IMP
Process View
The network for 'ectodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
ectodermal cell fate specification
The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| alas2 | aminolevulinate, delta-, synthetase 2 | 0.642 | |
| krt8 | keratin 8 | 0.606 | |
| tagln2 | transgelin 2 | 0.352 | |
| cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.335 | |
| krt4 | keratin 4 | 0.327 | |
| gadd45ba | growth arrest and DNA-damage-inducible, beta a | 0.299 | |
| foxa3 | forkhead box A3 | 0.233 | |
| epb41 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.180 | |
| perp | PERP, TP53 apoptosis effector | 0.168 | |
| jun | jun proto-oncogene | 0.162 | |
| nfkbiab | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b | 0.155 | |
| hspb1 | heat shock protein, alpha-crystallin-related, 1 | 0.155 | |
| cdh1 | cadherin 1, epithelial | 0.143 | |
| slc4a1a | solute carrier family 4, anion exchanger, member 1a | 0.143 | |
| ets1a | v-ets erythroblastosis virus E26 oncogene homolog 1a | 0.133 | |
| tp63 | tumor protein p63 | 0.121 | |
| klf2a | Kruppel-like factor 2a | 0.112 | |
| krt5 | keratin 5 | 0.095 | |
| sdprb | serum deprivation response b | 0.094 | |
| anxa5b | annexin A5b | 0.090 | |
| acvr1b | activin A receptor, type IB | 0.084 | |
| sfrp1a | secreted frizzled-related protein 1a | 0.083 | |
| nfkbiaa | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a | 0.080 | |
| hspa5 | heat shock protein 5 | 0.079 | |
| gata2a | GATA-binding protein 2a | 0.077 | |
| drl | draculin | 0.074 | |
| aldocb | aldolase C, fructose-bisphosphate, b | 0.073 | |
| ptgs2a | prostaglandin-endoperoxide synthase 2a | 0.073 | |
| fos | v-fos FBJ murine osteosarcoma viral oncogene homolog | 0.065 | |
| fzd7a | frizzled homolog 7a | 0.064 | |
| rhov | ras homolog gene family, member V | 0.063 | |
| rasl11b | RAS-like, family 11, member B | 0.062 | |
| atp1b1a | ATPase, Na+/K+ transporting, beta 1a polypeptide | 0.060 | |
| amotl2a | angiomotin like 2a | 0.058 | |
| gapdhs | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 0.057 | |
| btg2 | B-cell translocation gene 2 | 0.057 | |
| klf4 | Kruppel-like factor 4 | 0.057 | |
| dspa | desmoplakin a | 0.057 | |
| mych | myelocytomatosis oncogene homolog | 0.056 | |
| pea3 | ETS-domain transcription factor pea3 | 0.055 | |
| dact2 | dapper homolog 2, antagonist of beta-catenin (xenopus) | 0.055 | |
| blf | bloody fingers | 0.053 | |
| bmper | BMP binding endothelial regulator | 0.052 | |
| zfand5a | zinc finger, AN1-type domain 5a | 0.051 | |
| klf2b | Kruppel-like factor 2b | 0.050 | |
| wif1 | wnt inhibitory factor 1 | 0.049 | |
| tfap2c | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.049 | |
| krt18 | keratin 18 | 0.046 | |
| irf6 | interferon regulatory factor 6 | 0.045 | |
| ippk | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | 0.042 | |
| dlx3b | distal-less homeobox gene 3b | 0.041 | |
| celsr1a | cadherin EGF LAG seven-pass G-type receptor 1a | 0.039 | |
| wu:fc24e06 | wu:fc24e06 | 0.038 | |
| socs3a | suppressor of cytokine signaling 3a | 0.036 | |
| apoeb | apolipoprotein Eb | 0.035 | |
| llgl2 | lethal giant larvae homolog 2 (Drosophila) | 0.035 | |
| anxa1a | annexin A1a | 0.035 | |
| mmp2 | matrix metalloproteinase 2 | 0.034 | |
| jup | junction plakoglobin | 0.034 | |
| id1 | inhibitor of DNA binding 1 | 0.034 | |
| gata3 | GATA-binding protein 3 | 0.033 | |
| aplnrb | apelin receptor b | 0.033 | |
| stat3 | signal transduction and activation of transcription 3 | 0.033 | |
| zgc:91870 | zgc:91870 | 0.033 | |
| cahz | carbonic anhydrase | 0.032 | |
| cxcr4a | chemokine (C-X-C motif) receptor 4a | 0.031 | |
| junbl | jun B proto-oncogene, like | 0.031 | |
| gata1a | GATA binding protein 1a | 0.031 | |
| urod | uroporphyrinogen decarboxylase | 0.030 | |
| bmpr1aa | bone morphogenetic protein receptor, type 1aa | 0.029 | |
| aqp1a.1 | aquaporin 1a, tandem duplicate 1 | 0.028 | |
| foxb1.2 | forkhead box B1.2 | 0.028 | |
| mvp | major vault protein | 0.027 | |
| pabpc1b | poly A binding protein, cytoplasmic 1 b | 0.027 | |
| alcamb | activated leukocyte cell adhesion molecule b | 0.026 | |
| gnb1a | guanine nucleotide binding protein (G protein), beta polypeptide 1a | 0.026 | |
| junb | jun B proto-oncogene | 0.026 | |
| fzd7b | frizzled homolog 7b | 0.026 | |
| sox3 | SRY-box containing gene 3 | 0.026 | |
| sptb | spectrin, beta, erythrocytic | 0.026 | |
| dsc2l | desmocollin 2 like | 0.024 | |
| dusp5 | dual specificity phosphatase 5 | 0.024 | |
| pdlim1 | PDZ and LIM domain 1 (elfin) | 0.024 | |
| zgc:55813 | zgc:55813 | 0.023 | |
| gmds | GDP-mannose 4,6-dehydratase | 0.023 | |
| tal1 | T-cell acute lymphocytic leukemia 1 | 0.022 | |
| bhlhe40 | basic helix-loop-helix family, member e40 | 0.022 | |
| dusp2 | dual specificity phosphatase 2 | 0.022 | |
| brd2a | bromodomain-containing 2a | 0.022 | |
| cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.021 | |
| gadd45bb | growth arrest and DNA-damage-inducible, beta b | 0.021 | |
| gsna | gelsolin a | 0.020 | |
| si:ch211-166a6.5 | si:ch211-166a6.5 | 0.020 | |
| appa | amyloid beta (A4) precursor protein a | 0.020 | |
| pfn1 | profilin 1 | 0.020 | |
| inka1a | induced in neural crest by AP2, 1a | 0.020 | |
| ctsl1b | cathepsin L, 1 b | 0.019 | |
| calm1a | calmodulin 1a | 0.018 | |
| her6 | hairy-related 6 | 0.018 | |
| nrarpa | notch-regulated ankyrin repeat protein a | 0.018 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| BBS10 | Bardet-Biedl syndrome 10 | 0.517 | |
| WNT3A | wingless-type MMTV integration site family, member 3A | 0.234 | |
| SMAD1 | SMAD family member 1 | 0.199 | |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.195 | |
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 0.182 | |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | 0.140 | |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.115 | |
| NDP | Norrie disease (pseudoglioma) | 0.106 | |
| RGS2 | regulator of G-protein signaling 2, 24kDa | 0.100 | |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.087 | |
| EHF | ets homologous factor | 0.086 | |
| DUSP1 | dual specificity phosphatase 1 | 0.073 | |
| SFRP1 | secreted frizzled-related protein 1 | 0.039 | |
| GPR124 | G protein-coupled receptor 124 | 0.037 | |
| OGN | osteoglycin | 0.031 | |
| RHOB | ras homolog gene family, member B | 0.028 | |
| FOXF2 | forkhead box F2 | 0.025 | |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.024 | |
| DACT1 | dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) | 0.021 | |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.019 | |
| LUM | lumican | 0.019 | |
| MFAP5 | microfibrillar associated protein 5 | 0.019 | |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.018 | |
| COL5A2 | collagen, type V, alpha 2 | 0.018 | |
| LRRC17 | leucine rich repeat containing 17 | 0.017 | |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.016 | |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.016 | |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.015 | |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 0.015 | |
| OLFML1 | olfactomedin-like 1 | 0.015 | |
| PRRX1 | paired related homeobox 1 | 0.015 | |
| FBLN1 | fibulin 1 | 0.015 | |
| OMD | osteomodulin | 0.014 | |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.014 | |
| TRAF4 | TNF receptor-associated factor 4 | 0.014 | |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.013 | |
| PLXDC1 | plexin domain containing 1 | 0.013 | |
| BMP4 | bone morphogenetic protein 4 | 0.013 | |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.013 | |
| POSTN | periostin, osteoblast specific factor | 0.013 | |
| COL5A1 | collagen, type V, alpha 1 | 0.013 | |
| GPC4 | glypican 4 | 0.013 | |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.013 | |
| KCNE4 | potassium voltage-gated channel, Isk-related family, member 4 | 0.012 | |
| TWIST1 | twist homolog 1 (Drosophila) | 0.012 | |
| C7 | complement component 7 | 0.012 | |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.012 | |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.012 | |
| MFAP4 | microfibrillar-associated protein 4 | 0.011 | |
| KLF4 | Kruppel-like factor 4 (gut) | 0.011 | |
| RAI2 | retinoic acid induced 2 | 0.011 | |
| PPAP2B | phosphatidic acid phosphatase type 2B | 0.011 | |
| GAS1 | growth arrest-specific 1 | 0.011 | |
| SFRP2 | secreted frizzled-related protein 2 | 0.011 | |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.011 | |
| UBQLN4 | ubiquilin 4 | 0.011 | |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.011 | |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.011 | |
| BBS7 | Bardet-Biedl syndrome 7 | 0.010 | |
| LAMA2 | laminin, alpha 2 | 0.010 | |
| IER2 | immediate early response 2 | 0.010 | |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | 0.010 | |
| SULF1 | sulfatase 1 | 0.010 | |
| SOX17 | SRY (sex determining region Y)-box 17 | 0.010 | |
| CTSK | cathepsin K | 0.010 | |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.010 |