IMP
Process View
The network for 'non canonical wnt signaling pathway via mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
non canonical wnt signaling pathway via mapk cascade
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| DVL1 | dishevelled, dsh homolog 1 (Drosophila) | 1.000 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.997 | |
| ZNF512B | zinc finger protein 512B | 0.992 | |
| CEP164 | centrosomal protein 164kDa | 0.967 | |
| CSNK1E | casein kinase 1, epsilon | 0.938 | |
| WNT3A | wingless-type MMTV integration site family, member 3A | 0.915 | |
| WT1 | Wilms tumor 1 | 0.911 | |
| FZD1 | frizzled homolog 1 (Drosophila) | 0.910 | |
| LRRK2 | leucine-rich repeat kinase 2 | 0.900 | |
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 0.873 | |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | 0.778 | |
| SFRP1 | secreted frizzled-related protein 1 | 0.753 | |
| PIK3CB | phosphoinositide-3-kinase, catalytic, beta polypeptide | 0.721 | |
| FGF18 | fibroblast growth factor 18 | 0.712 | |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.699 | |
| NDP | Norrie disease (pseudoglioma) | 0.489 | |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.447 | |
| GDF10 | growth differentiation factor 10 | 0.280 | |
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.274 | |
| WIF1 | WNT inhibitory factor 1 | 0.265 | |
| BMP4 | bone morphogenetic protein 4 | 0.264 | |
| MMP11 | matrix metallopeptidase 11 (stromelysin 3) | 0.251 | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.232 | |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.230 | |
| PRPF3 | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.224 | |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.194 | |
| AXIN1 | axin 1 | 0.187 | |
| IHH | Indian hedgehog | 0.186 | |
| WNT11 | wingless-type MMTV integration site family, member 11 | 0.183 | |
| FOXF2 | forkhead box F2 | 0.150 | |
| KLHL12 | kelch-like 12 (Drosophila) | 0.145 | |
| MXRA5 | matrix-remodelling associated 5 | 0.144 | |
| WNT3 | wingless-type MMTV integration site family, member 3 | 0.119 | |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.118 | |
| EHF | ets homologous factor | 0.113 | |
| BMP7 | bone morphogenetic protein 7 | 0.112 | |
| OGN | osteoglycin | 0.100 | |
| OMD | osteomodulin | 0.098 | |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.093 | |
| MFAP5 | microfibrillar associated protein 5 | 0.092 | |
| GPR124 | G protein-coupled receptor 124 | 0.090 | |
| FZD8 | frizzled homolog 8 (Drosophila) | 0.089 | |
| FBLN1 | fibulin 1 | 0.089 | |
| FZD10 | frizzled homolog 10 (Drosophila) | 0.083 | |
| BAHD1 | bromo adjacent homology domain containing 1 | 0.079 | |
| PITX1 | paired-like homeodomain 1 | 0.078 | |
| ROR2 | receptor tyrosine kinase-like orphan receptor 2 | 0.078 | |
| SOX21 | SRY (sex determining region Y)-box 21 | 0.078 | |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.077 | |
| FGF4 | fibroblast growth factor 4 | 0.076 | |
| C7orf36 | chromosome 7 open reading frame 36 | 0.076 | |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | 0.076 | |
| MYST2 | MYST histone acetyltransferase 2 | 0.072 | |
| SMAD1 | SMAD family member 1 | 0.064 | |
| CSNK1D | casein kinase 1, delta | 0.064 | |
| EPHB3 | EPH receptor B3 | 0.062 | |
| CCDC92 | coiled-coil domain containing 92 | 0.061 | |
| WNT7A | wingless-type MMTV integration site family, member 7A | 0.061 | |
| ITIH5 | inter-alpha (globulin) inhibitor H5 | 0.060 | |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.060 | |
| TNFAIP8L1 | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.060 | |
| NKAP | NFKB activating protein | 0.058 | |
| THBS2 | thrombospondin 2 | 0.057 | |
| PLXDC1 | plexin domain containing 1 | 0.056 | |
| PRRX2 | paired related homeobox 2 | 0.055 | |
| WNT10A | wingless-type MMTV integration site family, member 10A | 0.055 | |
| FOXF1 | forkhead box F1 | 0.055 | |
| EPHB2 | EPH receptor B2 | 0.054 | |
| SFRP4 | secreted frizzled-related protein 4 | 0.054 | |
| CACNA1G | calcium channel, voltage-dependent, T type, alpha 1G subunit | 0.054 | |
| FZD7 | frizzled homolog 7 (Drosophila) | 0.054 | |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.054 | |
| HS3ST6 | heparan sulfate (glucosamine) 3-O-sulfotransferase 6 | 0.053 | |
| GRP | gastrin-releasing peptide | 0.052 | |
| AQP5 | aquaporin 5 | 0.052 | |
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.052 | |
| PRPH | peripherin | 0.051 | |
| LRRC17 | leucine rich repeat containing 17 | 0.051 | |
| WNT6 | wingless-type MMTV integration site family, member 6 | 0.050 | |
| TNMD | tenomodulin | 0.048 | |
| LBX1 | ladybird homeobox 1 | 0.047 | |
| HMX1 | H6 family homeobox 1 | 0.047 | |
| HOXD11 | homeobox D11 | 0.046 | |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 0.045 | |
| AXIN2 | axin 2 | 0.045 | |
| OLFML1 | olfactomedin-like 1 | 0.045 | |
| ITGA8 | integrin, alpha 8 | 0.045 | |
| WNT5B | wingless-type MMTV integration site family, member 5B | 0.045 | |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.044 | |
| JAG1 | jagged 1 | 0.044 | |
| GPC4 | glypican 4 | 0.043 | |
| INHBB | inhibin, beta B | 0.043 | |
| KCNK9 | potassium channel, subfamily K, member 9 | 0.043 | |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.042 | |
| USH1G | Usher syndrome 1G (autosomal recessive) | 0.042 | |
| GUCA2A | guanylate cyclase activator 2A (guanylin) | 0.042 | |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.041 | |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.041 | |
| PDGFC | platelet derived growth factor C | 0.041 | |
| OCA2 | oculocutaneous albinism II | 0.041 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Dvl2 | dishevelled 2, dsh homolog (Drosophila) | 1.000 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 1.000 | |
| Dvl3 | dishevelled 3, dsh homolog (Drosophila) | 1.000 | |
| Vangl1 | vang-like 1 (van gogh, Drosophila) | 1.000 | |
| Dvl1 | dishevelled, dsh homolog 1 (Drosophila) | 0.995 | |
| Smurf2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.829 | |
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.825 | |
| Dact1 | dapper homolog 1, antagonist of beta-catenin (xenopus) | 0.814 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.793 | |
| Pax2 | paired box gene 2 | 0.671 | |
| Fgf8 | fibroblast growth factor 8 | 0.593 | |
| T | brachyury | 0.578 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.521 | |
| Pcsk5 | proprotein convertase subtilisin/kexin type 5 | 0.510 | |
| Efna4 | ephrin A4 | 0.445 | |
| Lhx1 | LIM homeobox protein 1 | 0.435 | |
| Tbx2 | T-box 2 | 0.396 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.339 | |
| Pvrl1 | poliovirus receptor-related 1 | 0.323 | |
| Wnt10b | wingless related MMTV integration site 10b | 0.300 | |
| Pax8 | paired box gene 8 | 0.288 | |
| Fgf18 | fibroblast growth factor 18 | 0.258 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.258 | |
| Vax1 | ventral anterior homeobox containing gene 1 | 0.254 | |
| Dact3 | dapper homolog 3, antagonist of beta-catenin (xenopus) | 0.251 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.210 | |
| Pax1 | paired box gene 1 | 0.200 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.198 | |
| Nkd1 | naked cuticle 1 homolog (Drosophila) | 0.197 | |
| Ret | ret proto-oncogene | 0.183 | |
| Amh | anti-Mullerian hormone | 0.178 | |
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.157 | |
| Axin2 | axin2 | 0.155 | |
| Bmp7 | bone morphogenetic protein 7 | 0.155 | |
| Fzd8 | frizzled homolog 8 (Drosophila) | 0.153 | |
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.138 | |
| Gli1 | GLI-Kruppel family member GLI1 | 0.132 | |
| Rarg | retinoic acid receptor, gamma | 0.129 | |
| Hoxa13 | homeobox A13 | 0.128 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.116 | |
| Foxf1a | forkhead box F1a | 0.116 | |
| Npas1 | neuronal PAS domain protein 1 | 0.115 | |
| Hoxc9 | homeobox C9 | 0.114 | |
| Clic3 | chloride intracellular channel 3 | 0.113 | |
| Grin2d | glutamate receptor, ionotropic, NMDA2D (epsilon 4) | 0.113 | |
| Wnt1 | wingless-related MMTV integration site 1 | 0.104 | |
| Rspo1 | R-spondin homolog (Xenopus laevis) | 0.103 | |
| P2rx6 | purinergic receptor P2X, ligand-gated ion channel, 6 | 0.102 | |
| Tead3 | TEA domain family member 3 | 0.100 | |
| Ntn3 | netrin 3 | 0.099 | |
| Fgfr4 | fibroblast growth factor receptor 4 | 0.097 | |
| Wnt7a | wingless-related MMTV integration site 7A | 0.095 | |
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.094 | |
| Sema6a | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.092 | |
| Barx2 | BarH-like homeobox 2 | 0.092 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.092 | |
| Tctex1d4 | Tctex1 domain containing 4 | 0.089 | |
| Wnt9a | wingless-type MMTV integration site 9A | 0.087 | |
| Sult5a1 | sulfotransferase family 5A, member 1 | 0.085 | |
| Barx1 | BarH-like homeobox 1 | 0.085 | |
| Col13a1 | collagen, type XIII, alpha 1 | 0.085 | |
| Emid2 | EMI domain containing 2 | 0.083 | |
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 0.082 | |
| Sim2 | single-minded homolog 2 (Drosophila) | 0.081 | |
| Kcnj4 | potassium inwardly-rectifying channel, subfamily J, member 4 | 0.080 | |
| Fzd10 | frizzled homolog 10 (Drosophila) | 0.080 | |
| Krt15 | keratin 15 | 0.080 | |
| Bik | BCL2-interacting killer | 0.079 | |
| Des | desmin | 0.077 | |
| Zbtb7c | zinc finger and BTB domain containing 7C | 0.077 | |
| Jph2 | junctophilin 2 | 0.073 | |
| Mesp1 | mesoderm posterior 1 | 0.073 | |
| Fgf10 | fibroblast growth factor 10 | 0.072 | |
| Tbx3 | T-box 3 | 0.070 | |
| Foxd2 | forkhead box D2 | 0.069 | |
| Axin1 | axin 1 | 0.069 | |
| Hoxd11 | homeobox D11 | 0.069 | |
| Nkd2 | naked cuticle 2 homolog (Drosophila) | 0.068 | |
| Scube1 | signal peptide, CUB domain, EGF-like 1 | 0.068 | |
| Hoxa2 | homeobox A2 | 0.065 | |
| Epha1 | Eph receptor A1 | 0.065 | |
| Gja5 | gap junction protein, alpha 5 | 0.065 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.065 | |
| Hoxb1 | homeobox B1 | 0.064 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.063 | |
| Dlx4 | distal-less homeobox 4 | 0.062 | |
| Porcn | porcupine homolog (Drosophila) | 0.062 | |
| En1 | engrailed 1 | 0.061 | |
| Efna2 | ephrin A2 | 0.060 | |
| Slc34a2 | solute carrier family 34 (sodium phosphate), member 2 | 0.059 | |
| Irx4 | Iroquois related homeobox 4 (Drosophila) | 0.057 | |
| Fgf15 | fibroblast growth factor 15 | 0.057 | |
| Cdx1 | caudal type homeobox 1 | 0.057 | |
| Zfp651 | zinc finger protein 651 | 0.056 | |
| Ror1 | receptor tyrosine kinase-like orphan receptor 1 | 0.056 | |
| Gata6 | GATA binding protein 6 | 0.055 | |
| Rbpjl | recombination signal binding protein for immunoglobulin kappa J region-like | 0.055 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.055 | |
| Zfp771 | zinc finger protein 771 | 0.055 | |
| BC024139 | cDNA sequence BC024139 | 0.054 |