IMP

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Homo sapiens

2 genes annotated in human

definitive hemopoiesis

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "definitive hemopoiesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "definitive hemopoiesis" (in gray)

Name	Description	Probability	Func Analog Organism
TAL1	T-cell acute lymphocytic leukemia 1	0.974	Zebrafish Mouse
RUNX1	runt-related transcription factor 1	0.963	Mouse
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.955
HIPK2	homeodomain interacting protein kinase 2	0.830
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.551
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.478
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.315
CREBBP	CREB binding protein	0.188
TRIP6	thyroid hormone receptor interactor 6	0.149
GATA2	GATA binding protein 2	0.144	Human Mouse
PTBP1	polypyrimidine tract binding protein 1	0.128
NLK	nemo-like kinase	0.119
USPL1	ubiquitin specific peptidase like 1	0.111
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.109
PML	promyelocytic leukemia	0.089
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.086
PPARA	peroxisome proliferator-activated receptor alpha	0.083
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.069
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.064
RANGAP1	Ran GTPase activating protein 1	0.054
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.051
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.049
PIAS4	protein inhibitor of activated STAT, 4	0.049
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.046
EP300	E1A binding protein p300	0.045
SP100	SP100 nuclear antigen	0.043
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.042
QKI	quaking homolog, KH domain RNA binding (mouse)	0.041
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.037
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.036
KLF13	Kruppel-like factor 13	0.034
GLIS2	GLIS family zinc finger 2	0.033
TCF12	transcription factor 12	0.033
DAXX	death-domain associated protein	0.032
MBD1	methyl-CpG binding domain protein 1	0.029
ELF4	E74-like factor 4 (ets domain transcription factor)	0.027
CDK6	cyclin-dependent kinase 6	0.026
MTA1	metastasis associated 1	0.025
POU2F1	POU class 2 homeobox 1	0.024
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.024
WWOX	WW domain containing oxidoreductase	0.024
USP39	ubiquitin specific peptidase 39	0.023
LMO2	LIM domain only 2 (rhombotin-like 1)	0.023
LST1	leukocyte specific transcript 1	0.022
TBX5	T-box 5	0.022
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.022
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.021
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.020
RBPMS	RNA binding protein with multiple splicing	0.019
TRIM28	tripartite motif containing 28	0.019
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.019
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.019
CLK2	CDC-like kinase 2	0.019
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.018
HOXB4	homeobox B4	0.018	Mouse
FTSJD2	FtsJ methyltransferase domain containing 2	0.017
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.017
HDAC4	histone deacetylase 4	0.017
ZBTB16	zinc finger and BTB domain containing 16	0.017
PIAS2	protein inhibitor of activated STAT, 2	0.017
HCK	hemopoietic cell kinase	0.017
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.017
ARID1A	AT rich interactive domain 1A (SWI-like)	0.016
RBBP4	retinoblastoma binding protein 4	0.016
CDK9	cyclin-dependent kinase 9	0.016
SKIL	SKI-like oncogene	0.016
PIAS1	protein inhibitor of activated STAT, 1	0.016
ATN1	atrophin 1	0.016
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.016
TDG	thymine-DNA glycosylase	0.015
NCOA1	nuclear receptor coactivator 1	0.015
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.015
HOXB5	homeobox B5	0.015
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.015
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.015
HOXB3	homeobox B3	0.014	Mouse
CHD3	chromodomain helicase DNA binding protein 3	0.014
SP1	Sp1 transcription factor	0.014	Mouse
LIN9	lin-9 homolog (C. elegans)	0.014
NUMBL	numb homolog (Drosophila)-like	0.014
PHTF2	putative homeodomain transcription factor 2	0.014
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.014
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.013
LYL1	lymphoblastic leukemia derived sequence 1	0.013	Mouse
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.013
BANP	BTG3 associated nuclear protein	0.013
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.013
KLF5	Kruppel-like factor 5 (intestinal)	0.013
MEF2A	myocyte enhancer factor 2A	0.013
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.013	Zebrafish
SUMO4	SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)	0.013
SENP1	SUMO1/sentrin specific peptidase 1	0.013	Mouse
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
HOXB2	homeobox B2	0.012
TGIF1	TGFB-induced factor homeobox 1	0.012
LRRC25	leucine rich repeat containing 25	0.012
CLTC	clathrin, heavy chain (Hc)	0.012
CSNK1G2	casein kinase 1, gamma 2	0.011
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.011
SMARCD2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	0.011
KLF2	Kruppel-like factor 2 (lung)	0.011
HIP1	huntingtin interacting protein 1	0.011
RHOT2	ras homolog gene family, member T2	0.011
PELP1	proline, glutamate and leucine rich protein 1	0.011
PRDM1	PR domain containing 1, with ZNF domain	0.011
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011
HOXB9	homeobox B9	0.011
STAT5A	signal transducer and activator of transcription 5A	0.011
FOXO1	forkhead box O1	0.011
ATXN3	ataxin 3	0.011
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.011
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	0.011
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.010
BICD1	bicaudal D homolog 1 (Drosophila)	0.010
SATB1	SATB homeobox 1	0.010
HOXA1	homeobox A1	0.010
CTBP2	C-terminal binding protein 2	0.010