IMP

Process View

Homo sapiens

7 genes annotated in human

Multi-species View

negative regulation of bone mineralization

GO:0030502

Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of bone mineralization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of bone mineralization" (in gray)

Name	Description	Probability	Func Analog Organism
CCL5	chemokine (C-C motif) ligand 5	1.000	Human
CCR5	chemokine (C-C motif) receptor 5	1.000	Human
CCL4	chemokine (C-C motif) ligand 4	0.992	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.918
CCR7	chemokine (C-C motif) receptor 7	0.907	Human
IL8	interleukin 8	0.893
CCR4	chemokine (C-C motif) receptor 4	0.878	Human
CCL2	chemokine (C-C motif) ligand 2	0.795	Human
CCL22	chemokine (C-C motif) ligand 22	0.735	Human
CCL8	chemokine (C-C motif) ligand 8	0.583	Human
CCL3	chemokine (C-C motif) ligand 3	0.520
IFNG	interferon, gamma	0.497
IL2RB	interleukin 2 receptor, beta	0.470
CCR2	chemokine (C-C motif) receptor 2	0.465	Human
CCL13	chemokine (C-C motif) ligand 13	0.464	Human
IL1B	interleukin 1, beta	0.417
CXCL2	chemokine (C-X-C motif) ligand 2	0.328
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.270
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.244
VCAN	versican	0.222
IL10	interleukin 10	0.217
IRF4	interferon regulatory factor 4	0.188
CCL11	chemokine (C-C motif) ligand 11	0.174	Human
IL6	interleukin 6 (interferon, beta 2)	0.169
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.165	Human
CCL19	chemokine (C-C motif) ligand 19	0.162	Human
KDM2B	lysine (K)-specific demethylase 2B	0.154
PDCD6IP	programmed cell death 6 interacting protein	0.148
EGLN1	egl nine homolog 1 (C. elegans)	0.145
CXCL3	chemokine (C-X-C motif) ligand 3	0.139
CXCL13	chemokine (C-X-C motif) ligand 13	0.136
CD40LG	CD40 ligand	0.133
DPP4	dipeptidyl-peptidase 4	0.121
CXCR3	chemokine (C-X-C motif) receptor 3	0.091	Human
SLAMF7	SLAM family member 7	0.089
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.089
CXCL11	chemokine (C-X-C motif) ligand 11	0.062
MATK	megakaryocyte-associated tyrosine kinase	0.062
TNF	tumor necrosis factor	0.050
IDE	insulin-degrading enzyme	0.047
CCL7	chemokine (C-C motif) ligand 7	0.046	Human
CLEC7A	C-type lectin domain family 7, member A	0.046
IL2RG	interleukin 2 receptor, gamma	0.045
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.044
RGS1	regulator of G-protein signaling 1	0.040
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.039
CXCL5	chemokine (C-X-C motif) ligand 5	0.038
CCR3	chemokine (C-C motif) receptor 3	0.037	Human
CCR6	chemokine (C-C motif) receptor 6	0.036	Human
CD86	CD86 molecule	0.035
CXCR6	chemokine (C-X-C motif) receptor 6	0.034	Human
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.034
IL1F5	interleukin 1 family, member 5 (delta)	0.034
TAL1	T-cell acute lymphocytic leukemia 1	0.033
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.033
IL1R2	interleukin 1 receptor, type II	0.029
CXCR5	chemokine (C-X-C motif) receptor 5	0.029	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.029
SELE	selectin E	0.027
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.027
SOCS3	suppressor of cytokine signaling 3	0.026
CCL20	chemokine (C-C motif) ligand 20	0.025	Human
ADAMDEC1	ADAM-like, decysin 1	0.025
CXCR2	chemokine (C-X-C motif) receptor 2	0.024	Human
IL21R	interleukin 21 receptor	0.022
IL2RA	interleukin 2 receptor, alpha	0.022
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.022
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.021
CLEC10A	C-type lectin domain family 10, member A	0.021
IL10RA	interleukin 10 receptor, alpha	0.020
ALB	albumin	0.020
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.020
CCR8	chemokine (C-C motif) receptor 8	0.019	Human
CCR1	chemokine (C-C motif) receptor 1	0.019
CCR9	chemokine (C-C motif) receptor 9	0.019	Human
CCL1	chemokine (C-C motif) ligand 1	0.018	Human
TRAF1	TNF receptor-associated factor 1	0.017
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.017
IL18RAP	interleukin 18 receptor accessory protein	0.017
IL7R	interleukin 7 receptor	0.017
FPR3	formyl peptide receptor 3	0.015
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.015
CCL21	chemokine (C-C motif) ligand 21	0.015
SLAMF1	signaling lymphocytic activation molecule family member 1	0.014
CD2	CD2 molecule	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.012
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.012
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
CD84	CD84 molecule	0.011
TBX21	T-box 21	0.011
BCAR1	breast cancer anti-estrogen resistance 1	0.011
CD163	CD163 molecule	0.011
EBI3	Epstein-Barr virus induced 3	0.011
IL1RN	interleukin 1 receptor antagonist	0.011
DNASE1L3	deoxyribonuclease I-like 3	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.010
CSF1R	colony stimulating factor 1 receptor	0.010
IL13	interleukin 13	0.010
C3AR1	complement component 3a receptor 1	0.010
PTPRE	protein tyrosine phosphatase, receptor type, E	0.010