The network for 'antimicrobial humoral response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antimicrobial humoral response

An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.

Danio rerio
Name Description Probability Func Analog Organism
LOC557072 caspase recruitment domain-containing protein 11-like 0.688
socs3a suppressor of cytokine signaling 3a 0.485
etv2 ets variant gene 2 0.356
junb jun B proto-oncogene 0.345
tal1 T-cell acute lymphocytic leukemia 1 0.317
pycard PYD and CARD domain containing 0.289
egr1 early growth response 1 0.256
spaw southpaw 0.223
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.209
tmem88a transmembrane protein 88 a 0.204
nod1 nucleotide-binding oligomerization domain containing 1 0.180
per2 period homolog 2 (Drosophila) 0.178
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.157
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.155
caspa caspase a 0.154
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.145
gata1a GATA binding protein 1a 0.143
foxd3 forkhead box D3 0.135
card14 caspase recruitment domain family, member 14 0.134
junbl jun B proto-oncogene, like 0.133
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.127
mitfa microphthalmia-associated transcription factor a 0.127
si:ch211-195h23.3 si:ch211-195h23.3 0.127
hand2 heart and neural crest derivatives expressed transcript 2 0.124
mef2cb myocyte enhancer factor 2cb 0.124
alcama activated leukocyte cell adhesion molecule a 0.124
runx1 runt-related transcription factor 1 0.122
nr1d1 nuclear receptor subfamily 1, group d, member 1 0.122
znf148 zinc finger protein 148 0.121
zgc:92851 zgc:92851 0.119
atf3 activating transcription factor 3 0.117
jun jun proto-oncogene 0.117
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.113
dll4 delta-like 4 (Drosophila) 0.112
epor erythropoietin receptor 0.111
hdr hematopoietic death receptor 0.111
zgc:153997 zgc:153997 0.109
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.107
socs3b suppressor of cytokine signaling 3b 0.104
LOC100000934 hypothetical protein LOC100000934 0.104
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.103
spi1l spleen focus forming virus (SFFV) proviral integration oncogene spi1 like 0.102
dnm2 dynamin 2 0.101
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.099
esyt3 extended synaptotagmin-like protein 3 0.096
arf2 ADP-ribosylation factor 2 0.093
twist3 twist3 0.092
lft2 lefty2 0.089
card9 caspase recruitment domain family, member 9 0.087
oep one-eyed pinhead 0.085
LOC100331484 hypothetical protein LOC100331484 0.083
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.083
crip2 cysteine-rich protein 2 0.082
ppox protoporphyrinogen oxidase 0.081
hoxb3a homeo box B3a 0.080
gata5 GATA-binding protein 5 0.078
myl7 myosin, light polypeptide 7, regulatory 0.078
itih2 inter-alpha (globulin) inhibitor H2 0.076
tie1 endothelium-specific receptor tyrosine kinase 1 0.076
vwf von Willebrand factor 0.073
fli1a friend leukemia integration 1a 0.072
pou1f1 POU domain, class 1, transcription factor 1 0.070
mapk7 mitogen-activated protein kinase 7 0.067
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.067
cdh5 cadherin 5 0.066
tlr21 toll-like receptor 21 0.065
cry3 cryptochrome 3 0.064
otpb orthopedia homolog b 0.062
cry1a cryptochrome 1a 0.062
fabp2 fatty acid binding protein 2, intestinal 0.061
si:dkey-236e20.2 si:dkey-236e20.2 0.060
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.060
tie2 endothelium-specific receptor tyrosine kinase 2 0.060
st8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.059
dlb deltaB 0.058
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.057
ecscr endothelial cell-specific chemotaxis regulator 0.057
tnnt2a troponin T2a, cardiac 0.057
dkk1b dickkopf 1b 0.056
epas1a endothelial PAS domain protein 1a 0.055
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.055
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.055
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.054
mc2r melanocortin 2 receptor 0.053
skia nuclear oncoprotein skia 0.052
alk anaplastic lymphoma kinase (Ki-1) 0.052
pparg peroxisome proliferator activated receptor gamma 0.051
tsen54 tRNA splicing endonuclease 54 homolog (S. cerevisiae) 0.051
fech ferrochelatase 0.051
ifnphi1 interferon phi 1 0.050
rel v-rel reticuloendotheliosis viral oncogene homolog 0.050
lman2 lectin, mannose-binding 2 0.050
flncb filamin C, gamma b (actin binding protein 280) 0.050
gclc glutamate-cysteine ligase, catalytic subunit 0.050
cmyb transcription factor cmyb 0.050
zgc:110340 zgc:110340 0.049
foxo3b forkhead box O3b 0.049
tfa transferrin-a 0.049
mc5ra melanocortin 5a receptor 0.048
myf6 myogenic factor 6 0.048
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rel Relish 0.999
AttA Attacin-A 0.993
PGRP-LC Peptidoglycan recognition protein LC 0.978
Tl Toll 0.966
grass Gram-positive Specific Serine protease 0.953
SPE Spatzle-Processing Enzyme 0.943
DptB Diptericin B 0.918
ird5 immune response deficient 5 0.906
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.901
Myd88 CG2078 gene product from transcript CG2078-RA 0.900
Pvr PDGF- and VEGF-receptor related 0.849
Spn27A Serpin 27A 0.834
PGRP-SA Peptidoglycan recognition protein SA 0.833
spz spatzle 0.790
ttk tramtrack 0.724
BG4 CG12297 gene product from transcript CG12297-RA 0.719
imd immune deficiency 0.692
Spn1 Serine protease inhibitor 1 0.679
cact cactus 0.670
Dredd Death related ced-3/Nedd2-like protein 0.669
Glt Glutactin 0.626
CecC Cecropin C 0.618
Irc Immune-regulated catalase 0.612
Mtk Metchnikowin 0.608
Spn28D Serpin 28D 0.589
AGO2 Argonaute 2 0.479
GNBP3 Gram-negative bacteria binding protein 3 0.441
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.431
AttC Attacin-C 0.404
Sp7 Serine protease 7 0.403
CG32185 CG32185 gene product from transcript CG32185-RA 0.355
CecA2 Cecropin A2 0.350
Egfr Epidermal growth factor receptor 0.322
pirk poor Imd response upon knock-in 0.305
bowl brother of odd with entrails limited 0.300
Dpt Diptericin 0.293
Mpk2 CG5475 gene product from transcript CG5475-RB 0.293
modSP modular serine protease 0.288
CecA1 Cecropin A1 0.277
Tak1 TGF-beta activated kinase 1 0.273
key kenny 0.273
PGRP-LB Peptidoglycan recognition protein LB 0.267
CG15065 CG15065 gene product from transcript CG15065-RA 0.266
sc scute 0.264
aop anterior open 0.259
CG13422 CG13422 gene product from transcript CG13422-RA 0.228
raps rapsynoid 0.226
baz bazooka 0.221
fon fondue 0.219
He Hemese 0.212
MED15 Mediator complex subunit 15 0.211
Hop Hsp70/Hsp90 organizing protein homolog 0.209
hb hunchback 0.205
rev7 CG2948 gene product from transcript CG2948-RA 0.202
HLHmbeta E(spl) region transcript mbeta 0.194
ird1 immune response deficient 1 0.189
foxo forkhead box, sub-group O 0.185
Adf1 Adh transcription factor 1 0.183
GNBP1 Gram-negative bacteria binding protein 1 0.182
msn misshapen 0.182
IM18 Immune induced molecule 18 0.182
Drs Drosomycin 0.180
Ndae1 Na[+]-driven anion exchanger 1 0.176
Traf6 TNF-receptor-associated factor 6 0.174
bib big brain 0.173
Cg25C Collagen type IV 0.171
PGRP-SB1 CG9681 gene product from transcript CG9681-RA 0.168
IM1 Immune induced molecule 1 0.165
psh persephone 0.152
th thread 0.152
CG9184 CG9184 gene product from transcript CG9184-RB 0.151
Dro Drosocin 0.147
Dp DP transcription factor 0.141
Duox Dual oxidase 0.140
caz cabeza 0.140
Cka Connector of kinase to AP-1 0.139
Med Medea 0.137
mask multiple ankyrin repeats single KH domain 0.134
eater CG6124 gene product from transcript CG6124-RB 0.132
CG12766 CG12766 gene product from transcript CG12766-RA 0.121
CG18594 CG18594 gene product from transcript CG18594-RA 0.120
Btk29A Btk family kinase at 29A 0.119
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.117
Gap1 GTPase-activating protein 1 0.115
tna tonalli 0.112
drk downstream of receptor kinase 0.112
wdb widerborst 0.112
dl dorsal 0.111
cora coracle 0.109
raw CG12437 gene product from transcript CG12437-RB 0.108
dome domeless 0.107
CecB Cecropin B 0.105
Cortactin CG3637 gene product from transcript CG3637-RA 0.104
nopo no poles 0.103
hep hemipterous 0.101
spirit Serine Protease Immune Response Integrator 0.101
sno strawberry notch 0.099
Pxn Peroxidasin 0.098
chic chickadee 0.097
sec6 CG5341 gene product from transcript CG5341-RA 0.096
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.999
JUN jun proto-oncogene 0.988
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.988
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.986
HIST1H2BD histone cluster 1, H2bd 0.986
BCL3 B-cell CLL/lymphoma 3 0.975
HIST1H2BE histone cluster 1, H2be 0.952
HIST1H2AC histone cluster 1, H2ac 0.924
HIST1H2BF histone cluster 1, H2bf 0.901
JUNB jun B proto-oncogene 0.896
FOS FBJ murine osteosarcoma viral oncogene homolog 0.891
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.885
HIST1H1C histone cluster 1, H1c 0.834
HIST1H2BH histone cluster 1, H2bh 0.759
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.727
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.665
LAT linker for activation of T cells 0.651
HIST1H2BG histone cluster 1, H2bg 0.626
EP300 E1A binding protein p300 0.592
HIST1H2BI histone cluster 1, H2bi 0.590
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.560
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.555
INSR insulin receptor 0.520
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.472
CDK2 cyclin-dependent kinase 2 0.471
ATF3 activating transcription factor 3 0.455
ZFYVE9 zinc finger, FYVE domain containing 9 0.427
SOS1 son of sevenless homolog 1 (Drosophila) 0.390
HIST1H3D histone cluster 1, H3d 0.340
ATF2 activating transcription factor 2 0.332
MAPK14 mitogen-activated protein kinase 14 0.321
JUND jun D proto-oncogene 0.316
CHUK conserved helix-loop-helix ubiquitous kinase 0.287
SOX10 SRY (sex determining region Y)-box 10 0.274
NCOA3 nuclear receptor coactivator 3 0.272
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.257
GAB1 GRB2-associated binding protein 1 0.247
NCOA1 nuclear receptor coactivator 1 0.241
NRP1 neuropilin 1 0.226
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.220
DUSP1 dual specificity phosphatase 1 0.213
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.190
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.179
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.159
SOCS3 suppressor of cytokine signaling 3 0.155
RARA retinoic acid receptor, alpha 0.154
HIST1H2AE histone cluster 1, H2ae 0.143
HIST1H2AJ histone cluster 1, H2aj 0.116
RXRA retinoid X receptor, alpha 0.109
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.109
HIST1H2BC histone cluster 1, H2bc 0.105
IL4R interleukin 4 receptor 0.104
JAK2 Janus kinase 2 0.103
ANG angiogenin, ribonuclease, RNase A family, 5 0.101
HIST2H2AA4 histone cluster 2, H2aa4 0.100
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.095
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.095
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.093
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.089
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.088
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.087
RNASE4 ribonuclease, RNase A family, 4 0.083
PGF placental growth factor 0.082
IGF1R insulin-like growth factor 1 receptor 0.077
MAP2K4 mitogen-activated protein kinase kinase 4 0.076
NLRC4 NLR family, CARD domain containing 4 0.076
KDM6B lysine (K)-specific demethylase 6B 0.070
STAP2 signal transducing adaptor family member 2 0.070
MAPK8 mitogen-activated protein kinase 8 0.067
EGFR epidermal growth factor receptor 0.064
IER2 immediate early response 2 0.061
HIST1H2BK histone cluster 1, H2bk 0.060
TPT1 tumor protein, translationally-controlled 1 0.060
HDAC4 histone deacetylase 4 0.055
CPNE6 copine VI (neuronal) 0.055
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.053
IRAK2 interleukin-1 receptor-associated kinase 2 0.053
GSK3B glycogen synthase kinase 3 beta 0.052
VEGFA vascular endothelial growth factor A 0.052
IL1R1 interleukin 1 receptor, type I 0.051
IRAK1 interleukin-1 receptor-associated kinase 1 0.051
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.051
RYBP RING1 and YY1 binding protein 0.049
CD28 CD28 molecule 0.049
TNIP2 TNFAIP3 interacting protein 2 0.048
BCAR1 breast cancer anti-estrogen resistance 1 0.046
GAB2 GRB2-associated binding protein 2 0.046
MED16 mediator complex subunit 16 0.045
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.043
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.042
ZC3H12A zinc finger CCCH-type containing 12A 0.042
ARID1A AT rich interactive domain 1A (SWI-like) 0.041
FOSL1 FOS-like antigen 1 0.040
YY1 YY1 transcription factor 0.039
MEF2C myocyte enhancer factor 2C 0.039
HDAC9 histone deacetylase 9 0.038
MET met proto-oncogene (hepatocyte growth factor receptor) 0.037
SOS2 son of sevenless homolog 2 (Drosophila) 0.036
TCF4 transcription factor 4 0.036
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.035
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.272
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.260
Jun Jun oncogene 0.246
Mapk14 mitogen-activated protein kinase 14 0.227
Ikbkg inhibitor of kappaB kinase gamma 0.219
Tnf tumor necrosis factor 0.191
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.171
Tlr4 toll-like receptor 4 0.137
Lyz2 lysozyme 2 0.131
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.114
Fos FBJ osteosarcoma oncogene 0.106
Atf2 activating transcription factor 2 0.104
Ccl2 chemokine (C-C motif) ligand 2 0.083
Myd88 myeloid differentiation primary response gene 88 0.077
Rxra retinoid X receptor alpha 0.073
Gata4 GATA binding protein 4 0.056
Stat3 signal transducer and activator of transcription 3 0.052
Stat5b signal transducer and activator of transcription 5B 0.051
Il1rn interleukin 1 receptor antagonist 0.049
E2f1 E2F transcription factor 1 0.045
Plcg1 phospholipase C, gamma 1 0.044
Hdac4 histone deacetylase 4 0.044
Stat5a signal transducer and activator of transcription 5A 0.043
Gata6 GATA binding protein 6 0.037
Csf1 colony stimulating factor 1 (macrophage) 0.036
Kdr kinase insert domain protein receptor 0.036
Met met proto-oncogene 0.035
Gm10104 predicted gene 10104 0.034
Rb1 retinoblastoma 1 0.033
Gm14850 predicted gene 14850 0.033
Tnip1 TNFAIP3 interacting protein 1 0.030
Zfp36 zinc finger protein 36 0.030
Fbn1 fibrillin 1 0.029
Cxcl2 chemokine (C-X-C motif) ligand 2 0.028
Foxp3 forkhead box P3 0.026
Per2 period homolog 2 (Drosophila) 0.025
Cdx2 caudal type homeobox 2 0.025
Defa-rs1 defensin, alpha, related sequence 1 0.025
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.024
Egr1 early growth response 1 0.024
Pax2 paired box gene 2 0.024
Hmx3 H6 homeobox 3 0.022
Gm15308 predicted gene 15308 0.022
Mapk8 mitogen-activated protein kinase 8 0.021
Pycard PYD and CARD domain containing 0.021
Fpr2 formyl peptide receptor 2 0.021
Gm15315 predicted gene 15315 0.020
Hdac5 histone deacetylase 5 0.020
Defa20 defensin, alpha, 20 0.020
Defa21 defensin, alpha, 21 0.020
Grb2 growth factor receptor bound protein 2 0.020
Defa17 defensin, alpha, 17 0.020
S1pr2 sphingosine-1-phosphate receptor 2 0.019
Il1b interleukin 1 beta 0.018
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.018
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.017
Defa-rs7 defensin, alpha, related sequence 7 0.017
Cyld cylindromatosis (turban tumor syndrome) 0.017
Guca2b guanylate cyclase activator 2b (retina) 0.017
Ticam1 toll-like receptor adaptor molecule 1 0.017
Cxcl1 chemokine (C-X-C motif) ligand 1 0.017
Aim2 absent in melanoma 2 0.016
Cd44 CD44 antigen 0.016
Cbl Casitas B-lineage lymphoma 0.016
Dbp D site albumin promoter binding protein 0.016
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.015
Atf3 activating transcription factor 3 0.015
Ctcf CCCTC-binding factor 0.015
Mapk11 mitogen-activated protein kinase 11 0.015
Orm2 orosomucoid 2 0.015
Rel reticuloendotheliosis oncogene 0.015
Irf1 interferon regulatory factor 1 0.014
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.014
Prf1 perforin 1 (pore forming protein) 0.014
C3ar1 complement component 3a receptor 1 0.014
Defa22 defensin, alpha, 22 0.013
Il10 interleukin 10 0.013
Cd19 CD19 antigen 0.013
Clec4d C-type lectin domain family 4, member d 0.012
Jag1 jagged 1 0.012
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.012
Gm15293 predicted gene 15293 0.011
Shc1 src homology 2 domain-containing transforming protein C1 0.011
Rps14 ribosomal protein S14 0.011
Gmnn geminin 0.011
Chuk conserved helix-loop-helix ubiquitous kinase 0.011
Bdkrb2 bradykinin receptor, beta 2 0.011
Il18 interleukin 18 0.011
Ldlr low density lipoprotein receptor 0.011
Hand2 heart and neural crest derivatives expressed transcript 2 0.011
Men1 multiple endocrine neoplasia 1 0.011
Erbb2ip Erbb2 interacting protein 0.010
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.010
Foxc2 forkhead box C2 0.010
Fosl2 fos-like antigen 2 0.010
Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) 0.010
Mta1 metastasis associated 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism