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Homo sapiens

22 genes annotated in human

pigmentation

The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pigmentation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pigmentation" (in gray)

Name	Description	Probability	Func Analog Organism
DTNBP1	dystrobrevin binding protein 1	0.532
PLDN	pallidin homolog (mouse)	0.487
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.447
BCL2L1	BCL2-like 1	0.325
RAB27A	RAB27A, member RAS oncogene family	0.284	Mouse
EP300	E1A binding protein p300	0.264
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.232
PSEN1	presenilin 1	0.232	Zebrafish
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.224	Human
VIPAR	VPS33B interacting protein, apical-basolateral polarity regulator	0.216
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.206
POU3F2	POU class 3 homeobox 2	0.198
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.189
MAPK1	mitogen-activated protein kinase 1	0.180
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.174
MEOX2	mesenchyme homeobox 2	0.157
POU5F1	POU class 5 homeobox 1	0.156
EPS15	epidermal growth factor receptor pathway substrate 15	0.108
GSK3B	glycogen synthase kinase 3 beta	0.102
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.098
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.090
MAPK3	mitogen-activated protein kinase 3	0.081
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.075
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.065
CTBP1	C-terminal binding protein 1	0.061
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.060
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.059
COPB2	coatomer protein complex, subunit beta 2 (beta prime)	0.059
MLPH	melanophilin	0.050	Mouse
ARRB1	arrestin, beta 1	0.047
ADORA2A	adenosine A2a receptor	0.046
BCAP31	B-cell receptor-associated protein 31	0.045
SNAPIN	SNAP-associated protein	0.045
PGK1	phosphoglycerate kinase 1	0.044
MUTED	muted homolog (mouse)	0.044
BAK1	BCL2-antagonist/killer 1	0.044
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.042
TM9SF2	transmembrane 9 superfamily member 2	0.042
RAB14	RAB14, member RAS oncogene family	0.041
APLP2	amyloid beta (A4) precursor-like protein 2	0.041
SMAD1	SMAD family member 1	0.040
CLASP1	cytoplasmic linker associated protein 1	0.039
DSG2	desmoglein 2	0.038
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.038
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.037
PDZD11	PDZ domain containing 11	0.036
EXOC7	exocyst complex component 7	0.035
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.034
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.034
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.033
RAB10	RAB10, member RAS oncogene family	0.033
EEF2K	eukaryotic elongation factor-2 kinase	0.033
UBQLN1	ubiquilin 1	0.032
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.031
HDAC2	histone deacetylase 2	0.031
SH3BP4	SH3-domain binding protein 4	0.031
CTNND1	catenin (cadherin-associated protein), delta 1	0.031
EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	0.030
KITLG	KIT ligand	0.030	Mouse
BBS2	Bardet-Biedl syndrome 2	0.029
OCRL	oculocerebrorenal syndrome of Lowe	0.029
JUP	junction plakoglobin	0.027
PCM1	pericentriolar material 1	0.027
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.027
FLNB	filamin B, beta	0.026
TCF4	transcription factor 4	0.025
GRB7	growth factor receptor-bound protein 7	0.025
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.025
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.025
GDI2	GDP dissociation inhibitor 2	0.025
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.025
PDIA3	protein disulfide isomerase family A, member 3	0.024
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.023
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.023
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.022	Zebrafish Mouse
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.022
BECN1	beclin 1, autophagy related	0.021
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.021
BBS1	Bardet-Biedl syndrome 1	0.021
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.021	Fly
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.021
DUSP3	dual specificity phosphatase 3	0.020
RNR2	l-rRNA	0.019
CTSA	cathepsin A	0.019
COPG	coatomer protein complex, subunit gamma	0.018
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.018
YY1	YY1 transcription factor	0.018
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.017	Zebrafish
QKI	quaking homolog, KH domain RNA binding (mouse)	0.017
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.017
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.017
MYO5A	myosin VA (heavy chain 12, myoxin)	0.017	Mouse Rat
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.016
PKM2	pyruvate kinase, muscle	0.016
TGIF1	TGFB-induced factor homeobox 1	0.016
RNF144B	ring finger protein 144B	0.016
PRSS8	protease, serine, 8	0.016
ZFYVE1	zinc finger, FYVE domain containing 1	0.016
FXYD3	FXYD domain containing ion transport regulator 3	0.016
MTF1	metal-regulatory transcription factor 1	0.016
NAMPT	nicotinamide phosphoribosyltransferase	0.015
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.015
RAB5A	RAB5A, member RAS oncogene family	0.015
TIMP1	TIMP metallopeptidase inhibitor 1	0.015
AR	androgen receptor	0.015
BBS9	Bardet-Biedl syndrome 9	0.015
RABIF	RAB interacting factor	0.015
HDAC9	histone deacetylase 9	0.014
LAMP1	lysosomal-associated membrane protein 1	0.014
LDOC1	leucine zipper, down-regulated in cancer 1	0.014
BAD	BCL2-associated agonist of cell death	0.014
COPA	coatomer protein complex, subunit alpha	0.013
ARF4	ADP-ribosylation factor 4	0.013
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.013	Fly
COPB1	coatomer protein complex, subunit beta 1	0.013
RUNX1	runt-related transcription factor 1	0.013
VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	0.013
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.013
BIK	BCL2-interacting killer (apoptosis-inducing)	0.013
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.013
BID	BH3 interacting domain death agonist	0.013
VDAC1	voltage-dependent anion channel 1	0.012
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
PTK6	PTK6 protein tyrosine kinase 6	0.012
YAP1	Yes-associated protein 1	0.012
CIB1	calcium and integrin binding 1 (calmyrin)	0.012
AP1M2	adaptor-related protein complex 1, mu 2 subunit	0.012	Human
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.012
PSAP	prosaposin	0.012
HIC1	hypermethylated in cancer 1	0.012
C19orf46	chromosome 19 open reading frame 46	0.012
ATP6V1E1	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1	0.012
CD9	CD9 molecule	0.011
EGR1	early growth response 1	0.011
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.011
CLINT1	clathrin interactor 1	0.011
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.011
TTC8	tetratricopeptide repeat domain 8	0.011
PIAS4	protein inhibitor of activated STAT, 4	0.011
ADAM10	ADAM metallopeptidase domain 10	0.011
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.011
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.011
RNF111	ring finger protein 111	0.011
BCAT2	branched chain amino-acid transaminase 2, mitochondrial	0.011
LDHA	lactate dehydrogenase A	0.011
SMAD3	SMAD family member 3	0.011
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.010
MEF2A	myocyte enhancer factor 2A	0.010
PEA15	phosphoprotein enriched in astrocytes 15	0.010
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.010
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.010
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.010	Zebrafish
NEU1	sialidase 1 (lysosomal sialidase)	0.010