IMP

Process View

Mus musculus

1 genes annotated in mouse

dibenzo p dioxin metabolic process

The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dibenzo p dioxin metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dibenzo p dioxin metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.682
Hsd3b6	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6	0.591	Rat
Hsd3b2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.501	Rat
Ces3a	carboxylesterase 3A	0.421
Hoxa10	homeobox A10	0.337
C9	complement component 9	0.301
Ahsg	alpha-2-HS-glycoprotein	0.295
Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	0.294
Akr1c21	aldo-keto reductase family 1, member C21	0.275
Cyp2a12	cytochrome P450, family 2, subfamily a, polypeptide 12	0.272
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.203
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.186
Cps1	carbamoyl-phosphate synthetase 1	0.169
Dmgdh	dimethylglycine dehydrogenase precursor	0.167
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.146
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.143
Mbl2	mannose-binding lectin (protein C) 2	0.143
Cdhr5	cadherin-related family member 5	0.139
G6pc	glucose-6-phosphatase, catalytic	0.134
Hrg	histidine-rich glycoprotein	0.130
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.130
Slc12a1	solute carrier family 12, member 1	0.124
Hgd	homogentisate 1, 2-dioxygenase	0.118
Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	0.111
Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.102
Apoc4	apolipoprotein C-IV	0.094
Upp2	uridine phosphorylase 2	0.093
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.093
Mc2r	melanocortin 2 receptor	0.091
Adra2b	adrenergic receptor, alpha 2b	0.084
Hao2	hydroxyacid oxidase 2	0.084
Aadat	aminoadipate aminotransferase	0.075
Otc	ornithine transcarbamylase	0.073
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.071
Bhmt	betaine-homocysteine methyltransferase	0.071
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.069
Afm	afamin	0.069
Mep1a	meprin 1 alpha	0.068
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.067
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.066
F13b	coagulation factor XIII, beta subunit	0.065
Ar	androgen receptor	0.064
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.064
Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.063	Rat
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.062
Akr1c6	aldo-keto reductase family 1, member C6	0.060
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.059
Klk1b4	kallikrein 1-related pepidase b4	0.058
Mug2	murinoglobulin 2	0.057
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.056
Hoxd8	homeobox D8	0.055
Apoh	apolipoprotein H	0.055
Klkb1	kallikrein B, plasma 1	0.053
Masp1	mannan-binding lectin serine peptidase 1	0.050
Inhbc	inhibin beta-C	0.048
Ces1g	carboxylesterase 1G	0.048
Rdh7	retinol dehydrogenase 7	0.047
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.047
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.045
Aqp8	aquaporin 8	0.045
Tnp1	transition protein 1	0.045
Crh	corticotropin releasing hormone	0.044
Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	0.044
Aadac	arylacetamide deacetylase (esterase)	0.043
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.043
Star	steroidogenic acute regulatory protein	0.043
Tdo2	tryptophan 2,3-dioxygenase	0.042
Fshr	follicle stimulating hormone receptor	0.041
Lox	lysyl oxidase	0.041
Gsta2	glutathione S-transferase, alpha 2 (Yc2)	0.040
Agxt	alanine-glyoxylate aminotransferase	0.040
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.039
Rdh16	retinol dehydrogenase 16	0.038
Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	0.038
Svs5	seminal vesicle secretory protein 5	0.038
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.038
Dct	dopachrome tautomerase	0.038
Sardh	sarcosine dehydrogenase	0.037
Mup4	major urinary protein 4	0.036
Fabp1	fatty acid binding protein 1, liver	0.036
Cyp2c38	cytochrome P450, family 2, subfamily c, polypeptide 38	0.034
Apob	apolipoprotein B	0.034
Cyp17a1	cytochrome P450, family 17, subfamily a, polypeptide 1	0.033	Mouse Rat
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.033
Enam	enamelin	0.033
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.032
Azgp1	alpha-2-glycoprotein 1, zinc	0.031
Sult1b1	sulfotransferase family 1B, member 1	0.031
Spam1	sperm adhesion molecule 1	0.031
Dhh	desert hedgehog	0.030
Prlr	prolactin receptor	0.030
Fbp1	fructose bisphosphatase 1	0.030
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.030
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.030
Foxc1	forkhead box C1	0.030
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.030
Hnf4a	hepatic nuclear factor 4, alpha	0.029
Lipc	lipase, hepatic	0.029
Mas1	MAS1 oncogene	0.028
Car5a	carbonic anhydrase 5a, mitochondrial	0.027
Mat1a	methionine adenosyltransferase I, alpha	0.027
Omt2b	oocyte maturation, beta	0.027
Mrap	melanocortin 2 receptor accessory protein	0.027
Pomc	pro-opiomelanocortin-alpha	0.026
Gcgr	glucagon receptor	0.025
Lect2	leukocyte cell-derived chemotaxin 2	0.024
Pde8b	phosphodiesterase 8B	0.024
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.024
Cyp2c54	cytochrome P450, family 2, subfamily c, polypeptide 54	0.024
Alb	albumin	0.024
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.023
Tat	tyrosine aminotransferase	0.023
Prl2b1	prolactin family 2, subfamily b, member 1	0.023
Pemt	phosphatidylethanolamine N-methyltransferase	0.023
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.023
Hoxd10	homeobox D10	0.023
F12	coagulation factor XII (Hageman factor)	0.022
Hoxb9	homeobox B9	0.022
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.022
Lrp2	low density lipoprotein receptor-related protein 2	0.022
Dcpp1	demilune cell and parotid protein 1	0.021
Vmn1r51	vomeronasal 1 receptor 51	0.021
F9	coagulation factor IX	0.021
Tff3	trefoil factor 3, intestinal	0.021
Cct6b	chaperonin containing Tcp1, subunit 6b (zeta)	0.020
C4bp	complement component 4 binding protein	0.020
Sult1d1	sulfotransferase family 1D, member 1	0.020
Gata6	GATA binding protein 6	0.020
Cyp2d12	cytochrome P450, family 2, subfamily d, polypeptide 12	0.020
Aldob	aldolase B, fructose-bisphosphate	0.020
Tsku	tsukushin	0.020
Klk1b5	kallikrein 1-related peptidase b5	0.019
Pdha2	pyruvate dehydrogenase E1 alpha 2	0.019
Apoa5	apolipoprotein A-V	0.018
Habp2	hyaluronic acid binding protein 2	0.018
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.018
Hoxd4	homeobox D4	0.018
Smcp	sperm mitochondria-associated cysteine-rich protein	0.017
Ces1c	carboxylesterase 1C	0.017
Prl7a1	prolactin family 7, subfamily a, member 1	0.017
Serpina5	serine (or cysteine) peptidase inhibitor, clade A, member 5	0.017
Izumo3	IZUMO family member 3	0.017
Apoa2	apolipoprotein A-II	0.017
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.017
Akr1d1	aldo-keto reductase family 1, member D1	0.017
Rab17	RAB17, member RAS oncogene family	0.017
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.017
Hmgb4	high-mobility group box 4	0.016
Hal	histidine ammonia lyase	0.016
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.016
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.016	Mouse
Cyp2d9	cytochrome P450, family 2, subfamily d, polypeptide 9	0.016	Mouse
Pah	phenylalanine hydroxylase	0.016
Pipox	pipecolic acid oxidase	0.016
Hoxb13	homeobox B13	0.016
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.016
Fam167b	family with sequence similarity 167, member B	0.016
Apoa4	apolipoprotein A-IV	0.016
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.015
Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	0.015
Bhmt2	betaine-homocysteine methyltransferase 2	0.015
Gm14743	predicted gene 14743	0.015
Saa2	serum amyloid A 2	0.015
Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	0.015
Apoa1	apolipoprotein A-I	0.015
Klk1b1	kallikrein 1-related peptidase b1	0.015
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.015
Trim61	tripartite motif-containing 61	0.015
Acsm3	acyl-CoA synthetase medium-chain family member 3	0.015
Accn5	amiloride-sensitive cation channel 5, intestinal	0.015
Cyp4b1	cytochrome P450, family 4, subfamily b, polypeptide 1	0.015
Spink12	serine peptidase inhibitor, Kazal type 11	0.015
Proc	protein C	0.014
Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	0.014
AU021092	expressed sequence AU021092	0.014
Mug1	murinoglobulin 1	0.014
Cyp2c39	cytochrome P450, family 2, subfamily c, polypeptide 39	0.014
Krt72-ps	keratin 72, pseudogene	0.014
Gml	GPI anchored molecule like protein	0.014
Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2	0.014
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.014
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.013
Prr15	proline rich 15	0.013
Sgk2	serum/glucocorticoid regulated kinase 2	0.013
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.013
Pik3c2g	phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide	0.013
Rbmy1a1	RNA binding motif protein, Y chromosome, family 1, member A1	0.013
Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	0.013
H1foo	H1 histone family, member O, oocyte-specific	0.013
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.013
Hoxc8	homeobox C8	0.013
F8	coagulation factor VIII	0.012
Acot12	acyl-CoA thioesterase 12	0.012
Cfd	complement factor D (adipsin)	0.012
Klk1b16	kallikrein 1-related peptidase b16	0.012
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.012	Rat
Slco1b2	solute carrier organic anion transporter family, member 1b2	0.012
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.012
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
Ces2e	carboxylesterase 2E	0.012
Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	0.012
C730048C13Rik	RIKEN cDNA C730048C13 gene	0.012
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.012
Gsg1	germ cell-specific gene 1	0.012
Ldhc	lactate dehydrogenase C	0.012
Tcf21	transcription factor 21	0.012
Clec4f	C-type lectin domain family 4, member f	0.012
Klk1b8	kallikrein 1-related peptidase b8	0.011
1300017J02Rik	RIKEN cDNA 1300017J02 gene	0.011
Ptafr	platelet-activating factor receptor	0.011
Klk1b3	kallikrein 1-related peptidase b3	0.011
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
Sult2a2	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	0.011
Mup5	major urinary protein 5	0.011
Car1	carbonic anhydrase 1	0.011
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.011
Dnajb8	DnaJ (Hsp40) homolog, subfamily B, member 8	0.011
Aldh8a1	aldehyde dehydrogenase 8 family, member A1	0.010
Flt4	FMS-like tyrosine kinase 4	0.010
Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	0.010
Amhr2	anti-Mullerian hormone type 2 receptor	0.010
Bik	BCL2-interacting killer	0.010
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.010
Vnn3	vanin 3	0.010
Oaz3	ornithine decarboxylase antizyme 3	0.010
Prodh2	proline dehydrogenase (oxidase) 2	0.010
Slc22a12	solute carrier family 22 (organic anion/cation transporter), member 12	0.010
Rgn	regucalcin	0.010
Tshr	thyroid stimulating hormone receptor	0.010
Crisp4	cysteine-rich secretory protein 4	0.010