The network for 'positive regulation of heart contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of heart contraction

Any process that activates or increases the frequency, rate or extent of heart contraction.

Danio rerio
Name Description Probability Func Analog Organism
myog myogenin 0.512
actc1a actin, alpha, cardiac muscle 1a 0.380
vmhc ventricular myosin heavy chain 0.377
cmlc1 cardiac myosin light chain-1 0.335
tnnt2a troponin T2a, cardiac 0.251
tnnc1b troponin C type 1b (slow) 0.242
actc1b actin, alpha, cardiac muscle 1b 0.222
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.204
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.197
unc45b unc-45 homolog B (C. elegans) 0.170
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.166
ttna titin a 0.164
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.146
wnt11r wingless-type MMTV integration site family, member 11, related 0.128
nkx2.5 NK2 transcription factor related 5 0.115
zgc:66286 zgc:66286 0.101
tnnc2 troponin C type 2 (fast) 0.093
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.093
acta1b actin, alpha 1b, skeletal muscle 0.086
cdh2 cadherin 2, neuronal 0.086
tnnc1a troponin C type 1a (slow) 0.085
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.085
tbx5b T-box 5b 0.078
nppa natriuretic peptide precursor A 0.077
tbx1 T-box 1 0.077
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.073
tbx5a T-box 5a 0.073
ckma creatine kinase, muscle a 0.071
synpo2lb synaptopodin 2-like b 0.067
myod1 myogenic differentiation 1 0.066
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.063
dpf3 D4, zinc and double PHD fingers, family 3 0.063
vcana versican a 0.062
cav3 caveolin 3 0.061
xirp1 xin actin-binding repeat containing 1 0.059
nexn nexilin (F actin binding protein) 0.058
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.056
tgfb3 transforming growth factor, beta 3 0.056
agr2 anterior gradient homolog 2 (Xenopus laevis) 0.053
pvalb8 parvalbumin 8 0.052
atp1a1a.3 ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide 0.051
aldoab aldolase a, fructose-bisphosphate, b 0.051
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.050
scn12aa sodium channel, voltage gated, type XII, alpha a 0.050
glula glutamate-ammonia ligase (glutamine synthase) a 0.046
myl7 myosin, light polypeptide 7, regulatory 0.046
ttnb titin b 0.046
rbm24b RNA binding motif protein 24b 0.045
crip2 cysteine-rich protein 2 0.045
acta1a actin, alpha 1a, skeletal muscle 0.044
bmp10 bone morphogenetic protein 10 0.043
lrrc10 leucine rich repeat containing 10 0.040
scn3b sodium channel, voltage-gated, type III, beta 0.040
smyd1b SET and MYND domain containing 1b 0.040
myl1 myosin, light chain 1, alkali; skeletal, fast 0.040
fabp2 fatty acid binding protein 2, intestinal 0.039
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.039
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.039
pvalb4 parvalbumin 4 0.038
slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.037
wu:fb01h12 wu:fb01h12 0.036
pax9 paired box gene 9 0.035
edn1 endothelin 1 0.034
mylk3 myosin light chain kinase 3 0.034
cldnh claudin h 0.033
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.033
scn2b sodium channel, voltage-gated, type II, beta 0.033
mef2cb myocyte enhancer factor 2cb 0.032
scn12ab sodium channel, voltage gated, type XII, alpha b 0.032
tnni2b.1 troponin I, skeletal, fast 2b.1 0.031
tmem38a transmembrane protein 38A 0.031
plekha7 pleckstrin homology domain containing, family A member 7 0.029
bcdo2l beta-carotene 15, 15-dioxygenase 2, like 0.029
tpm4 tropomyosin 4 0.028
copeb core promoter element binding protein 0.028
scn4ba sodium channel, voltage-gated, type IV, beta a 0.027
gja3 gap junction protein, alpha 3 0.027
adrb2a adrenergic receptor, beta 2a 0.027
ldb3b LIM domain binding 3b 0.026
csrp3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.026
wu:fc31e07 wu:fc31e07 0.026
tnni1b troponin I, skeletal, slow b 0.025
myca myelocytomatosis oncogene a 0.025
gpia glucose phosphate isomerase a 0.025
anxa11a annexin A11a 0.024
adipoql adiponectin, C1Q and collagen domain containing, like 0.024
txnipa thioredoxin interacting protein a 0.024
six2a sine oculis-related homeobox 2a 0.024
tgfbr2 transforming growth factor, beta receptor II 0.023
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.023
pvalb7 parvalbumin 7 0.022
eef2l2 eukaryotic translation elongation factor 2, like 2 0.022
desma desmin a 0.022
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.022
eya4 eyes absent homolog 4 (Drosophila) 0.022
pes pescadillo 0.021
pabpc4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.021
s100b S100 calcium binding protein, beta (neural) 0.020
ckmb creatine kinase, muscle b 0.020
jam2a junctional adhesion molecule 2a 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FOS FBJ murine osteosarcoma viral oncogene homolog 0.130
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.079
ATF3 activating transcription factor 3 0.048
TBX5 T-box 5 0.047
JUN jun proto-oncogene 0.039
CYR61 cysteine-rich, angiogenic inducer, 61 0.037
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.029
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.028
ENG endoglin 0.026
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.023
JUND jun D proto-oncogene 0.023
DDIT3 DNA-damage-inducible transcript 3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Tbx5 T-box 5 0.828
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.776
Hand1 heart and neural crest derivatives expressed transcript 1 0.763
Cckbr cholecystokinin B receptor 0.599
Fos FBJ osteosarcoma oncogene 0.487
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.474
Gja5 gap junction protein, alpha 5 0.459
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.441
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.399
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.266
Pnpla2 patatin-like phospholipase domain containing 2 0.262
Scn5a sodium channel, voltage-gated, type V, alpha 0.233
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.224
Gata4 GATA binding protein 4 0.223
Hand2 heart and neural crest derivatives expressed transcript 2 0.193
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.189
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.188
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.180
Smyd1 SET and MYND domain containing 1 0.163
Ryr2 ryanodine receptor 2, cardiac 0.159
Efnb2 ephrin B2 0.158
Grm2 glutamate receptor, metabotropic 2 0.138
Tbx3 T-box 3 0.135
Ldb3 LIM domain binding 3 0.130
Zfpm2 zinc finger protein, multitype 2 0.123
Kcnk3 potassium channel, subfamily K, member 3 0.111
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.095
Lhx6 LIM homeobox protein 6 0.093
Actn2 actinin alpha 2 0.093
Pthlh parathyroid hormone-like peptide 0.091
Drd2 dopamine receptor D2 0.090
Ache acetylcholinesterase 0.084
Kl klotho 0.081
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.076
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.073
Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 0.073
Hbegf heparin-binding EGF-like growth factor 0.072
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.064
Galr1 galanin receptor 1 0.062
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.060
Crhr2 corticotropin releasing hormone receptor 2 0.057
Sstr1 somatostatin receptor 1 0.053
Gh growth hormone 0.053
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.052
Drd4 dopamine receptor D4 0.051
Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 0.051
Sstr4 somatostatin receptor 4 0.051
Ighmbp2 immunoglobulin mu binding protein 2 0.049
Fndc7 fibronectin type III domain containing 7 0.043
Myl3 myosin, light polypeptide 3 0.041
Xirp1 xin actin-binding repeat containing 1 0.041
Ntf3 neurotrophin 3 0.040
ND6 NADH dehydrogenase subunit 6 0.040
Casq2 calsequestrin 2 0.036
Gpr27 G protein-coupled receptor 27 0.035
Myoz1 myozenin 1 0.034
Ckm creatine kinase, muscle 0.034
Prox1 prospero-related homeobox 1 0.033
Sfrp5 secreted frizzled-related sequence protein 5 0.033
Adrb2 adrenergic receptor, beta 2 0.033
Shc3 src homology 2 domain-containing transforming protein C3 0.033
Lag3 lymphocyte-activation gene 3 0.033
Clcn1 chloride channel 1 0.032
Fgf8 fibroblast growth factor 8 0.032
Adra1b adrenergic receptor, alpha 1b 0.032
Ckmt2 creatine kinase, mitochondrial 2 0.032
P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 0.032
Nppb natriuretic peptide type B 0.032
Ednrb endothelin receptor type B 0.032
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.031
Krtap5-1 keratin associated protein 5-1 0.031
Tff1 trefoil factor 1 0.031
Colq collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.031
Has1 hyaluronan synthase1 0.031
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.030
Cox8b cytochrome c oxidase, subunit VIIIb 0.030
Mobp myelin-associated oligodendrocytic basic protein 0.030
Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 0.029
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.029
Oprd1 opioid receptor, delta 1 0.029
Sox10 SRY-box containing gene 10 0.028
Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 0.028
Mybpc3 myosin binding protein C, cardiac 0.028
Foxe1 forkhead box E1 0.028
Hrh1 histamine receptor H1 0.026
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.025
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.025
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.024
Atf3 activating transcription factor 3 0.024
Lalba lactalbumin, alpha 0.024
Phkg1 phosphorylase kinase gamma 1 0.024
Otog otogelin 0.024
Ntsr2 neurotensin receptor 2 0.023
Nrap nebulin-related anchoring protein 0.023
Lrrk2 leucine-rich repeat kinase 2 0.023
Rgs4 regulator of G-protein signaling 4 0.023
Nkx3-1 NK-3 transcription factor, locus 1 (Drosophila) 0.023
Sstr5 somatostatin receptor 5 0.023
Actc1 actin, alpha, cardiac muscle 1 0.022
Gjc2 gap junction protein, gamma 2 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.753
Insrr insulin receptor-related receptor 0.355
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.230
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.216
Lim2 lens intrinsic membrane protein 2 0.189
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.171
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.165
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.155
Hspa8 heat shock protein 8 0.151
Fgf14 fibroblast growth factor 14 0.149
Hrh2 histamine receptor H 2 0.140
Dspp dentin sialophosphoprotein 0.130
Hsph1 heat shock 105/110 protein 1 0.119
Trhr2 thyrotropin releasing hormone receptor 2 0.108
Ncan neurocan 0.093
Ucn urocortin 0.086
Fev FEV (ETS oncogene family) 0.085
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.084
Psp parotid secretory protein 0.083
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.080
RGD1310262 hypothetical LOC304650 0.079
RGD1564327 similar to integrin alpha 8 0.078
Pgc progastricsin (pepsinogen C) 0.078
Gpr12 G protein-coupled receptor 12 0.077
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.077
Mc5r melanocortin 5 receptor 0.076
Csf1 colony stimulating factor 1 (macrophage) 0.075
Ccbp2 chemokine binding protein 2 0.073
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.072
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.067
Notch3 Notch homolog 3 (Drosophila) 0.066
Gjd2 gap junction protein, delta 2 0.066
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.066
Dlg4 discs, large homolog 4 (Drosophila) 0.065
Olr1082 olfactory receptor 1082 0.064
Cckar cholecystokinin A receptor 0.063
Oprk1 opioid receptor, kappa 1 0.062
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.062
Cd28 Cd28 molecule 0.062
Testin testin gene 0.060
Crhbp corticotropin releasing hormone binding protein 0.059
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.059
Aqp5 aquaporin 5 0.058
Afap1 actin filament associated protein 1 0.058
Fgf16 fibroblast growth factor 16 0.057
Gfra2 GDNF family receptor alpha 2 0.057
Chrm5 cholinergic receptor, muscarinic 5 0.056
Syt8 synaptotagmin VIII 0.056
Pla2g5 phospholipase A2, group V 0.055
Omp olfactory marker protein 0.054
Cd40lg CD40 ligand 0.054
Ctsj cathepsin J 0.054
Hspd1 heat shock protein 1 (chaperonin) 0.053
Eef2 eukaryotic translation elongation factor 2 0.053
Csrnp2 cysteine-serine-rich nuclear protein 2 0.053
Olr287 olfactory receptor 287 0.053
Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.051
Olr1500 olfactory receptor 1500 0.050
Teddm1 transmembrane epididymal protein 1 0.050
LOC100360919 Immunoglobulin lambda-like polypeptide 1-like 0.049
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.046
Iapp islet amyloid polypeptide 0.046
Fam83f family with sequence similarity 83, member F 0.046
Sema6c sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 0.045
Rin1 Ras and Rab interactor 1 0.044
Rho rhodopsin 0.044
Glp1r glucagon-like peptide 1 receptor 0.043
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.043
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.043
Trpv6 transient receptor potential cation channel, subfamily V, member 6 0.043
Edn1 endothelin 1 0.042
Folh1 folate hydrolase 1 0.042
Kalrn kalirin, RhoGEF kinase 0.042
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.042
Fgf7 fibroblast growth factor 7 0.041
Il4 interleukin 4 0.041
Gpr88 G-protein coupled receptor 88 0.040
Olr1641 olfactory receptor 1641 0.040
Tacr3 tachykinin receptor 3 0.039
Olr226 olfactory receptor 226 0.039
Scnn1a sodium channel, nonvoltage-gated 1 alpha 0.039
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.038
Cntn3 contactin 3 (plasmacytoma associated) 0.038
Hrh3 histamine receptor H3 0.038
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.038
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.038
Pmch pro-melanin-concentrating hormone 0.038
Cntfr ciliary neurotrophic factor receptor 0.038
Egr4 early growth response 4 0.037
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.037
Cnga1 cyclic nucleotide gated channel alpha 1 0.036
Gpr1 G protein-coupled receptor 1 0.036
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.036
Syn3 synapsin III 0.035
RGD1308165 similar to hypothetical protein MGC17337 0.035
Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.034
Bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.033
Fshb follicle stimulating hormone, beta polypeptide 0.033
Trim47 tripartite motif-containing 47 0.033
LOC689154 hypothetical protein LOC689154 0.033
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism