IMP

Process View

Homo sapiens

8 genes annotated in human

Multi-species View

regulation of chromatin silencing

GO:0031935

Any process that affects the rate, extent or location of chromatin silencing.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of chromatin silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of chromatin silencing" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	0.976
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.940
EP300	E1A binding protein p300	0.732
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.666
SP1	Sp1 transcription factor	0.625
HDAC2	histone deacetylase 2	0.578
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.518
CBX5	chromobox homolog 5	0.441	Fly
CREBBP	CREB binding protein	0.436
RB1	retinoblastoma 1	0.299
ESR1	estrogen receptor 1	0.201
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.173
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.164
PAX3	paired box 3	0.157
MCM6	minichromosome maintenance complex component 6	0.134
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.126
ORC6	origin recognition complex, subunit 6	0.126
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.118
MCM4	minichromosome maintenance complex component 4	0.113
HCFC1	host cell factor C1 (VP16-accessory protein)	0.112
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.107
BCOR	BCL6 corepressor	0.098
ARID1A	AT rich interactive domain 1A (SWI-like)	0.091
CBX3	chromobox homolog 3	0.089	Fly
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.088
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.084
ADNP	activity-dependent neuroprotector homeobox	0.068
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.066
RBBP4	retinoblastoma binding protein 4	0.063
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.056
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.046
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.043
ORC2	origin recognition complex, subunit 2	0.042
FOXD3	forkhead box D3	0.041
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.039
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.039
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.038	Yeast
MCM2	minichromosome maintenance complex component 2	0.037
MCM3	minichromosome maintenance complex component 3	0.037
MAPK14	mitogen-activated protein kinase 14	0.034
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.032
SMAD3	SMAD family member 3	0.029
CHD4	chromodomain helicase DNA binding protein 4	0.028
HTT	huntingtin	0.028
SAP30	Sin3A-associated protein, 30kDa	0.027
HIST1H3B	histone cluster 1, H3b	0.026
EED	embryonic ectoderm development	0.026
MSL2	male-specific lethal 2 homolog (Drosophila)	0.026
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.025
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.023
NCOR2	nuclear receptor corepressor 2	0.023
ORC3	origin recognition complex, subunit 3	0.023
PCNA	proliferating cell nuclear antigen	0.021
POGZ	pogo transposable element with ZNF domain	0.021
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.021
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.020
SETD7	SET domain containing (lysine methyltransferase) 7	0.019
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.019
CDYL	chromodomain protein, Y-like	0.018
CBX1	chromobox homolog 1	0.018	Fly
SMAD7	SMAD family member 7	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.017
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.017
PARP1	poly (ADP-ribose) polymerase 1	0.017
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.017
SOX2	SRY (sex determining region Y)-box 2	0.015
NQO1	NAD(P)H dehydrogenase, quinone 1	0.015
TALDO1	transaldolase 1	0.014
ORC4	origin recognition complex, subunit 4	0.014
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.014
RCOR1	REST corepressor 1	0.014
HMGA1	high mobility group AT-hook 1	0.014
NCOA3	nuclear receptor coactivator 3	0.013
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.013
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.013
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.012
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.012
CHD3	chromodomain helicase DNA binding protein 3	0.012
DBF4	DBF4 homolog (S. cerevisiae)	0.012
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
MBD1	methyl-CpG binding domain protein 1	0.011
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.011
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.011
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.010
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.010
NCOA1	nuclear receptor coactivator 1	0.010
SOCS1	suppressor of cytokine signaling 1	0.010
RBBP7	retinoblastoma binding protein 7	0.010