IMP

Process View

Mus musculus

3 genes annotated in mouse

Multi-species View

negative regulation of complement activation

GO:0045916

Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of complement activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of complement activation" (in gray)

Name	Description	Probability	Func Analog Organism
Cd59a	CD59a antigen	0.996
Spna1	spectrin alpha 1	0.625
Cd59b	CD59b antigen	0.553
Cp	ceruloplasmin	0.465
Dcn	decorin	0.420
Lum	lumican	0.379
Cfh	complement component factor h	0.347
Cd55	CD55 antigen	0.222	Human Mouse
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.189
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.172
Alb	albumin	0.167
Adam4	a disintegrin and metallopeptidase domain 4	0.161
Lbp	lipopolysaccharide binding protein	0.132
Fxyd1	FXYD domain-containing ion transport regulator 1	0.130
Lect2	leukocyte cell-derived chemotaxin 2	0.130
F9	coagulation factor IX	0.116
Aadac	arylacetamide deacetylase (esterase)	0.112
C1s	complement component 1, s subcomponent	0.102
Mug1	murinoglobulin 1	0.092
Apoe	apolipoprotein E	0.088
C1ra	complement component 1, r subcomponent A	0.088
Ank1	ankyrin 1, erythroid	0.075
Bgn	biglycan	0.072
Rarres2	retinoic acid receptor responder (tazarotene induced) 2	0.068
Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.062
Fmo1	flavin containing monooxygenase 1	0.057
C9	complement component 9	0.056
Apoc4	apolipoprotein C-IV	0.054
Mgp	matrix Gla protein	0.052
Crp	C-reactive protein, pentraxin-related	0.051
Rnase4	ribonuclease, RNase A family 4	0.047
Cxcl12	chemokine (C-X-C motif) ligand 12	0.047
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.046
Akr1c6	aldo-keto reductase family 1, member C6	0.045
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.045
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.044
Ifitm3	interferon induced transmembrane protein 3	0.044
Col3a1	collagen, type III, alpha 1	0.042
Cfi	complement component factor i	0.042
C1rb	complement component 1, r subcomponent B	0.042
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.042
Plg	plasminogen	0.042
C4b	complement component 4B (Childo blood group)	0.041
F2	coagulation factor II	0.040
Cd302	CD302 antigen	0.038
Dpt	dermatopontin	0.037
Pklr	pyruvate kinase liver and red blood cell	0.036
Sdc2	syndecan 2	0.036
Afm	afamin	0.034
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.034
Hgd	homogentisate 1, 2-dioxygenase	0.033
Mbl2	mannose-binding lectin (protein C) 2	0.031
Pros1	protein S (alpha)	0.031
Apoa1	apolipoprotein A-I	0.031
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.031
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.030
Gstt1	glutathione S-transferase, theta 1	0.030
Rbp1	retinol binding protein 1, cellular	0.029
B2m	beta-2 microglobulin	0.028
Tmem176b	transmembrane protein 176B	0.027
Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	0.026
Inhbe	inhibin beta E	0.026
Apcs	serum amyloid P-component	0.026
Hsd3b6	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6	0.025
Tdo2	tryptophan 2,3-dioxygenase	0.025
Fgb	fibrinogen beta chain	0.024
Gc	group specific component	0.024
Prss58	protease, serine 58	0.024
Fgg	fibrinogen gamma chain	0.023
Omt2b	oocyte maturation, beta	0.023
Saa4	serum amyloid A 4	0.023
Col5a2	collagen, type V, alpha 2	0.023
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.022
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.022
Fbxo15	F-box protein 15	0.022
Kng1	kininogen 1	0.022
Klkb1	kallikrein B, plasma 1	0.022
Ahsg	alpha-2-HS-glycoprotein	0.022
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.021
Ogn	osteoglycin	0.021
Apof	apolipoprotein F	0.021
C3	complement component 3	0.021
Ttr	transthyretin	0.021
Cryba1	crystallin, beta A1	0.021
Fga	fibrinogen alpha chain	0.021
Fn1	fibronectin 1	0.021
Casp12	caspase 12	0.020
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.020
Lox	lysyl oxidase	0.020
Ambp	alpha 1 microglobulin/bikunin	0.020
Egfr	epidermal growth factor receptor	0.020
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.020
Apob	apolipoprotein B	0.020
Tcn2	transcobalamin 2	0.019
Serpina3c	serine (or cysteine) peptidase inhibitor, clade A, member 3C	0.019
C1qb	complement component 1, q subcomponent, beta polypeptide	0.019
Mrc1	mannose receptor, C type 1	0.019
Adam1a	a disintegrin and metallopeptidase domain 1a	0.019
Dnajb7	DnaJ (Hsp40) homolog, subfamily B, member 7	0.018
Uros	uroporphyrinogen III synthase	0.018
Rdh7	retinol dehydrogenase 7	0.018
Hamp	hepcidin antimicrobial peptide	0.018
Muc3	mucin 3, intestinal	0.018
Itih2	inter-alpha trypsin inhibitor, heavy chain 2	0.017
Igf1	insulin-like growth factor 1	0.017
Mug2	murinoglobulin 2	0.017
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.017
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.017
Ghr	growth hormone receptor	0.017
Sepp1	selenoprotein P, plasma, 1	0.017
Aadat	aminoadipate aminotransferase	0.017
Postn	periostin, osteoblast specific factor	0.017
Folr2	folate receptor 2 (fetal)	0.016
Gsta4	glutathione S-transferase, alpha 4	0.016
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.016
Copz2	coatomer protein complex, subunit zeta 2	0.016
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.016
Fech	ferrochelatase	0.016
Prelp	proline arginine-rich end leucine-rich repeat	0.016
Nat1	N-acetyl transferase 1	0.016
Tmem176a	transmembrane protein 176A	0.016
Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.015
Ms4a4d	membrane-spanning 4-domains, subfamily A, member 4D	0.015
Star	steroidogenic acute regulatory protein	0.015
Rdh16	retinol dehydrogenase 16	0.015
Fkbp7	FK506 binding protein 7	0.015
Pipox	pipecolic acid oxidase	0.015
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.015
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.015
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.015
Osmr	oncostatin M receptor	0.014
Ces1c	carboxylesterase 1C	0.014
Pcolce	procollagen C-endopeptidase enhancer protein	0.014
Add2	adducin 2 (beta)	0.014
Uox	urate oxidase	0.014
Lipc	lipase, hepatic	0.014
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.014
Abcg2	ATP-binding cassette, sub-family G (WHITE), member 2	0.014
Sri	sorcin	0.014
Tfpi	tissue factor pathway inhibitor	0.013
Vtn	vitronectin	0.013
Cmbl	carboxymethylenebutenolidase-like (Pseudomonas)	0.013
Ifitm2	interferon induced transmembrane protein 2	0.013
Ccdc80	coiled-coil domain containing 80	0.013
Apoa5	apolipoprotein A-V	0.013
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.012
Ces3a	carboxylesterase 3A	0.012
Colec12	collectin sub-family member 12	0.012
Nid1	nidogen 1	0.012
Nnmt	nicotinamide N-methyltransferase	0.012
Sult1b1	sulfotransferase family 1B, member 1	0.012
Aspn	asporin	0.012
Hpx	hemopexin	0.012
Tsga13	testis specific gene A13	0.012
Cct6b	chaperonin containing Tcp1, subunit 6b (zeta)	0.012
Pemt	phosphatidylethanolamine N-methyltransferase	0.012
Pzp	pregnancy zone protein	0.012
Hspb8	heat shock protein 8	0.012
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.012
Ctsh	cathepsin H	0.012
Cyp2a12	cytochrome P450, family 2, subfamily a, polypeptide 12	0.012
Rhd	Rh blood group, D antigen	0.012
Crisp2	cysteine-rich secretory protein 2	0.012
F12	coagulation factor XII (Hageman factor)	0.012
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.012
Naalad2	N-acetylated alpha-linked acidic dipeptidase 2	0.012
Otc	ornithine transcarbamylase	0.012
Apoa2	apolipoprotein A-II	0.012
Gpx8	glutathione peroxidase 8 (putative)	0.011
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.011
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.011
C1qc	complement component 1, q subcomponent, C chain	0.011
2610015P09Rik	RIKEN cDNA 2610015P09 gene	0.011
F8	coagulation factor VIII	0.011
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.011
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.011
Rbp4	retinol binding protein 4, plasma	0.011
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.011
Efemp1	epidermal growth factor-containing fibulin-like extracellular matrix protein 1	0.011
Mup3	major urinary protein 3	0.011
Avil	advillin	0.011
Fah	fumarylacetoacetate hydrolase	0.010
Hc	hemolytic complement	0.010
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.010
Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A	0.010
Rras	Harvey rat sarcoma oncogene, subgroup R	0.010
Ephx2	epoxide hydrolase 2, cytoplasmic	0.010
Olfml3	olfactomedin-like 3	0.010
Pon3	paraoxonase 3	0.010
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.010
Zscan2	zinc finger and SCAN domain containing 2	0.010
Elk4	ELK4, member of ETS oncogene family	0.010
Gstk1	glutathione S-transferase kappa 1	0.010
1700074P13Rik	RIKEN cDNA 1700074P13 gene	0.010
F13b	coagulation factor XIII, beta subunit	0.010
Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	0.010
Aqp8	aquaporin 8	0.010