IMP

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Mus musculus

14 genes annotated in mouse

Multi-species View

establishment of skin barrier

GO:0061436

Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of skin barrier"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of skin barrier" (in gray)

Name	Description	Probability	Func Analog Organism
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.896	Mouse
Sprr1a	small proline-rich protein 1A	0.711
Krt6a	keratin 6A	0.667	Mouse
Tgm3	transglutaminase 3, E polypeptide	0.629
Irf6	interferon regulatory factor 6	0.526
Trp63	transformation related protein 63	0.488
Krt17	keratin 17	0.464
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.320	Mouse
Cela3b	chymotrypsin-like elastase family, member 3B	0.314	Mouse
Krt18	keratin 18	0.273
Crb3	crumbs homolog 3 (Drosophila)	0.265
Krt33b	keratin 33B	0.243
Krt19	keratin 19	0.231
Krt72-ps	keratin 72, pseudogene	0.231	Mouse
Krt14	keratin 14	0.231
Rdh8	retinol dehydrogenase 8	0.211
Cldn3	claudin 3	0.211	Mouse
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.198
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.186
Krtap8-1	keratin associated protein 8-1	0.172
Asprv1	aspartic peptidase, retroviral-like 1	0.172
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.168
Krt33a	keratin 33A	0.165
Trp53	transformation related protein 53	0.163	Mouse
Flg	filaggrin	0.155
Krtap3-1	keratin associated protein 3-1	0.152
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.147	Mouse
Wnt10a	wingless related MMTV integration site 10a	0.141
Rpgrip1l	Rpgrip1-like	0.131
Krt8	keratin 8	0.129	Mouse
Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.128
Trpv5	transient receptor potential cation channel, subfamily V, member 5	0.123
Psapl1	prosaposin-like 1	0.112
Ppl	periplakin	0.107
Foxn1	forkhead box N1	0.103
Dlx3	distal-less homeobox 3	0.102
Krt75	keratin 75	0.098	Mouse
Sfn	stratifin	0.096
Casp14	caspase 14	0.095
Cdcp1	CUB domain containing protein 1	0.095
Cyp26c1	cytochrome P450, family 26, subfamily c, polypeptide 1	0.094	Mouse
Lrrk2	leucine-rich repeat kinase 2	0.091
Krt31	keratin 31	0.090
Gm13011	predicted gene 13011	0.089	Mouse
Krt5	keratin 5	0.089	Mouse
Ggt1	gamma-glutamyltransferase 1	0.089
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.087	Mouse
Wfdc2	WAP four-disulfide core domain 2	0.082
Krt71	keratin 71	0.073	Mouse
Krt36	keratin 36	0.066
Cel	carboxyl ester lipase	0.066
Pkp1	plakophilin 1	0.064
Wnk4	WNK lysine deficient protein kinase 4	0.063
Krt85	keratin 85	0.062
Ly6g6c	lymphocyte antigen 6 complex, locus G6C	0.061
Spint1	serine protease inhibitor, Kunitz type 1	0.057
Il1f5	interleukin 1 family, member 5 (delta)	0.054
Cpa1	carboxypeptidase A1	0.054
Lgals7	lectin, galactose binding, soluble 7	0.054
1600029D21Rik	RIKEN cDNA 1600029D21 gene	0.053
Rab25	RAB25, member RAS oncogene family	0.052
Slurp1	secreted Ly6/Plaur domain containing 1	0.050
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.049
Elf3	E74-like factor 3	0.049
Cldn7	claudin 7	0.048	Mouse
Fam83f	family with sequence similarity 83, member F	0.047
Upk3a	uroplakin 3A	0.046
S100a14	S100 calcium binding protein A14	0.045
Ptch2	patched homolog 2	0.044
Tmprss2	transmembrane protease, serine 2	0.044
Slc46a2	solute carrier family 46, member 2	0.043
Calm4	calmodulin 4	0.043
Tjp1	tight junction protein 1	0.042
Prss8	protease, serine, 8 (prostasin)	0.042
Mpdz	multiple PDZ domain protein	0.042
Dsg2	desmoglein 2	0.041
Chia	chitinase, acidic	0.038
Aqp2	aquaporin 2	0.038
Alox12e	arachidonate lipoxygenase, epidermal	0.038	Mouse
Krtap14	keratin associated protein 14	0.038
Slc23a3	solute carrier family 23 (nucleobase transporters), member 3	0.037
Pdzk1ip1	PDZK1 interacting protein 1	0.037
Clic3	chloride intracellular channel 3	0.036
Krt13	keratin 13	0.036
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.036
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.035
Prss2	protease, serine, 2	0.033
Pten	phosphatase and tensin homolog	0.033
Tsc2	tuberous sclerosis 2	0.033
Krt35	keratin 35	0.032
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.032
Sycn	syncollin	0.032
Trim29	tripartite motif-containing 29	0.032
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.031
Tmem79	transmembrane protein 79	0.031
Krt4	keratin 4	0.031	Mouse
Sprr1b	small proline-rich protein 1B	0.031
Fam83h	family with sequence similarity 83, member H	0.030
Pkp3	plakophilin 3	0.030
Mybph	myosin binding protein H	0.030
Lce1a1	late cornified envelope 1A1	0.029
Npc1	Niemann Pick type C1	0.029
Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.029
Padi3	peptidyl arginine deiminase, type III	0.029
Psca	prostate stem cell antigen	0.028
Trpv6	transient receptor potential cation channel, subfamily V, member 6	0.028
Gjb1	gap junction protein, beta 1	0.027
Tjp3	tight junction protein 3	0.027
Tff1	trefoil factor 1	0.026
Tacstd2	tumor-associated calcium signal transducer 2	0.026
Abcg5	ATP-binding cassette, sub-family G (WHITE), member 5	0.025
Aanat	arylalkylamine N-acetyltransferase	0.025
Prss29	protease, serine, 29	0.025
Alox15	arachidonate 15-lipoxygenase	0.024	Mouse
Cuzd1	CUB and zona pellucida-like domains 1	0.024
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.024
S100a3	S100 calcium binding protein A3	0.023
Duoxa1	dual oxidase maturation factor 1	0.023
Lamc2	laminin, gamma 2	0.023
Ppy	pancreatic polypeptide	0.023
Trp73	transformation related protein 73	0.023	Mouse
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.022
Mt4	metallothionein 4	0.022
Krtap5-1	keratin associated protein 5-1	0.022
Mal	myelin and lymphocyte protein, T-cell differentiation protein	0.022
Col17a1	collagen, type XVII, alpha 1	0.022
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.022
Tmem54	transmembrane protein 54	0.022
Cdh1	cadherin 1	0.021
Guca2b	guanylate cyclase activator 2b (retina)	0.021
Krt27	keratin 27	0.021
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.021
Padi4	peptidyl arginine deiminase, type IV	0.021
Htr3a	5-hydroxytryptamine (serotonin) receptor 3A	0.021
Dsc3	desmocollin 3	0.021
Ripk4	receptor-interacting serine-threonine kinase 4	0.020
Hoxb2	homeobox B2	0.020
Klk6	kallikrein related-peptidase 6	0.020
Treh	trehalase (brush-border membrane glycoprotein)	0.020
9130017N09Rik	RIKEN cDNA 9130017N09 gene	0.020
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.020	Mouse
Gpr37l1	G protein-coupled receptor 37-like 1	0.020
Krt34	keratin 34	0.019
Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	0.019
9930023K05Rik	RIKEN cDNA 9930023K05 gene	0.019
Sprr3	small proline-rich protein 3	0.019
Gprc5d	G protein-coupled receptor, family C, group 5, member D	0.019
Fshb	follicle stimulating hormone beta	0.018
Krtap6-2	keratin associated protein 6-2	0.018
Scnn1g	sodium channel, nonvoltage-gated 1 gamma	0.018
Lad1	ladinin	0.018
Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	0.018
Krtap10-4	keratin associated protein 10-4	0.018
Gpr87	G protein-coupled receptor 87	0.018
Ptges	prostaglandin E synthase	0.017
Stra6	stimulated by retinoic acid gene 6	0.017
Sult5a1	sulfotransferase family 5A, member 1	0.017
Rab17	RAB17, member RAS oncogene family	0.017
Elane	elastase, neutrophil expressed	0.017
Fut1	fucosyltransferase 1	0.017
Pthlh	parathyroid hormone-like peptide	0.017
Cblc	Casitas B-lineage lymphoma c	0.017
Upk2	uroplakin 2	0.017
Krt2	keratin 2	0.016	Mouse
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.016
Krt32	keratin 32	0.016
Emx1	empty spiracles homolog 1 (Drosophila)	0.016
Tbc1d4	TBC1 domain family, member 4	0.016
Esr1	estrogen receptor 1 (alpha)	0.016
Itgb4	integrin beta 4	0.016
Uts2r	urotensin 2 receptor	0.015
Treml1	triggering receptor expressed on myeloid cells-like 1	0.015
Mogat2	monoacylglycerol O-acyltransferase 2	0.015
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.015
Ovol1	OVO homolog-like 1 (Drosophila)	0.015
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.015
Sult2b1	sulfotransferase family, cytosolic, 2B, member 1	0.015
Defa-rs12	defensin, alpha, related sequence 12	0.015
Ins1	insulin I	0.015
Foxq1	forkhead box Q1	0.015
Tcfap2c	transcription factor AP-2, gamma	0.015
Cldn4	claudin 4	0.014	Mouse
Tulp1	tubby like protein 1	0.014
Fgf22	fibroblast growth factor 22	0.014
Pla2g2c	phospholipase A2, group IIC	0.014
Wnt6	wingless-related MMTV integration site 6	0.014
Hr	hairless	0.014
Igfbp1	insulin-like growth factor binding protein 1	0.014
Defb1	defensin beta 1	0.014
Epcam	epithelial cell adhesion molecule	0.014
Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	0.014
Mapk13	mitogen-activated protein kinase 13	0.014
Il12rb2	interleukin 12 receptor, beta 2	0.014
Gif	gastric intrinsic factor	0.014
2310014L17Rik	RIKEN cDNA 2310014L17 gene	0.014
Oxt	oxytocin	0.014
Chrdl2	chordin-like 2	0.013
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.013
Arhgap8	Rho GTPase activating protein 8	0.013
Bnipl	BCL2/adenovirus E1B 19kD interacting protein like	0.013
Dmkn	dermokine	0.013
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.013
Krtdap	keratinocyte differentiation associated protein	0.013
Cpz	carboxypeptidase Z	0.013
Bsnd	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	0.013
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.013
Kcnk7	potassium channel, subfamily K, member 7	0.013
Odf3	outer dense fiber of sperm tails 3	0.013
Sebox	SEBOX homeobox	0.013
Klk11	kallikrein related-peptidase 11	0.013
Strc	stereocilin	0.012
Clcnka	chloride channel Ka	0.012
Vgll1	vestigial like 1 homolog (Drosophila)	0.012
Krt6b	keratin 6B	0.012	Mouse
Lhb	luteinizing hormone beta	0.012
Defb6	defensin beta 6	0.012
Ildr1	immunoglobulin-like domain containing receptor 1	0.012
Tmem30b	transmembrane protein 30B	0.012
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.012
Mall	mal, T-cell differentiation protein-like	0.012
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.012
Apoe	apolipoprotein E	0.012
Tg	thyroglobulin	0.012
Crygc	crystallin, gamma C	0.012
Krtap1-5	keratin associated protein 1-5	0.012
Myoz1	myozenin 1	0.012
Lrp1	low density lipoprotein receptor-related protein 1	0.011
Clps	colipase, pancreatic	0.011
Lypd3	Ly6/Plaur domain containing 3	0.011
Slc22a12	solute carrier family 22 (organic anion/cation transporter), member 12	0.011
Adra2b	adrenergic receptor, alpha 2b	0.011
Ptf1a	pancreas specific transcription factor, 1a	0.011
Alox8	arachidonate 8-lipoxygenase	0.011	Mouse
Pla2g1b	phospholipase A2, group IB, pancreas	0.011
Ucn2	urocortin 2	0.011
Kiss1	KiSS-1 metastasis-suppressor	0.011
Lgals12	lectin, galactose binding, soluble 12	0.011
Cnfn	cornifelin	0.011
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.011
Krtap5-2	keratin associated protein 5-2	0.011
Phlda2	pleckstrin homology-like domain, family A, member 2	0.011
Asb9	ankyrin repeat and SOCS box-containing 9	0.011
Hils1	histone H1-like protein in spermatids 1	0.011
Pitpnm1	phosphatidylinositol transfer protein, membrane-associated 1	0.011
Rln1	relaxin 1	0.011
Fam25c	family with sequence similarity 25, member C	0.011
Edar	ectodysplasin-A receptor	0.011
Ivl	involucrin	0.011
Dsc1	desmocollin 1	0.011
Sftpd	surfactant associated protein D	0.011
Plekhg6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Krt15	keratin 15	0.011
Sost	sclerostin	0.010
Cela2a	chymotrypsin-like elastase family, member 2A	0.010
Psors1c2	psoriasis susceptibility 1 candidate 2 (human)	0.010
Adig	adipogenin	0.010
Ccl1	chemokine (C-C motif) ligand 1	0.010
Klk1b11	kallikrein 1-related peptidase b11	0.010
Syt8	synaptotagmin VIII	0.010
Il1f6	interleukin 1 family, member 6	0.010
Cwh43	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	0.010
2310042E22Rik	RIKEN cDNA 2310042E22 gene	0.010
Tff3	trefoil factor 3, intestinal	0.010
Ocln	occludin	0.010