The network for 'negative regulation of nucleic acid templated transcription' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nucleic acid templated transcription

Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.

Rattus norvegicus
Name Description Probability Func Analog Organism
Jun Jun oncogene 0.956
Dusp1 dual specificity phosphatase 1 0.825
Junb jun B proto-oncogene 0.824
Fos FBJ osteosarcoma oncogene 0.811
Nfib nuclear factor I/B 0.739
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.546
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.544
Ahr aryl hydrocarbon receptor 0.471
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.407
Adra2b adrenergic, alpha-2B-, receptor 0.399
Rhob ras homolog gene family, member B 0.397
Pcna proliferating cell nuclear antigen 0.396
Hes1 hairy and enhancer of split 1 (Drosophila) 0.396
Btg2 BTG family, member 2 0.394
Tcf4 transcription factor 4 0.375
Hoxc4 homeo box C4 0.359
Vim vimentin 0.355
Pgam1 phosphoglycerate mutase 1 (brain) 0.323
Eif4h eukaryotic translation initiation factor 4H 0.317
Ier2 immediate early response 2 0.315
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.313
Nfya nuclear transcription factor-Y alpha 0.305
Hand2 heart and neural crest derivatives expressed 2 0.301
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.300
Dusp6 dual specificity phosphatase 6 0.300
Hoxb7 homeo box B7 0.294
Klf2 Kruppel-like factor 2 (lung) 0.290
Shox2 short stature homeobox 2 0.277
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.270
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.266
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.260
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.259
Id1 inhibitor of DNA binding 1 0.245
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.240
Alx1 ALX homeobox 1 0.240
Sp1 Sp1 transcription factor 0.233
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.233
Klf6 Kruppel-like factor 6 0.232
Otx1 orthodenticle homeobox 1 0.231
Pde4b phosphodiesterase 4B, cAMP specific 0.231
Taok1 TAO kinase 1 0.231
Purb purine rich element binding protein B 0.230
Stat6 signal transducer and activator of transcription 6 0.230
Tgfbr2 transforming growth factor, beta receptor II 0.229
Shh sonic hedgehog 0.222
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.221
Smad7 SMAD family member 7 0.218
Tcfe2a transcription factor E2a 0.216
Myc myelocytomatosis oncogene 0.214
S100a8 S100 calcium binding protein A8 0.211
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.207
Fzd2 frizzled homolog 2 (Drosophila) 0.206
Dynll1 dynein light chain LC8-type 1 0.202
S100a9 S100 calcium binding protein A9 0.199
Hoxd3 homeo box D3 0.197
Trim28 tripartite motif-containing 28 0.196
Hist1h1d histone cluster 1, H1d 0.196
Met met proto-oncogene 0.192
Palm paralemmin 0.191
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.190
Tulp1 tubby like protein 1 0.189
Grk1 G protein-coupled receptor kinase 1 0.188
Anxa2 annexin A2 0.186
Kdm6b lysine (K)-specific demethylase 6B 0.186
Gse1 genetic suppressor element 1 0.184
Errfi1 ERBB receptor feedback inhibitor 1 0.183
Asgr1 asialoglycoprotein receptor 1 0.180
Wbp11 WW domain binding protein 11 0.178
Neurog1 neurogenin 1 0.177
Smad6 SMAD family member 6 0.177
Rap1b RAP1B, member of RAS oncogene family 0.175
Siah1a seven in absentia 1A 0.174
Crybb3 crystallin, beta B3 0.171
Dgkz diacylglycerol kinase zeta 0.171
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.171
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.169
Gast gastrin 0.168
Vax2 ventral anterior homeobox 2 0.165
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.162
Cd9 CD9 molecule 0.160
Atf3 activating transcription factor 3 0.158
Cdc42 cell division cycle 42 (GTP binding protein) 0.156
Megf10 multiple EGF-like domains 10 0.154
Uts2r urotensin 2 receptor 0.151
Dlg4 discs, large homolog 4 (Drosophila) 0.151
Dbp D site of albumin promoter (albumin D-box) binding protein 0.150
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.149
A4galt alpha 1,4-galactosyltransferase 0.148
Bmp7 bone morphogenetic protein 7 0.144
Homer3 homer homolog 3 (Drosophila) 0.144
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.142
Cyss cystatin S 0.142
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.140
Gata3 GATA binding protein 3 0.138
Stip1 stress-induced phosphoprotein 1 0.136
Foxd1 forkhead box D1 0.136
Nrp1 neuropilin 1 0.135
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.135
S100a10 S100 calcium binding protein A10 0.134
Cd63 Cd63 molecule 0.134
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.956
pha-4 Protein PHA-4 0.725
his-1 Protein HIS-1 0.586
his-16 Protein HIS-16 0.570
elt-6 Protein ELT-6 0.507
his-64 Protein HIS-64 0.497
his-61 Protein HIS-61 0.451
let-502 Protein LET-502 0.415
mes-4 Protein MES-4 0.394
ceh-27 Protein CEH-27 0.345
F39B2.1 Protein F39B2.1 0.329
nhr-67 Protein NHR-67 0.325
his-46 Protein HIS-46 0.317
egl-46 Protein EGL-46 0.306
let-418 Protein LET-418 0.277
atg-2 Protein ATG-2 0.264
vab-3 Protein VAB-3 0.264
mcm-2 Protein MCM-2 0.250
his-29 Protein HIS-29 0.215
his-3 Protein HIS-3 0.215
lmn-1 Protein LMN-1 0.208
his-45 Protein HIS-45 0.200
rnr-1 Protein RNR-1 0.198
lsy-2 Protein LSY-2 0.197
klp-19 Protein KLP-19 0.197
his-5 Protein HIS-5 0.196
daf-3 Protein DAF-3 0.193
his-38 Protein HIS-38 0.187
nhr-25 Protein NHR-25 0.186
his-42 Protein HIS-42 0.186
hcp-3 Protein HCP-3 0.184
mab-5 Protein MAB-5 0.180
prp-8 Protein PRP-8 0.176
mat-3 Protein MAT-3 0.174
nhr-2 Protein NHR-2 0.167
tbx-8 Protein TBX-8 0.166
his-30 Protein HIS-30 0.158
mcm-7 Protein MCM-7 0.156
lin-11 Protein LIN-11 0.155
egl-27 Protein EGL-27 0.150
ran-1 Protein RAN-1 0.149
unc-62 Protein UNC-62 0.147
hbl-1 Protein HBL-1 0.145
plc-1 Protein PLC-1 0.141
hlh-1 Protein HLH-1 0.140
attf-2 Protein ATTF-2 0.139
cdt-2 Protein CDT-2 0.138
hil-2 Protein HIL-2 0.138
cnd-1 Protein CND-1 0.136
mix-1 Protein MIX-1 0.135
his-51 Protein HIS-51 0.132
lin-17 Protein LIN-17 0.126
zyg-1 Protein ZYG-1 0.121
his-9 Protein HIS-9 0.120
lin-53 Protein LIN-53 0.119
hum-5 Protein HUM-5 0.115
his-62 Protein HIS-62 0.112
rad-26 Protein RAD-26 0.111
tag-319 Protein TAG-319 0.110
zip-7 Protein ZIP-7 0.110
cfim-2 Protein CFIM-2 0.109
his-68 Protein HIS-68 0.108
Y48E1A.1 Protein Y48E1A.1 0.104
lin-66 Protein LIN-66 0.103
egl-13 Protein EGL-13 0.103
ztf-2 Protein ZTF-2 0.102
his-63 Protein HIS-63 0.099
lin-12 Protein LIN-12 0.098
CELE_C24H12.5 Protein C24H12.5 0.098
aph-2 Protein APH-2 0.098
his-31 Protein HIS-31 0.097
mtk-1 Protein MTK-1 0.097
top-2 Protein TOP-2 0.097
sna-2 Protein SNA-2 0.096
F46G10.2 Protein F46G10.2 0.096
his-72 Protein HIS-72 0.095
set-2 Protein SET-2 0.094
daf-1 Protein DAF-1 0.094
swsn-4 Protein SWSN-4 0.093
mcm-5 Protein MCM-5 0.091
cdl-1 Protein CDL-1 0.089
sur-2 Protein SUR-2 0.089
unc-42 Protein UNC-42 0.089
egl-38 Protein EGL-38 0.087
Y65A5A.1 Protein Y65A5A.1 0.087
acs-4 Protein ACS-4 0.087
daf-4 Protein DAF-4 0.085
hlh-2 Protein HLH-2 0.085
mec-3 Protein MEC-3 0.085
his-15 Protein HIS-15 0.084
npp-22 Protein NPP-22 0.084
his-52 Protein HIS-52 0.083
lin-29 Protein LIN-29 0.082
dcr-1 Protein DCR-1 0.082
F42G9.1 Protein F42G9.1 0.082
mep-1 Protein MEP-1 0.081
cpf-2 Protein CPF-2 0.081
CELE_F19F10.9 Protein F19F10.9 0.081
mom-2 Protein MOM-2 0.080
hlh-11 Protein HLH-11 0.079
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Danio rerio
Name Description Probability Func Analog Organism
jag2 jagged 2 0.832
dlx2a distal-less homeobox gene 2a 0.806
ndr2 nodal-related 2 0.758
gata6 GATA-binding protein 6 0.701
chd chordin 0.691
gli1 GLI-Kruppel family member 1 0.673
snai1b snail homolog 1b (Drosophila) 0.663
foxa3 forkhead box A3 0.645
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.598
wnt5b wingless-type MMTV integration site family, member 5b 0.544
pcna proliferating cell nuclear antigen 0.518
twist3 twist3 0.504
otx1b orthodenticle homolog 1b 0.483
pitx2 paired-like homeodomain transcription factor 2 0.477
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.431
nkx2.5 NK2 transcription factor related 5 0.405
mab21l2 mab-21-like 2 0.396
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.385
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.380
dlx5a distal-less homeobox gene 5a 0.372
vsx2 visual system homeobox 2 0.358
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.357
vsx1 visual system homeobox 1 homolog, chx10-like 0.345
hoxc4a homeo box C4a 0.341
sox10 SRY-box containing gene 10 0.326
sox19a SRY-box containing gene 19a 0.318
snai1a snail homolog 1a (Drosophila) 0.316
ascl1a achaete-scute complex-like 1a (Drosophila) 0.297
lhx5 LIM homeobox 5 0.292
her1 hairy-related 1 0.288
gro1 groucho 1 0.284
hmx1 H6 homeo box 1 0.281
bmp4 bone morphogenetic protein 4 0.276
sox9b SRY-box containing gene 9b 0.272
wnt1 wingless-type MMTV integration site family, member 1 0.272
pax8 paired box gene 8 0.270
rx3 retinal homeobox gene 3 0.253
tbx6 T-box gene 6 0.252
gpia glucose phosphate isomerase a 0.251
lhx1a LIM homeobox 1a 0.242
flh floating head 0.241
ripply1 ripply1 0.240
fgf3 fibroblast growth factor 3 0.239
ptf1a pancreas specific transcription factor, 1a 0.235
gsc goosecoid 0.235
hoxb1b homeo box B1b 0.232
bmp2b bone morphogenetic protein 2b 0.223
ef1a elongation factor 1-alpha 0.221
pax6a paired box gene 6a 0.217
tll1 tolloid-like 1 0.215
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.211
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.208
dct dopachrome tautomerase 0.207
her15.1 hairy and enhancer of split-related 15.1 0.206
hp1bp3 heterochromatin protein 1, binding protein 3 0.205
spaw southpaw 0.199
alcama activated leukocyte cell adhesion molecule a 0.198
sesn1 sestrin 1 0.192
dusp6 dual specificity phosphatase 6 0.190
msxc muscle segment homeobox C 0.187
dlx3b distal-less homeobox gene 3b 0.183
gbx2 gastrulation brain homeo box 2 0.179
nkx2.1b NK2 homeobox 1b 0.178
eomesa eomesodermin homolog a 0.178
meis2.1 myeloid ecotropic viral integration site 2.1 0.175
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.175
fgf19 fibroblast growth factor 19 0.172
esr2a estrogen receptor 2a 0.172
axin2 axin 2 (conductin, axil) 0.167
msgn1 mesogenin 1 0.166
thrb thyroid hormone receptor beta 0.166
nog2 noggin 2 0.166
dlc deltaC 0.165
evx1 even-skipped homeobox 1 0.165
eng1a engrailed 1a 0.162
prdm14 PR domain containing 14 0.159
meis3 myeloid ecotropic viral integration site 3 0.157
hnf1ba HNF1 homeobox Ba 0.156
pnx posterior neuron-specific homeobox 0.154
per2 period homolog 2 (Drosophila) 0.154
satb2 SATB homeobox 2 0.152
foxp1b forkhead box P1b 0.152
ola1 Obg-like ATPase 1 0.152
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.145
dkk1b dickkopf 1b 0.143
wt1a wilms tumor 1a 0.139
plagl2 pleiomorphic adenoma gene-like 2 0.138
fzd8a frizzled homolog 8a 0.137
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.134
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.133
wif1 wnt inhibitory factor 1 0.130
pou1f1 POU domain, class 1, transcription factor 1 0.130
gcm2 glial cells missing homolog 2 (Drosophila) 0.129
rxrbb retinoid x receptor, beta b 0.129
kctd15a potassium channel tetramerisation domain containing 15a 0.128
sp7 Sp7 transcription factor 0.127
emx1 empty spiracles homeobox 1 0.127
dld deltaD 0.127
shha sonic hedgehog a 0.124
tbx16 T-box gene 16 0.123
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Snr1 Snf5-related 1 0.999
hep hemipterous 0.999
ci cubitus interruptus 0.998
Pcl Polycomblike 0.998
E(spl) Enhancer of split 0.998
E(z) Enhancer of zeste 0.996
CTCF CG8591 gene product from transcript CG8591-RA 0.988
gpp grappa 0.984
spen split ends 0.982
ato atonal 0.981
pan pangolin 0.978
phyl phyllopod 0.973
Rpd3 CG7471 gene product from transcript CG7471-RA 0.971
Sir2 CG5216 gene product from transcript CG5216-RA 0.968
ash1 absent, small, or homeotic discs 1 0.960
gro groucho 0.958
N Notch 0.956
D1 D1 chromosomal protein 0.954
mirr mirror 0.952
dco discs overgrown 0.950
mam mastermind 0.948
gsb gooseberry 0.948
brk brinker 0.946
ss spineless 0.945
Scm Sex comb on midleg 0.945
Mad Mothers against dpp 0.939
mrn marionette 0.931
Iswi Imitation SWI 0.930
kay kayak 0.918
hth homothorax 0.916
smt3 CG4494 gene product from transcript CG4494-RA 0.915
wapl wings apart-like 0.911
Mob2 CG11711 gene product from transcript CG11711-RC 0.909
Pten CG5671 gene product from transcript CG5671-RB 0.900
trx trithorax 0.891
ara araucan 0.891
Kr-h1 Kruppel homolog 1 0.885
egg eggless 0.880
yki yorkie 0.879
crm cramped 0.878
Ubx Ultrabithorax 0.873
tll tailless 0.867
Taf1 TBP-associated factor 1 0.867
hb hunchback 0.863
pdm2 POU domain protein 2 0.850
tin tinman 0.848
hkb huckebein 0.847
shn schnurri 0.843
HLHmdelta E(spl) region transcript mdelta 0.842
esc extra sexcombs 0.839
eyg eyegone 0.836
osa CG7467 gene product from transcript CG7467-RD 0.834
Su(H) Suppressor of Hairless 0.831
lin lines 0.831
slp1 sloppy paired 1 0.826
pb proboscipedia 0.825
sna snail 0.817
Rga Regena 0.816
noc no ocelli 0.815
brat brain tumor 0.812
Antp Antennapedia 0.809
Jarid2 CG3654 gene product from transcript CG3654-RD 0.804
abd-A abdominal A 0.804
al aristaless 0.797
sxc super sex combs 0.794
sim single-minded 0.792
garz gartenzwerg 0.788
bowl brother of odd with entrails limited 0.787
Pc Polycomb 0.787
en engrailed 0.784
barr barren 0.780
sty sprouty 0.768
klu klumpfuss 0.762
sca scabrous 0.762
Src42A Src oncogene at 42A 0.760
Acf1 ATP-dependent chromatin assembly factor large subunit 0.760
ush u-shaped 0.749
kni knirps 0.734
Sce Sex combs extra 0.734
nub nubbin 0.733
Doc2 Dorsocross2 0.732
CtBP C-terminal Binding Protein 0.732
InR Insulin-like receptor 0.732
prd paired 0.723
Rbf Retinoblastoma-family protein 0.721
how held out wings 0.718
Tip60 CG6121 gene product from transcript CG6121-RA 0.717
ems empty spiracles 0.712
ecd ecdysoneless 0.710
SoxN SoxNeuro 0.708
os outstretched 0.707
nej nejire 0.705
Dref DNA replication-related element factor 0.705
opa odd paired 0.705
HLHmbeta E(spl) region transcript mbeta 0.702
Dp DP transcription factor 0.697
kn knot 0.695
nkd naked cuticle 0.694
E(var)3-9 Enhancer of variegation 3-9 0.691
esg escargot 0.677
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HHT1 Hht1p 0.996
RPD3 Rpd3p 0.995
RAP1 Rap1p 0.995
HHF1 Hhf1p 0.993
SIR2 Sir2p 0.989
RXT2 Rxt2p 0.967
RLF2 Rlf2p 0.964
HDA1 Hda1p 0.959
ISW2 Isw2p 0.956
SIN3 Sin3p 0.949
ORC2 Orc2p 0.944
SDS3 Sds3p 0.940
SUM1 Sum1p 0.935
SIR4 Sir4p 0.931
PHO23 Pho23p 0.931
SIN4 Sin4p 0.929
RCO1 Rco1p 0.918
SET1 Set1p 0.915
SET2 Set2p 0.905
SNF1 Snf1p 0.893
ORC5 Orc5p 0.887
RIM101 Rim101p 0.887
SIR3 Sir3p 0.879
EAF3 Eaf3p 0.879
CTI6 Cti6p 0.878
RIF1 Rif1p 0.867
FKH2 Fkh2p 0.856
RPN4 Rpn4p 0.848
HDA3 Hda3p 0.837
GAL11 Gal11p 0.822
SET3 Set3p 0.822
SSN3 Ssn3p 0.799
CYC8 Cyc8p 0.798
UBP8 Ubp8p 0.786
PAP2 Pap2p 0.785
HAT1 Hat1p 0.784
SPT21 Spt21p 0.783
RGR1 Rgr1p 0.755
PGD1 Pgd1p 0.747
HTZ1 Htz1p 0.743
DOA1 Doa1p 0.710
CDC6 Cdc6p 0.708
SLX5 Slx5p 0.705
SRP1 Srp1p 0.695
SAS2 Sas2p 0.690
CKA2 Cka2p 0.689
IFH1 Ifh1p 0.687
RTT106 Rtt106p 0.682
HMO1 Hmo1p 0.682
NHP6A Nhp6ap 0.676
ESA1 Esa1p 0.666
NAT1 Nat1p 0.662
GLN3 Gln3p 0.661
RSC4 Rsc4p 0.661
GCR2 Gcr2p 0.655
CSE2 Cse2p 0.648
SNT1 Snt1p 0.643
DEP1 Dep1p 0.638
MET4 Met4p 0.637
GCN5 Gcn5p 0.631
HOG1 Hog1p 0.628
STH1 Sth1p 0.620
ASF1 Asf1p 0.608
SPT16 Spt16p 0.603
SPT10 Spt10p 0.599
UME1 Ume1p 0.586
BMH2 Bmh2p 0.582
IZH4 Izh4p 0.579
IXR1 Ixr1p 0.564
CTF18 Ctf18p 0.553
MED2 Med2p 0.552
RIM20 Rim20p 0.550
FOB1 Fob1p 0.550
SWI4 Swi4p 0.543
HAA1 Haa1p 0.539
IES3 Ies3p 0.537
SCH9 Sch9p 0.532
HTB1 Htb1p 0.528
YSC84 Ysc84p 0.525
ROX3 Rox3p 0.520
REG1 Reg1p 0.515
ORC6 Orc6p 0.513
HIR1 Hir1p 0.511
ACT1 Act1p 0.489
CDC14 Cdc14p 0.489
NRG1 Nrg1p 0.477
YTA7 Yta7p 0.476
SAS4 Sas4p 0.473
PHO4 Pho4p 0.464
ADR1 Adr1p 0.464
YAK1 Yak1p 0.455
HAT2 Hat2p 0.453
HCM1 Hcm1p 0.452
MCM2 Mcm2p 0.450
FKH1 Fkh1p 0.450
SLX8 Slx8p 0.446
CTK1 Ctk1p 0.438
SNF5 Snf5p 0.435
HHF2 Hhf2p 0.435
BMH1 Bmh1p 0.429