IMP

Process View

Mus musculus

9 genes annotated in mouse

transition between fast and slow fiber

The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "transition between fast and slow fiber"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "transition between fast and slow fiber" (in gray)

Name	Description	Probability	Func Analog Organism
Hrc	histidine rich calcium binding protein	0.980
Tnni2	troponin I, skeletal, fast 2	0.959	Mouse
Tnnt3	troponin T3, skeletal, fast	0.864	Mouse
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.844
Ldb3	LIM domain binding 3	0.700
Actn2	actinin alpha 2	0.677
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.551	Mouse
Yap1	yes-associated protein 1	0.419
Casq1	calsequestrin 1	0.418
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.358
Tnnc2	troponin C2, fast	0.355	Mouse
Cox6a2	cytochrome c oxidase, subunit VI a, polypeptide 2	0.347
Ryr1	ryanodine receptor 1, skeletal muscle	0.335
Actn3	actinin alpha 3	0.304
Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle	0.291
Csrp3	cysteine and glycine-rich protein 3	0.269
Myom2	myomesin 2	0.262
Actc1	actin, alpha, cardiac muscle 1	0.245
Pgam2	phosphoglycerate mutase 2	0.242
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.231
Myh4	myosin, heavy polypeptide 4, skeletal muscle	0.215	Mouse
Des	desmin	0.212
Tcap	titin-cap	0.207
Nrap	nebulin-related anchoring protein	0.189
Myl3	myosin, light polypeptide 3	0.186
Ckmt2	creatine kinase, mitochondrial 2	0.155
Casq2	calsequestrin 2	0.155
Tnnt2	troponin T2, cardiac	0.147
Ckm	creatine kinase, muscle	0.137
Mybph	myosin binding protein H	0.122
Srpk3	serine/arginine-rich protein specific kinase 3	0.117
Ttn	titin	0.112
Myom1	myomesin 1	0.111
Cav3	caveolin 3	0.106
Myl1	myosin, light polypeptide 1	0.101
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.100
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.098
Myoz1	myozenin 1	0.093
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.084
Xirp1	xin actin-binding repeat containing 1	0.081
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.080
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.079	Mouse
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.073	Mouse
Cox8b	cytochrome c oxidase, subunit VIIIb	0.070
Acta1	actin, alpha 1, skeletal muscle	0.069
Tnnt1	troponin T1, skeletal, slow	0.061
Hspb2	heat shock protein 2	0.056
Tead1	TEA domain family member 1	0.050
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.049
Pvalb	parvalbumin	0.046
Tnni1	troponin I, skeletal, slow 1	0.045
Trim54	tripartite motif-containing 54	0.044
Myh3	myosin, heavy polypeptide 3, skeletal muscle, embryonic	0.043
Myh8	myosin, heavy polypeptide 8, skeletal muscle, perinatal	0.041
Tnnc1	troponin C, cardiac/slow skeletal	0.041
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.039	Mouse
Crhr2	corticotropin releasing hormone receptor 2	0.039
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.038
Prkce	protein kinase C, epsilon	0.037
Wwtr1	WW domain containing transcription regulator 1	0.037
Pygm	muscle glycogen phosphorylase	0.035
Flnc	filamin C, gamma	0.033
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.032
Tuba8	tubulin, alpha 8	0.031
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.028
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.027
Nppa	natriuretic peptide type A	0.027
Tnni3	troponin I, cardiac 3	0.025	Mouse
Wnt11	wingless-related MMTV integration site 11	0.023
Tpm2	tropomyosin 2, beta	0.023
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.022
Prx	periaxin	0.021
Myh2	myosin, heavy polypeptide 2, skeletal muscle, adult	0.021
Mfap4	microfibrillar-associated protein 4	0.020
Fbp2	fructose bisphosphatase 2	0.019
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.019
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.019
Adcy4	adenylate cyclase 4	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.018
Fbxo32	F-box protein 32	0.018
Myl7	myosin, light polypeptide 7, regulatory	0.018
Rrad	Ras-related associated with diabetes	0.017
Myl4	myosin, light polypeptide 4	0.017
Myoz2	myozenin 2	0.017
Ager	advanced glycosylation end product-specific receptor	0.017
Lmod2	leiomodin 2 (cardiac)	0.017
Mb	myoglobin	0.017
Mef2a	myocyte enhancer factor 2A	0.017
Rapsn	receptor-associated protein of the synapse	0.016
Mybpc3	myosin binding protein C, cardiac	0.015
Tbx15	T-box 15	0.015
Popdc3	popeye domain containing 3	0.015
Myf6	myogenic factor 6	0.015
Itgb3	integrin beta 3	0.015
Notch4	Notch gene homolog 4 (Drosophila)	0.014
Foxf1a	forkhead box F1a	0.014
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.014
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Spry4	sprouty homolog 4 (Drosophila)	0.014
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.013
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.013
Art1	ADP-ribosyltransferase 1	0.013
Capn3	calpain 3	0.012
Fgf18	fibroblast growth factor 18	0.012
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.012	Mouse
Tcf15	transcription factor 15	0.012
Rasgrp2	RAS, guanyl releasing protein 2	0.012
Tead2	TEA domain family member 2	0.012	Mouse
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.012
Hfe2	hemochromatosis type 2 (juvenile) (human homolog)	0.011
Smpx	small muscle protein, X-linked	0.011
Stk4	serine/threonine kinase 4	0.011
Fbn2	fibrillin 2	0.011
Tmod4	tropomodulin 4	0.011
Akap5	A kinase (PRKA) anchor protein 5	0.011
Nrk	Nik related kinase	0.011
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.011
Qk	quaking	0.011
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.011
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.011
Mapk12	mitogen-activated protein kinase 12	0.010