The network for 'response to increased oxygen levels' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to increased oxygen levels

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.

Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.905
Col3a1 collagen, type III, alpha 1 0.384
Col12a1 collagen, type XII, alpha 1 0.332
Bgn biglycan 0.254
Egr2 early growth response 2 0.226
Col1a2 collagen, type I, alpha 2 0.226
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.138
Col5a1 collagen, type V, alpha 1 0.128
COX3 cytochrome c oxidase subunit 3 0.122
LOC305103 cell surface glycoprotein gp42 0.108
Csf3 colony stimulating factor 3 (granulocyte) 0.101
Tpo thyroid peroxidase 0.096
RT1-M5 RT1 class Ib, locus M5 0.093
Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 0.082
Eln elastin 0.078
Loxl1 lysyl oxidase-like 1 0.077
Mas1 MAS1 oncogene 0.075
Acvrl1 activin A receptor type II-like 1 0.070
Tbxa2r thromboxane A2 receptor 0.068
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.064
Chrm1 cholinergic receptor, muscarinic 1 0.064
Fos FBJ osteosarcoma oncogene 0.064
Phex phosphate regulating endopeptidase homolog, X-linked 0.064
Ccl4 chemokine (C-C motif) ligand 4 0.063
Rhoj ras homolog gene family, member J 0.062
Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 0.057
Prl2b1 Prolactin family 2, subfamily b, member 1 0.054
Adora2a adenosine A2a receptor 0.054
Aebp1 AE binding protein 1 0.053
Lef1 lymphoid enhancer binding factor 1 0.053
LOC100361569 mage-d3-like 0.053
S1pr2 sphingosine-1-phosphate receptor 2 0.051
Tpsab1 tryptase alpha/beta 1 0.050
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.050
Cd4 Cd4 molecule 0.049
Lipogenin Lipogenin 0.049
Col5a2 collagen, type V, alpha 2 0.048
Cd44 Cd44 molecule 0.048
Pla1a phospholipase A1 member A 0.047
Zp3 zona pellucida glycoprotein 3 (sperm receptor) 0.047
Postn periostin, osteoblast specific factor 0.046
Mmp7 matrix metallopeptidase 7 0.045
Col14a1 collagen, type XIV, alpha 1 0.045
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.045
Fn1 fibronectin 1 0.045
Fstl1 follistatin-like 1 0.044
Aqp2 aquaporin 2 (collecting duct) 0.043
Foxd3 forkhead box D3 0.042
Col15a1 collagen, type XV, alpha 1 0.042
Egr1 early growth response 1 0.042
Ncf1 neutrophil cytosolic factor 1 0.042
Ttll3 tubulin tyrosine ligase-like family, member 3 0.042
Adam6 a disintegrin and metallopeptidase domain 6 0.042
Col10a1 collagen, type X, alpha 1 0.041
Junb jun B proto-oncogene 0.041
G6pc glucose-6-phosphatase, catalytic subunit 0.041
Plcb2 phospholipase C, beta 2 0.040
Rup2 urinary protein 2 0.040
Pcolce procollagen C-endopeptidase enhancer 0.039
Dab2 disabled homolog 2 (Drosophila) 0.039
Gpr20 G protein-coupled receptor 20 0.039
Ccr2 chemokine (C-C motif) receptor 2 0.039
S100b S100 calcium binding protein B 0.038
Arpp21 cAMP-regulated phosphoprotein 21 0.038
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.038
COX1 cytochrome c oxidase subunit 1 0.037
Crx cone-rod homeobox 0.037
Plau plasminogen activator, urokinase 0.037
Gata1 GATA binding protein 1 0.037
Gckr glucokinase (hexokinase 4) regulator 0.036
Mmp8 matrix metallopeptidase 8 0.036
Gpc3 glypican 3 0.036
Icam1 intercellular adhesion molecule 1 0.036
Ypel5 yippee-like 5 (Drosophila) 0.035
Gna15 guanine nucleotide binding protein, alpha 15 0.035
Igfals insulin-like growth factor binding protein, acid labile subunit 0.035
LOC100361445 mCG7602-like 0.034
Lox lysyl oxidase 0.034
Itgad integrin, alpha D 0.034
Lum lumican 0.033
Irs1 insulin receptor substrate 1 0.033
Grm4 glutamate receptor, metabotropic 4 0.033
Onecut1 one cut homeobox 1 0.033
Col9a2 collagen, type IX, alpha 2 0.033
Cel carboxyl ester lipase 0.033
Plaur plasminogen activator, urokinase receptor 0.033
Psgb1 pregnancy-specific beta 1-glycoprotein 0.033
Scnn1a sodium channel, nonvoltage-gated 1 alpha 0.032
Prm3 protamine 3 0.032
Kcns1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 0.032
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.032
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.031
Cdx1 caudal type homeo box 1 0.031
Cpz carboxypeptidase Z 0.031
Fkbp10 FK506 binding protein 10 0.031
Acads acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain 0.031
Teddm1 transmembrane epididymal protein 1 0.030
Slc7a13 solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 0.030
Tcrb T-cell receptor beta chain 0.030
LOC686539 similar to immunoglobulin superfamily containing leucine-rich repeat 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Gyc-89Db Guanylyl cyclase at 89Db 0.015
Gyc-89Da Guanylyl cyclase at 89Da 0.014
CG14686 CG14686 gene product from transcript CG14686-RA 0.013
sev sevenless 0.011
ImpL2 Ecdysone-inducible gene L2 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.955
NOSTRIN nitric oxide synthase trafficker 0.942
FADD Fas (TNFRSF6)-associated via death domain 0.929
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.921
CFLAR CASP8 and FADD-like apoptosis regulator 0.906
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.868
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.850
FAS Fas (TNF receptor superfamily, member 6) 0.655
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.574
COTL1 coactosin-like 1 (Dictyostelium) 0.529
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.511
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.510
PLAU plasminogen activator, urokinase 0.469
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.462
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.435
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.389
PLAUR plasminogen activator, urokinase receptor 0.371
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.291
AR androgen receptor 0.288
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.285
PTEN phosphatase and tensin homolog 0.249
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.248
THBS1 thrombospondin 1 0.238
NCF4 neutrophil cytosolic factor 4, 40kDa 0.236
CAV1 caveolin 1, caveolae protein, 22kDa 0.235
PDGFA platelet-derived growth factor alpha polypeptide 0.223
PLAT plasminogen activator, tissue 0.218
CCL5 chemokine (C-C motif) ligand 5 0.215
TRADD TNFRSF1A-associated via death domain 0.203
PDGFC platelet derived growth factor C 0.187
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.184
COL6A1 collagen, type VI, alpha 1 0.182
KAT2B K(lysine) acetyltransferase 2B 0.169
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.149
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.144
TGFB1 transforming growth factor, beta 1 0.142
COL1A2 collagen, type I, alpha 2 0.139
NCOA2 nuclear receptor coactivator 2 0.128
BMP1 bone morphogenetic protein 1 0.121
A2M alpha-2-macroglobulin 0.119
FGFR1 fibroblast growth factor receptor 1 0.114
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.108
TIMP2 TIMP metallopeptidase inhibitor 2 0.107
SNAI1 snail homolog 1 (Drosophila) 0.106
IGFBP3 insulin-like growth factor binding protein 3 0.099
BID BH3 interacting domain death agonist 0.097
EGFR epidermal growth factor receptor 0.096
ENG endoglin 0.094
DAXX death-domain associated protein 0.091
BCAR1 breast cancer anti-estrogen resistance 1 0.091
HDAC2 histone deacetylase 2 0.090
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.089
COL4A1 collagen, type IV, alpha 1 0.085
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.085
F2R coagulation factor II (thrombin) receptor 0.077
CXCR4 chemokine (C-X-C motif) receptor 4 0.075
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.070
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.069
PTPRF protein tyrosine phosphatase, receptor type, F 0.067
PRKCDBP protein kinase C, delta binding protein 0.063
CCR1 chemokine (C-C motif) receptor 1 0.062
FHL2 four and a half LIM domains 2 0.058
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.058
NRP1 neuropilin 1 0.057
COL1A1 collagen, type I, alpha 1 0.055
THBS2 thrombospondin 2 0.053
ESR1 estrogen receptor 1 0.050
CXCR6 chemokine (C-X-C motif) receptor 6 0.050
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.050
TXNRD1 thioredoxin reductase 1 0.049
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.049
COL3A1 collagen, type III, alpha 1 0.048
COL7A1 collagen, type VII, alpha 1 0.048
TUBB6 tubulin, beta 6 0.046
NCOA1 nuclear receptor coactivator 1 0.045
RUNX1 runt-related transcription factor 1 0.045
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.044
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.044
HTT huntingtin 0.042
ORM1 orosomucoid 1 0.041
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.041
CAV2 caveolin 2 0.038
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.038
SPHK1 sphingosine kinase 1 0.038
NGEF neuronal guanine nucleotide exchange factor 0.037
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.036
NCOA6 nuclear receptor coactivator 6 0.035
FOS FBJ murine osteosarcoma viral oncogene homolog 0.035
DYNLT1 dynein, light chain, Tctex-type 1 0.035
SFTPD surfactant protein D 0.035
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.035
S100A8 S100 calcium binding protein A8 0.034
GJA1 gap junction protein, alpha 1, 43kDa 0.034
TTR transthyretin 0.033
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.033
ESRRG estrogen-related receptor gamma 0.032
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.031
FZD1 frizzled homolog 1 (Drosophila) 0.031
PTAFR platelet-activating factor receptor 0.030
CD59 CD59 molecule, complement regulatory protein 0.030
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.938
Nos3 nitric oxide synthase 3, endothelial cell 0.927
Lepr leptin receptor 0.845
Ptgs2 prostaglandin-endoperoxide synthase 2 0.743
Apoe apolipoprotein E 0.722
Csf1 colony stimulating factor 1 (macrophage) 0.715
Cav1 caveolin 1, caveolae protein 0.712
Mmp9 matrix metallopeptidase 9 0.660
Pten phosphatase and tensin homolog 0.603
Lep leptin 0.596
Lyz2 lysozyme 2 0.394
Col1a1 collagen, type I, alpha 1 0.384
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.334
Vegfa vascular endothelial growth factor A 0.296
Vhl von Hippel-Lindau tumor suppressor 0.289
Ldlr low density lipoprotein receptor 0.282
Apc adenomatosis polyposis coli 0.248
Vdr vitamin D receptor 0.241
Tlr4 toll-like receptor 4 0.239
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.237
Plat plasminogen activator, tissue 0.230
Ccl2 chemokine (C-C motif) ligand 2 0.229
Cd44 CD44 antigen 0.170
Selp selectin, platelet 0.157
Col4a3 collagen, type IV, alpha 3 0.139
Nos2 nitric oxide synthase 2, inducible 0.124
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.120
Tgfb1 transforming growth factor, beta 1 0.119
Lmna lamin A 0.119
Ghr growth hormone receptor 0.115
Pparg peroxisome proliferator activated receptor gamma 0.099
Nos1 nitric oxide synthase 1, neuronal 0.085
Ccr2 chemokine (C-C motif) receptor 2 0.081
Tgfbr2 transforming growth factor, beta receptor II 0.078
Il10 interleukin 10 0.075
Fbn1 fibrillin 1 0.070
Fos FBJ osteosarcoma oncogene 0.066
Il6st interleukin 6 signal transducer 0.066
Kiss1 KiSS-1 metastasis-suppressor 0.065
Notch1 Notch gene homolog 1 (Drosophila) 0.064
Spp1 secreted phosphoprotein 1 0.062
Alox5ap arachidonate 5-lipoxygenase activating protein 0.061
Hif1a hypoxia inducible factor 1, alpha subunit 0.058
Gja1 gap junction protein, alpha 1 0.054
Notch2 Notch gene homolog 2 (Drosophila) 0.053
Agtr2 angiotensin II receptor, type 2 0.053
Ar androgen receptor 0.051
Ifng interferon gamma 0.051
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.047
Ltbp3 latent transforming growth factor beta binding protein 3 0.042
Ifngr1 interferon gamma receptor 1 0.039
Esr1 estrogen receptor 1 (alpha) 0.039
Lif leukemia inhibitory factor 0.038
Kit kit oncogene 0.037
Ctsk cathepsin K 0.035
Tlr2 toll-like receptor 2 0.035
Ahr aryl-hydrocarbon receptor 0.035
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.034
Fcgr2b Fc receptor, IgG, low affinity IIb 0.034
Il6 interleukin 6 0.033
Prkch protein kinase C, eta 0.033
Prx periaxin 0.032
Agtr1a angiotensin II receptor, type 1a 0.029
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.029
Cyr61 cysteine rich protein 61 0.029
Orai1 ORAI calcium release-activated calcium modulator 1 0.027
Fas Fas (TNF receptor superfamily member 6) 0.027
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.027
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.027
Tal1 T-cell acute lymphocytic leukemia 1 0.027
Pnpla2 patatin-like phospholipase domain containing 2 0.026
Ptrf polymerase I and transcript release factor 0.026
Tgfb2 transforming growth factor, beta 2 0.024
Tmprss11e transmembrane protease, serine 11e 0.023
Ctnnb1 catenin (cadherin associated protein), beta 1 0.023
Egr2 early growth response 2 0.023
Insr insulin receptor 0.022
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.022
Tcf21 transcription factor 21 0.022
Plin1 perilipin 1 0.021
Wdfy2 WD repeat and FYVE domain containing 2 0.021
Sox13 SRY-box containing gene 13 0.021
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.021
Sele selectin, endothelial cell 0.021
Pdgfb platelet derived growth factor, B polypeptide 0.020
Smad3 MAD homolog 3 (Drosophila) 0.020
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.020
Ivd isovaleryl coenzyme A dehydrogenase 0.020
Adipoq adiponectin, C1Q and collagen domain containing 0.020
Nab2 Ngfi-A binding protein 2 0.019
Kl klotho 0.019
Foxa2 forkhead box A2 0.019
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.018
Lama2 laminin, alpha 2 0.018
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.018
Prdx1 peroxiredoxin 1 0.018
Cnn1 calponin 1 0.018
Amhr2 anti-Mullerian hormone type 2 receptor 0.018
Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.017
Rxra retinoid X receptor alpha 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism