 0.012
ptr-11 Protein PTR-11 0.012
hbl-1 Protein HBL-1 0.012
set-16 Protein SET-16 0.012
grd-1 Protein GRD-1 0.012
ins-2 Protein INS-2 0.011
ztf-2 Protein ZTF-2 0.011
let-60 Protein LET-60 0.011
tbx-8 Protein TBX-8 0.011
trim-9 Protein TRIM-9 0.011
CELE_E01G4.6 Protein E01G4.6 0.011
F41C3.2 Protein F41C3.2 0.011
eak-3 Protein EAK-3 0.011
snt-5 Protein SNT-5 0.011
hum-2 Protein HUM-2 0.011
daf-12 Protein DAF-12 0.011
vab-1 Protein VAB-1 0.011
F09A5.4 Protein F09A5.4 0.011
wrt-3 Protein WRT-3 0.011
jac-1 Protein JAC-1 0.010
nhr-6 Protein NHR-6 0.010
B0303.11 Protein B0303.11 0.010
mcp-1 Protein MCP-1 0.010
col-111 Protein COL-111 0.010
sav-1 Protein SAV-1 0.010
frpr-4 Protein FRPR-4 0.010
F59F4.2 Protein F59F4.2 0.010
zoo-1 Protein ZOO-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
epha4a eph receptor A4a 0.675
efnb2a ephrin B2a 0.602
barhl1.2 BarH-like 1.2 0.492
dlc deltaC 0.424
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.372
cdh2 cadherin 2, neuronal 0.336
pax2a paired box gene 2a 0.336
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.309
fgfr1b fibroblast growth factor receptor 1b 0.307
notch3 notch homolog 3 0.284
ntn1a netrin 1a 0.271
neurod4 neurogenic differentiation 4 0.202
egr1 early growth response 1 0.194
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.189
ptf1a pancreas specific transcription factor, 1a 0.183
gli1 GLI-Kruppel family member 1 0.154
pax6b paired box gene 6b 0.150
hoxb2a homeo box B2a 0.141
barhl2 BarH-like 2 0.125
emx3 empty spiracles homeobox 3 0.123
alcamb activated leukocyte cell adhesion molecule b 0.110
lhx2b LIM homeobox 2b 0.110
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.100
notch1a notch homolog 1a 0.093
gsna gelsolin a 0.092
her11 hairy-related 11 0.089
par1 paraxis 0.085
vsx2 visual system homeobox 2 0.081
evx1 even-skipped homeobox 1 0.078
otpb orthopedia homolog b 0.077
foxg1a forkhead box G1a 0.073
nova2 neuro-oncological ventral antigen 2 0.066
scube2 signal peptide, CUB domain, EGF-like 2 0.065
igfbp3 insulin-like growth factor binding protein 3 0.064
sp5l Sp5 transcription factor-like 0.063
atoh1a atonal homolog 1a 0.060
mib mind bomb 0.060
dla deltaA 0.058
efnb3b ephrin B3b 0.057
otx2 orthodenticle homolog 2 0.056
egr2a early growth response 2a 0.056
slit3 slit (Drosophila) homolog 3 0.055
gro2 groucho 2 0.054
celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.051
robo1 roundabout homolog 1 0.050
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.049
etv2 ets variant gene 2 0.048
col7a1l collagen type VII alpha 1-like 0.048
eng1a engrailed 1a 0.048
onecutl one cut domain, family member, like 0.047
ptprk protein tyrosine phosphatase, receptor type, K 0.046
irx7 iroquois homeobox protein 7 0.045
eng2a engrailed 2a 0.045
ptpro protein tyrosine phosphatase, receptor type, O 0.045
mab21l2 mab-21-like 2 0.044
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.044
szl sizzled 0.043
znf703 zinc finger protein 703 0.043
nkd1 naked cuticle homolog 1 (Drosophila) 0.043
pcdh17 protocadherin 17 0.043
slit1b slit homolog 1b (Drosophila) 0.043
dlb deltaB 0.043
plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.042
cobl cordon-bleu homolog (mouse) 0.041
six3b sine oculis homeobox homolog 3b 0.041
hoxd3a homeo box D3a 0.040
eng2b engrailed 2b 0.040
wt1b wilms tumor 1b 0.039
fgfr3 fibroblast growth factor receptor 3 0.039
fgf8b fibroblast growth factor 8 b 0.039
ctsl1b cathepsin L, 1 b 0.038
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.036
igf1rb insulin-like growth factor 1b receptor 0.036
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.034
foxp2 forkhead box P2 0.034
lhx1a LIM homeobox 1a 0.033
hoxb1a homeo box B1a 0.033
her3 hairy-related 3 0.033
pcdh8 protocadherin 8 0.033
sox19b SRY-box containing gene 19b 0.033
axin1 axin 1 0.032
gro1 groucho 1 0.032
mafl v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L 0.032
dld deltaD 0.031
nrarpb notch-regulated ankyrin repeat protein b 0.031
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.029
boc brother of CDO 0.029
lama5 laminin, alpha 5 0.029
efnb1 ephrin B1 0.029
msgn1 mesogenin 1 0.029
dag1 dystroglycan 1 0.029
ascl1b achaete-scute complex-like 1b (Drosophila) 0.028
gbx1 gastrulation brain homeobox 1 0.028
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.028
sema3aa semaphorin 3aa 0.028
mmp2 matrix metalloproteinase 2 0.027
smad1 MAD homolog 1 (Drosophila) 0.026
vegfaa vascular endothelial growth factor Aa 0.026
fabp11a fatty acid binding protein 11a 0.026
fzd2 frizzled homolog 2 0.025
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Fgfr2 fibroblast growth factor receptor 2 0.943
Smad4 MAD homolog 4 (Drosophila) 0.918
Gli3 GLI-Kruppel family member GLI3 0.813
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.744
Bmp7 bone morphogenetic protein 7 0.737
Otx2 orthodenticle homolog 2 (Drosophila) 0.721
Slit3 slit homolog 3 (Drosophila) 0.684
Ntn1 netrin 1 0.681
Robo1 roundabout homolog 1 (Drosophila) 0.677
Hes1 hairy and enhancer of split 1 (Drosophila) 0.611
Gli2 GLI-Kruppel family member GLI2 0.530
Slit2 slit homolog 2 (Drosophila) 0.528
Sox2 SRY-box containing gene 2 0.527
Smad3 MAD homolog 3 (Drosophila) 0.506
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.423
Ptch1 patched homolog 1 0.368
Ctnnb1 catenin (cadherin associated protein), beta 1 0.292
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.272
Msx1 homeobox, msh-like 1 0.255
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.221
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.220
Fgf8 fibroblast growth factor 8 0.201
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.146
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.135
Bmp4 bone morphogenetic protein 4 0.134
Nodal nodal 0.130
Nrg1 neuregulin 1 0.129
Wnt5a wingless-related MMTV integration site 5A 0.128
En1 engrailed 1 0.128
Notch1 Notch gene homolog 1 (Drosophila) 0.121
Smad2 MAD homolog 2 (Drosophila) 0.117
Robo2 roundabout homolog 2 (Drosophila) 0.109
Evl Ena-vasodilator stimulated phosphoprotein 0.102
Pou5f1 POU domain, class 5, transcription factor 1 0.100
Slit1 slit homolog 1 (Drosophila) 0.100
Lama5 laminin, alpha 5 0.095
Gdf5 growth differentiation factor 5 0.090
Smo smoothened homolog (Drosophila) 0.089
Smad6 MAD homolog 6 (Drosophila) 0.087
Dll4 delta-like 4 (Drosophila) 0.084
Chrd chordin 0.083
Axin1 axin 1 0.078
Zfp362 zinc finger protein 362 0.077
Gdf1 growth differentiation factor 1 0.075
Efnb1 ephrin B1 0.074
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.073
Otx1 orthodenticle homolog 1 (Drosophila) 0.070
Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 0.068
Unc5c unc-5 homolog C (C. elegans) 0.066
Bhlhe22 basic helix-loop-helix family, member e22 0.063
Arid1a AT rich interactive domain 1A (SWI-like) 0.056
Lrp2 low density lipoprotein receptor-related protein 2 0.055
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.054
Jag1 jagged 1 0.053
Hand1 heart and neural crest derivatives expressed transcript 1 0.052
Smad1 MAD homolog 1 (Drosophila) 0.051
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.049
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.049
Vangl2 vang-like 2 (van gogh, Drosophila) 0.048
Vasp vasodilator-stimulated phosphoprotein 0.048
Bcam basal cell adhesion molecule 0.044
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.039
Bdnf brain derived neurotrophic factor 0.038
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.037
Gas1 growth arrest specific 1 0.037
Sox18 SRY-box containing gene 18 0.037
Enah enabled homolog (Drosophila) 0.037
Hand2 heart and neural crest derivatives expressed transcript 2 0.036
Tdgf1 teratocarcinoma-derived growth factor 1 0.035
Dll1 delta-like 1 (Drosophila) 0.035
Nog noggin 0.034
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.034
Msx2 homeobox, msh-like 2 0.033
Gdf6 growth differentiation factor 6 0.031
Fgfr1 fibroblast growth factor receptor 1 0.030
Cdx2 caudal type homeobox 2 0.029
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.028
Foxc1 forkhead box C1 0.028
Tcf21 transcription factor 21 0.028
Foxh1 forkhead box H1 0.027
Arx aristaless related homeobox 0.027
Tbx3 T-box 3 0.027
Fgfr3 fibroblast growth factor receptor 3 0.027
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.026
Fzd8 frizzled homolog 8 (Drosophila) 0.025
Isl1 ISL1 transcription factor, LIM/homeodomain 0.025
Tbx2 T-box 2 0.024
She src homology 2 domain-containing transforming protein E 0.024
Emx1 empty spiracles homolog 1 (Drosophila) 0.024
Zfp503 zinc finger protein 503 0.024
Foxf1a forkhead box F1a 0.023
Gata4 GATA binding protein 4 0.023
Gbx2 gastrulation brain homeobox 2 0.023
Npr3 natriuretic peptide receptor 3 0.022
Pax2 paired box gene 2 0.022
Zic3 zinc finger protein of the cerebellum 3 0.022
Lmx1b LIM homeobox transcription factor 1 beta 0.021
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.021
Tcf15 transcription factor 15 0.021
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism