The network for 'regulation of multicellular organismal metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of multicellular organismal metabolic process

Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.

Danio rerio
Name Description Probability Func Analog Organism
itgb1b integrin, beta 1b 0.645
itgb1b.2 integrin, beta 1b.2 0.521
itgb1a integrin, beta 1a 0.364
adrb2a adrenergic receptor, beta 2a 0.350
il6st interleukin 6 signal transducer 0.216
bmp2b bone morphogenetic protein 2b 0.186
col11a1a collagen, type XI, alpha 1a 0.109
spry4 sprouty (Drosophila) homolog 4 0.108
zgc:77714 zgc:77714 0.100
itgb1b.1 integrin, beta 1b.1 0.081
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.079
igfbp6b insulin-like growth factor binding protein 6b 0.077
npy8ar neuropeptide Y receptor Y8a 0.075
ptch1 patched 1 0.067
igfbp6a insulin-like growth factor binding protein 6a 0.059
alk anaplastic lymphoma kinase (Ki-1) 0.056
osr1 odd-skipped related 1 (Drosophila) 0.055
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.053
fgf20a fibroblast growth factor 20a 0.053
arrdc2 arrestin domain containing 2 0.051
b2m beta-2-microglobulin 0.050
map1lc3a microtubule-associated protein 1 light chain 3 alpha 0.049
btg1 B-cell translocation gene 1 0.048
lifrb leukemia inhibitory factor receptor alpha b 0.044
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.044
pparg peroxisome proliferator activated receptor gamma 0.044
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.041
fgfrl1b fibroblast growth factor receptor-like 1b 0.041
duox dual oxidase 0.038
zgc:77744 zgc:77744 0.038
sh3gl1b SH3-domain GRB2-like 1b 0.038
si:ch211-15d5.5 si:ch211-15d5.5 0.038
cfdl complement factor D (adipsin) like 0.036
kiss1rb KISS1 receptor b 0.035
ptch2 patched 2 0.035
iclp1 invariant chain-like protein 1 0.034
plagl2 pleiomorphic adenoma gene-like 2 0.034
tgfb2 transforming growth factor, beta 2 0.034
erlin1 ER lipid raft associated 1 0.034
gpr126 G protein-coupled receptor 126 0.033
lrp2 low density lipoprotein-related protein 2 0.032
b3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 0.032
mc5rb melanocortin 5b receptor 0.032
pfkfb4l 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, like 0.031
serpinb1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.031
twist1b twist1b 0.031
LOC100334776 phosphatase and actin regulator 1-like 0.030
sparc secreted acidic cysteine rich glycoprotein 0.029
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.029
jun jun proto-oncogene 0.029
calcrla calcitonin receptor-like a 0.029
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.029
zgc:55813 zgc:55813 0.029
rhoaa ras homolog gene family, member Aa 0.029
junbl jun B proto-oncogene, like 0.029
rgs4 regulator of G-protein signalling 4 0.028
sepw1 selenoprotein W, 1 0.028
tppp3 tubulin polymerization-promoting protein family member 3 0.028
smtnb smoothelin b 0.027
valopa vertebrate ancient long opsin a 0.027
has3 hyaluronan synthase 3 0.027
hapln1a hyaluronan and proteoglycan link protein 1a 0.027
rbp1a retinol binding protein 1a, cellular 0.026
ildr1b immunoglobulin-like domain containing receptor 1b 0.026
hdc histidine decarboxylase 0.026
kita kit receptor a 0.026
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.026
wu:fa97a01 wu:fa97a01 0.026
prrx1a paired related homeobox 1a 0.025
serpina1l serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like 0.025
zfp36l1b zinc finger protein 36, C3H type-like 1b 0.025
rpl7a ribosomal protein L7a 0.025
zgc:171553 zgc:171553 0.025
foxj1a forkhead box J1a 0.025
tcf7l1b transcription factor 7-like 1b (T-cell specific, HMG-box) 0.024
col10a1 collagen, type X, alpha 1 0.024
si:ch211-173b8.2 si:ch211-173b8.2 0.024
vtg3 vitellogenin 3, phosvitinless 0.023
crygm4 crystallin, gamma M4 0.023
bglap bone gamma-carboxyglutamate (gla) protein 0.023
hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.023
mtp microsomal triglyceride transfer protein 0.023
tgm2b transglutaminase 2b 0.023
spon2a spondin 2a, extracellular matrix protein 0.022
zgc:92715 zgc:92715 0.022
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.022
tlr3 toll-like receptor 3 0.022
si:rp71-1g18.9 si:rp71-1g18.9 0.022
cxcl14 chemokine (C-X-C motif) ligand 14 0.022
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.022
LOC797331 novel protein similar to vertebrate solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5) 0.021
slc20a1a solute carrier family 20, member 1a 0.021
zgc:111821 zgc:111821 0.021
LOC569128 hypothetical protein LOC569128 0.021
sox9a SRY-box containing gene 9a 0.021
ada adenosine deaminase 0.021
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.021
vegfab vascular endothelial growth factor Ab 0.021
agrp agouti related protein homolog 0.021
eda ectodysplasin A 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.992
TEK TEK tyrosine kinase, endothelial 0.991
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.991
FGA fibrinogen alpha chain 0.939
FSTL1 follistatin-like 1 0.824
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.763
TGFB1 transforming growth factor, beta 1 0.762
ENG endoglin 0.739
BMPR1A bone morphogenetic protein receptor, type IA 0.671
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.600
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.543
PTEN phosphatase and tensin homolog 0.342
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.339
ITGA6 integrin, alpha 6 0.335
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.305
CYR61 cysteine-rich, angiogenic inducer, 61 0.279
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.274
BMPR1B bone morphogenetic protein receptor, type IB 0.271
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.247
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.233
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.179
CAV1 caveolin 1, caveolae protein, 22kDa 0.163
FGG fibrinogen gamma chain 0.146
CYTH1 cytohesin 1 0.145
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.143
CXCL12 chemokine (C-X-C motif) ligand 12 0.106
IL6R interleukin 6 receptor 0.105
ALB albumin 0.096
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.092
PLEC plectin 0.089
S100B S100 calcium binding protein B 0.084
CAV2 caveolin 2 0.083
IL6 interleukin 6 (interferon, beta 2) 0.083
FLNB filamin B, beta 0.082
MYO10 myosin X 0.067
CXCL2 chemokine (C-X-C motif) ligand 2 0.067
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.066
TGFB2 transforming growth factor, beta 2 0.052
FGF18 fibroblast growth factor 18 0.046
NRP1 neuropilin 1 0.045
MET met proto-oncogene (hepatocyte growth factor receptor) 0.043
TGFB3 transforming growth factor, beta 3 0.040
F3 coagulation factor III (thromboplastin, tissue factor) 0.039
BMP4 bone morphogenetic protein 4 0.038
COL17A1 collagen, type XVII, alpha 1 0.038
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.036
THBS1 thrombospondin 1 0.035
EPS8 epidermal growth factor receptor pathway substrate 8 0.034
FGF4 fibroblast growth factor 4 0.034
SLA Src-like-adaptor 0.033
CFD complement factor D (adipsin) 0.033
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.031
CD9 CD9 molecule 0.031
TGFBR3 transforming growth factor, beta receptor III 0.030
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.029
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.029
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028
ANGPT2 angiopoietin 2 0.028
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.028
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.026
CCL22 chemokine (C-C motif) ligand 22 0.026
CST2 cystatin SA 0.024
RANBP9 RAN binding protein 9 0.023
FGB fibrinogen beta chain 0.022
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.022
ANGPT1 angiopoietin 1 0.022
TGFBR1 transforming growth factor, beta receptor 1 0.021
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.021
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.020
PDGFA platelet-derived growth factor alpha polypeptide 0.020
DCN decorin 0.019
BABAM1 BRISC and BRCA1 A complex member 1 0.019
IL8 interleukin 8 0.019
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.019
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.018
ANGPTL4 angiopoietin-like 4 0.018
TBC1D10A TBC1 domain family, member 10A 0.018
TIMP1 TIMP metallopeptidase inhibitor 1 0.018
TIMP2 TIMP metallopeptidase inhibitor 2 0.018
WNT1 wingless-type MMTV integration site family, member 1 0.017
LUM lumican 0.017
CTSA cathepsin A 0.017
ARRDC3 arrestin domain containing 3 0.016
AHSG alpha-2-HS-glycoprotein 0.016
CD81 CD81 molecule 0.016
LAT linker for activation of T cells 0.016
BMP2 bone morphogenetic protein 2 0.016
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.016
HGFAC HGF activator 0.016
NNMT nicotinamide N-methyltransferase 0.016
FLNA filamin A, alpha 0.016
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.015
NOG noggin 0.015
CARD10 caspase recruitment domain family, member 10 0.014
CST1 cystatin SN 0.014
PXN paxillin 0.014
PLG plasminogen 0.013
F10 coagulation factor X 0.013
ITGB7 integrin, beta 7 0.013
COL2A1 collagen, type II, alpha 1 0.013
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Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 0.610
Shh sonic hedgehog 0.444
Foxc1 forkhead box C1 0.416
Gli3 GLI-Kruppel family member GLI3 0.347
Hoxd13 homeobox D13 0.293
Lep leptin 0.279
Pnpla2 patatin-like phospholipase domain containing 2 0.265
Fgfr3 fibroblast growth factor receptor 3 0.265
Tgfb2 transforming growth factor, beta 2 0.264
Neurog2 neurogenin 2 0.233
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.232
Pax3 paired box gene 3 0.222
Hand1 heart and neural crest derivatives expressed transcript 1 0.217
Tcfap2a transcription factor AP-2, alpha 0.191
Adrb1 adrenergic receptor, beta 1 0.186
Gata4 GATA binding protein 4 0.152
Fgfr2 fibroblast growth factor receptor 2 0.151
Sox9 SRY-box containing gene 9 0.137
Msx1 homeobox, msh-like 1 0.130
Runx2 runt related transcription factor 2 0.119
Neurod4 neurogenic differentiation 4 0.118
Neurod1 neurogenic differentiation 1 0.114
Irx1 Iroquois related homeobox 1 (Drosophila) 0.111
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.108
Neurog3 neurogenin 3 0.101
Irx2 Iroquois related homeobox 2 (Drosophila) 0.100
Zeb1 zinc finger E-box binding homeobox 1 0.093
Gja1 gap junction protein, alpha 1 0.090
Hoxa13 homeobox A13 0.090
Pkd1 polycystic kidney disease 1 homolog 0.089
Foxd2 forkhead box D2 0.087
Gas1 growth arrest specific 1 0.086
Ptf1a pancreas specific transcription factor, 1a 0.082
Hand2 heart and neural crest derivatives expressed transcript 2 0.080
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.076
Foxc2 forkhead box C2 0.074
Onecut1 one cut domain, family member 1 0.073
Vegfa vascular endothelial growth factor A 0.073
Atoh7 atonal homolog 7 (Drosophila) 0.070
Pthlh parathyroid hormone-like peptide 0.068
Gdf3 growth differentiation factor 3 0.065
Il6st interleukin 6 signal transducer 0.065
Fgf15 fibroblast growth factor 15 0.062
Fgf9 fibroblast growth factor 9 0.061
Adrb2 adrenergic receptor, beta 2 0.060
Pax6 paired box gene 6 0.060
Smo smoothened homolog (Drosophila) 0.059
Kiss1 KiSS-1 metastasis-suppressor 0.057
Pitx2 paired-like homeodomain transcription factor 2 0.055
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.054
Sox10 SRY-box containing gene 10 0.054
Cyr61 cysteine rich protein 61 0.053
Pdx1 pancreatic and duodenal homeobox 1 0.051
Bmp4 bone morphogenetic protein 4 0.050
Lmx1b LIM homeobox transcription factor 1 beta 0.049
Nos3 nitric oxide synthase 3, endothelial cell 0.048
Fgf18 fibroblast growth factor 18 0.048
Nos1 nitric oxide synthase 1, neuronal 0.048
Bdkrb2 bradykinin receptor, beta 2 0.048
Col1a1 collagen, type I, alpha 1 0.047
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.047
Hoxb1 homeobox B1 0.046
Mmp24 matrix metallopeptidase 24 0.046
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.045
Kl klotho 0.044
Acvrl1 activin A receptor, type II-like 1 0.044
Mstn myostatin 0.043
Gli2 GLI-Kruppel family member GLI2 0.042
Alx3 aristaless-like homeobox 3 0.041
Nppa natriuretic peptide type A 0.041
Olfr70 olfactory receptor 70 0.040
Npy6r neuropeptide Y receptor Y6 0.038
Cckbr cholecystokinin B receptor 0.038
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.037
Lmx1a LIM homeobox transcription factor 1 alpha 0.037
Gdf6 growth differentiation factor 6 0.036
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.036
Rxra retinoid X receptor alpha 0.036
Pparg peroxisome proliferator activated receptor gamma 0.035
Hoxa10 homeobox A10 0.035
Prph2 peripherin 2 0.035
Tcfap2b transcription factor AP-2 beta 0.034
Zfpm2 zinc finger protein, multitype 2 0.034
Cldn16 claudin 16 0.034
Epha8 Eph receptor A8 0.033
Adrb3 adrenergic receptor, beta 3 0.032
Gata1 GATA binding protein 1 0.032
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.032
Foxh1 forkhead box H1 0.031
Sebox SEBOX homeobox 0.031
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.031
Fgf4 fibroblast growth factor 4 0.031
Adra2b adrenergic receptor, alpha 2b 0.031
Dlx4 distal-less homeobox 4 0.031
En1 engrailed 1 0.030
Gpr50 G-protein-coupled receptor 50 0.030
Fgf8 fibroblast growth factor 8 0.030
Drd2 dopamine receptor D2 0.029
Nos2 nitric oxide synthase 2, inducible 0.029
Edn3 endothelin 3 0.029
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism