IMP

Process View

Rattus norvegicus

25 genes annotated in rat

response to amphetamine

GO:0001975

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to amphetamine"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to amphetamine" (in gray)

Name	Description	Probability	Func Analog Organism
Junb	jun B proto-oncogene	0.994
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.893
Fos	FBJ osteosarcoma oncogene	0.836
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.772
Ccl2	chemokine (C-C motif) ligand 2	0.589
Egr2	early growth response 2	0.557	Rat
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.276
Btg2	BTG family, member 2	0.205
Adora2a	adenosine A2a receptor	0.200	Mouse
Egr1	early growth response 1	0.175
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.148	Mouse Rat
Drd1a	dopamine receptor D1A	0.142
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.120
Dlg4	discs, large homolog 4 (Drosophila)	0.112
Ier2	immediate early response 2	0.087
Il6	interleukin 6	0.086
Atf3	activating transcription factor 3	0.072
Chrnb4	cholinergic receptor, nicotinic, beta 4	0.069
Il1r2	interleukin 1 receptor, type II	0.068
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.068
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.067
Fosl1	fos-like antigen 1	0.067
Irf1	interferon regulatory factor 1	0.064
Gucy2d	guanylate cyclase 2d	0.064
Grin1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.060	Mouse
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.059
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.058
Arc	activity-regulated cytoskeleton-associated protein	0.056
Ccl20	chemokine (C-C motif) ligand 20	0.054
Cox8a	cytochrome c oxidase subunit VIIIa	0.054
Fev	FEV (ETS oncogene family)	0.054
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.051
Sub1	SUB1 homolog (S. cerevisiae)	0.051
Cd14	CD14 molecule	0.049
Nfasc	neurofascin	0.049
Pou2f2	POU class 2 homeobox 2	0.047
Shox2	short stature homeobox 2	0.045
Zfp36	zinc finger protein 36	0.044
Calm1	calmodulin 1	0.042
Olr1082	olfactory receptor 1082	0.041
Dusp1	dual specificity phosphatase 1	0.041
Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	0.041
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.039
Ptgs2	prostaglandin-endoperoxide synthase 2	0.039
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.039
Prrxl1	paired related homeobox protein-like 1	0.038
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.037
Timp1	TIMP metallopeptidase inhibitor 1	0.037
LOC60591	calcium-activated potassium channel beta subunit	0.037
Hal	histidine ammonia lyase	0.036
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.036
Il1b	interleukin 1 beta	0.036
Stmn1	stathmin 1	0.035
Klra22	killer cell lectin-like receptor subfamily A, member 22	0.035
Arpp21	cAMP-regulated phosphoprotein 21	0.034
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.033
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.033
Cyr61	cysteine-rich, angiogenic inducer, 61	0.033
Oprm1	opioid receptor, mu 1	0.033
Tspan7	tetraspanin 7	0.032
Calm2	calmodulin 2	0.032
Mylk2	myosin light chain kinase 2	0.031
Olr1278	olfactory receptor 1278	0.031
Krtap1-5	keratin associated protein 1-5	0.030
Cacng3	calcium channel, voltage-dependent, gamma subunit 3	0.030
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.030
Socs3	suppressor of cytokine signaling 3	0.030
Dlg3	discs, large homolog 3 (Drosophila)	0.030
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.029
Gpr6	G protein-coupled receptor 6	0.029
Cxcl10	chemokine (C-X-C motif) ligand 10	0.028	Rat
Mrfap1	Mof4 family associated protein 1	0.028
Csf1	colony stimulating factor 1 (macrophage)	0.028
Clstn3	calsyntenin 3	0.028
Reg3g	regenerating islet-derived 3 gamma	0.028
Shank1	SH3 and multiple ankyrin repeat domains 1	0.028
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.028
Pdpn	podoplanin	0.028
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.027
Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.027
Grin3a	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	0.027	Rat
Dio2	deiodinase, iodothyronine, type II	0.027
Ifitm3	interferon induced transmembrane protein 3	0.027
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.027	Mouse
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.027
Casr	calcium-sensing receptor	0.026
Cpb1	carboxypeptidase B1 (tissue)	0.026
Prrx1	paired related homeobox 1	0.026
Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.026
Nrxn2	neurexin 2	0.026
Col10a1	collagen, type X, alpha 1	0.025
Tnp2	transition protein 2	0.025
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.025
Kcnh4	potassium voltage-gated channel, subfamily H (eag-related), member 4	0.025
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.025
Th	tyrosine hydroxylase	0.025
Tbr1	T-box, brain, 1	0.025
Dlgap2	discs, large (Drosophila) homolog-associated protein 2	0.025
Apcs	amyloid P component, serum	0.024
Si	sucrase-isomaltase (alpha-glucosidase)	0.024
Prl	prolactin	0.024
Itgam	integrin, alpha M	0.024
Homer1	homer homolog 1 (Drosophila)	0.023
Mep1b	meprin 1 beta	0.023
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.023
Lhx1	LIM homeobox 1	0.023
Ier3	immediate early response 3	0.023
Neurl3	neuralized homolog 3 (Drosophila)	0.022
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.022
Nrarp	Notch-regulated ankyrin repeat protein	0.022
Baat	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.022
Olr1078	olfactory receptor 1078	0.022
Ghrh	growth hormone releasing hormone	0.022
LOC100360019	hypothetical protein LOC100360019	0.022
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.022
Kcnf1	potassium voltage-gated channel, subfamily F, member 1	0.022
Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.022
Sctr	secretin receptor	0.022
Grpr	gastrin releasing peptide receptor	0.021
Dcc	deleted in colorectal carcinoma	0.021
Cntfr	ciliary neurotrophic factor receptor	0.021
Neu2	sialidase 2 (cytosolic sialidase)	0.021
Klkb1	kallikrein B, plasma 1	0.020
Pgc	progastricsin (pepsinogen C)	0.020
Hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.020
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.020
Dusp6	dual specificity phosphatase 6	0.020
Chrm3	cholinergic receptor, muscarinic 3	0.020
Pdha2	pyruvate dehydrogenase (lipoamide) alpha 2	0.019
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.019
Uncx	UNC homeobox	0.019
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.019
Il1rn	interleukin 1 receptor antagonist	0.019
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.019
Nptn	neuroplastin	0.019
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.019
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.019
Ttc3	tetratricopeptide repeat domain 3	0.019
Olr1280	olfactory receptor 1280	0.019
Acvr1c	activin A receptor, type IC	0.018
N5	DNA binding protein N5	0.018
Impg2	interphotoreceptor matrix proteoglycan 2	0.018
Cox6c	cytochrome c oxidase, subunit VIc	0.018
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.018
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.018
Chrna5	cholinergic receptor, nicotinic, alpha 5	0.018
Cacna1f	calcium channel, voltage-dependent, L type, alpha 1F subunit	0.018
Gal	galanin prepropeptide	0.018
Pdzd4	PDZ domain containing 4	0.017
Mmp7	matrix metallopeptidase 7	0.017
Myt1l	myelin transcription factor 1-like	0.017
Serpind1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.017
Sstr1	somatostatin receptor 1	0.017
Syt5	synaptotagmin V	0.017
Unc13a	unc-13 homolog A (C. elegans)	0.017
Clec4f	C-type lectin domain family 4, member f	0.017
Grik1	glutamate receptor, ionotropic, kainate 1	0.017
Scg5	secretogranin V	0.017
Spta1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.017
Olr1361	olfactory receptor 1361	0.017
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.017
LOC679840	similar to germinal histone H4 gene	0.017
Calcr	calcitonin receptor	0.017
Foxg1	forkhead box G1	0.016
Cpe	carboxypeptidase E	0.016
Camk2d	calcium/calmodulin-dependent protein kinase II delta	0.016
Spp2	secreted phosphoprotein 2	0.016
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.016
Dlg1	discs, large homolog 1 (Drosophila)	0.016
Prl2a1	Prolactin family 2, subfamily a, member 1	0.016
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.016
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.016
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.016
Fgf2	fibroblast growth factor 2	0.016
Drd2	dopamine receptor D2	0.016
Rgs9	regulator of G-protein signaling 9	0.016
Epor	erythropoietin receptor	0.016
Adm	adrenomedullin	0.016
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.016
S100a9	S100 calcium binding protein A9	0.016
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.016
Gpr12	G protein-coupled receptor 12	0.016
Mcat	malonyl CoA:ACP acyltransferase (mitochondrial)	0.015
Tspyl1	TSPY-like 1	0.015
Rgs14	regulator of G-protein signaling 14	0.015
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.015
Lcn2	lipocalin 2	0.015
Syngap1	synaptic Ras GTPase activating protein 1 homolog (rat)	0.015
Vcam1	vascular cell adhesion molecule 1	0.015
Prm1	protamine 1	0.015
Grid1	glutamate receptor, ionotropic, delta 1	0.015
Xylt1	xylosyltransferase 1	0.015
Fshr	follicle stimulating hormone receptor	0.015
Nmbr	neuromedin B receptor	0.015
Gsk3a	glycogen synthase kinase 3 alpha	0.015
Avpr2	arginine vasopressin receptor 2	0.015	Rat
Chl1	cell adhesion molecule with homology to L1CAM	0.014
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.014	Rat
Itm2c	integral membrane protein 2C	0.014
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.014
Sv2c	synaptic vesicle glycoprotein 2c	0.014
Fxyd4	FXYD domain-containing ion transport regulator 4	0.014
Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.014
Cckbr	cholecystokinin B receptor	0.014
Nkx6-1	NK6 homeobox 1	0.014
Reg3a	regenerating islet-derived 3 alpha	0.014
Onecut1	one cut homeobox 1	0.014
Vgf	VGF nerve growth factor inducible	0.014
Grm2	glutamate receptor, metabotropic 2	0.014
Cuzd1	CUB and zona pellucida-like domains 1	0.014
RGD1564865	similar to 20-alpha-hydroxysteroid dehydrogenase	0.014
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.014
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.014
Uox	urate oxidase	0.014
Hcn1	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	0.014
Purb	purine rich element binding protein B	0.014
Hoxb7	homeo box B7	0.013
Hcrtr2	hypocretin (orexin) receptor 2	0.013
Kcnd3	potassium voltage-gated channel, Shal-related subfamily, member 3	0.013
Gbp2	guanylate binding protein 2	0.013
Ntf3	neurotrophin 3	0.013
Arl3	ADP-ribosylation factor-like 3	0.013
Dpys	dihydropyrimidinase	0.013	Rat
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.013
LOC100361547	Cytochrome P450, family 2, subfamily c, polypeptide 7-like	0.013
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.013
Icam1	intercellular adhesion molecule 1	0.013
Sox11	SRY (sex determining region Y)-box 11	0.013
Slpi	secretory leukocyte peptidase inhibitor	0.013
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.013
Ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.013
Mmp10	matrix metallopeptidase 10	0.013
Ate1	arginyltransferase 1	0.013
Marcksl1	MARCKS-like 1	0.013
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.013
Syn1	synapsin I	0.013
Prnp	prion protein	0.013
Olr1356	olfactory receptor 1356	0.013
Slco1a1	solute carrier organic anion transporter family, member 1a1	0.013
Tdo2	tryptophan 2,3-dioxygenase	0.013
Mip	major intrinsic protein of lens fiber	0.013
Syn2	synapsin II	0.012
Cxcr5	chemokine (C-X-C motif) receptor 5	0.012
Runx1	runt-related transcription factor 1	0.012
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.012
Lrfn2	leucine rich repeat and fibronectin type III domain containing 2	0.012
Crh	corticotropin releasing hormone	0.012
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.012
Etv1	ets variant 1	0.012
Rtn1	reticulon 1	0.012
Tgm1	transglutaminase 1, K polypeptide	0.012
Pth2r	parathyroid hormone 2 receptor	0.012
Slfn3	schlafen 3	0.012
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.012
Grm1	glutamate receptor, metabotropic 1	0.012
Adamts4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	0.012
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.012
LOC312273	Trypsin V-A	0.012
Nlgn2	neuroligin 2	0.012
Umod	uromodulin	0.012
Lrrc7	leucine rich repeat containing 7	0.012
Vamp1	vesicle-associated membrane protein 1	0.012
Armcx2	armadillo repeat containing, X-linked 2	0.012
Nrxn3	neurexin 3	0.012
Dusp5	dual specificity phosphatase 5	0.012
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
Ephb1	Eph receptor B1	0.012
Crtac1	cartilage acidic protein 1	0.012
Slc22a25	solute carrier family 22, member 25	0.012
Tff1	trefoil factor 1	0.012
Olr1283	olfactory receptor 1283	0.012
Bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.012
Arl5c	ADP-ribosylation factor-like 5C	0.012
Camkv	CaM kinase-like vesicle-associated	0.012
Trim35	tripartite motif-containing 35	0.012
Slc16a3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.012
Glra1	glycine receptor, alpha 1	0.012
Cgm4	carcinoembryonic antigen gene family 4	0.012
Pthlh	parathyroid hormone-like hormone	0.011
Hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.011
Cyp2d3	cytochrome P450, family 2, subfamily d, polypeptide 3	0.011
Cyp4f1	cytochrome P450, family 4, subfamily f, polypeptide 1	0.011
Rem2	RAS (RAD and GEM) like GTP binding 2	0.011
Chrm1	cholinergic receptor, muscarinic 1	0.011
Mchr1	melanin-concentrating hormone receptor 1	0.011
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.011
Sst	somatostatin	0.011
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.011
Ccl7	chemokine (C-C motif) ligand 7	0.011
A1i3	alpha-1-inhibitor III	0.011
Pgam1	phosphoglycerate mutase 1 (brain)	0.011
Ces1e	carboxylesterase 1E	0.011
Aqp4	aquaporin 4	0.011
Scn9a	sodium channel, voltage-gated, type IX, alpha	0.011
Smgb	neonatal submandibular gland protein B	0.011
Tcof1	Treacher Collins-Franceschetti syndrome 1 homolog (human)	0.011
Rhoj	ras homolog gene family, member J	0.011
Orm1	orosomucoid 1	0.011
Fut4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	0.011
Ier5	immediate early response 5	0.011
Gabarapl2	GABA(A) receptor-associated protein like 2	0.011
Adam7	ADAM metallopeptidase domain 7	0.011
Sv2a	synaptic vesicle glycoprotein 2a	0.011
Atp5g3	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)	0.011
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.011
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.011
Sox17	SRY (sex determining region Y)-box 17	0.011
Gh1	growth hormone 1	0.011
Gch1	GTP cyclohydrolase 1	0.011
Necab2	N-terminal EF-hand calcium binding protein 2	0.011
Ghrhr	growth hormone releasing hormone receptor	0.011
Vom2r18	vomeronasal 2 receptor, 18	0.011
Penk	proenkephalin	0.011
Defb24	defensin beta 24	0.011
Stmn4	stathmin-like 4	0.011
Abi2	abl-interactor 2	0.011
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.011
Pou1f1	POU class 1 homeobox 1	0.011
Pigl	phosphatidylinositol glycan anchor biosynthesis, class L	0.011
Akr1c12	aldo-keto reductase family 1, member C12	0.010
Treh	trehalase (brush-border membrane glycoprotein)	0.010
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.010
Lgals4	lectin, galactoside-binding, soluble, 4	0.010
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.010
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.010
Cxcl2	chemokine (C-X-C motif) ligand 2	0.010
Olr442	olfactory receptor 442	0.010
Prp2	proline rich protein 2	0.010
Sag	S-antigen; retina and pineal gland (arrestin)	0.010
Hes3	hairy and enhancer of split 3 (Drosophila)	0.010
Dynll1	dynein light chain LC8-type 1	0.010
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.010
Thpo	thrombopoietin	0.010
RGD1564664	similar to LOC387763 protein	0.010
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.010
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.010
Egr4	early growth response 4	0.010	Rat
Scg3	secretogranin III	0.010
Obp2b	odorant binding protein 2B	0.010
Mr1	major histocompatibility complex, class I-related	0.010
Adrbk2	adrenergic, beta, receptor kinase 2	0.010
Unc5a	unc-5 homolog A (C. elegans)	0.010