The network for 'negative regulation of cell cell adhesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell cell adhesion

Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.

Drosophila melanogaster
Name Description Probability Func Analog Organism
baz bazooka 0.582
dpp decapentaplegic 0.578
crb crumbs 0.513
ena enabled 0.408
l(2)gl lethal (2) giant larvae 0.338
dsh dishevelled 0.323
shg shotgun 0.285
pnt pointed 0.183
Egfr Epidermal growth factor receptor 0.167
hh hedgehog 0.149
rho rhomboid 0.146
Med Medea 0.130
ttk tramtrack 0.089
usp ultraspiracle 0.079
Su(H) Suppressor of Hairless 0.074
arm armadillo 0.072
argos CG4531 gene product from transcript CG4531-RA 0.060
Rab11 Rab-protein 11 0.054
rok Rho-kinase 0.054
insc inscuteable 0.053
NFAT NFAT homolog 0.046
tbce tubulin-specific chaperone E 0.045
thr three rows 0.043
ttv tout-velu 0.040
spi spitz 0.039
yu CG3249 gene product from transcript CG3249-RA 0.038
aop anterior open 0.036
wb wing blister 0.036
Tl Toll 0.035
rst roughest 0.035
EcR Ecdysone receptor 0.033
sna snail 0.031
tld tolloid 0.030
wun wunen 0.030
gbb glass bottom boat 0.027
Mmp1 Matrix metalloproteinase 1 0.027
tai taiman 0.026
Fs Follistatin 0.026
ed echinoid 0.025
babo baboon 0.025
pan pangolin 0.025
Btk29A Btk family kinase at 29A 0.024
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.023
Mad Mothers against dpp 0.023
Gef26 CG9491 gene product from transcript CG9491-RB 0.023
gcm glial cells missing 0.022
sens senseless 0.022
Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 0.022
smo smoothened 0.021
por porcupine 0.021
a arc 0.021
csw corkscrew 0.019
Fhos CG42610 gene product from transcript CG42610-RC 0.019
Sema-1a CG18405 gene product from transcript CG18405-RD 0.019
wg wingless 0.018
ft fat 0.018
neb nebbish 0.018
eya eyes absent 0.018
rap retina aberrant in pattern 0.017
Krn Keren 0.017
Met Methoprene-tolerant 0.017
slpr slipper 0.017
Trh Tryptophan hydroxylase 0.017
tll tailless 0.015
bchs blue cheese 0.015
hpo hippo 0.015
nkd naked cuticle 0.015
Cdk5alpha Cdk5 activator-like protein 0.014
so sine oculis 0.014
Cul-2 Cullin-2 0.014
ptc patched 0.014
stai stathmin 0.014
Deaf1 Deformed epidermal autoregulatory factor-1 0.014
Cyp18a1 Cytochrome P450-18a1 0.013
Tre1 trapped in endoderm-1 0.013
Phm Peptidylglycine-alpha-hydroxylating monooxygenase 0.013
BicD Bicaudal D 0.013
Akt1 CG4006 gene product from transcript CG4006-RA 0.013
repo reversed polarity 0.013
Mmp2 Matrix metalloproteinase 2 0.013
haf hattifattener 0.012
dock dreadlocks 0.012
pnr pannier 0.012
puc puckered 0.012
esg escargot 0.012
gt giant 0.012
pex1 peroxin 1 0.012
hb hunchback 0.012
comt comatose 0.012
dco discs overgrown 0.011
Spn27A Serpin 27A 0.011
mav maverick 0.011
ush u-shaped 0.011
pbl pebble 0.011
CtBP C-terminal Binding Protein 0.011
ds dachsous 0.011
l(2)k16918 lethal (2) k16918 0.011
stumps CG31317 gene product from transcript CG31317-RC 0.011
Dap160 Dynamin associated protein 160 0.010
CG6854 CG6854 gene product from transcript CG6854-RC 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.755
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.214
aplnra apelin receptor a 0.173
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.173
oep one-eyed pinhead 0.128
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.119
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.085
f2r coagulation factor II (thrombin) receptor 0.079
wnt5b wingless-type MMTV integration site family, member 5b 0.061
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.057
nrarpa notch-regulated ankyrin repeat protein a 0.053
tac1 tachykinin 1 0.044
twist1a twist1a 0.043
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.043
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.040
zgc:100942 zgc:100942 0.039
msxb muscle segment homeobox B 0.037
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.034
prkci protein kinase C, iota 0.029
wtip Wilms tumor 1 interacting protein 0.024
pea3 ETS-domain transcription factor pea3 0.023
gnas GNAS complex locus 0.020
s100b S100 calcium binding protein, beta (neural) 0.019
gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.019
ccm2 cerebral cavernous malformation 2 0.019
gna14 guanine nucleotide binding protein (G protein), alpha 14 0.018
grhl1 grainyhead-like 1 (Drosophila) 0.018
egr1 early growth response 1 0.017
cntn2 contactin 2 0.017
bmp4 bone morphogenetic protein 4 0.017
anxa2a annexin A2a 0.016
sulf1 sulfatase 1 0.016
vgll4l vestigial like 4 like 0.016
dlc deltaC 0.015
emp2 epithelial membrane protein 2 0.015
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.015
LOC100332929 guanine nucleotide-binding protein subunit alpha-15-like 0.014
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.014
arr3a arrestin 3a, retinal (X-arrestin) 0.014
gnaz guanine nucleotide binding protein (G protein), alpha z polypeptide 0.014
si:dkey-261h17.1 si:dkey-261h17.1 0.014
tnnt2a troponin T2a, cardiac 0.014
spns2 spinster homolog 2 (Drosophila) 0.014
ahnak AHNAK nucleoprotein 0.013
gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.013
dlg1 discs, large (Drosophila) homolog 1 0.012
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.012
wnt4a wingless-type MMTV integration site family, member 4a 0.012
boc brother of CDO 0.012
epas1b endothelial PAS domain protein 1b 0.012
fgf3 fibroblast growth factor 3 0.012
dkk1b dickkopf 1b 0.011
sdprb serum deprivation response b 0.011
gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.011
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.011
hspa12b heat shock protein 12B 0.011
mapk12 mitogen-activated protein kinase 12 0.011
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.011
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.010
frem3 Fras1 related extracellular matrix 3 0.010
si:dkey-204a24.2 si:dkey-204a24.2 0.010
icn ictacalcin 0.010
zgc:92392 zgc:92392 0.010
zgc:123178 zgc:123178 0.010
zgc:101761 zgc:101761 0.010
fbn2b fibrillin 2b 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.812
IL1R1 interleukin 1 receptor, type I 0.772
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.698
EGFR epidermal growth factor receptor 0.679
C1QA complement component 1, q subcomponent, A chain 0.618
BCAR1 breast cancer anti-estrogen resistance 1 0.481
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.310
NRP1 neuropilin 1 0.237
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.181
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.154
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.149
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.140
C1QC complement component 1, q subcomponent, C chain 0.127
CD44 CD44 molecule (Indian blood group) 0.127
FSTL1 follistatin-like 1 0.126
JUP junction plakoglobin 0.117
BMPR1A bone morphogenetic protein receptor, type IA 0.115
KLF6 Kruppel-like factor 6 0.093
ENG endoglin 0.087
DSG2 desmoglein 2 0.086
PSEN1 presenilin 1 0.081
MUC1 mucin 1, cell surface associated 0.073
APOC1 apolipoprotein C-I 0.068
HP haptoglobin 0.064
CAV1 caveolin 1, caveolae protein, 22kDa 0.063
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.060
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.059
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.057
MED28 mediator complex subunit 28 0.055
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.055
KLF4 Kruppel-like factor 4 (gut) 0.053
A2M alpha-2-macroglobulin 0.053
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.053
SCHIP1 schwannomin interacting protein 1 0.050
CDCP1 CUB domain containing protein 1 0.049
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.049
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.049
DUSP1 dual specificity phosphatase 1 0.049
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.047
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.041
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.041
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.040
FZD1 frizzled homolog 1 (Drosophila) 0.038
PTK2 PTK2 protein tyrosine kinase 2 0.037
ADAM15 ADAM metallopeptidase domain 15 0.036
AGTR2 angiotensin II receptor, type 2 0.035
C1QB complement component 1, q subcomponent, B chain 0.035
MAP2K5 mitogen-activated protein kinase kinase 5 0.035
EZR ezrin 0.034
CTNND1 catenin (cadherin-associated protein), delta 1 0.034
GLIS2 GLIS family zinc finger 2 0.033
PLAU plasminogen activator, urokinase 0.032
DSP desmoplakin 0.032
TCF4 transcription factor 4 0.030
SOCS1 suppressor of cytokine signaling 1 0.030
PTK2B PTK2B protein tyrosine kinase 2 beta 0.030
SPRR2A small proline-rich protein 2A 0.030
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.029
PTPRA protein tyrosine phosphatase, receptor type, A 0.029
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.029
PRKCA protein kinase C, alpha 0.029
DNM1 dynamin 1 0.029
APP amyloid beta (A4) precursor protein 0.028
RHOA ras homolog gene family, member A 0.027
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.027
SRCIN1 SRC kinase signaling inhibitor 1 0.027
THBS1 thrombospondin 1 0.025
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.025
MAPK7 mitogen-activated protein kinase 7 0.024
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.024
COL4A1 collagen, type IV, alpha 1 0.023
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.023
SFN stratifin 0.022
SOCS3 suppressor of cytokine signaling 3 0.022
ICAM1 intercellular adhesion molecule 1 0.022
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.022
CTNNBIP1 catenin, beta interacting protein 1 0.022
ZFYVE9 zinc finger, FYVE domain containing 9 0.021
LCAT lecithin-cholesterol acyltransferase 0.021
CD63 CD63 molecule 0.021
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.020
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.020
HIC1 hypermethylated in cancer 1 0.020
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.020
FOSL2 FOS-like antigen 2 0.020
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.020
PGF placental growth factor 0.019
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.019
RIN1 Ras and Rab interactor 1 0.019
SNX9 sorting nexin 9 0.019
GRB2 growth factor receptor-bound protein 2 0.018
INHBA inhibin, beta A 0.018
CLDN1 claudin 1 0.017
CLDN4 claudin 4 0.017
AXL AXL receptor tyrosine kinase 0.017
NCF1 neutrophil cytosolic factor 1 0.017
VEGFC vascular endothelial growth factor C 0.017
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.017
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.016
DDR2 discoidin domain receptor tyrosine kinase 2 0.016
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Syt8 synaptotagmin VIII 0.029
Nckap1 NCK-associated protein 1 0.019
Fgf14 fibroblast growth factor 14 0.015
Pctk2 PCTAIRE protein kinase 2 0.015
Agtr1a angiotensin II receptor, type 1a 0.012
Fgfr2 fibroblast growth factor receptor 2 0.010
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism