IMP

Process View

Homo sapiens

2 genes annotated in human

negative regulation of glomerulus development

Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of glomerulus development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of glomerulus development" (in gray)

Name	Description	Probability	Func Analog Organism
BMPR1A	bone morphogenetic protein receptor, type IA	1.000
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	1.000
BMPR1B	bone morphogenetic protein receptor, type IB	1.000
NOG	noggin	0.991
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.980
FSTL1	follistatin-like 1	0.922
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.909
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.905
BMP2	bone morphogenetic protein 2	0.676	Human
ZFYVE9	zinc finger, FYVE domain containing 9	0.391
NPM3	nucleophosmin/nucleoplasmin 3	0.270
TAOK1	TAO kinase 1	0.202
COL2A1	collagen, type II, alpha 1	0.118
ZNF205	zinc finger protein 205	0.090
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.085
CER1	cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)	0.058
ACAN	aggrecan	0.056
EFNB3	ephrin-B3	0.045
FZD10	frizzled homolog 10 (Drosophila)	0.043
ZNF512B	zinc finger protein 512B	0.043
CEP164	centrosomal protein 164kDa	0.038
SFRP4	secreted frizzled-related protein 4	0.037
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.036
ALX4	ALX homeobox 4	0.036
MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	0.035
BMP6	bone morphogenetic protein 6	0.034	Human
SLIT3	slit homolog 3 (Drosophila)	0.033
TGFB1	transforming growth factor, beta 1	0.033
NTN1	netrin 1	0.032
PITX2	paired-like homeodomain 2	0.030
FGF4	fibroblast growth factor 4	0.028
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.028
CDX1	caudal type homeobox 1	0.027
BMP4	bone morphogenetic protein 4	0.025
TGFB2	transforming growth factor, beta 2	0.025
FGF16	fibroblast growth factor 16	0.025
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.025
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.025
GDF5	growth differentiation factor 5	0.024	Human
SOX21	SRY (sex determining region Y)-box 21	0.024
HAND1	heart and neural crest derivatives expressed 1	0.023
BMP7	bone morphogenetic protein 7	0.023
WNT11	wingless-type MMTV integration site family, member 11	0.021
PALM	paralemmin	0.021
GAS1	growth arrest-specific 1	0.020
BMP3	bone morphogenetic protein 3	0.020	Human
CHD6	chromodomain helicase DNA binding protein 6	0.019
FOXF2	forkhead box F2	0.019
ELN	elastin	0.019
EDN1	endothelin 1	0.019
FOXF1	forkhead box F1	0.018
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.018
RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	0.018
SOSTDC1	sclerostin domain containing 1	0.018
SOX1	SRY (sex determining region Y)-box 1	0.017
SEPT4	septin 4	0.017
HOXD10	homeobox D10	0.017
ACVR2B	activin A receptor, type IIB	0.016
DLX4	distal-less homeobox 4	0.016
SOX2	SRY (sex determining region Y)-box 2	0.016
LGALS13	lectin, galactoside-binding, soluble, 13	0.016
HOXC8	homeobox C8	0.016
LECT1	leukocyte cell derived chemotaxin 1	0.016
FOXD3	forkhead box D3	0.016
PRPH	peripherin	0.015
GDNF	glial cell derived neurotrophic factor	0.015
TG	thyroglobulin	0.015
PRKG1	protein kinase, cGMP-dependent, type I	0.014
AMHR2	anti-Mullerian hormone receptor, type II	0.014
WT1	Wilms tumor 1	0.014	Mouse
WNT4	wingless-type MMTV integration site family, member 4	0.014
NKX3-2	NK3 homeobox 2	0.014
ANP32D	acidic (leucine-rich) nuclear phosphoprotein 32 family, member D	0.014
FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	0.014
DLX5	distal-less homeobox 5	0.014
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.013
FZD8	frizzled homolog 8 (Drosophila)	0.013
BMP8B	bone morphogenetic protein 8b	0.013	Human
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.013
FST	follistatin	0.013
PTCH1	patched 1	0.013
EYA2	eyes absent homolog 2 (Drosophila)	0.013
S100G	S100 calcium binding protein G	0.013
BFSP1	beaded filament structural protein 1, filensin	0.013
ALPPL2	alkaline phosphatase, placental-like 2	0.013
A4GALT	alpha 1,4-galactosyltransferase	0.013
YBX2	Y box binding protein 2	0.013
NPPC	natriuretic peptide C	0.013
GPR50	G protein-coupled receptor 50	0.012
GPC3	glypican 3	0.012
PAWR	PRKC, apoptosis, WT1, regulator	0.012
LEFTY1	left-right determination factor 1	0.012
CST2	cystatin SA	0.012
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.012
WNT6	wingless-type MMTV integration site family, member 6	0.012
PHEX	phosphate regulating endopeptidase homolog, X-linked	0.012
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.012
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.012
PRDM14	PR domain containing 14	0.012
CCNO	cyclin O	0.012
CHRNA3	cholinergic receptor, nicotinic, alpha 3	0.012
NTF3	neurotrophin 3	0.012
L1TD1	LINE-1 type transposase domain containing 1	0.012
GPR124	G protein-coupled receptor 124	0.011
NXPH4	neurexophilin 4	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
EN2	engrailed homeobox 2	0.011
WNT1	wingless-type MMTV integration site family, member 1	0.011
MFI2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.011
BAHD1	bromo adjacent homology domain containing 1	0.011
NPY5R	neuropeptide Y receptor Y5	0.011
GDF9	growth differentiation factor 9	0.011
PITX1	paired-like homeodomain 1	0.011
CDH7	cadherin 7, type 2	0.011
HOXD11	homeobox D11	0.011
PSG9	pregnancy specific beta-1-glycoprotein 9	0.011
KCNH4	potassium voltage-gated channel, subfamily H (eag-related), member 4	0.011
SCUBE2	signal peptide, CUB domain, EGF-like 2	0.011
FGFR3	fibroblast growth factor receptor 3	0.011
CRTAC1	cartilage acidic protein 1	0.010
BEND6	BEN domain containing 6	0.010
HPD	4-hydroxyphenylpyruvate dioxygenase	0.010
RBP1	retinol binding protein 1, cellular	0.010
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.010
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.010
TCF21	transcription factor 21	0.010
DIO3	deiodinase, iodothyronine, type III	0.010
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.010
EDAR	ectodysplasin A receptor	0.010
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.010
GJA5	gap junction protein, alpha 5, 40kDa	0.010
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.010
COMP	cartilage oligomeric matrix protein	0.010
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.010