IMP
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intra s dna damage checkpoint
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
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Click on a gene's description to view its network relationships with genes known to be involved in "intra s dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| JUN | jun proto-oncogene | 0.984 | Human | |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.929 | ||
| ATF3 | activating transcription factor 3 | 0.777 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.735 | ||
| JUNB | jun B proto-oncogene | 0.584 | Human | |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.515 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.398 | ||
| BRCA1 | breast cancer 1, early onset | 0.377 | ||
| NBN | nibrin | 0.352 | ||
| ATF2 | activating transcription factor 2 | 0.290 | ||
| ATF4 | activating transcription factor 4 (tax-responsive enhancer element B67) | 0.210 | ||
| DUSP1 | dual specificity phosphatase 1 | 0.188 | ||
| JUND | jun D proto-oncogene | 0.155 | Human | |
| JDP2 | Jun dimerization protein 2 | 0.148 | ||
| DDIT3 | DNA-damage-inducible transcript 3 | 0.142 | ||
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.114 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.104 | ||
| MAPK14 | mitogen-activated protein kinase 14 | 0.093 | ||
| RAD17 | RAD17 homolog (S. pombe) | 0.093 | ||
| MAPK8 | mitogen-activated protein kinase 8 | 0.089 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.080 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.075 | Mouse | |
| MSH3 | mutS homolog 3 (E. coli) | 0.068 | ||
| OCIAD1 | OCIA domain containing 1 | 0.068 | ||
| RB1 | retinoblastoma 1 | 0.065 | ||
| ATM | ataxia telangiectasia mutated | 0.061 | ||
| NEK6 | NIMA (never in mitosis gene a)-related kinase 6 | 0.061 | ||
| CLSPN | claspin | 0.053 | ||
| RPL39 | ribosomal protein L39 | 0.050 | ||
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.048 | ||
| FOSL1 | FOS-like antigen 1 | 0.043 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.043 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.039 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.037 | ||
| RFWD2 | ring finger and WD repeat domain 2 | 0.035 | ||
| MAPK10 | mitogen-activated protein kinase 10 | 0.032 | ||
| RPA2 | replication protein A2, 32kDa | 0.030 | ||
| ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | 0.028 | ||
| FHL2 | four and a half LIM domains 2 | 0.026 | ||
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.026 | ||
| RPL41 | ribosomal protein L41 | 0.024 | ||
| HUS1 | HUS1 checkpoint homolog (S. pombe) | 0.023 | ||
| TIMELESS | timeless homolog (Drosophila) | 0.023 | ||
| IER2 | immediate early response 2 | 0.021 | ||
| BRCA2 | breast cancer 2, early onset | 0.021 | ||
| FANCE | Fanconi anemia, complementation group E | 0.020 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.020 | ||
| RAD1 | RAD1 homolog (S. pombe) | 0.019 | ||
| BTRC | beta-transducin repeat containing | 0.019 | ||
| RPL34 | ribosomal protein L34 | 0.018 | ||
| SMAD1 | SMAD family member 1 | 0.018 | ||
| IRF2BP1 | interferon regulatory factor 2 binding protein 1 | 0.018 | ||
| EIF1 | eukaryotic translation initiation factor 1 | 0.017 | ||
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.017 | ||
| RECQL4 | RecQ protein-like 4 | 0.016 | ||
| ERCC4 | excision repair cross-complementing rodent repair deficiency, complementation group 4 | 0.016 | ||
| GLS | glutaminase | 0.015 | ||
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.015 | ||
| BCL6 | B-cell CLL/lymphoma 6 | 0.015 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.015 | ||
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 | 0.014 | ||
| ATXN3 | ataxin 3 | 0.013 | ||
| TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | 0.013 | ||
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.013 | ||
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.012 | ||
| ATR | ataxia telangiectasia and Rad3 related | 0.012 | ||
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.012 | ||
| RPS27 | ribosomal protein S27 | 0.012 | ||
| POLH | polymerase (DNA directed), eta | 0.011 | ||
| MAPK9 | mitogen-activated protein kinase 9 | 0.011 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.011 | ||
| TSC22D1 | TSC22 domain family, member 1 | 0.011 | ||
| BTG2 | BTG family, member 2 | 0.011 | ||
| ZFP36 | zinc finger protein 36, C3H type, homolog (mouse) | 0.010 | ||
| MUTYH | mutY homolog (E. coli) | 0.010 | ||
| PGR | progesterone receptor | 0.010 | ||
| CREBBP | CREB binding protein | 0.010 | ||
| CUX1 | cut-like homeobox 1 | 0.010 | ||
| RAD9A | RAD9 homolog A (S. pombe) | 0.010 | Mouse | |
| RFC1 | replication factor C (activator 1) 1, 145kDa | 0.010 | ||
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.010 |