IMP

Process View

Mus musculus

3 genes annotated in mouse

g protein coupled glutamate receptor signaling pathway

A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "g protein coupled glutamate receptor signaling pathway"

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Name	Description	Probability	Func Analog Organism
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.999
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.998
Shank2	SH3/ankyrin domain gene 2	0.950
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.942
Homer1	homer homolog 1 (Drosophila)	0.901
Fbxo41	F-box protein 41	0.724
Drd1a	dopamine receptor D1A	0.586
Mpped1	metallophosphoesterase domain containing 1	0.465
Shisa9	shisa homolog 9 (Xenopus laevis)	0.455
Dlg2	discs, large homolog 2 (Drosophila)	0.415
Gpr26	G protein-coupled receptor 26	0.385
3110047P20Rik	RIKEN cDNA 3110047P20 gene	0.350
Grm5	glutamate receptor, metabotropic 5	0.343	Human Mouse Rat
Il1rapl1	interleukin 1 receptor accessory protein-like 1	0.303
Grm1	glutamate receptor, metabotropic 1	0.302	Mouse
Adcy1	adenylate cyclase 1	0.256
Hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.253
Gad2	glutamic acid decarboxylase 2	0.242
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.225
Gpr123	G protein-coupled receptor 123	0.221
D130043K22Rik	RIKEN cDNA D130043K22 gene	0.219
Arc	activity regulated cytoskeletal-associated protein	0.193
Prkcc	protein kinase C, gamma	0.185
Crhr1	corticotropin releasing hormone receptor 1	0.174
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.169
Syt1	synaptotagmin I	0.158
Vwc2l	von Willebrand factor C domain-containing protein 2-like	0.146
Col19a1	collagen, type XIX, alpha 1	0.142
Syt2	synaptotagmin II	0.141
Emx1	empty spiracles homolog 1 (Drosophila)	0.139
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.131
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.128
Csmd1	CUB and Sushi multiple domains 1	0.124
Cit	citron	0.111
Rph3a	rabphilin 3A	0.110
Iqsec3	IQ motif and Sec7 domain 3	0.108
Clec2l	C-type lectin domain family, member L	0.105
Olfm3	olfactomedin 3	0.104
Myt1l	myelin transcription factor 1-like	0.103
Ankrd34a	ankyrin repeat domain 34A	0.101
Cntn4	contactin 4	0.100
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.096
Kcnv1	potassium channel, subfamily V, member 1	0.096
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.092
Xkr4	X Kell blood group precursor related family member 4	0.091
Hecw1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.086
Pak7	p21 protein (Cdc42/Rac)-activated kinase 7	0.085
Mgat5b	mannoside acetylglucosaminyltransferase 5, isoenzyme B	0.084
Tmem132d	transmembrane protein 132D	0.081
Accn4	amiloride-sensitive cation channel 4, pituitary	0.080
Nxph2	neurexophilin 2	0.078
Grm2	glutamate receptor, metabotropic 2	0.076
Bdnf	brain derived neurotrophic factor	0.074
Rims1	regulating synaptic membrane exocytosis 1	0.074
Jph4	junctophilin 4	0.073
Gjd3	gap junction protein, delta 3	0.070
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.069
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.067
Neurod6	neurogenic differentiation 6	0.063
Grid1	glutamate receptor, ionotropic, delta 1	0.062
Ryr3	ryanodine receptor 3	0.060
Npy5r	neuropeptide Y receptor Y5	0.060
Synpr	synaptoporin	0.059
Rorb	RAR-related orphan receptor beta	0.058
Kctd8	potassium channel tetramerisation domain containing 8	0.056
Cntnap4	contactin associated protein-like 4	0.055
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.053
Srrm4	serine/arginine repetitive matrix 4	0.052
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.051
Nptx2	neuronal pentraxin 2	0.051
Braf	Braf transforming gene	0.051
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	0.050
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1	0.049
Pvalb	parvalbumin	0.048
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.048
Tmem198	transmembrane protein 198	0.047
Kcnq3	potassium voltage-gated channel, subfamily Q, member 3	0.046
Frmpd3	FERM and PDZ domain containing 3	0.044
Pou4f2	POU domain, class 4, transcription factor 2	0.044
Cbln3	cerebellin 3 precursor protein	0.044
Prkcb	protein kinase C, beta	0.043
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.043
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.043
Megf11	multiple EGF-like-domains 11	0.043
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.042
Kcnt1	potassium channel, subfamily T, member 1	0.041
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.039
6430704M03Rik	RIKEN cDNA 6430704M03 gene	0.039
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.039
Lhfpl3	lipoma HMGIC fusion partner-like 3	0.038
Cpne4	copine IV	0.038
Hrh3	histamine receptor H3	0.037
Arpp21	cyclic AMP-regulated phosphoprotein, 21	0.037
Tacr3	tachykinin receptor 3	0.037
Ina	internexin neuronal intermediate filament protein, alpha	0.037
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.037
Vstm2b	V-set and transmembrane domain containing 2B	0.036
Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	0.036
Cdh8	cadherin 8	0.036
Grik4	glutamate receptor, ionotropic, kainate 4	0.036
Nrxn3	neurexin III	0.035
Nsf	N-ethylmaleimide sensitive fusion protein	0.035
Rims4	regulating synaptic membrane exocytosis 4	0.035
Pcdh10	protocadherin 10	0.035
Car10	carbonic anhydrase 10	0.033
Nrip3	nuclear receptor interacting protein 3	0.033
Tmem151a	transmembrane protein 151A	0.033
Tmem169	transmembrane protein 169	0.032
Scn1a	sodium channel, voltage-gated, type I, alpha	0.032
Sez6	seizure related gene 6	0.032
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.032
Cadm2	cell adhesion molecule 2	0.030
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.029
AI593442	expressed sequence AI593442	0.029
Cnih3	cornichon homolog 3 (Drosophila)	0.028
Homer2	homer homolog 2 (Drosophila)	0.028
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.028
Cdh7	cadherin 7, type 2	0.028
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.028
Olig1	oligodendrocyte transcription factor 1	0.027
C2cd4c	C2 calcium-dependent domain containing 4C	0.027
Fbll1	fibrillarin-like 1	0.027
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.026
AI118078	expressed sequence AI118078	0.026
Ankrd34b	ankyrin repeat domain 34B	0.026
Nos1	nitric oxide synthase 1, neuronal	0.025
Nell1	NEL-like 1 (chicken)	0.025
Grm4	glutamate receptor, metabotropic 4	0.025	Human Mouse
Prrt3	proline-rich transmembrane protein 3	0.025
Dlg3	discs, large homolog 3 (Drosophila)	0.025
Slco1c1	solute carrier organic anion transporter family, member 1c1	0.025
Kremen2	kringle containing transmembrane protein 2	0.025
Slitrk4	SLIT and NTRK-like family, member 4	0.024
Dmrtc1a	DMRT-like family C1a	0.024
Panx2	pannexin 2	0.024
Tmem90b	transmembrane protein 90B	0.024
Car7	carbonic anhydrase 7	0.023
Gad1	glutamic acid decarboxylase 1	0.023
Ppfia2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	0.023
Lrrtm1	leucine rich repeat transmembrane neuronal 1	0.022
Golga7b	golgi autoantigen, golgin subfamily a, 7B	0.022
Trank1	tetratricopeptide repeat and ankyrin repeat containing 1	0.022
Slc6a7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.021
Epha5	Eph receptor A5	0.021
Slitrk5	SLIT and NTRK-like family, member 5	0.021
Prkce	protein kinase C, epsilon	0.020
Mtap2	microtubule-associated protein 2	0.020
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.019
Pla2g3	phospholipase A2, group III	0.019
Sv2b	synaptic vesicle glycoprotein 2 b	0.018
Cbln2	cerebellin 2 precursor protein	0.018
Pnma2	paraneoplastic antigen MA2	0.018
Lrfn5	leucine rich repeat and fibronectin type III domain containing 5	0.018
Cyp46a1	cytochrome P450, family 46, subfamily a, polypeptide 1	0.018
Fam184b	family with sequence similarity 184, member B	0.018
Prr18	proline rich region 18	0.018
Cdh10	cadherin 10	0.018
Trhde	TRH-degrading enzyme	0.017
Tff1	trefoil factor 1	0.017
Slc35f3	solute carrier family 35, member F3	0.017
Rab9b	RAB9B, member RAS oncogene family	0.016
Rit2	Ras-like without CAAX 2	0.016
Pcdh20	protocadherin 20	0.016
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.016
Col25a1	collagen, type XXV, alpha 1	0.016
Galnt13	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13	0.016
Gabbr1	gamma-aminobutyric acid (GABA) B receptor, 1	0.016
Rimbp2	RIMS binding protein 2	0.016
Cbln4	cerebellin 4 precursor protein	0.016
Grm3	glutamate receptor, metabotropic 3	0.016
Epha6	Eph receptor A6	0.015
Cntnap2	contactin associated protein-like 2	0.015
Ripply2	ripply2 homolog (zebrafish)	0.015
Trim66	tripartite motif-containing 66	0.015
Grm7	glutamate receptor, metabotropic 7	0.015	Human Mouse
Vstm2l	V-set and transmembrane domain containing 2-like	0.015
Atp13a5	ATPase type 13A5	0.015
Ntsr2	neurotensin receptor 2	0.015
Caskin1	CASK interacting protein 1	0.015
Lingo3	leucine rich repeat and Ig domain containing 3	0.015
Trpm3	transient receptor potential cation channel, subfamily M, member 3	0.015
Neurod2	neurogenic differentiation 2	0.015
Celf5	CUGBP, Elav-like family member 5	0.015
Fam189a1	family with sequence similarity 189, member A1	0.015
Celf6	CUGBP, Elav-like family member 6	0.015
Nrg3	neuregulin 3	0.015
Mobp	myelin-associated oligodendrocytic basic protein	0.014
Gpr6	G protein-coupled receptor 6	0.014
E130309F12Rik	RIKEN cDNA E130309F12 gene	0.014
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.014
Pax7	paired box gene 7	0.014
Adarb2	adenosine deaminase, RNA-specific, B2	0.014
Pnpla3	patatin-like phospholipase domain containing 3	0.014
Lrrtm2	leucine rich repeat transmembrane neuronal 2	0.013
Ptprt	protein tyrosine phosphatase, receptor type, T	0.013
6330403A02Rik	RIKEN cDNA 6330403A02 gene	0.013
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.013
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.013
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.013
Qrfp	pyroglutamylated RFamide peptide	0.013
Cpne9	copine family member IX	0.013
Mei1	meiosis defective 1	0.013
Gm1568	predicted gene 1568	0.013
Nxph3	neurexophilin 3	0.013
Actn2	actinin alpha 2	0.013
Matk	megakaryocyte-associated tyrosine kinase	0.013
Dmrta2	doublesex and mab-3 related transcription factor like family A2	0.012
Gpr12	G-protein coupled receptor 12	0.012
Cdh2	cadherin 2	0.012
Ermn	ermin, ERM-like protein	0.012
Trim9	tripartite motif-containing 9	0.012
Vstm2a	V-set and transmembrane domain containing 2A	0.012
Dclk3	doublecortin-like kinase 3	0.012
Lypd1	Ly6/Plaur domain containing 1	0.012
Pla2g4e	phospholipase A2, group IVE	0.011
Stxbp5l	syntaxin binding protein 5-like	0.011
Baalc	brain and acute leukemia, cytoplasmic	0.011
Lhx2	LIM homeobox protein 2	0.011
Kctd4	potassium channel tetramerisation domain containing 4	0.011
Fut9	fucosyltransferase 9	0.011
Klk6	kallikrein related-peptidase 6	0.011
Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.010
Sox21	SRY-box containing gene 21	0.010
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.010
Grik1	glutamate receptor, ionotropic, kainate 1	0.010
Sprn	shadow of prion protein	0.010
Hapln4	hyaluronan and proteoglycan link protein 4	0.010
Onecut2	one cut domain, family member 2	0.010
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.010
Trfr2	transferrin receptor 2	0.010
BC030499	cDNA sequence BC030499	0.010
Faim2	Fas apoptotic inhibitory molecule 2	0.010
Prrt1	proline-rich transmembrane protein 1	0.010
Kirrel3	kin of IRRE like 3 (Drosophila)	0.010
Col24a1	collagen, type XXIV, alpha 1	0.010