The network for 'positive regulation of acute inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of acute inflammatory response

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.

Homo sapiens
Name Description Probability Func Analog Organism
IL8 interleukin 8 1.000
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.000
PLAUR plasminogen activator, urokinase receptor 0.999
CXCL2 chemokine (C-X-C motif) ligand 2 0.997
IL1B interleukin 1, beta 0.991
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.988
SYK spleen tyrosine kinase 0.988
CCL2 chemokine (C-C motif) ligand 2 0.976
CCR5 chemokine (C-C motif) receptor 5 0.970
CXCL3 chemokine (C-X-C motif) ligand 3 0.963
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.959
IL1R1 interleukin 1 receptor, type I 0.959
IL6 interleukin 6 (interferon, beta 2) 0.959
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.921
CCL20 chemokine (C-C motif) ligand 20 0.822
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.731
ICAM1 intercellular adhesion molecule 1 0.708
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.706
CCL4 chemokine (C-C motif) ligand 4 0.673
BCL2A1 BCL2-related protein A1 0.635
SRGN serglycin 0.610
IL1RN interleukin 1 receptor antagonist 0.585
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.576
IL1RAP interleukin 1 receptor accessory protein 0.512
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.508
CFH complement factor H 0.448
PLEK pleckstrin 0.446
IER3 immediate early response 3 0.401
CCR1 chemokine (C-C motif) receptor 1 0.325
MET met proto-oncogene (hepatocyte growth factor receptor) 0.324
PTX3 pentraxin 3, long 0.315
CFI complement factor I 0.310
IL6R interleukin 6 receptor 0.299
VSIG4 V-set and immunoglobulin domain containing 4 0.299
CCL8 chemokine (C-C motif) ligand 8 0.257
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.251
IL7R interleukin 7 receptor 0.238
APOH apolipoprotein H (beta-2-glycoprotein I) 0.232
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.226
TLR2 toll-like receptor 2 0.217
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.209
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.202
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.193
C1S complement component 1, s subcomponent 0.180
SLA Src-like-adaptor 0.177
CD163 CD163 molecule 0.173
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.169
CXCL5 chemokine (C-X-C motif) ligand 5 0.167
BLNK B-cell linker 0.167
CFB complement factor B 0.166
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.162
CXCL10 chemokine (C-X-C motif) ligand 10 0.162
C3AR1 complement component 3a receptor 1 0.162
OSMR oncostatin M receptor 0.139
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.135
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.134
BBS10 Bardet-Biedl syndrome 10 0.128
SOD2 superoxide dismutase 2, mitochondrial 0.120
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.119
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.119
INHBA inhibin, beta A 0.119
F13A1 coagulation factor XIII, A1 polypeptide 0.117
S100A8 S100 calcium binding protein A8 0.116
TREM1 triggering receptor expressed on myeloid cells 1 0.115
TYROBP TYRO protein tyrosine kinase binding protein 0.113
CD53 CD53 molecule 0.106
ZC3H12A zinc finger CCCH-type containing 12A 0.106
RNASE6 ribonuclease, RNase A family, k6 0.101
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.099
UBASH3B ubiquitin associated and SH3 domain containing B 0.097
RGS1 regulator of G-protein signaling 1 0.096
NNMT nicotinamide N-methyltransferase 0.095
CSF1R colony stimulating factor 1 receptor 0.094
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.094
S100A9 S100 calcium binding protein A9 0.091
KNG1 kininogen 1 0.091
LMO4 LIM domain only 4 0.090
C1orf93 chromosome 1 open reading frame 93 0.089
DPP4 dipeptidyl-peptidase 4 0.088
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.088
CD83 CD83 molecule 0.088
RGS2 regulator of G-protein signaling 2, 24kDa 0.087
CXCR4 chemokine (C-X-C motif) receptor 4 0.085
HCK hemopoietic cell kinase 0.084
CXCL9 chemokine (C-X-C motif) ligand 9 0.082
THBS1 thrombospondin 1 0.081
TRAF5 TNF receptor-associated factor 5 0.080
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.074
TNC tenascin C 0.070
GEM GTP binding protein overexpressed in skeletal muscle 0.070
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.068
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.067
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.066
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.066
CCL7 chemokine (C-C motif) ligand 7 0.063
SELE selectin E 0.062
AQP9 aquaporin 9 0.062
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.061
C5AR1 complement component 5a receptor 1 0.061
TFPI2 tissue factor pathway inhibitor 2 0.060
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.991
Tnf tumor necrosis factor 0.977
Cd44 CD44 antigen 0.934
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.882
Ccl2 chemokine (C-C motif) ligand 2 0.859
Il4 interleukin 4 0.772
Ifng interferon gamma 0.746
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.742
Ptgs2 prostaglandin-endoperoxide synthase 2 0.662
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.627
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.626
Il1b interleukin 1 beta 0.585
Ccr1 chemokine (C-C motif) receptor 1 0.508
Apoe apolipoprotein E 0.489
Ccr2 chemokine (C-C motif) receptor 2 0.487
Cd40 CD40 antigen 0.426
Cxcl13 chemokine (C-X-C motif) ligand 13 0.418
Il1r1 interleukin 1 receptor, type I 0.395
Cd19 CD19 antigen 0.382
Tlr4 toll-like receptor 4 0.382
Icos inducible T-cell co-stimulator 0.366
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.363
Ptprc protein tyrosine phosphatase, receptor type, C 0.361
Xcr1 chemokine (C motif) receptor 1 0.343
Nos2 nitric oxide synthase 2, inducible 0.339
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.333
Lta lymphotoxin A 0.298
Selp selectin, platelet 0.289
Mmp9 matrix metallopeptidase 9 0.286
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.284
Ccr6 chemokine (C-C motif) receptor 6 0.282
Il10 interleukin 10 0.254
Gpr132 G protein-coupled receptor 132 0.246
Igh immunoglobulin heavy chain complex 0.245
Lyz2 lysozyme 2 0.216
Myd88 myeloid differentiation primary response gene 88 0.216
Spp1 secreted phosphoprotein 1 0.175
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.174
Ifngr1 interferon gamma receptor 1 0.149
Il6 interleukin 6 0.145
Tlr2 toll-like receptor 2 0.142
Il2rg interleukin 2 receptor, gamma chain 0.140
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.136
C3ar1 complement component 3a receptor 1 0.128
Il1a interleukin 1 alpha 0.126
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.126
Cxcr5 chemokine (C-X-C motif) receptor 5 0.125
Ccl3 chemokine (C-C motif) ligand 3 0.125
Ccl4 chemokine (C-C motif) ligand 4 0.123
C5ar1 complement component 5a receptor 1 0.121
Pdcd1 programmed cell death 1 0.118
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.116
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.115
Ccr5 chemokine (C-C motif) receptor 5 0.115
Slpi secretory leukocyte peptidase inhibitor 0.109
Stat3 signal transducer and activator of transcription 3 0.101
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.100
Ltb lymphotoxin B 0.090
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.089
Il7 interleukin 7 0.089
Ccr3 chemokine (C-C motif) receptor 3 0.089
Plau plasminogen activator, urokinase 0.087
Ch25h cholesterol 25-hydroxylase 0.083
Irg1 immunoresponsive gene 1 0.081
Cxcr2 chemokine (C-X-C motif) receptor 2 0.081
Ubd ubiquitin D 0.075
Art2a-ps ADP-ribosyltransferase 2a, pseudogene 0.074
Tgm2 transglutaminase 2, C polypeptide 0.074
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.074
Cd28 CD28 antigen 0.073
C3 complement component 3 0.072
Il1rn interleukin 1 receptor antagonist 0.072
Casp1 caspase 1 0.069
Icam1 intercellular adhesion molecule 1 0.069
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.065
Fasl Fas ligand (TNF superfamily, member 6) 0.063
Il27ra interleukin 27 receptor, alpha 0.062
Mefv Mediterranean fever 0.061
Efna1 ephrin A1 0.061
Blk B lymphoid kinase 0.061
Cst7 cystatin F (leukocystatin) 0.060
Fas Fas (TNF receptor superfamily member 6) 0.057
Gzmk granzyme K 0.056
Lck lymphocyte protein tyrosine kinase 0.056
Ccl8 chemokine (C-C motif) ligand 8 0.056
Cxcl10 chemokine (C-X-C motif) ligand 10 0.055
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.055
Osmr oncostatin M receptor 0.055
Mcpt8 mast cell protease 8 0.054
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.053
Cxcl2 chemokine (C-X-C motif) ligand 2 0.052
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.052
Cr2 complement receptor 2 0.051
Ccl12 chemokine (C-C motif) ligand 12 0.050
Folr2 folate receptor 2 (fetal) 0.050
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.050
Mpl myeloproliferative leukemia virus oncogene 0.049
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.049
Bcl3 B-cell leukemia/lymphoma 3 0.048
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.030
Ccl2 chemokine (C-C motif) ligand 2 0.021
Cd14 CD14 molecule 0.019
Il6 interleukin 6 0.013
Ccl3 chemokine (C-C motif) ligand 3 0.012
Cxcl2 chemokine (C-X-C motif) ligand 2 0.011
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism