The network for 'secretory granule organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.

Mus musculus
Name Description Probability Func Analog Organism
Hps1 Hermansky-Pudlak syndrome 1 homolog (human) 0.971
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.760
Mitf microphthalmia-associated transcription factor 0.725
Gtf2a1 general transcription factor II A, 1 0.591
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.580
Ap3b1 adaptor-related protein complex 3, beta 1 subunit 0.565
Rab27a RAB27A, member RAS oncogene family 0.537
Hps6 Hermansky-Pudlak syndrome 6 0.403
Hps5 Hermansky-Pudlak syndrome 5 homolog (human) 0.400
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.390
Cno cappuccino 0.315
Taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.313
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.213
Sh3gl3 SH3-domain GRB2-like 3 0.185
Apoe apolipoprotein E 0.183
Slc24a5 solute carrier family 24, member 5 0.179
Amelx amelogenin X chromosome 0.177
Tyr tyrosinase 0.164
Fads2 fatty acid desaturase 2 0.152
Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 0.134
Npc1 Niemann Pick type C1 0.133
Myo5a myosin VA 0.131
a nonagouti 0.124
Tyrp1 tyrosinase-related protein 1 0.122
Uba2 ubiquitin-like modifier activating enzyme 2 0.112
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.112
Pou5f1 POU domain, class 5, transcription factor 1 0.111
Atf1 activating transcription factor 1 0.089
Pmel premelanosome protein 0.085
Mlph melanophilin 0.082
Lbr lamin B receptor 0.079
Hnrpll heterogeneous nuclear ribonucleoprotein L-like 0.074
Dek DEK oncogene (DNA binding) 0.067
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.063
Mta2 metastasis-associated gene family, member 2 0.063
Pldn pallidin 0.056
Btbd10 BTB (POZ) domain containing 10 0.051
Capza1 capping protein (actin filament) muscle Z-line, alpha 1 0.050
Dtnb dystrobrevin, beta 0.047
Smndc1 survival motor neuron domain containing 1 0.047
Agfg1 ArfGAP with FG repeats 1 0.045
Rab38 RAB38, member of RAS oncogene family 0.044
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.043
Oca2 oculocutaneous albinism II 0.042
Tinagl1 tubulointerstitial nephritis antigen-like 1 0.041
Zfp143 zinc finger protein 143 0.039
Hps3 Hermansky-Pudlak syndrome 3 homolog (human) 0.039
Sec23ip Sec23 interacting protein 0.039
Ptpn2 protein tyrosine phosphatase, non-receptor type 2 0.039
Nfya nuclear transcription factor-Y alpha 0.038
Pknox1 Pbx/knotted 1 homeobox 0.037
Fam49b family with sequence similarity 49, member B 0.036
Fam20a family with sequence similarity 20, member A 0.036
Lrp5 low density lipoprotein receptor-related protein 5 0.035
Eps15 epidermal growth factor receptor pathway substrate 15 0.035
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.034
Zfpm1 zinc finger protein, multitype 1 0.034
Gtf2b general transcription factor IIB 0.033
Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.032
Tnks1bp1 tankyrase 1 binding protein 1 0.031
Lsm14a LSM14 homolog A (SCD6, S. cerevisiae) 0.031
Gdap2 ganglioside-induced differentiation-associated-protein 2 0.030
Foxp4 forkhead box P4 0.029
Epha2 Eph receptor A2 0.029
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.028
Cyr61 cysteine rich protein 61 0.027
Cldn3 claudin 3 0.027
Ifrd1 interferon-related developmental regulator 1 0.026
Procr protein C receptor, endothelial 0.025
Ptgs2 prostaglandin-endoperoxide synthase 2 0.025
Lrp1 low density lipoprotein receptor-related protein 1 0.025
Api5 apoptosis inhibitor 5 0.024
Nras neuroblastoma ras oncogene 0.024
Clip1 CAP-GLY domain containing linker protein 1 0.024
Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 0.024
Max Max protein 0.023
Tbpl1 TATA box binding protein-like 1 0.023
Tmprss11e transmembrane protease, serine 11e 0.023
Sntb2 syntrophin, basic 2 0.023
Zfp131 zinc finger protein 131 0.023
Xiap X-linked inhibitor of apoptosis 0.023
Rnf2 ring finger protein 2 0.023
Muc1 mucin 1, transmembrane 0.023
Crebl2 cAMP responsive element binding protein-like 2 0.022
Taf5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.022
Kitl kit ligand 0.022
Lyst lysosomal trafficking regulator 0.022
Dtna dystrobrevin alpha 0.022
Epha1 Eph receptor A1 0.022
Rad17 RAD17 homolog (S. pombe) 0.021
S1pr1 sphingosine-1-phosphate receptor 1 0.021
Atf3 activating transcription factor 3 0.021
Elf3 E74-like factor 3 0.020
Ap3d1 adaptor-related protein complex 3, delta 1 subunit 0.020
Hbegf heparin-binding EGF-like growth factor 0.019
Samd4b sterile alpha motif domain containing 4B 0.019
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.019
Il2rg interleukin 2 receptor, gamma chain 0.019
Errfi1 ERBB receptor feedback inhibitor 1 0.019
Cebpg CCAAT/enhancer binding protein (C/EBP), gamma 0.018
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
AP-1gamma CG9113 gene product from transcript CG9113-RD 0.416
Vps16B Vacuolar protein sorting 16B 0.307
Tango1 Transport and Golgi organization 1 0.228
CG14568 CG14568 gene product from transcript CG14568-RA 0.142
GM130 CG11061 gene product from transcript CG11061-RB 0.071
beta'Cop beta'-coatomer protein 0.066
betaCop beta-coatomer protein 0.056
sec63 CG8583 gene product from transcript CG8583-RA 0.052
CG9132 CG9132 gene product from transcript CG9132-RA 0.039
sll slalom 0.038
CG30069 CG30069 gene product from transcript CG30069-RA 0.033
CG8683 CG8683 gene product from transcript CG8683-RB 0.031
Csat CG2675 gene product from transcript CG2675-RA 0.028
CG5850 CG5850 gene product from transcript CG5850-RC 0.025
Aats-thr Threonyl-tRNA synthetase 0.024
Gfat2 Glutamine:fructose-6-phosphate aminotransferase 2 0.022
pgant3 polypeptide GalNAc transferase 3 0.022
Cerk Ceramide kinase 0.017
CG10777 CG10777 gene product from transcript CG10777-RB 0.015
CG15099 CG15099 gene product from transcript CG15099-RA 0.013
rtet tetracycline resistance 0.013
pgant4 polypeptide GalNAc transferase 4 0.012
CG30463 CG30463 gene product from transcript CG30463-RB 0.012
Unc-76 CG3981 gene product from transcript CG3981-RB 0.012
CG10413 CG10413 gene product from transcript CG10413-RA 0.011
Eaf ELL-associated factor 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.568
VIPAR VPS33B interacting protein, apical-basolateral polarity regulator 0.386
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.271
CREBBP CREB binding protein 0.119
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.108
RAB14 RAB14, member RAS oncogene family 0.075
NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 0.068
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.047
OCRL oculocerebrorenal syndrome of Lowe 0.046
MTF1 metal-regulatory transcription factor 1 0.044
VCAN versican 0.040
STX12 syntaxin 12 0.037
LDOC1 leucine zipper, down-regulated in cancer 1 0.036
GATAD2B GATA zinc finger domain containing 2B 0.029
FXR2 fragile X mental retardation, autosomal homolog 2 0.028
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.024
NCOA3 nuclear receptor coactivator 3 0.023
CSNK1G2 casein kinase 1, gamma 2 0.022
CHD3 chromodomain helicase DNA binding protein 3 0.022
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.022
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.022
MAP2K4 mitogen-activated protein kinase kinase 4 0.020
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.020
KIAA2026 KIAA2026 0.019
APC adenomatous polyposis coli 0.019
CLINT1 clathrin interactor 1 0.019
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.019
CCDC6 coiled-coil domain containing 6 0.018
NCOA2 nuclear receptor coactivator 2 0.018
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.018
HSF1 heat shock transcription factor 1 0.018
RAB5A RAB5A, member RAS oncogene family 0.016
AP1B1 adaptor-related protein complex 1, beta 1 subunit 0.016
KAT2B K(lysine) acetyltransferase 2B 0.016
RNF111 ring finger protein 111 0.016
EP300 E1A binding protein p300 0.016
MTA3 metastasis associated 1 family, member 3 0.016
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.016
MTA2 metastasis associated 1 family, member 2 0.016
WAPAL wings apart-like homolog (Drosophila) 0.015
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.015
NCOA1 nuclear receptor coactivator 1 0.015
EPS15 epidermal growth factor receptor pathway substrate 15 0.014
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 0.014
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.014
GTF2B general transcription factor IIB 0.014
YTHDF3 YTH domain family, member 3 0.014
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.013
FCHO2 FCH domain only 2 0.013
EGLN3 egl nine homolog 3 (C. elegans) 0.012
FOXO1 forkhead box O1 0.012
UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.011
PVRL4 poliovirus receptor-related 4 0.011
RAB35 RAB35, member RAS oncogene family 0.011
SYNRG synergin, gamma 0.011
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.011
GATAD2A GATA zinc finger domain containing 2A 0.011
TRIP12 thyroid hormone receptor interactor 12 0.011
NFYA nuclear transcription factor Y, alpha 0.011
MBD3 methyl-CpG binding domain protein 3 0.011
KDM1A lysine (K)-specific demethylase 1A 0.011
SS18 synovial sarcoma translocation, chromosome 18 0.011
HIPK3 homeodomain interacting protein kinase 3 0.010
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.010
NCOA6 nuclear receptor coactivator 6 0.010
SP1 Sp1 transcription factor 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism