IMP

Process View

Homo sapiens

26 genes annotated in human

membrane depolarization

The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "membrane depolarization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "membrane depolarization" (in gray)

Name	Description	Probability	Func Analog Organism
DLG4	discs, large homolog 4 (Drosophila)	0.970	Rat
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.957
GRB2	growth factor receptor-bound protein 2	0.619
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.574	Mouse
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.494	Human
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.382
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.374	Human
SPRR2A	small proline-rich protein 2A	0.294
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.253
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.223	Human
SMN1	survival of motor neuron 1, telomeric	0.197	Fly
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.196	Human
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.188	Human
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.126
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.096
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.085	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.072	Human
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.067
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.065
DRD2	dopamine receptor D2	0.064
SFN	stratifin	0.062	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.054
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.051
FYN	FYN oncogene related to SRC, FGR, YES	0.050	Human
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.048	Human
HDAC4	histone deacetylase 4	0.046
TNK2	tyrosine kinase, non-receptor, 2	0.046
SNAP25	synaptosomal-associated protein, 25kDa	0.044
NLRC4	NLR family, CARD domain containing 4	0.041
YAP1	Yes-associated protein 1	0.038
MAPT	microtubule-associated protein tau	0.038
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.037
GHR	growth hormone receptor	0.036
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.035
SNTG2	syntrophin, gamma 2	0.034
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.033
BAI1	brain-specific angiogenesis inhibitor 1	0.032
BLNK	B-cell linker	0.032
LCK	lymphocyte-specific protein tyrosine kinase	0.032	Human
CHDH	choline dehydrogenase	0.031
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.031
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.031	Human
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.030
HCK	hemopoietic cell kinase	0.029	Human
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.029
APP	amyloid beta (A4) precursor protein	0.028
PDCD6IP	programmed cell death 6 interacting protein	0.027
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.027
SMAD4	SMAD family member 4	0.027
AKAP12	A kinase (PRKA) anchor protein 12	0.026
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.026
NCK1	NCK adaptor protein 1	0.026
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.024	Mouse Rat
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.023
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.023	Mouse
CAV2	caveolin 2	0.023
MED28	mediator complex subunit 28	0.023
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.022
ARRDC3	arrestin domain containing 3	0.022
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.021
GAS7	growth arrest-specific 7	0.020
HIPK2	homeodomain interacting protein kinase 2	0.020
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.020
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.019
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.019	Human
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.018	Human
TNS4	tensin 4	0.018
NRXN1	neurexin 1	0.018	Mouse
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.018	Human
FRS2	fibroblast growth factor receptor substrate 2	0.017
PDE4DIP	phosphodiesterase 4D interacting protein	0.016
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.016
ACTL6B	actin-like 6B	0.016
SMAD1	SMAD family member 1	0.016
WIPF1	WAS/WASL interacting protein family, member 1	0.016
MYO16	myosin XVI	0.016
STMN2	stathmin-like 2	0.015
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.015
CCKBR	cholecystokinin B receptor	0.014
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.014	Mouse Rat
PTEN	phosphatase and tensin homolog	0.014	Mouse
MATK	megakaryocyte-associated tyrosine kinase	0.014
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.014	Human
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.014
ATN1	atrophin 1	0.014
APLP1	amyloid beta (A4) precursor-like protein 1	0.014
EGFR	epidermal growth factor receptor	0.013
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.013
MEF2A	myocyte enhancer factor 2A	0.013
AMOTL1	angiomotin like 1	0.013
PTK2	PTK2 protein tyrosine kinase 2	0.013
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.013
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.013
ATF3	activating transcription factor 3	0.013
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.013
SOD1	superoxide dismutase 1, soluble	0.013
LRRK2	leucine-rich repeat kinase 2	0.013
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.012
PRKCG	protein kinase C, gamma	0.012
FAS	Fas (TNF receptor superfamily, member 6)	0.012
ADORA1	adenosine A1 receptor	0.012	Mouse Rat
DOCK7	dedicator of cytokinesis 7	0.012
SH3KBP1	SH3-domain kinase binding protein 1	0.012
AR	androgen receptor	0.012
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.012
MAP2K6	mitogen-activated protein kinase kinase 6	0.012
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.012
EP300	E1A binding protein p300	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.011	Mouse
CABLES1	Cdk5 and Abl enzyme substrate 1	0.011
KRT5	keratin 5	0.011
GRIK5	glutamate receptor, ionotropic, kainate 5	0.011
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.011
DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.011
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.011
TXNIP	thioredoxin interacting protein	0.011
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.011
EPAS1	endothelial PAS domain protein 1	0.011
SCN5A	sodium channel, voltage-gated, type V, alpha subunit	0.011
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
ARHGAP22	Rho GTPase activating protein 22	0.011
FBXL15	F-box and leucine-rich repeat protein 15	0.011
MARK1	MAP/microtubule affinity-regulating kinase 1	0.011
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.011
NGF	nerve growth factor (beta polypeptide)	0.011
CNR1	cannabinoid receptor 1 (brain)	0.010
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.010	Mouse
BAI2	brain-specific angiogenesis inhibitor 2	0.010
DLG2	discs, large homolog 2 (Drosophila)	0.010
CD33	CD33 molecule	0.010
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.010
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.010
ZFYVE9	zinc finger, FYVE domain containing 9	0.010
MAP1B	microtubule-associated protein 1B	0.010
BAD	BCL2-associated agonist of cell death	0.010
ANKRD13A	ankyrin repeat domain 13A	0.010
PSD	pleckstrin and Sec7 domain containing	0.010
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.010
UBASH3B	ubiquitin associated and SH3 domain containing B	0.010
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.010
BTK	Bruton agammaglobulinemia tyrosine kinase	0.010	Human
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.010