IMP

Process View

Homo sapiens

27 genes annotated in human

alternative mrna splicing via spliceosome

The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "alternative mrna splicing via spliceosome"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "alternative mrna splicing via spliceosome" (in gray)

Name	Description	Probability	Func Analog Organism
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.993	Fly
SRPK2	SRSF protein kinase 2	0.968
SRRM1	serine/arginine repetitive matrix 1	0.911
RBM39	RNA binding motif protein 39	0.895	Fly
SUGP1	SURP and G patch domain containing 1	0.886
PRPF38A	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A	0.876
EIF4A3	eukaryotic translation initiation factor 4A3	0.834
SRSF3	serine/arginine-rich splicing factor 3	0.816
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.810
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.793
RBM8A	RNA binding motif protein 8A	0.777
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.766
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.722
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.705
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.677
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.647
SRSF7	serine/arginine-rich splicing factor 7	0.639
PNN	pinin, desmosome associated protein	0.564
LUC7L3	LUC7-like 3 (S. cerevisiae)	0.551
RNPS1	RNA binding protein S1, serine-rich domain	0.549
SFPQ	splicing factor proline/glutamine-rich	0.539
SRSF1	serine/arginine-rich splicing factor 1	0.498
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.466
QKI	quaking homolog, KH domain RNA binding (mouse)	0.451	Worm Fly
FUBP1	far upstream element (FUSE) binding protein 1	0.448	Fly
SRSF2	serine/arginine-rich splicing factor 2	0.418	Mouse Fly
EED	embryonic ectoderm development	0.411
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.395
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.395
PCBP1	poly(rC) binding protein 1	0.385	Fly
SNRPA	small nuclear ribonucleoprotein polypeptide A	0.385
TOP1	topoisomerase (DNA) I	0.345
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.292	Mouse
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.285
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.273
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.259	Mouse Fly
TARDBP	TAR DNA binding protein	0.258
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.245	Worm
ARGLU1	arginine and glutamate rich 1	0.231
SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	0.220
SF1	splicing factor 1	0.214
TRA2B	transformer 2 beta homolog (Drosophila)	0.211
THOC4	THO complex 4	0.206
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.191
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.191
CTNNBL1	catenin, beta like 1	0.175
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.169	Fly
SON	SON DNA binding protein	0.166
YTHDC1	YTH domain containing 1	0.160
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.152
ILF3	interleukin enhancer binding factor 3, 90kDa	0.151
BCLAF1	BCL2-associated transcription factor 1	0.148
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.145
SNIP1	Smad nuclear interacting protein 1	0.143
RBMX	RNA binding motif protein, X-linked	0.141
TCERG1	transcription elongation regulator 1	0.133
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.130
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.127
PUF60	poly-U binding splicing factor 60KDa	0.124	Fly
SAP30BP	SAP30 binding protein	0.122
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.113
PTBP1	polypyrimidine tract binding protein 1	0.111
DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.111
SRSF5	serine/arginine-rich splicing factor 5	0.101	Human Fly
SREK1	splicing regulatory glutamine/lysine-rich protein 1	0.099	Fly
SNRNP200	small nuclear ribonucleoprotein 200kDa (U5)	0.098	Fly
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.096	Fly
SNRPA1	small nuclear ribonucleoprotein polypeptide A'	0.091
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.087	Fly
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.084
LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.082
SF3B2	splicing factor 3b, subunit 2, 145kDa	0.078
ZNF830	zinc finger protein 830	0.074
PABPC1	poly(A) binding protein, cytoplasmic 1	0.073
SNW1	SNW domain containing 1	0.070
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.067
ZCCHC10	zinc finger, CCHC domain containing 10	0.065
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.063
MATR3	matrin 3	0.063
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.063
SRPK1	SRSF protein kinase 1	0.061
DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	0.058	Fly
LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.057
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.055	Fly
SRRM2	serine/arginine repetitive matrix 2	0.055
THOC1	THO complex 1	0.054
SRRT	serrate RNA effector molecule homolog (Arabidopsis)	0.053
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.052
SAFB2	scaffold attachment factor B2	0.052	Fly
PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	0.051
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.046
ZNF207	zinc finger protein 207	0.046
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa	0.045
FNBP4	formin binding protein 4	0.043
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.043
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.043
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.042
BMI1	BMI1 polycomb ring finger oncogene	0.041
SAFB	scaffold attachment factor B	0.040	Fly
SRSF9	serine/arginine-rich splicing factor 9	0.039
LUC7L	LUC7-like (S. cerevisiae)	0.039
CHTOP	chromatin target of PRMT1	0.039
ESR1	estrogen receptor 1	0.039
ACIN1	apoptotic chromatin condensation inducer 1	0.038
SRSF11	serine/arginine-rich splicing factor 11	0.037	Fly
U2SURP	U2 snRNP-associated SURP domain containing	0.036
PTBP2	polypyrimidine tract binding protein 2	0.035	Human
SRSF4	serine/arginine-rich splicing factor 4	0.034	Human Fly
TOE1	target of EGR1, member 1 (nuclear)	0.033
ATXN1	ataxin 1	0.032
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.032	Human Fly
MFAP1	microfibrillar-associated protein 1	0.032	Worm
WDR83	WD repeat domain 83	0.031
CCAR1	cell division cycle and apoptosis regulator 1	0.030
SNRPE	small nuclear ribonucleoprotein polypeptide E	0.030
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.029	Fly
CLK2	CDC-like kinase 2	0.027
SFRS18	splicing factor, arginine/serine-rich 18	0.026
NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit	0.026
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.025
UPF3A	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.025
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.024
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.024
LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.024	Fly
PQBP1	polyglutamine binding protein 1	0.023
AQR	aquarius homolog (mouse)	0.023
SRSF10	serine/arginine-rich splicing factor 10	0.023	Human
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.023
NKAP	NFKB activating protein	0.023
SRSF6	serine/arginine-rich splicing factor 6	0.022
SNRPD2	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	0.021
TRRAP	transformation/transcription domain-associated protein	0.021
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.021
RHOXF2	Rhox homeobox family, member 2	0.021
SF3B3	splicing factor 3b, subunit 3, 130kDa	0.020
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.020
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.020
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.019
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.019
ISY1	ISY1 splicing factor homolog (S. cerevisiae)	0.019
RBM25	RNA binding motif protein 25	0.019
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.019
PRPF38B	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B	0.019
PLDN	pallidin homolog (mouse)	0.018
CDK7	cyclin-dependent kinase 7	0.017
SF3A3	splicing factor 3a, subunit 3, 60kDa	0.017
H3F3B	H3 histone, family 3B (H3.3B)	0.016
SART1	squamous cell carcinoma antigen recognized by T cells	0.016
DCAF7	DDB1 and CUL4 associated factor 7	0.016
FAM76B	family with sequence similarity 76, member B	0.016
DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.016	Fly
CPSF6	cleavage and polyadenylation specific factor 6, 68kDa	0.016	Fly
AKAP8	A kinase (PRKA) anchor protein 8	0.015
ZRANB2	zinc finger, RAN-binding domain containing 2	0.015
RBM4	RNA binding motif protein 4	0.015
SMU1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.015	Worm
CUL3	cullin 3	0.015
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.015
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.015	Fly
RBM14	RNA binding motif protein 14	0.014
CELF1	CUGBP, Elav-like family member 1	0.014	Human Fly
WBP11	WW domain binding protein 11	0.014
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.014
CHERP	calcium homeostasis endoplasmic reticulum protein	0.014
THOC2	THO complex 2	0.014
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.013
RBM7	RNA binding motif protein 7	0.013	Human
MAT2A	methionine adenosyltransferase II, alpha	0.013
DGCR14	DiGeorge syndrome critical region gene 14	0.013
DDX42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.013
EIF3G	eukaryotic translation initiation factor 3, subunit G	0.013
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.013
XPO1	exportin 1 (CRM1 homolog, yeast)	0.012
RBM5	RNA binding motif protein 5	0.012
PRRC2C	proline-rich coiled-coil 2C	0.012
PABPN1	poly(A) binding protein, nuclear 1	0.012
CAPRIN1	cell cycle associated protein 1	0.012
SARNP	SAP domain containing ribonucleoprotein	0.012
EIF4H	eukaryotic translation initiation factor 4H	0.012
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.012
PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	0.012
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.011
METTL3	methyltransferase like 3	0.011
CPSF7	cleavage and polyadenylation specific factor 7, 59kDa	0.011	Fly
RBBP6	retinoblastoma binding protein 6	0.011
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.011
RSRC2	arginine/serine-rich coiled-coil 2	0.011
PCBP2	poly(rC) binding protein 2	0.011
SOBP	sine oculis binding protein homolog (Drosophila)	0.011
NKTR	natural killer-tumor recognition sequence	0.011
NCOA2	nuclear receptor coactivator 2	0.011
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.011
SCAF4	SR-related CTD-associated factor 4	0.010
CIRBP	cold inducible RNA binding protein	0.010
YTHDC2	YTH domain containing 2	0.010
NCOA1	nuclear receptor coactivator 1	0.010
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.010