IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of phagocytosis engulfment

Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of phagocytosis engulfment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of phagocytosis engulfment" (in gray)

Name	Description	Probability	Func Analog Organism
TFF1	trefoil factor 1	0.986
HIPK2	homeodomain interacting protein kinase 2	0.924
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.537
HK3	hexokinase 3 (white cell)	0.517
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.508
RIN1	Ras and Rab interactor 1	0.504
MSH5	mutS homolog 5 (E. coli)	0.433
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.345
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.195
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.194
SIGLEC7	sialic acid binding Ig-like lectin 7	0.167	Mouse
ZFYVE9	zinc finger, FYVE domain containing 9	0.145
MAVS	mitochondrial antiviral signaling protein	0.117
PTAFR	platelet-activating factor receptor	0.115
CD300C	CD300c molecule	0.114	Human
CYTH4	cytohesin 4	0.114
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.089
SIGLEC9	sialic acid binding Ig-like lectin 9	0.089	Mouse
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.086
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.069
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.068
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.065
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.063
CD33	CD33 molecule	0.063
MUC1	mucin 1, cell surface associated	0.061
ABI2	abl-interactor 2	0.054
SASH3	SAM and SH3 domain containing 3	0.054
NFAM1	NFAT activating protein with ITAM motif 1	0.053
NCKAP1	NCK-associated protein 1	0.050
SIGLEC5	sialic acid binding Ig-like lectin 5	0.049
SPRR2A	small proline-rich protein 2A	0.048
CD300A	CD300a molecule	0.043
WASF1	WAS protein family, member 1	0.039
APOBR	apolipoprotein B receptor	0.038
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.038
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.037
HIPK3	homeodomain interacting protein kinase 3	0.034
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.034
TREM1	triggering receptor expressed on myeloid cells 1	0.032
TRPM2	transient receptor potential cation channel, subfamily M, member 2	0.029
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.027
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.027
BCAR1	breast cancer anti-estrogen resistance 1	0.027
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.026
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.026
PILRA	paired immunoglobin-like type 2 receptor alpha	0.025
PARVG	parvin, gamma	0.024
APOC2	apolipoprotein C-II	0.023
FPR2	formyl peptide receptor 2	0.022
PIK3R6	phosphoinositide-3-kinase, regulatory subunit 6	0.022
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.021
DCAF7	DDB1 and CUL4 associated factor 7	0.020	Worm
SOS1	son of sevenless homolog 1 (Drosophila)	0.020
LRRC25	leucine rich repeat containing 25	0.020
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.020
CD101	CD101 molecule	0.020
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.019
PLCB2	phospholipase C, beta 2	0.019
CD180	CD180 molecule	0.019
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.019
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.018
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.018
ASGR2	asialoglycoprotein receptor 2	0.018
IL12RB1	interleukin 12 receptor, beta 1	0.016
SPN	sialophorin	0.016
LZTS2	leucine zipper, putative tumor suppressor 2	0.016
RIN3	Ras and Rab interactor 3	0.016
TNFAIP8L2	tumor necrosis factor, alpha-induced protein 8-like 2	0.016
PTK6	PTK6 protein tyrosine kinase 6	0.015
OSCAR	osteoclast associated, immunoglobulin-like receptor	0.015
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.015
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.015
ABI3	ABI family, member 3	0.015
C5AR1	complement component 5a receptor 1	0.015
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.015
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.015
FPR3	formyl peptide receptor 3	0.014
FES	feline sarcoma oncogene	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
TNS4	tensin 4	0.014
DPEP2	dipeptidase 2	0.014
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.014
FPR1	formyl peptide receptor 1	0.014
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.014
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.014
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.013
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.013
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.013
RENBP	renin binding protein	0.013
CDK8	cyclin-dependent kinase 8	0.013
CLEC5A	C-type lectin domain family 5, member A	0.013
GPR132	G protein-coupled receptor 132	0.013
GPR84	G protein-coupled receptor 84	0.012
CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	0.012
SIGLEC10	sialic acid binding Ig-like lectin 10	0.012
C19orf59	chromosome 19 open reading frame 59	0.012
TREM2	triggering receptor expressed on myeloid cells 2	0.012
SIGLEC12	sialic acid binding Ig-like lectin 12	0.012
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.012	Worm
TLN2	talin 2	0.012
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.012
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.012
TRIM37	tripartite motif containing 37	0.012
CMKLR1	chemokine-like receptor 1	0.012
HAMP	hepcidin antimicrobial peptide	0.011
RUNX1	runt-related transcription factor 1	0.011
TGFBR1	transforming growth factor, beta receptor 1	0.011
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.011
NLRP3	NLR family, pyrin domain containing 3	0.011
SORBS1	sorbin and SH3 domain containing 1	0.011
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.011
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.011
RAD52	RAD52 homolog (S. cerevisiae)	0.011
MYO1F	myosin IF	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.010
GRB10	growth factor receptor-bound protein 10	0.010
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.010
DLG4	discs, large homolog 4 (Drosophila)	0.010
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.010
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010
DHTKD1	dehydrogenase E1 and transketolase domain containing 1	0.010
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.010
ADAM19	ADAM metallopeptidase domain 19	0.010
ADORA3	adenosine A3 receptor	0.010
KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	0.010
C10orf54	chromosome 10 open reading frame 54	0.010
FFAR2	free fatty acid receptor 2	0.010
P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	0.010