IMP
Process View
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BRCA1 | breast cancer 1, early onset | 0.550 | ||
| TP53 | tumor protein p53 | 0.517 | ||
| CCNE1 | cyclin E1 | 0.387 | ||
| EP300 | E1A binding protein p300 | 0.370 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.295 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.220 | ||
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | 0.176 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.148 | ||
| FANCE | Fanconi anemia, complementation group E | 0.140 | ||
| MAPK14 | mitogen-activated protein kinase 14 | 0.128 | ||
| PML | promyelocytic leukemia | 0.125 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.100 | ||
| DAXX | death-domain associated protein | 0.099 | ||
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.095 | ||
| MAPK3 | mitogen-activated protein kinase 3 | 0.068 | ||
| PRKCA | protein kinase C, alpha | 0.054 | ||
| ATM | ataxia telangiectasia mutated | 0.043 | ||
| COASY | CoA synthase | 0.041 | ||
| MAPK1 | mitogen-activated protein kinase 1 | 0.041 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.038 | ||
| WWOX | WW domain containing oxidoreductase | 0.038 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.036 | ||
| KRT5 | keratin 5 | 0.035 | ||
| TADA3 | transcriptional adaptor 3 | 0.032 | ||
| ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 0.031 | ||
| EEF2K | eukaryotic elongation factor-2 kinase | 0.027 | ||
| LIMD1 | LIM domains containing 1 | 0.025 | ||
| IFI16 | interferon, gamma-inducible protein 16 | 0.024 | ||
| CREB1 | cAMP responsive element binding protein 1 | 0.023 | ||
| USP42 | ubiquitin specific peptidase 42 | 0.023 | ||
| PLK1 | polo-like kinase 1 | 0.022 | ||
| TOX4 | TOX high mobility group box family member 4 | 0.022 | ||
| SP100 | SP100 nuclear antigen | 0.021 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.021 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.021 | ||
| MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | 0.021 | ||
| DMC1 | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 0.020 | ||
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.020 | ||
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.020 | ||
| CCND3 | cyclin D3 | 0.019 | ||
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.018 | ||
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.017 | ||
| CDC25B | cell division cycle 25 homolog B (S. pombe) | 0.017 | ||
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.017 | ||
| PHF11 | PHD finger protein 11 | 0.016 | ||
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 0.015 | ||
| MKRN1 | makorin ring finger protein 1 | 0.015 | ||
| SETD7 | SET domain containing (lysine methyltransferase) 7 | 0.015 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.014 | ||
| LIMK2 | LIM domain kinase 2 | 0.013 | ||
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.012 | ||
| GLUL | glutamate-ammonia ligase | 0.012 | ||
| ARIH2 | ariadne homolog 2 (Drosophila) | 0.012 | ||
| DVL2 | dishevelled, dsh homolog 2 (Drosophila) | 0.012 | ||
| CDC25A | cell division cycle 25 homolog A (S. pombe) | 0.011 | ||
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 0.011 | ||
| FBN3 | fibrillin 3 | 0.011 | ||
| C19orf46 | chromosome 19 open reading frame 46 | 0.011 | ||
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.011 | ||
| CCND1 | cyclin D1 | 0.011 | ||
| RBBP5 | retinoblastoma binding protein 5 | 0.011 | ||
| SP140L | SP140 nuclear body protein-like | 0.010 | Human |