IMP

Process View

Mus musculus

2 genes annotated in mouse

negative regulation of protein kinase activity by regulation of protein phosphorylation

The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein kinase activity by regulation of protein phosphorylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein kinase activity by regulation of protein phosphorylation" (in gray)

Name	Description	Probability	Func Analog Organism
Fos	FBJ osteosarcoma oncogene	0.978
Jun	Jun oncogene	0.959
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.704
Egr1	early growth response 1	0.567
Btg2	B-cell translocation gene 2, anti-proliferative	0.548
Ier2	immediate early response 2	0.445
Junb	Jun-B oncogene	0.300
Rhob	ras homolog gene family, member B	0.258
Zfp36	zinc finger protein 36	0.249
Ier3	immediate early response 3	0.166
Errfi1	ERBB receptor feedback inhibitor 1	0.157
Atf3	activating transcription factor 3	0.153
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.141
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.132
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.089
Dusp1	dual specificity phosphatase 1	0.085	Mouse
Egr2	early growth response 2	0.068
Cyr61	cysteine rich protein 61	0.064
Klf6	Kruppel-like factor 6	0.061
Mapk1	mitogen-activated protein kinase 1	0.056
Bhlhe40	basic helix-loop-helix family, member e40	0.056
Phlda1	pleckstrin homology-like domain, family A, member 1	0.046
Csrnp1	cysteine-serine-rich nuclear protein 1	0.040
Mapt	microtubule-associated protein tau	0.039
Ier5	immediate early response 5	0.033
Fosb	FBJ osteosarcoma oncogene B	0.033
Ncoa3	nuclear receptor coactivator 3	0.030
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.029
Mapk14	mitogen-activated protein kinase 14	0.029
Skil	SKI-like	0.028
Per1	period homolog 1 (Drosophila)	0.027
Homer1	homer homolog 1 (Drosophila)	0.027
Rusc2	RUN and SH3 domain containing 2	0.027
Ddit4	DNA-damage-inducible transcript 4	0.027
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.026
Plk3	polo-like kinase 3 (Drosophila)	0.026
Tmcc2	transmembrane and coiled-coil domains 2	0.024
Klk8	kallikrein related-peptidase 8	0.023
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.022
Inpp5a	inositol polyphosphate-5-phosphatase A	0.021
Sgk1	serum/glucocorticoid regulated kinase 1	0.021
Zfp295	zinc finger protein 295	0.021
Dnajb1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.020
Smad7	MAD homolog 7 (Drosophila)	0.020
Dusp5	dual specificity phosphatase 5	0.020
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.020
Klf13	Kruppel-like factor 13	0.020
Sult4a1	sulfotransferase family 4A, member 1	0.019
Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	0.019
Midn	midnolin	0.019
Stat2	signal transducer and activator of transcription 2	0.019
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.019
Tnp1	transition protein 1	0.018
Rell1	RELT-like 1	0.018
Klf7	Kruppel-like factor 7 (ubiquitous)	0.018
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.018
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.017
Csnk1e	casein kinase 1, epsilon	0.017
Klf10	Kruppel-like factor 10	0.017
Sh2d3c	SH2 domain containing 3C	0.016
Sertad2	SERTA domain containing 2	0.016
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.016
Ubc	ubiquitin C	0.016
Klf2	Kruppel-like factor 2 (lung)	0.015
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.015
Tob2	transducer of ERBB2, 2	0.015
Mapk11	mitogen-activated protein kinase 11	0.015
Ctnna2	catenin (cadherin associated protein), alpha 2	0.015
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.015
Svop	SV2 related protein	0.015
Fam108c	family with sequence similarity 108, member C	0.015
Etv5	ets variant gene 5	0.015
Otud7b	OTU domain containing 7B	0.014
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.014
Hbegf	heparin-binding EGF-like growth factor	0.014
Mlc1	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	0.014
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.014
Atp8b2	ATPase, class I, type 8B, member 2	0.014
Arl4c	ADP-ribosylation factor-like 4C	0.014
Ttc7b	tetratricopeptide repeat domain 7B	0.014
E130012A19Rik	RIKEN cDNA E130012A19 gene	0.014
Lef1	lymphoid enhancer binding factor 1	0.014
Sema4c	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	0.014
B4galt2	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	0.014
Arl5b	ADP-ribosylation factor-like 5B	0.014
Ctgf	connective tissue growth factor	0.013
Mef2d	myocyte enhancer factor 2D	0.013
Klf4	Kruppel-like factor 4 (gut)	0.013
Stk40	serine/threonine kinase 40	0.013
Btg1	B-cell translocation gene 1, anti-proliferative	0.013
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.013
Sertad1	SERTA domain containing 1	0.013
Jund	Jun proto-oncogene related gene d	0.013
Tmod2	tropomodulin 2	0.013
Uba7	ubiquitin-like modifier activating enzyme 7	0.013
Hspa1a	heat shock protein 1A	0.013
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.013
Pde4b	phosphodiesterase 4B, cAMP specific	0.013
Ubqln4	ubiquilin 4	0.013
Dusp6	dual specificity phosphatase 6	0.013	Mouse
Irf7	interferon regulatory factor 7	0.012
Bcl10	B-cell leukemia/lymphoma 10	0.012
Lmo4	LIM domain only 4	0.012
Sik1	salt inducible kinase 1	0.012
Plk2	polo-like kinase 2 (Drosophila)	0.012
Slc38a2	solute carrier family 38, member 2	0.012
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.012
Mcl1	myeloid cell leukemia sequence 1	0.012
6430527G18Rik	RIKEN cDNA 6430527G18 gene	0.012
Nt5dc3	5'-nucleotidase domain containing 3	0.012
Ggt7	gamma-glutamyltransferase 7	0.012
Iffo2	intermediate filament family orphan 2	0.011
Ier5l	immediate early response 5-like	0.011
Zswim6	zinc finger, SWIM domain containing 6	0.011
Rps6ka2	ribosomal protein S6 kinase, polypeptide 2	0.011
Ppp2r5b	protein phosphatase 2, regulatory subunit B (B56), beta isoform	0.011
Trib1	tribbles homolog 1 (Drosophila)	0.011
Otud1	OTU domain containing 1	0.011
Slc20a1	solute carrier family 20, member 1	0.011
Pim1	proviral integration site 1	0.011
Myo10	myosin X	0.011
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.011
Slc41a3	solute carrier family 41, member 3	0.011
Nuak1	NUAK family, SNF1-like kinase, 1	0.011
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.011
Chka	choline kinase alpha	0.011
Nle1	notchless homolog 1 (Drosophila)	0.011
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.011
Tgif1	TGFB-induced factor homeobox 1	0.010
Tspan7	tetraspanin 7	0.010
Cd8b1	CD8 antigen, beta chain 1	0.010
Arhgef26	Rho guanine nucleotide exchange factor (GEF) 26	0.010
Pim3	proviral integration site 3	0.010
Siah2	seven in absentia 2	0.010
Mapk6	mitogen-activated protein kinase 6	0.010
Camkk1	calcium/calmodulin-dependent protein kinase kinase 1, alpha	0.010
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.010
Grik1	glutamate receptor, ionotropic, kainate 1	0.010