IMP

Process View

Homo sapiens

3 genes annotated in human

positive regulation of myotube differentiation

Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of myotube differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of myotube differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	0.980
IL4R	interleukin 4 receptor	0.869	Mouse
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.745
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.544
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.474
H3F3C	H3 histone, family 3C	0.302
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.230
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.200
DPP4	dipeptidyl-peptidase 4	0.175
MAP2K3	mitogen-activated protein kinase kinase 3	0.170
PTRF	polymerase I and transcript release factor	0.166
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.138
NCOA6	nuclear receptor coactivator 6	0.138
IL4	interleukin 4	0.134	Mouse
ANKFY1	ankyrin repeat and FYVE domain containing 1	0.121
MED31	mediator complex subunit 31	0.115
NOTCH1	notch 1	0.108
LRRK2	leucine-rich repeat kinase 2	0.106
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.090
AKT1S1	AKT1 substrate 1 (proline-rich)	0.085
RPTOR	regulatory associated protein of MTOR, complex 1	0.079
IL2RG	interleukin 2 receptor, gamma	0.079
MAPK1	mitogen-activated protein kinase 1	0.077
IGFBP4	insulin-like growth factor binding protein 4	0.051
MICALL1	MICAL-like 1	0.044
MAP2K6	mitogen-activated protein kinase kinase 6	0.040
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.040
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.039
MAPK9	mitogen-activated protein kinase 9	0.039
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.038
DEPTOR	DEP domain containing MTOR-interacting protein	0.037
MAPK3	mitogen-activated protein kinase 3	0.033
DUSP1	dual specificity phosphatase 1	0.033
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.033
RARA	retinoic acid receptor, alpha	0.029
RBM4B	RNA binding motif protein 4B	0.029
DUSP7	dual specificity phosphatase 7	0.029
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.028
PEA15	phosphoprotein enriched in astrocytes 15	0.028
MED1	mediator complex subunit 1	0.025
STK10	serine/threonine kinase 10	0.024
VIM	vimentin	0.024
BAX	BCL2-associated X protein	0.023
MDFI	MyoD family inhibitor	0.023
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.023
DUSP3	dual specificity phosphatase 3	0.022
PTPRR	protein tyrosine phosphatase, receptor type, R	0.021
BIK	BCL2-interacting killer (apoptosis-inducing)	0.021
BCL2L2	BCL2-like 2	0.020
MAPK8	mitogen-activated protein kinase 8	0.020
BAD	BCL2-associated agonist of cell death	0.020
NCOA1	nuclear receptor coactivator 1	0.019
GSK3B	glycogen synthase kinase 3 beta	0.019
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.019
BBC3	BCL2 binding component 3	0.019
EHD4	EH-domain containing 4	0.018
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.018
NCOR2	nuclear receptor corepressor 2	0.017
BCL2A1	BCL2-related protein A1	0.017
IQGAP1	IQ motif containing GTPase activating protein 1	0.017
RHEB	Ras homolog enriched in brain	0.017
ELSPBP1	epididymal sperm binding protein 1	0.016
PRR5	proline rich 5 (renal)	0.015
EPOR	erythropoietin receptor	0.015
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.015
RHEBL1	Ras homolog enriched in brain like 1	0.014
CXCL11	chemokine (C-X-C motif) ligand 11	0.014
TNNI1	troponin I type 1 (skeletal, slow)	0.014
MYOCD	myocardin	0.014
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.013
AKAP11	A kinase (PRKA) anchor protein 11	0.013
MKL1	megakaryoblastic leukemia (translocation) 1	0.013
MAP2K1	mitogen-activated protein kinase kinase 1	0.013
TP53BP2	tumor protein p53 binding protein, 2	0.013
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.013
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.013
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.013
TRIOBP	TRIO and F-actin binding protein	0.012
MYOD1	myogenic differentiation 1	0.012
RICTOR	RPTOR independent companion of MTOR, complex 2	0.012
MKL2	MKL/myocardin-like 2	0.012
OLFML2A	olfactomedin-like 2A	0.012
MYF5	myogenic factor 5	0.012	Human
MYOG	myogenin (myogenic factor 4)	0.012	Human Mouse
PDLIM1	PDZ and LIM domain 1	0.012
ANKRD35	ankyrin repeat domain 35	0.012
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	0.011
TNS1	tensin 1	0.011
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.011
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.011
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.011
JAG1	jagged 1	0.011
SYNPO2L	synaptopodin 2-like	0.011
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.010
EP300	E1A binding protein p300	0.010
PRKCZ	protein kinase C, zeta	0.010
LOXL1	lysyl oxidase-like 1	0.010