IMP

Process View

Mus musculus

6 genes annotated in mouse

formation of anatomical boundary

The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "formation of anatomical boundary"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "formation of anatomical boundary" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Fgfr2	fibroblast growth factor receptor 2	0.943
Smad4	MAD homolog 4 (Drosophila)	0.918
Gli3	GLI-Kruppel family member GLI3	0.813
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.744
Bmp7	bone morphogenetic protein 7	0.737	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.721
Slit3	slit homolog 3 (Drosophila)	0.684	Fly
Ntn1	netrin 1	0.681	Fly
Robo1	roundabout homolog 1 (Drosophila)	0.677	Fly
Hes1	hairy and enhancer of split 1 (Drosophila)	0.611
Gli2	GLI-Kruppel family member GLI2	0.530
Slit2	slit homolog 2 (Drosophila)	0.528	Fly
Sox2	SRY-box containing gene 2	0.527
Smad3	MAD homolog 3 (Drosophila)	0.506	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.423
Ptch1	patched homolog 1	0.368
Ctnnb1	catenin (cadherin associated protein), beta 1	0.292
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.272
Msx1	homeobox, msh-like 1	0.255
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.221
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.220
Fgf8	fibroblast growth factor 8	0.201
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.146	Fly
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.135
Bmp4	bone morphogenetic protein 4	0.134	Mouse
Nodal	nodal	0.130
Nrg1	neuregulin 1	0.129
Wnt5a	wingless-related MMTV integration site 5A	0.128
En1	engrailed 1	0.128	Worm
Notch1	Notch gene homolog 1 (Drosophila)	0.121	Zebrafish Fly
Smad2	MAD homolog 2 (Drosophila)	0.117	Mouse
Robo2	roundabout homolog 2 (Drosophila)	0.109	Fly
Evl	Ena-vasodilator stimulated phosphoprotein	0.102	Fly
Pou5f1	POU domain, class 5, transcription factor 1	0.100
Slit1	slit homolog 1 (Drosophila)	0.100	Fly
Lama5	laminin, alpha 5	0.095
Gdf5	growth differentiation factor 5	0.090	Mouse
Smo	smoothened homolog (Drosophila)	0.089
Smad6	MAD homolog 6 (Drosophila)	0.087	Mouse
Dll4	delta-like 4 (Drosophila)	0.084
Chrd	chordin	0.083
Axin1	axin 1	0.078
Zfp362	zinc finger protein 362	0.077
Gdf1	growth differentiation factor 1	0.075	Mouse
Efnb1	ephrin B1	0.074
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.073
Otx1	orthodenticle homolog 1 (Drosophila)	0.070
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.068
Unc5c	unc-5 homolog C (C. elegans)	0.066	Fly
Bhlhe22	basic helix-loop-helix family, member e22	0.063
Arid1a	AT rich interactive domain 1A (SWI-like)	0.056
Lrp2	low density lipoprotein receptor-related protein 2	0.055
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.054
Jag1	jagged 1	0.053
Hand1	heart and neural crest derivatives expressed transcript 1	0.052
Smad1	MAD homolog 1 (Drosophila)	0.051	Mouse
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.049
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.049
Vangl2	vang-like 2 (van gogh, Drosophila)	0.048
Vasp	vasodilator-stimulated phosphoprotein	0.048	Fly
Bcam	basal cell adhesion molecule	0.044
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.039
Bdnf	brain derived neurotrophic factor	0.038	Mouse
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.037
Gas1	growth arrest specific 1	0.037
Sox18	SRY-box containing gene 18	0.037
Enah	enabled homolog (Drosophila)	0.037	Fly
Hand2	heart and neural crest derivatives expressed transcript 2	0.036
Tdgf1	teratocarcinoma-derived growth factor 1	0.035
Dll1	delta-like 1 (Drosophila)	0.035
Nog	noggin	0.034
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.034
Msx2	homeobox, msh-like 2	0.033
Gdf6	growth differentiation factor 6	0.031	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.030
Cdx2	caudal type homeobox 2	0.029
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.028
Foxc1	forkhead box C1	0.028
Tcf21	transcription factor 21	0.028
Foxh1	forkhead box H1	0.027
Arx	aristaless related homeobox	0.027
Tbx3	T-box 3	0.027
Fgfr3	fibroblast growth factor receptor 3	0.027
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.026
Fzd8	frizzled homolog 8 (Drosophila)	0.025
Isl1	ISL1 transcription factor, LIM/homeodomain	0.025
Tbx2	T-box 2	0.024
She	src homology 2 domain-containing transforming protein E	0.024
Emx1	empty spiracles homolog 1 (Drosophila)	0.024
Zfp503	zinc finger protein 503	0.024
Foxf1a	forkhead box F1a	0.023
Gata4	GATA binding protein 4	0.023
Gbx2	gastrulation brain homeobox 2	0.023
Npr3	natriuretic peptide receptor 3	0.022
Pax2	paired box gene 2	0.022
Zic3	zinc finger protein of the cerebellum 3	0.022
Lmx1b	LIM homeobox transcription factor 1 beta	0.021
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.021
Tcf15	transcription factor 15	0.021
Sox11	SRY-box containing gene 11	0.020
Fgf15	fibroblast growth factor 15	0.020
Tgfb2	transforming growth factor, beta 2	0.020
Fgf9	fibroblast growth factor 9	0.020
Gdf3	growth differentiation factor 3	0.019
Gli1	GLI-Kruppel family member GLI1	0.019
Phox2a	paired-like homeobox 2a	0.019
Fgf17	fibroblast growth factor 17	0.018
Itga3	integrin alpha 3	0.018	Fly
Erbb2ip	Erbb2 interacting protein	0.018
Efna2	ephrin A2	0.018
Sox13	SRY-box containing gene 13	0.017
Sycn	syncollin	0.017
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.017
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.017
Ptk7	PTK7 protein tyrosine kinase 7	0.017
Crb2	crumbs homolog 2 (Drosophila)	0.017
Ephb2	Eph receptor B2	0.016
Ntf3	neurotrophin 3	0.016	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.016
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Jag2	jagged 2	0.015
Zfp423	zinc finger protein 423	0.015
Cpeb3	cytoplasmic polyadenylation element binding protein 3	0.014
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.014
Chd7	chromodomain helicase DNA binding protein 7	0.013
Alx4	aristaless-like homeobox 4	0.013
Fgfr4	fibroblast growth factor receptor 4	0.013
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.013
Pbx1	pre B-cell leukemia transcription factor 1	0.013
Hes3	hairy and enhancer of split 3 (Drosophila)	0.013	Fly
Mark1	MAP/microtubule affinity-regulating kinase 1	0.012
Fzd2	frizzled homolog 2 (Drosophila)	0.012
Gpc3	glypican 3	0.012	Fly
Hif1a	hypoxia inducible factor 1, alpha subunit	0.012
Kdm2b	lysine (K)-specific demethylase 2B	0.012
Lmx1a	LIM homeobox transcription factor 1 alpha	0.012
Podxl	podocalyxin-like	0.012
Tagln	transgelin	0.012
Pofut1	protein O-fucosyltransferase 1	0.012
Apc	adenomatosis polyposis coli	0.012
Efna4	ephrin A4	0.011
Stx12	syntaxin 12	0.011
Pnliprp2	pancreatic lipase-related protein 2	0.011
Ret	ret proto-oncogene	0.011
Smad7	MAD homolog 7 (Drosophila)	0.011	Mouse
Ube2i	ubiquitin-conjugating enzyme E2I	0.011
Fgf4	fibroblast growth factor 4	0.011
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.011
Phox2b	paired-like homeobox 2b	0.010
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.010
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.010