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Process View

Homo sapiens

20 genes annotated in human

glutathione metabolic process

The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "glutathione metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "glutathione metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
GSTM2	glutathione S-transferase mu 2 (muscle)	1.000
GSTM1	glutathione S-transferase mu 1	1.000
GSTM4	glutathione S-transferase mu 4	1.000
GGT1	gamma-glutamyltransferase 1	1.000
GGTLC1	gamma-glutamyltransferase light chain 1	1.000	Human
GSTM3	glutathione S-transferase mu 3 (brain)	0.998
GCLM	glutamate-cysteine ligase, modifier subunit	0.992
TALDO1	transaldolase 1	0.987
GCLC	glutamate-cysteine ligase, catalytic subunit	0.984
TKT	transketolase	0.982
GGT2	gamma-glutamyltransferase 2	0.868	Human
HSPB1	heat shock 27kDa protein 1	0.688
TSPO	translocator protein (18kDa)	0.574
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.460
BLVRB	biliverdin reductase B (flavin reductase (NADPH))	0.430
NQO1	NAD(P)H dehydrogenase, quinone 1	0.353
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	0.258
GSTM5	glutathione S-transferase mu 5	0.254
TRAF3	TNF receptor-associated factor 3	0.242
GSTK1	glutathione S-transferase kappa 1	0.217
GLA	galactosidase, alpha	0.216
NAMPT	nicotinamide phosphoribosyltransferase	0.185
ATP6V1F	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	0.182
PGD	phosphogluconate dehydrogenase	0.139
GSR	glutathione reductase	0.109	Yeast Rat
NFIL3	nuclear factor, interleukin 3 regulated	0.107
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.091
IGSF21	immunoglobin superfamily, member 21	0.091
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.083
CSTB	cystatin B (stefin B)	0.077
CRYL1	crystallin, lambda 1	0.077
POLD4	polymerase (DNA-directed), delta 4	0.072
PRDX1	peroxiredoxin 1	0.056
ETHE1	ethylmalonic encephalopathy 1	0.051
ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.049
CHMP2A	chromatin modifying protein 2A	0.045
CRAT	carnitine O-acetyltransferase	0.043
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.041
ACAA1	acetyl-CoA acyltransferase 1	0.040
GLRX	glutaredoxin (thioltransferase)	0.038
MGST1	microsomal glutathione S-transferase 1	0.037	Mouse
CXCL2	chemokine (C-X-C motif) ligand 2	0.036
SC4MOL	sterol-C4-methyl oxidase-like	0.036
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.035
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.035
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.034
SLC38A7	solute carrier family 38, member 7	0.032
AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	0.031
ACSL1	acyl-CoA synthetase long-chain family member 1	0.030
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.030
SEPX1	selenoprotein X, 1	0.029
TPSB2	tryptase beta 2 (gene/pseudogene)	0.029
CAT	catalase	0.029
AP2S1	adaptor-related protein complex 2, sigma 1 subunit	0.029
CRYAB	crystallin, alpha B	0.029
MAPK3	mitogen-activated protein kinase 3	0.028
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.028
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.027
TPSAB1	tryptase alpha/beta 1	0.025
CTSL1	cathepsin L1	0.025
GPX1	glutathione peroxidase 1	0.025
CAV1	caveolin 1, caveolae protein, 22kDa	0.025
RIPK2	receptor-interacting serine-threonine kinase 2	0.024
RNASEK	ribonuclease, RNase K	0.024
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.024
TMEM173	transmembrane protein 173	0.024
MED31	mediator complex subunit 31	0.023
PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.023
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.023
MPG	N-methylpurine-DNA glycosylase	0.022
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.022
LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	0.022
DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	0.021
SQRDL	sulfide quinone reductase-like (yeast)	0.021
MT1F	metallothionein 1F	0.021
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.020
MAGEA11	melanoma antigen family A, 11	0.020
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.020
TCN2	transcobalamin II	0.020
PIR	pirin (iron-binding nuclear protein)	0.020
SLC22A18	solute carrier family 22, member 18	0.019
GSTP1	glutathione S-transferase pi 1	0.019
METRN	meteorin, glial cell differentiation regulator	0.018
NQO2	NAD(P)H dehydrogenase, quinone 2	0.018
SDCBP	syndecan binding protein (syntenin)	0.018
TRAPPC1	trafficking protein particle complex 1	0.017
HSD17B8	hydroxysteroid (17-beta) dehydrogenase 8	0.017
APOD	apolipoprotein D	0.017
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.016
GCH1	GTP cyclohydrolase 1	0.016
BID	BH3 interacting domain death agonist	0.016
MT1A	metallothionein 1A	0.015
CLEC3B	C-type lectin domain family 3, member B	0.015
OAZ1	ornithine decarboxylase antizyme 1	0.015
FMO4	flavin containing monooxygenase 4	0.014
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.014
CORO1B	coronin, actin binding protein, 1B	0.014
HEBP1	heme binding protein 1	0.014
GAMT	guanidinoacetate N-methyltransferase	0.014
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.013
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.013
ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	0.013
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.013
AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	0.013
TXN	thioredoxin	0.013
EPHX2	epoxide hydrolase 2, cytoplasmic	0.013
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.013	Mouse
AGTRAP	angiotensin II receptor-associated protein	0.012
CPT2	carnitine palmitoyltransferase 2	0.012
HGD	homogentisate 1,2-dioxygenase	0.012
CBR1	carbonyl reductase 1	0.012
PDK2	pyruvate dehydrogenase kinase, isozyme 2	0.012
HYI	hydroxypyruvate isomerase (putative)	0.012
TST	thiosulfate sulfurtransferase (rhodanese)	0.012
NDRG2	NDRG family member 2	0.012
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.012
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.012
GSTA4	glutathione S-transferase alpha 4	0.012
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.012
QPRT	quinolinate phosphoribosyltransferase	0.011
HTATIP2	HIV-1 Tat interactive protein 2, 30kDa	0.011
MGMT	O-6-methylguanine-DNA methyltransferase	0.011
MGST2	microsomal glutathione S-transferase 2	0.011
ECHDC2	enoyl CoA hydratase domain containing 2	0.011
FTL	ferritin, light polypeptide	0.011
PEPD	peptidase D	0.011
SUOX	sulfite oxidase	0.011
NOP10	NOP10 ribonucleoprotein homolog (yeast)	0.011
MGST3	microsomal glutathione S-transferase 3	0.010	Human
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.010
PINK1	PTEN induced putative kinase 1	0.010
CES1	carboxylesterase 1	0.010
FIS1	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	0.010
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.010
ARSA	arylsulfatase A	0.010
GLRX2	glutaredoxin 2	0.010
APOC2	apolipoprotein C-II	0.010
HSPB8	heat shock 22kDa protein 8	0.010