IMP

Process View

Danio rerio

9 genes annotated in zebrafish

Multi-species View

bone mineralization

GO:0030282

The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "bone mineralization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bone mineralization" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.808	Human Mouse
twist2	twist2	0.472
col10a1	collagen, type X, alpha 1	0.464
bmp4	bone morphogenetic protein 4	0.407	Human Rat
cdh2	cadherin 2, neuronal	0.267
col2a1a	collagen type II, alpha-1a	0.264
prdm5	PR domain containing 5	0.262
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.196
bmp2a	bone morphogenetic protein 2a	0.136	Human Mouse
bmp1a	bone morphogenetic protein 1a	0.132
mgp	matrix Gla protein	0.131
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.122
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.085
tbx5a	T-box 5a	0.083
rargb	retinoic acid receptor, gamma b	0.069
plod2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.067
mmp15b	matrix metallopeptidase 15b	0.065
notch3	notch homolog 3	0.064
dlx2a	distal-less homeobox gene 2a	0.063
zgc:111821	zgc:111821	0.050
shha	sonic hedgehog a	0.050
xylt1	xylosyltransferase 1	0.050
LOC556849	ectonucleoside triphosphate diphosphohydrolase 5-like	0.049
axin1	axin 1	0.047
sec31a	sec31 homolog A (S. cerevisiae)	0.042
cmyb	transcription factor cmyb	0.042
bon	bonnie and clyde	0.041
dusp6	dual specificity phosphatase 6	0.041
col1a2	collagen, type I, alpha 2	0.039
unc5c	unc-5 homolog C (C. elegans)	0.039
acvr1l	activin A receptor, type I like	0.038
sox9a	SRY-box containing gene 9a	0.035	Mouse
met	met proto-oncogene (hepatocyte growth factor receptor)	0.035
disp1	dispatched homolog 1 (Drosophila)	0.033
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.032
bambib	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b	0.030
prdm1a	PR domain containing 1a, with ZNF domain	0.029
nog3	noggin 3	0.029
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.029	Mouse
itga3b	integrin, alpha 3b	0.029
axin2	axin 2 (conductin, axil)	0.028	Mouse
gpm6aa	glycoprotein M6Aa	0.028
tgfb2	transforming growth factor, beta 2	0.028
wnt11r	wingless-type MMTV integration site family, member 11, related	0.026	Mouse
prdm16	PR domain containing 16	0.025
irf6	interferon regulatory factor 6	0.025
wnt10a	wingless-type MMTV integration site family, member 10a	0.024
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.024
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.022
fgfrl1b	fibroblast growth factor receptor-like 1b	0.020
inhbaa	inhibin, beta Aa	0.020
ctnnb1	catenin (cadherin-associated protein), beta 1	0.020
ptch2	patched 2	0.020
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.019
smoc2	secreted modular calcium binding protein 2	0.019
msxb	muscle segment homeobox B	0.019
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.018
gata3	GATA-binding protein 3	0.018
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.018
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.018
cdh1	cadherin 1, epithelial	0.018
enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.018
smad9	MAD homolog 9 (Drosophila)	0.017
zfand5a	zinc finger, AN1-type domain 5a	0.017
hsd17b12a	hydroxysteroid (17-beta) dehydrogenase 12a	0.016
raraa	retinoic acid receptor, alpha a	0.016
zgc:171553	zgc:171553	0.016
rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.016
smad5	MAD homolog 5 (Drosophila)	0.016
bglap	bone gamma-carboxyglutamate (gla) protein	0.016
foxi1	forkhead box I1	0.016
mecom	MDS1 and EVI1 complex locus	0.015
fgf20a	fibroblast growth factor 20a	0.015
col1a1a	collagen, type I, alpha 1a	0.015
neo1	neogenin 1	0.015
si:dkeyp-110g5.2	si:dkeyp-110g5.2	0.015
col11a2	collagen type XI alpha-2	0.015
igf3	insulin-like growth factor 3	0.015
slc4a2a	solute carrier family 4, anion exchanger, member 2a	0.015
ecrg4a	esophageal cancer related gene 4a	0.015
tbx2a	T-box gene 2a	0.014
trim71	tripartite motif-containing 71	0.014
ptgs1	prostaglandin-endoperoxide synthase 1	0.014
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.014
vcanb	versican b	0.014
c8a	complement component 8, alpha polypeptide	0.014
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.013
st3gal2l	ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like	0.013
hgfb	hepatocyte growth factor b	0.013
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.013
spry4	sprouty (Drosophila) homolog 4	0.013
lepr	leptin receptor	0.013
fgf10a	fibroblast growth factor 10a	0.013
LOC100148804	mucin-2-like	0.013
kdrl	kinase insert domain receptor like	0.013
pthlh	parathyroid hormone-like hormone	0.013
robo1	roundabout homolog 1	0.013
tp63	tumor protein p63	0.012
prmt1	protein arginine methyltransferase 1	0.012
sema3d	semaphorin 3d	0.012
fstl1a	follistatin-like 1a	0.012
chd	chordin	0.012
mmp9	matrix metalloproteinase 9	0.012
cldnb	claudin b	0.012
rpz	rapunzel	0.012
lats1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.012
wnt3	wingless-type MMTV integration site family, member 3	0.012
col11a1a	collagen, type XI, alpha 1a	0.012
tuba8l3	tubulin, alpha 8 like 3	0.012
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.012
mapk6	mitogen-activated protein kinase 6	0.012
scinla	scinderin like a	0.012
brd2b	bromodomain containing 2b	0.011
bcl2	B-cell leukemia/lymphoma 2	0.011
dlx4a	distal-less homeobox gene 4a	0.011
rxrab	retinoid x receptor, alpha b	0.011
tjp1	tight junction protein 1 (zona occludens 1)	0.011
gpm6bb	glycoprotein M6Bb	0.011	Human
runx3	runt-related transcription factor 3	0.011
dpysl5b	dihydropyrimidinase-like 5b	0.011
bmp7b	bone morphogenetic protein 7b	0.011	Human
foxe1	forkhead box E1 (thyroid transcription factor 2)	0.011
gpm6ba	glycoprotein M6Ba	0.011	Human
adipor1b	adiponectin receptor 1b	0.011
lama5	laminin, alpha 5	0.011
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.011
ihha	Indian hedgehog homolog a	0.011
hapln1a	hyaluronan and proteoglycan link protein 1a	0.010
gpr126	G protein-coupled receptor 126	0.010
si:ch211-173o4.2	si:ch211-173o4.2	0.010
robo3	roundabout homolog 3	0.010
hoxa13a	homeo box A13a	0.010
twist3	twist3	0.010