IMP
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epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade
The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB.
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Click on a gene's description to view its network relationships with genes known to be involved in "epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.998 | ||
| Hipk1 | homeodomain interacting protein kinase 1 | 0.944 | ||
| Stk4 | serine/threonine kinase 4 | 0.408 | ||
| Daxx | Fas death domain-associated protein | 0.388 | ||
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.358 | ||
| Prkcb | protein kinase C, beta | 0.284 | ||
| Rasa3 | RAS p21 protein activator 3 | 0.161 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.151 | ||
| Adcy7 | adenylate cyclase 7 | 0.149 | ||
| Evi2a | ecotropic viral integration site 2a | 0.122 | ||
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.113 | ||
| Coro1a | coronin, actin binding protein 1A | 0.107 | ||
| Rgs10 | regulator of G-protein signalling 10 | 0.101 | ||
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.078 | ||
| Gpsm3 | G-protein signalling modulator 3 (AGS3-like, C. elegans) | 0.061 | ||
| Laptm5 | lysosomal-associated protein transmembrane 5 | 0.061 | ||
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.061 | ||
| Sirpa | signal-regulatory protein alpha | 0.054 | ||
| 4632428N05Rik | RIKEN cDNA 4632428N05 gene | 0.052 | ||
| Trpv2 | transient receptor potential cation channel, subfamily V, member 2 | 0.052 | ||
| Stk10 | serine/threonine kinase 10 | 0.052 | ||
| Il17ra | interleukin 17 receptor A | 0.049 | ||
| Myo1f | myosin IF | 0.046 | ||
| Lsp1 | lymphocyte specific 1 | 0.042 | ||
| Arrb2 | arrestin, beta 2 | 0.042 | ||
| Arl4c | ADP-ribosylation factor-like 4C | 0.041 | ||
| Trp53 | transformation related protein 53 | 0.040 | ||
| Pld4 | phospholipase D family, member 4 | 0.036 | ||
| Thbs1 | thrombospondin 1 | 0.034 | ||
| Vav1 | vav 1 oncogene | 0.030 | ||
| Fam105a | family with sequence similarity 105, member A | 0.030 | ||
| Evl | Ena-vasodilator stimulated phosphoprotein | 0.030 | ||
| Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.028 | ||
| Abcg1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.027 | ||
| BC013712 | cDNA sequence BC013712 | 0.025 | ||
| Prkcd | protein kinase C, delta | 0.023 | ||
| Nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 0.023 | ||
| Sla | src-like adaptor | 0.023 | ||
| Fnbp1 | formin binding protein 1 | 0.021 | ||
| Map4k2 | mitogen-activated protein kinase kinase kinase kinase 2 | 0.021 | ||
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.021 | Mouse | |
| Fxyd5 | FXYD domain-containing ion transport regulator 5 | 0.021 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.021 | ||
| Prex1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.020 | ||
| Hmha1 | histocompatibility (minor) HA-1 | 0.019 | ||
| Lcp1 | lymphocyte cytosolic protein 1 | 0.019 | ||
| Akna | AT-hook transcription factor | 0.019 | ||
| Tm6sf1 | transmembrane 6 superfamily member 1 | 0.019 | ||
| Gmip | Gem-interacting protein | 0.018 | ||
| Ly86 | lymphocyte antigen 86 | 0.018 | ||
| Dock2 | dedicator of cyto-kinesis 2 | 0.018 | ||
| Fam65b | family with sequence similarity 65, member B | 0.018 | ||
| Plaur | plasminogen activator, urokinase receptor | 0.018 | ||
| Plxnc1 | plexin C1 | 0.017 | ||
| Cd83 | CD83 antigen | 0.017 | ||
| Cd52 | CD52 antigen | 0.017 | ||
| Lbh | limb-bud and heart | 0.017 | ||
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.017 | ||
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.016 | ||
| Cfp | complement factor properdin | 0.016 | ||
| Mast3 | microtubule associated serine/threonine kinase 3 | 0.015 | ||
| Selplg | selectin, platelet (p-selectin) ligand | 0.015 | ||
| Arhgdib | Rho, GDP dissociation inhibitor (GDI) beta | 0.015 | ||
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.014 | ||
| Cyfip2 | cytoplasmic FMR1 interacting protein 2 | 0.014 | ||
| Hpcal1 | hippocalcin-like 1 | 0.013 | ||
| Gltp | glycolipid transfer protein | 0.013 | ||
| Sh3bp5 | SH3-domain binding protein 5 (BTK-associated) | 0.013 | ||
| Smap2 | stromal membrane-associated GTPase-activating protein 2 | 0.013 | ||
| Hhex | hematopoietically expressed homeobox | 0.013 | ||
| Arhgap15 | Rho GTPase activating protein 15 | 0.013 | ||
| Cd53 | CD53 antigen | 0.012 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.012 | ||
| Mkl1 | MKL (megakaryoblastic leukemia)/myocardin-like 1 | 0.012 | ||
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.011 | ||
| Sh3kbp1 | SH3-domain kinase binding protein 1 | 0.011 | ||
| Arrb1 | arrestin, beta 1 | 0.011 | ||
| Fes | feline sarcoma oncogene | 0.011 | ||
| H2-DMa | histocompatibility 2, class II, locus DMa | 0.010 | ||
| Thy1 | thymus cell antigen 1, theta | 0.010 | ||
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.010 |