The network for 'cardiovascular system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiovascular system development

The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.

Drosophila melanogaster
Name Description Probability Func Analog Organism
ex expanded 0.997
Mad Mothers against dpp 0.989
sd scalloped 0.988
Egfr Epidermal growth factor receptor 0.986
Ubx Ultrabithorax 0.985
ci cubitus interruptus 0.982
N Notch 0.981
wg wingless 0.979
eya eyes absent 0.970
ush u-shaped 0.958
ap apterous 0.953
stumps CG31317 gene product from transcript CG31317-RC 0.914
pnr pannier 0.879
tin tinman 0.869
insc inscuteable 0.852
shn schnurri 0.851
mys myospheroid 0.847
nkd naked cuticle 0.843
LanB2 Laminin B2 0.838
nmo nemo 0.837
dsh dishevelled 0.832
dpp decapentaplegic 0.826
tkv thickveins 0.820
Dad Daughters against dpp 0.814
arm armadillo 0.791
Doc2 Dorsocross2 0.747
slp1 sloppy paired 1 0.747
lin lines 0.743
Ggamma1 G protein gamma 1 0.741
spi spitz 0.733
Mhc Myosin heavy chain 0.732
twi twist 0.730
dys dysfusion 0.695
stck steamer duck 0.693
htl heartless 0.683
bab2 CG9102 gene product from transcript CG9102-RA 0.668
Alk CG8250 gene product from transcript CG8250-RA 0.652
Antp Antennapedia 0.643
slou slouch 0.637
nau nautilus 0.632
mew multiple edematous wings 0.629
dac dachshund 0.617
LanB1 CG7123 gene product from transcript CG7123-RA 0.601
ago archipelago 0.599
HLH54F CG5005 gene product from transcript CG5005-RA 0.594
Rac1 CG2248 gene product from transcript CG2248-RA 0.580
bin biniou 0.578
vg vestigial 0.567
fng fringe 0.561
G-oalpha47A G protein oalpha 47A 0.561
sr stripe 0.551
bsk basket 0.549
lea leak 0.546
zfh1 Zn finger homeodomain 1 0.543
rl rolled 0.533
Stat92E Signal-transducer and activator of transcription protein at 92E 0.523
sax saxophone 0.508
ss spineless 0.484
wb wing blister 0.460
dally division abnormally delayed 0.450
NetB Netrin-B 0.450
smo smoothened 0.443
Hmgcr HMG Coenzyme A reductase 0.432
CkIIalpha Casein kinase II alpha subunit 0.414
pan pangolin 0.408
Dll Distal-less 0.407
coro CG9446 gene product from transcript CG9446-RC 0.406
jeb jelly belly 0.401
wun wunen 0.399
Atg1 Autophagy-specific gene 1 0.399
sns sticks and stones 0.396
dco discs overgrown 0.394
arr arrow 0.391
shi shibire 0.391
Mrtf Myocardin-related transcription factor 0.391
slmb supernumerary limbs 0.388
Fmr1 CG6203 gene product from transcript CG6203-RC 0.387
Atpalpha Na pump alpha subunit 0.386
numb CG3779 gene product from transcript CG3779-RB 0.386
sqz squeeze 0.382
kuz kuzbanian 0.377
Tif-IA CG3278 gene product from transcript CG3278-RA 0.372
gsb gooseberry 0.368
NFAT NFAT homolog 0.365
osa CG7467 gene product from transcript CG7467-RD 0.354
G-salpha60A G protein salpha 60A 0.350
wal walrus 0.350
csw corkscrew 0.347
tsh teashirt 0.347
how held out wings 0.347
babo baboon 0.346
CaMKII Calcium/calmodulin-dependent protein kinase II 0.344
Sema-1a CG18405 gene product from transcript CG18405-RD 0.343
en engrailed 0.338
Hand CG18144 gene product from transcript CG18144-RA 0.329
put punt 0.328
Sin3A CG8815 gene product from transcript CG8815-RC 0.325
Tollo CG6890 gene product from transcript CG6890-RA 0.321
Smox Smad on X 0.285
eve even skipped 0.283
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
EP300 E1A binding protein p300 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
SMAD3 SMAD family member 3 0.999
SMAD2 SMAD family member 2 0.999
TRIM63 tripartite motif containing 63 0.998
SP1 Sp1 transcription factor 0.998
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.996
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.994
VEGFA vascular endothelial growth factor A 0.992
TTN titin 0.989
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.988
ESR1 estrogen receptor 1 0.988
NOTCH1 notch 1 0.987
MYOD1 myogenic differentiation 1 0.987
FHL2 four and a half LIM domains 2 0.986
TAL1 T-cell acute lymphocytic leukemia 1 0.985
XIAP X-linked inhibitor of apoptosis 0.985
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.984
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.984
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.983
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.982
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.981
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.980
MET met proto-oncogene (hepatocyte growth factor receptor) 0.977
NCOR2 nuclear receptor corepressor 2 0.976
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.975
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.972
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.971
CSNK1E casein kinase 1, epsilon 0.970
FGFR2 fibroblast growth factor receptor 2 0.966
PAX3 paired box 3 0.965
BBS10 Bardet-Biedl syndrome 10 0.964
CTGF connective tissue growth factor 0.964
YAP1 Yes-associated protein 1 0.962
JAG1 jagged 1 0.961
CAV1 caveolin 1, caveolae protein, 22kDa 0.961
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.960
FOS FBJ murine osteosarcoma viral oncogene homolog 0.952
CDH5 cadherin 5, type 2 (vascular endothelium) 0.947
COL1A1 collagen, type I, alpha 1 0.942
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.942
ANXA1 annexin A1 0.940
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.937
FN1 fibronectin 1 0.931
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.929
FBN1 fibrillin 1 0.927
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.926
RXRA retinoid X receptor, alpha 0.925
NOTCH3 notch 3 0.923
FLNA filamin A, alpha 0.918
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.916
HOXB5 homeobox B5 0.913
TPM1 tropomyosin 1 (alpha) 0.907
THBS1 thrombospondin 1 0.905
ENG endoglin 0.904
RUNX1 runt-related transcription factor 1 0.903
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.902
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.901
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.901
FGFR1 fibroblast growth factor receptor 1 0.901
NCK1 NCK adaptor protein 1 0.893
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.893
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.892
BCL2L1 BCL2-like 1 0.887
NCOA1 nuclear receptor coactivator 1 0.884
SMAD1 SMAD family member 1 0.884
FAS Fas (TNF receptor superfamily, member 6) 0.881
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.877
FGF1 fibroblast growth factor 1 (acidic) 0.875
VCAN versican 0.874
TGFB1 transforming growth factor, beta 1 0.874
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.871
CAV2 caveolin 2 0.870
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.870
MEF2C myocyte enhancer factor 2C 0.869
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.869
H2AFX H2A histone family, member X 0.866
NRP1 neuropilin 1 0.861
JUP junction plakoglobin 0.861
AR androgen receptor 0.854
NCOR1 nuclear receptor corepressor 1 0.851
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.851
COL4A2 collagen, type IV, alpha 2 0.847
DUSP1 dual specificity phosphatase 1 0.841
DSP desmoplakin 0.840
FKBP8 FK506 binding protein 8, 38kDa 0.840
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.840
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.838
TP53 tumor protein p53 0.838
CD34 CD34 molecule 0.837
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.834
PDX1 pancreatic and duodenal homeobox 1 0.833
TNNI1 troponin I type 1 (skeletal, slow) 0.832
EPAS1 endothelial PAS domain protein 1 0.821
JUN jun proto-oncogene 0.821
BMP2 bone morphogenetic protein 2 0.820
TP73 tumor protein p73 0.815
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.806
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.805
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.516
Dab2 disabled homolog 2 (Drosophila) 0.470
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.462
Pitx3 paired-like homeodomain 3 0.456
Mmp10 matrix metallopeptidase 10 0.456
Id3 inhibitor of DNA binding 3 0.409
Itgad integrin, alpha D 0.397
F13a1 coagulation factor XIII, A1 polypeptide 0.380
Fgfr1 Fibroblast growth factor receptor 1 0.367
Col1a1 collagen, type I, alpha 1 0.365
Alb albumin 0.358
Hsp90b1 heat shock protein 90, beta, member 1 0.354
Ptafr platelet-activating factor receptor 0.350
Twist2 twist homolog 2 (Drosophila) 0.342
Adra1a adrenergic, alpha-1A-, receptor 0.334
Cd4 Cd4 molecule 0.331
Utrn utrophin 0.325
Bcl2 B-cell CLL/lymphoma 2 0.324
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.322
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.319
Egr2 early growth response 2 0.317
Musk muscle, skeletal, receptor tyrosine kinase 0.315
Sdc3 syndecan 3 0.315
Ptgfr prostaglandin F receptor 0.313
Ccl4 chemokine (C-C motif) ligand 4 0.311
Fos FBJ osteosarcoma oncogene 0.295
Tacr2 tachykinin receptor 2 0.292
Sell selectin L 0.290
Aqp1 aquaporin 1 0.285
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.285
Gnrhr gonadotropin releasing hormone receptor 0.284
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.281
F2r coagulation factor II (thrombin) receptor 0.279
Tgfbr2 transforming growth factor, beta receptor II 0.279
Nrp1 neuropilin 1 0.276
Sox13 SRY (sex determining region Y)-box 13 0.274
Ednrb endothelin receptor type B 0.268
Dchs1 dachsous 1 (Drosophila) 0.263
Slit3 slit homolog 3 (Drosophila) 0.261
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.258
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.256
Ngf nerve growth factor (beta polypeptide) 0.256
Gper G protein-coupled estrogen receptor 1 0.251
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.249
Fgfr2 fibroblast growth factor receptor 2 0.246
Cga glycoprotein hormones, alpha polypeptide 0.244
Ghr growth hormone receptor 0.243
Irs1 insulin receptor substrate 1 0.240
Mprip myosin phosphatase Rho interacting protein 0.238
Casq2 calsequestrin 2 (cardiac muscle) 0.235
Fstl1 follistatin-like 1 0.229
Epor erythropoietin receptor 0.227
Flt1 FMS-related tyrosine kinase 1 0.224
Col8a1 collagen, type VIII, alpha 1 0.223
Chrnb1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.221
Fzd2 frizzled homolog 2 (Drosophila) 0.216
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.215
Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.213
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.208
Met met proto-oncogene 0.208
Fermt2 fermitin family homolog 2 (Drosophila) 0.206
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.205
Egr1 early growth response 1 0.205
Galr2 galanin receptor 2 0.203
Nfib nuclear factor I/B 0.203
Plxnd1 plexin D1 0.201
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.201
Vegfa vascular endothelial growth factor A 0.201
Smad3 SMAD family member 3 0.200
Egfl7 EGF-like-domain, multiple 7 0.199
Il7 interleukin 7 0.199
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.198
Acvrl1 activin A receptor type II-like 1 0.197
Trib1 tribbles homolog 1 (Drosophila) 0.196
Ifitm3 interferon induced transmembrane protein 3 0.193
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.193
Pip prolactin induced protein 0.193
Col12a1 collagen, type XII, alpha 1 0.192
Actc1 actin, alpha, cardiac muscle 1 0.190
Plb1 phospholipase B1 0.190
Il12b interleukin 12B 0.188
Tcfe2a transcription factor E2a 0.188
Agtr1a angiotensin II receptor, type 1a 0.182
Egr3 early growth response 3 0.182
Mapk3 mitogen activated protein kinase 3 0.181
Pgc progastricsin (pepsinogen C) 0.180
Lims1 LIM and senescent cell antigen-like domains 1 0.177
Vcan versican 0.177
Ccnd1 cyclin D1 0.177
Il1r1 interleukin 1 receptor, type I 0.176
Ccl2 chemokine (C-C motif) ligand 2 0.176
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.176
Arnt aryl hydrocarbon receptor nuclear translocator 0.174
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.173
Nos3 nitric oxide synthase 3, endothelial cell 0.172
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.171
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.170
Hoxa2 homeo box A2 0.169
Prrx1 paired related homeobox 1 0.167
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.167
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism