The network for 'g2 dna damage checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g2 dna damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.

Drosophila melanogaster
Name Description Probability Func Analog Organism
pic piccolo 0.984
BRWD3 CG31132 gene product from transcript CG31132-RA 0.943
mei-9 meiotic 9 0.939
lok loki 0.930
Rcd1 Reduction in Cnn dots 1 0.914
Rpd3 CG7471 gene product from transcript CG7471-RA 0.889
Brca2 Breast cancer 2, early onset homolog 0.876
CDC45L CG3658 gene product from transcript CG3658-RA 0.831
MED6 Mediator complex subunit 6 0.815
CSN3 COP9 complex homolog subunit 3 0.800
Iswi Imitation SWI 0.799
CSN5 COP9 complex homolog subunit 5 0.788
His2Av Histone H2A variant 0.754
cdm cadmus 0.753
rad50 CG6339 gene product from transcript CG6339-RD 0.725
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.720
spn-B spindle B 0.709
Caf1 Chromatin assembly factor 1 subunit 0.676
CG5524 CG5524 gene product from transcript CG5524-RA 0.651
CG9797 CG9797 gene product from transcript CG9797-RA 0.636
mus101 mutagen-sensitive 101 0.596
mus309 mutagen-sensitive 309 0.593
CG6066 CG6066 gene product from transcript CG6066-RA 0.578
mus312 mutagen-sensitive 312 0.504
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.493
mus201 mutagen-sensitive 201 0.490
Caf1-180 CG12109 gene product from transcript CG12109-RB 0.489
mus205 mutagen-sensitive 205 0.480
Mob4 CG3403 gene product from transcript CG3403-RA 0.465
CSN4 COP9 complex homolog subunit 4 0.431
fl(2)d female lethal d 0.419
MAGE CG10059 gene product from transcript CG10059-RA 0.418
tefu telomere fusion 0.415
CG10139 CG10139 gene product from transcript CG10139-RA 0.404
MBD-R2 CG10042 gene product from transcript CG10042-RB 0.402
MED17 Mediator complex subunit 17 0.377
mus209 mutagen-sensitive 209 0.374
dre4 CG1828 gene product from transcript CG1828-RB 0.374
CG1792 CG1792 gene product from transcript CG1792-RA 0.373
Pp1-87B Protein phosphatase 1 at 87B 0.362
CG8159 CG8159 gene product from transcript CG8159-RB 0.353
mei-41 meiotic 41 0.336
Cdc37 CG12019 gene product from transcript CG12019-RA 0.334
CtBP C-terminal Binding Protein 0.317
Vps35 Vacuolar protein sorting 35 0.308
cdc2c CG10498 gene product from transcript CG10498-RC 0.305
poly CG9829 gene product from transcript CG9829-RB 0.298
Mcm3 Minichromosome maintenance 3 0.298
hay haywire 0.293
eIF4AIII CG7483 gene product from transcript CG7483-RA 0.290
Nipped-A CG33554 gene product from transcript CG33554-RE 0.285
U2af50 U2 small nuclear riboprotein auxiliary factor 50 0.283
MED20 Mediator complex subunit 20 0.282
Mcm7 Minichromosome maintenance 7 0.281
CG7386 CG7386 gene product from transcript CG7386-RA 0.275
Srp54 CG4602 gene product from transcript CG4602-RA 0.273
c(3)G crossover suppressor on 3 of Gowen 0.264
mus304 mutagen-sensitive 304 0.260
CSN7 COP9 complex homolog subunit 7 0.250
MRG15 CG6363 gene product from transcript CG6363-RA 0.248
pie pineapple eye 0.237
RecQ5 homolog of RecQ 0.233
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.228
Dlic Dynein light intermediate chain 0.227
sxc super sex combs 0.224
key kenny 0.223
l(2)NC136 lethal (2) NC136 0.221
scny scrawny 0.218
emb embargoed 0.217
RanGap Ran GTPase activating protein 0.212
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.208
Fcp1 CG12252 gene product from transcript CG12252-RA 0.206
Hel25E Helicase at 25E 0.203
Pp2A-29B Protein phosphatase 2A at 29B 0.201
Tip60 CG6121 gene product from transcript CG6121-RA 0.194
stwl stonewall 0.191
Smc5 CG32438 gene product from transcript CG32438-RE 0.183
SuUR Suppressor of Under-Replication 0.179
mus301 mutagen-sensitive 301 0.171
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.167
RpII15 RNA polymerase II 15kD subunit 0.166
Sh3beta CG8582 gene product from transcript CG8582-RD 0.165
nbs CG6754 gene product from transcript CG6754-RC 0.164
Mcm5 Minichromosome maintenance 5 0.158
Bap55 Brahma associated protein 55kD 0.155
CG5491 CG5491 gene product from transcript CG5491-RA 0.154
alph alphabet 0.152
glu gluon 0.150
lic licorne 0.149
CG18764 CG18764 gene product from transcript CG18764-RA 0.146
Max CG9648 gene product from transcript CG9648-RA 0.146
CstF-64 Cleavage stimulation factor 64 kilodalton subunit 0.145
fzy fizzy 0.144
CG4785 CG4785 gene product from transcript CG4785-RA 0.144
l(3)01239 lethal (3) 01239 0.143
CG10414 CG10414 gene product from transcript CG10414-RA 0.143
SMC1 CG6057 gene product from transcript CG6057-RA 0.141
Ge-1 CG6181 gene product from transcript CG6181-RA 0.140
p53 CG33336 gene product from transcript CG33336-RB 0.137
CycK Cyclin K 0.136
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ccna2 cyclin A2 0.591
zff9 zinc finger protein 9 0.278
sass6 spindle assembly 6 homolog (C. elegans) 0.273
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.243
tfam transcription factor A, mitochondrial 0.183
brip1 BRCA1 interacting protein C-terminal helicase 1 0.173
ccnb1 cyclin B1 0.142
brd2b bromodomain containing 2b 0.136
npat nuclear protein, ataxia-telangiectasia locus 0.129
chaf1b chromatin assembly factor 1, subunit B 0.118
fmr1 fragile X mental retardation 1 0.112
cand1 cullin-associated and neddylation-dissociated 1 0.112
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.108
traip TRAF-interacting protein 0.108
zgc:56197 zgc:56197 0.108
ccdc94 coiled-coil domain containing 94 0.105
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.102
naa15b N(alpha)-acetyltransferase 15, NatA auxiliary subunit b 0.101
orc1 origin recognition complex, subunit 1 0.100
stil TAL1 (SCL) interrupting locus 0.096
pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.095
csnk1g2b casein kinase 1, gamma 2b 0.095
smc1al structural maintenance of chromosomes 1A, like 0.094
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.094
ppp2r5eb protein phosphatase 2, regulatory subunit B', epsilon isoform b 0.093
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.093
smarcb1a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a 0.092
kif14 kinesin family member 14 0.091
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.087
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.087
arhgap11a Rho GTPase activating protein 11A 0.084
trip13 thyroid hormone receptor interactor 13 0.082
cul3a cullin 3a 0.080
casc3 cancer susceptibility candidate 3 0.076
tbc1d23 TBC1 domain family, member 23 0.073
gnl2 guanine nucleotide binding protein-like 2 (nucleolar) 0.072
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.071
si:ch211-69g19.2 si:ch211-69g19.2 0.071
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.070
ctcf CCCTC-binding factor (zinc finger protein) 0.070
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.070
dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.069
hug HuG 0.069
lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.068
ppp2r2d protein phosphatase 2, regulatory subunit B, delta isoform 0.067
xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.067
myst2 MYST histone acetyltransferase 2 0.064
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.064
ccnt2b cyclin T2b 0.062
zgc:55448 zgc:55448 0.062
si:dkey-57a22.11 si:dkey-57a22.11 0.062
faf1 Fas associated factor 1 0.062
brd2a bromodomain-containing 2a 0.059
fanci Fanconi anemia, complementation group I 0.059
bon bonnie and clyde 0.058
acvr1l activin A receptor, type I like 0.058
aurkb aurora kinase B 0.057
ints6 integrator complex subunit 6 0.057
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.057
morf4l1 mortality factor 4 like 1 0.056
phf17 PHD finger protein 17 0.056
rtkn2 rhotekin 2 0.055
esco2 establishment of cohesion 1 homolog 2 0.054
depdc1a DEP domain containing 1a 0.053
LOC100536849 hypothetical protein LOC100536849 0.053
cdc7 cell division cycle 7 homolog (S. cerevisiae) 0.053
nono non-POU domain containing, octamer-binding 0.052
mkks McKusick-Kaufman syndrome 0.052
palb2 partner and localizer of BRCA2 0.052
supt6h suppressor of Ty 6 homolog 0.051
gps1 G protein pathway suppressor 1 0.051
klhl11 kelch-like 11 (Drosophila) 0.051
pask PAS domain containing serine/threonine kinase 0.050
lin52 lin-52 homolog (C. elegans) 0.050
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.050
caprin1a cell cycle associated protein 1a 0.050
ung uracil-DNA glycosylase 0.050
taf7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.049
tardbpl TAR DNA binding protein, like 0.049
si:ch211-156j22.4 si:ch211-156j22.4 0.049
nktr natural killer-tumor recognition sequence 0.049
LOC557062 hypothetical protein LOC557062 0.049
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.048
zgc:154089 zgc:154089 0.048
smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.047
setdb1a SET domain, bifurcated 1a 0.047
zgc:110337 zgc:110337 0.047
pld1a phospholipase D1a 0.047
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.046
pbx4 pre-B-cell leukemia transcription factor 4 0.046
ncapg non-SMC condensin I complex, subunit G 0.045
waca WW domain containing adaptor with coiled-coil a 0.045
cdk8 cyclin-dependent kinase 8 0.044
zgc:111944 zgc:111944 0.044
zgc:162344 zgc:162344 0.044
ap1g1 adaptor-related protein complex 1, gamma 1 subunit 0.044
lrrc42 leucine rich repeat containing 42 0.044
rmnd5b required for meiotic nuclear division 5 homolog B (S. cerevisiae) 0.043
hbs1l HBS1-like (S. cerevisiae) 0.043
cuedc2 CUE domain containing 2 0.043
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Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 1.000
CDK2 cyclin-dependent kinase 2 0.999
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.999
RB1 retinoblastoma 1 0.998
H2AFX H2A histone family, member X 0.986
E2F1 E2F transcription factor 1 0.983
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.980
FANCD2 Fanconi anemia, complementation group D2 0.975
CCNA2 cyclin A2 0.971
RAD50 RAD50 homolog (S. cerevisiae) 0.960
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.951
TP53 tumor protein p53 0.937
PARP1 poly (ADP-ribose) polymerase 1 0.934
NBN nibrin 0.928
MDC1 mediator of DNA-damage checkpoint 1 0.884
MSH6 mutS homolog 6 (E. coli) 0.867
PCNA proliferating cell nuclear antigen 0.864
RBL1 retinoblastoma-like 1 (p107) 0.858
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.841
TOPBP1 topoisomerase (DNA) II binding protein 1 0.837
MCM2 minichromosome maintenance complex component 2 0.833
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.832
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.803
CDT1 chromatin licensing and DNA replication factor 1 0.799
CLSPN claspin 0.787
COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 0.785
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.772
CUL1 cullin 1 0.768
RBBP8 retinoblastoma binding protein 8 0.761
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.760
SIRT2 sirtuin 2 0.756
BLM Bloom syndrome, RecQ helicase-like 0.755
BABAM1 BRISC and BRCA1 A complex member 1 0.754
SKP2 S-phase kinase-associated protein 2 (p45) 0.712
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.689
GFER growth factor, augmenter of liver regeneration 0.664
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.646
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.645
BTG1 B-cell translocation gene 1, anti-proliferative 0.599
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.572
MCM6 minichromosome maintenance complex component 6 0.563
CUL4A cullin 4A 0.562
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 0.562
UBXN7 UBX domain protein 7 0.548
ORC1 origin recognition complex, subunit 1 0.532
MCM7 minichromosome maintenance complex component 7 0.480
FAM175A family with sequence similarity 175, member A 0.478
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.462
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.448
FANCA Fanconi anemia, complementation group A 0.445
ATM ataxia telangiectasia mutated 0.440
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.426
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.420
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.390
MED29 mediator complex subunit 29 0.375
WRN Werner syndrome, RecQ helicase-like 0.366
COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.329
CDK1 cyclin-dependent kinase 1 0.323
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.304
MED10 mediator complex subunit 10 0.300
CSNK2B casein kinase 2, beta polypeptide 0.300
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.287
COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.271
CDK8 cyclin-dependent kinase 8 0.257
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.255
UIMC1 ubiquitin interaction motif containing 1 0.255
MED1 mediator complex subunit 1 0.254
RBL2 retinoblastoma-like 2 (p130) 0.253
MED23 mediator complex subunit 23 0.239
MED13 mediator complex subunit 13 0.231
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.221
CUL2 cullin 2 0.215
SMC1A structural maintenance of chromosomes 1A 0.211
MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 0.207
BRCA2 breast cancer 2, early onset 0.200
NEK9 NIMA (never in mitosis gene a)- related kinase 9 0.193
ATR ataxia telangiectasia and Rad3 related 0.192
CDC25A cell division cycle 25 homolog A (S. pombe) 0.191
EXO1 exonuclease 1 0.184
RPA1 replication protein A1, 70kDa 0.182
MAPK14 mitogen-activated protein kinase 14 0.181
PRNP prion protein 0.180
HSF1 heat shock transcription factor 1 0.174
PKM2 pyruvate kinase, muscle 0.171
HDGF hepatoma-derived growth factor 0.156
RPA2 replication protein A2, 32kDa 0.149
TOP1 topoisomerase (DNA) I 0.142
HSPB1 heat shock 27kDa protein 1 0.142
UBA1 ubiquitin-like modifier activating enzyme 1 0.132
CCNE1 cyclin E1 0.129
BARD1 BRCA1 associated RING domain 1 0.129
TFDP1 transcription factor Dp-1 0.128
CDC25C cell division cycle 25 homolog C (S. pombe) 0.122
RBBP4 retinoblastoma binding protein 4 0.118
MCM5 minichromosome maintenance complex component 5 0.118
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.116
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.116
CNOT8 CCR4-NOT transcription complex, subunit 8 0.115
CNOT1 CCR4-NOT transcription complex, subunit 1 0.115
CDCA2 cell division cycle associated 2 0.108
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Mus musculus
Name Description Probability Func Analog Organism
Brca1 breast cancer 1 0.848
Cdk4 cyclin-dependent kinase 4 0.536
Trp53 transformation related protein 53 0.397
Brca2 breast cancer 2 0.217
Mdm2 transformed mouse 3T3 cell double minute 2 0.140
Rb1 retinoblastoma 1 0.107
Nbn nibrin 0.078
E2f1 E2F transcription factor 1 0.073
Hells helicase, lymphoid specific 0.048
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.044
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.042
Atm ataxia telangiectasia mutated homolog (human) 0.042
Stag1 stromal antigen 1 0.038
H2afx H2A histone family, member X 0.030
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.028
Pten phosphatase and tensin homolog 0.026
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.025
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.022
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.019
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.019
Mybl2 myeloblastosis oncogene-like 2 0.019
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.018
Smad4 MAD homolog 4 (Drosophila) 0.018
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.017
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.016
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.016
Ccna2 cyclin A2 0.015
Prc1 protein regulator of cytokinesis 1 0.015
Dtl denticleless homolog (Drosophila) 0.014
Ruvbl2 RuvB-like protein 2 0.014
Rbbp5 retinoblastoma binding protein 5 0.014
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.014
Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 0.014
Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.014
Mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.014
Aurka aurora kinase A 0.014
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.013
Ccne1 cyclin E1 0.013
Ldha lactate dehydrogenase A 0.013
Ccnb1 cyclin B1 0.013
Phc2 polyhomeotic-like 2 (Drosophila) 0.013
Cdca7 cell division cycle associated 7 0.012
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.012
Egr2 early growth response 2 0.012
Smc2 structural maintenance of chromosomes 2 0.011
Men1 multiple endocrine neoplasia 1 0.011
Cdc45 cell division cycle 45 homolog (S. cerevisiae) 0.011
Tcf19 transcription factor 19 0.011
Tdp2 tyrosyl-DNA phosphodiesterase 2 0.011
Cdca5 cell division cycle associated 5 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pkm2 pyruvate kinase, muscle 0.032
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.030
Eno1 enolase 1, (alpha) 0.018
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.018
Slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.015
Gpi glucose phosphate isomerase 0.015
Tpi1 triosephosphate isomerase 1 0.014
Usp9x ubiquitin specific peptidase 9, X-linked 0.012
Aco2 aconitase 2, mitochondrial 0.012
Vdac2 voltage-dependent anion channel 2 0.011
Ldha lactate dehydrogenase A 0.011
Dctn3 dynactin 3 0.010
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPO26 Rpo26p 0.025
CDC6 Cdc6p 0.018
MCM6 Mcm6p 0.018
GBP2 Gbp2p 0.017
RPB11 Rpb11p 0.016
RPB7 Rpb7p 0.015
SPT5 Spt5p 0.014
MCM4 Mcm4p 0.014
MCM10 Mcm10p 0.014
CKS1 Cks1p 0.013
RPB10 Rpb10p 0.013
RAD53 Rad53p 0.012
MCM7 Mcm7p 0.012
MPT5 Mpt5p 0.012
CDC16 Cdc16p 0.011
THO2 Tho2p 0.011
MCM5 Mcm5p 0.010