The network for 'response to retinoic acid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to retinoic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.584
Col1a2 collagen, type I, alpha 2 0.555
Col1a1 collagen, type I, alpha 1 0.548
Col14a1 collagen, type XIV, alpha 1 0.453
Pitx3 paired-like homeodomain 3 0.351
Col12a1 collagen, type XII, alpha 1 0.350
Colec12 collectin sub-family member 12 0.236
Uox urate oxidase 0.200
Gata6 GATA binding protein 6 0.191
Foxo3 forkhead box O3 0.166
Sod3 superoxide dismutase 3, extracellular 0.162
Icam1 intercellular adhesion molecule 1 0.147
Fn1 fibronectin 1 0.145
Rara retinoic acid receptor, alpha 0.144
Bgn biglycan 0.141
Dusp4 dual specificity phosphatase 4 0.141
Defb4 defensin beta 4 0.138
Col5a1 collagen, type V, alpha 1 0.135
Igfals insulin-like growth factor binding protein, acid labile subunit 0.133
Scamp2 secretory carrier membrane protein 2 0.131
Cxcl3 chemokine (C-X-C motif) ligand 3 0.130
Gjb2 gap junction protein, beta 2 0.130
Cdx1 caudal type homeo box 1 0.127
Loxl1 lysyl oxidase-like 1 0.123
Foxd1 forkhead box D1 0.120
Hand2 heart and neural crest derivatives expressed 2 0.120
Postn periostin, osteoblast specific factor 0.116
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.115
Gna15 guanine nucleotide binding protein, alpha 15 0.115
Krt5 keratin 5 0.115
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.114
Foxe3 forkhead box E3 0.113
Fgfr2 fibroblast growth factor receptor 2 0.112
Oasl 2'-5'-oligoadenylate synthetase-like 0.109
Bmp7 bone morphogenetic protein 7 0.107
Hpn hepsin 0.106
Prl prolactin 0.106
Ptprh protein tyrosine phosphatase, receptor type, H 0.105
Cpxm2 carboxypeptidase X (M14 family), member 2 0.104
C1s complement component 1, s subcomponent 0.101
Slc6a20 solute carrier family 6 (proline IMINO transporter), member 20 0.101
Slc25a10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.100
Gas7 growth arrest specific 7 0.100
Aspg asparaginase homolog (S. cerevisiae) 0.099
Ucn urocortin 0.098
Chrm1 cholinergic receptor, muscarinic 1 0.097
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.097
Uts2r urotensin 2 receptor 0.096
Foxa3 forkhead box A3 0.095
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.094
Eln elastin 0.093
Gabre gamma-aminobutyric acid (GABA) A receptor, epsilon 0.089
Pla2g2c phospholipase A2, group IIC 0.089
Rt1.aa MHC class I RT1.Aa alpha-chain 0.088
Megf6 multiple EGF-like-domains 6 0.088
Csf3 colony stimulating factor 3 (granulocyte) 0.087
Fgf17 fibroblast growth factor 17 0.085
Il8ra interleukin 8 receptor, alpha 0.082
Klf2 Kruppel-like factor 2 (lung) 0.082
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.080
Bmp1 bone morphogenetic protein 1 0.080
LOC498222 similar to specifically androgen-regulated protein 0.080
Tmem176b transmembrane protein 176B 0.077
Pgcp plasma glutamate carboxypeptidase 0.077
Gpr182 G protein-coupled receptor 182 0.077
Plau plasminogen activator, urokinase 0.076
Prrx2 paired related homeobox 2 0.075
Crygd crystallin, gamma D 0.075
Ttc36 tetratricopeptide repeat domain 36 0.073
Evpl envoplakin 0.072
Isg15 ISG15 ubiquitin-like modifier 0.071
Kcna6 potassium voltage gated channel, shaker related subfamily, member 6 0.071
Ccl7 chemokine (C-C motif) ligand 7 0.071
C1qb complement component 1, q subcomponent, B chain 0.071
Calcb calcitonin-related polypeptide, beta 0.070
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.070
Mmp2 matrix metallopeptidase 2 0.070
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.069
Tgfbr2 transforming growth factor, beta receptor II 0.068
Igfbp1 insulin-like growth factor binding protein 1 0.067
Lect1 leukocyte cell derived chemotaxin 1 0.066
Megf10 multiple EGF-like domains 10 0.065
Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.065
Tulp1 tubby like protein 1 0.064
Msx1 msh homeobox 1 0.064
Il23a Interleukin 23, alpha subunit p19 0.064
Aebp1 AE binding protein 1 0.064
Unc5cl unc-5 homolog C (C. elegans)-like 0.064
Dchs1 dachsous 1 (Drosophila) 0.064
Gpx3 glutathione peroxidase 3 0.063
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.063
Defa defensin, alpha 5, Paneth cell-specific 0.063
Cnga3 cyclic nucleotide gated channel alpha 3 0.062
Rorb RAR-related orphan receptor B 0.062
Accn3 amiloride-sensitive cation channel 3 0.062
Sycn syncollin 0.062
Fstl1 follistatin-like 1 0.062
Gm2a GM2 ganglioside activator 0.061
S1pr2 sphingosine-1-phosphate receptor 2 0.061
Gata4 GATA binding protein 4 0.061
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.698
rarab retinoic acid receptor, alpha b 0.373
raraa retinoic acid receptor, alpha a 0.326
rxrga retinoid x receptor, gamma a 0.303
col5a1 procollagen, type V, alpha 1 0.295
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.164
sox11a SRY-box containing gene 11a 0.158
nkx2.5 NK2 transcription factor related 5 0.152
hnf1ba HNF1 homeobox Ba 0.151
hoxa3a homeo box A3a 0.121
her1 hairy-related 1 0.109
fgf8a fibroblast growth factor 8 a 0.105
lft2 lefty2 0.097
bmp2b bone morphogenetic protein 2b 0.090
rxraa retinoid X receptor, alpha a 0.088
sparc secreted acidic cysteine rich glycoprotein 0.075
sox9a SRY-box containing gene 9a 0.072
egr2b early growth response 2b 0.071
dlc deltaC 0.065
b2m beta-2-microglobulin 0.064
nr1d2b nuclear receptor subfamily 1, group D, member 2b 0.058
mespa mesoderm posterior a 0.056
irx7 iroquois homeobox protein 7 0.056
eve1 even-skipped-like1 0.055
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.054
tbx6 T-box gene 6 0.053
rxrab retinoid x receptor, alpha b 0.053
rxrba retinoid x receptor, beta a 0.049
col1a1a collagen, type I, alpha 1a 0.048
flt4 fms-related tyrosine kinase 4 0.046
stat1a signal transduction and activation of transcription 1a 0.043
tbp TATA box binding protein 0.042
flh floating head 0.040
gamt guanidinoacetate N-methyltransferase 0.039
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.038
lft1 lefty1 0.036
mespb mesoderm posterior b 0.034
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.034
tp73 tumor protein p73 0.030
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.030
hand2 heart and neural crest derivatives expressed transcript 2 0.029
klf4 Kruppel-like factor 4 0.028
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.028
nog1 noggin 1 0.028
thrab thyroid hormone receptor alpha b 0.028
myl7 myosin, light polypeptide 7, regulatory 0.027
nr1d2a nuclear receptor subfamily 1, group D, member 2a 0.026
satb2 SATB homeobox 2 0.026
hoxb1b homeo box B1b 0.025
gata5 GATA-binding protein 5 0.025
tgif1 TGFB-induced factor homeobox 1 0.024
shha sonic hedgehog a 0.024
acvr1l activin A receptor, type I like 0.024
postn periostin, osteoblast specific factor 0.024
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.023
her9 hairy-related 9 0.022
meis2.1 myeloid ecotropic viral integration site 2.1 0.022
vcanb versican b 0.022
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.022
zgc:64114 zgc:64114 0.021
ocrl oculocerebrorenal syndrome of Lowe 0.020
tbx2b T-box 2b 0.020
nkx2.3 NK2 transcription factor related 3 0.020
cfdl complement factor D (adipsin) like 0.019
efnb2a ephrin B2a 0.019
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.019
rag1 recombination activating gene 1 0.018
rargb retinoic acid receptor, gamma b 0.018
cacnb2b calcium channel, voltage-dependent, beta 2b 0.018
robo4 roundabout homolog 4 0.017
alcama activated leukocyte cell adhesion molecule a 0.016
igf3 insulin-like growth factor 3 0.016
fgf3 fibroblast growth factor 3 0.016
socs3a suppressor of cytokine signaling 3a 0.015
zgc:92533 zgc:92533 0.015
znf395b zinc finger protein 395b 0.015
ntrk2b neurotrophic tyrosine kinase, receptor, type 2b 0.015
dnmt6 DNA (cytosine-5-)-methyltransferase 6 0.015
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.015
tgfbi transforming growth factor, beta-induced 0.014
edn1 endothelin 1 0.014
bmp4 bone morphogenetic protein 4 0.014
tbx20 T-box 20 0.014
sox17 SRY-box containing gene 17 0.014
rorab RAR-related orphan receptor A, paralog b 0.014
nrarpa notch-regulated ankyrin repeat protein a 0.013
rxrgb retinoid X receptor, gamma b 0.013
irx3a iroquois homeobox protein 3a 0.013
hoxb3a homeo box B3a 0.013
pcdh8 protocadherin 8 0.013
zc4h2 zinc finger, C4H2 domain containing 0.013
nr1d1 nuclear receptor subfamily 1, group d, member 1 0.012
cry3 cryptochrome 3 0.012
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.012
mgp matrix Gla protein 0.012
ankra2 ankyrin repeat, family A (RFXANK-like), 2 0.012
her5 hairy-related 5 0.012
prdm5 PR domain containing 5 0.012
rhoub ras homolog gene family, member Ub 0.012
lfng lunatic fringe homolog 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.955
RXRA retinoid X receptor, alpha 0.875
FYN FYN oncogene related to SRC, FGR, YES 0.869
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.462
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.403
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.394
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.310
MED25 mediator complex subunit 25 0.281
SYK spleen tyrosine kinase 0.236
BCAR1 breast cancer anti-estrogen resistance 1 0.200
NCOA1 nuclear receptor coactivator 1 0.198
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.190
RARA retinoic acid receptor, alpha 0.188
GRB10 growth factor receptor-bound protein 10 0.176
XIAP X-linked inhibitor of apoptosis 0.161
NCOR2 nuclear receptor corepressor 2 0.154
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.146
MYD88 myeloid differentiation primary response gene (88) 0.124
HR hairless homolog (mouse) 0.109
CDK6 cyclin-dependent kinase 6 0.101
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.096
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.091
PCGF2 polycomb group ring finger 2 0.089
FOXD3 forkhead box D3 0.080
CCND1 cyclin D1 0.077
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.077
PLCG1 phospholipase C, gamma 1 0.075
ANGPT2 angiopoietin 2 0.071
EGFR epidermal growth factor receptor 0.071
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.070
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.064
HNF4A hepatocyte nuclear factor 4, alpha 0.064
CCND3 cyclin D3 0.062
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.062
SPRR2A small proline-rich protein 2A 0.059
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.058
MET met proto-oncogene (hepatocyte growth factor receptor) 0.055
YAP1 Yes-associated protein 1 0.051
CBX8 chromobox homolog 8 0.050
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.050
HIPK2 homeodomain interacting protein kinase 2 0.049
MDFI MyoD family inhibitor 0.047
LGALS3 lectin, galactoside-binding, soluble, 3 0.043
SOX2 SRY (sex determining region Y)-box 2 0.041
SMAD7 SMAD family member 7 0.040
APAF1 apoptotic peptidase activating factor 1 0.035
PPARG peroxisome proliferator-activated receptor gamma 0.035
FAM46A family with sequence similarity 46, member A 0.033
BMI1 BMI1 polycomb ring finger oncogene 0.032
EFNA1 ephrin-A1 0.032
INO80B INO80 complex subunit B 0.031
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.030
ESR1 estrogen receptor 1 0.028
COL6A1 collagen, type VI, alpha 1 0.028
BCR breakpoint cluster region 0.028
GRB2 growth factor receptor-bound protein 2 0.028
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.027
TGFB1 transforming growth factor, beta 1 0.027
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.027
INSR insulin receptor 0.027
PTEN phosphatase and tensin homolog 0.026
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.026
FGF18 fibroblast growth factor 18 0.026
CCND2 cyclin D2 0.026
EPHB2 EPH receptor B2 0.026
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.026
PPARA peroxisome proliferator-activated receptor alpha 0.026
LOX lysyl oxidase 0.026
BLNK B-cell linker 0.026
EFNA5 ephrin-A5 0.025
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.025
EPOR erythropoietin receptor 0.025
NCK1 NCK adaptor protein 1 0.025
CBX4 chromobox homolog 4 0.024
COL2A1 collagen, type II, alpha 1 0.024
SNX33 sorting nexin 33 0.024
SPOP speckle-type POZ protein 0.024
POU3F2 POU class 3 homeobox 2 0.024
COL4A1 collagen, type IV, alpha 1 0.024
LPXN leupaxin 0.024
SRCIN1 SRC kinase signaling inhibitor 1 0.024
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.023
FSTL1 follistatin-like 1 0.023
DNM1 dynamin 1 0.023
AMPH amphiphysin 0.022
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.022
ANGPT1 angiopoietin 1 0.022
KLF6 Kruppel-like factor 6 0.022
LY96 lymphocyte antigen 96 0.022
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.022
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.021
PDCD6IP programmed cell death 6 interacting protein 0.021
NCOA6 nuclear receptor coactivator 6 0.021
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.021
TJP1 tight junction protein 1 (zona occludens 1) 0.021
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.021
ESRRG estrogen-related receptor gamma 0.021
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.020
PCOLCE procollagen C-endopeptidase enhancer 0.020
THBS1 thrombospondin 1 0.020
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Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.986
Rarg retinoic acid receptor, gamma 0.984
Pax2 paired box gene 2 0.984
Hoxa1 homeobox A1 0.976
Foxc2 forkhead box C2 0.913
Yap1 yes-associated protein 1 0.899
Nos3 nitric oxide synthase 3, endothelial cell 0.888
Fgfr2 fibroblast growth factor receptor 2 0.871
Pax3 paired box gene 3 0.740
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.736
Rxra retinoid X receptor alpha 0.734
Tbx3 T-box 3 0.599
Sox4 SRY-box containing gene 4 0.584
Wwtr1 WW domain containing transcription regulator 1 0.572
Fgfr1 fibroblast growth factor receptor 1 0.556
Pten phosphatase and tensin homolog 0.543
Rara retinoic acid receptor, alpha 0.541
Hand1 heart and neural crest derivatives expressed transcript 1 0.531
Hoxd3 homeobox D3 0.526
Csf1 colony stimulating factor 1 (macrophage) 0.515
Jag1 jagged 1 0.493
Igh immunoglobulin heavy chain complex 0.489
Vegfa vascular endothelial growth factor A 0.487
Thrb thyroid hormone receptor beta 0.479
Fgf8 fibroblast growth factor 8 0.474
Gata4 GATA binding protein 4 0.468
Clk1 CDC-like kinase 1 0.465
Bmp4 bone morphogenetic protein 4 0.459
Otx2 orthodenticle homolog 2 (Drosophila) 0.454
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.439
Fyn Fyn proto-oncogene 0.433
Apoe apolipoprotein E 0.428
Col1a1 collagen, type I, alpha 1 0.425
Pou5f1 POU domain, class 5, transcription factor 1 0.422
Chd7 chromodomain helicase DNA binding protein 7 0.389
Rarb retinoic acid receptor, beta 0.384
Hoxa3 homeobox A3 0.383
Prrx1 paired related homeobox 1 0.369
Tead1 TEA domain family member 1 0.361
Hoxb2 homeobox B2 0.358
Runx1 runt related transcription factor 1 0.353
Hoxa2 homeobox A2 0.351
Fgfr3 fibroblast growth factor receptor 3 0.344
Pitx2 paired-like homeodomain transcription factor 2 0.340
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.337
Atoh7 atonal homolog 7 (Drosophila) 0.331
Lepr leptin receptor 0.328
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.328
Nrg1 neuregulin 1 0.310
She src homology 2 domain-containing transforming protein E 0.298
Sox9 SRY-box containing gene 9 0.295
Smad6 MAD homolog 6 (Drosophila) 0.290
Tbx1 T-box 1 0.282
Ntf3 neurotrophin 3 0.262
Hoxb3 homeobox B3 0.260
Gata6 GATA binding protein 6 0.259
Timp3 tissue inhibitor of metalloproteinase 3 0.250
Wt1 Wilms tumor 1 homolog 0.245
Sox2 SRY-box containing gene 2 0.243
Gata3 GATA binding protein 3 0.243
Lhx1 LIM homeobox protein 1 0.242
Phc2 polyhomeotic-like 2 (Drosophila) 0.241
Wnt6 wingless-related MMTV integration site 6 0.240
Eya1 eyes absent 1 homolog (Drosophila) 0.236
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.235
Clk4 CDC like kinase 4 0.234
Rnf2 ring finger protein 2 0.233
Foxh1 forkhead box H1 0.232
Nodal nodal 0.223
Nfib nuclear factor I/B 0.220
Apoa1 apolipoprotein A-I 0.215
Mmp9 matrix metallopeptidase 9 0.213
Vangl2 vang-like 2 (van gogh, Drosophila) 0.209
Pax8 paired box gene 8 0.206
Trp53 transformation related protein 53 0.206
Nos2 nitric oxide synthase 2, inducible 0.205
Ednra endothelin receptor type A 0.201
Cd19 CD19 antigen 0.195
Sall3 sal-like 3 (Drosophila) 0.194
Tal1 T-cell acute lymphocytic leukemia 1 0.187
Pou4f3 POU domain, class 4, transcription factor 3 0.186
Foxg1 forkhead box G1 0.183
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.181
Kdr kinase insert domain protein receptor 0.180
Esr1 estrogen receptor 1 (alpha) 0.180
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.178
Lrp6 low density lipoprotein receptor-related protein 6 0.177
Rag1 recombination activating gene 1 0.177
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.177
Lef1 lymphoid enhancer binding factor 1 0.175
Ccnl2 cyclin L2 0.171
Tgfbr2 transforming growth factor, beta receptor II 0.167
Fgf4 fibroblast growth factor 4 0.166
Isl1 ISL1 transcription factor, LIM/homeodomain 0.161
Sall4 sal-like 4 (Drosophila) 0.157
Hes1 hairy and enhancer of split 1 (Drosophila) 0.155
Hand2 heart and neural crest derivatives expressed transcript 2 0.155
Gsc goosecoid homeobox 0.154
Snai1 snail homolog 1 (Drosophila) 0.153
Myo6 myosin VI 0.148
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism