IMP
Process View
The network for 'positive regulation of macrophage differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of macrophage differentiation
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.993 | |
| XIAP | X-linked inhibitor of apoptosis | 0.989 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.955 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.946 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.928 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.923 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.775 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.741 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.622 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.577 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.377 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.351 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.335 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.227 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.221 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.203 | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.200 | |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.170 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.168 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.133 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.102 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.101 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.100 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.080 | |
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.080 | |
| SH2D4A | SH2 domain containing 4A | 0.074 | |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.070 | |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.059 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.055 | |
| IL8 | interleukin 8 | 0.054 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.042 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.042 | |
| PF4 | platelet factor 4 | 0.034 | |
| TRAF3 | TNF receptor-associated factor 3 | 0.031 | |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.028 | |
| UBD | ubiquitin D | 0.017 | |
| LRDD | leucine-rich repeats and death domain containing | 0.016 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.014 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.014 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.013 | |
| IFI44 | interferon-induced protein 44 | 0.012 | |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.012 | |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.011 | |
| NUCB2 | nucleobindin 2 | 0.011 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Pten | phosphatase and tensin homolog | 0.905 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.827 | |
| Trp53 | transformation related protein 53 | 0.701 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.456 | |
| Src | Rous sarcoma oncogene | 0.416 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.346 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.327 | |
| Ldb3 | LIM domain binding 3 | 0.286 | |
| Tcf3 | transcription factor 3 | 0.239 | |
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.238 | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.236 | |
| Casp8 | caspase 8 | 0.212 | |
| Rbl2 | retinoblastoma-like 2 | 0.152 | |
| Fgd1 | FYVE, RhoGEF and PH domain containing 1 | 0.125 | |
| Rbl1 | retinoblastoma-like 1 (p107) | 0.122 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.106 | |
| Apaf1 | apoptotic peptidase activating factor 1 | 0.105 | |
| Wdr1 | WD repeat domain 1 | 0.079 | |
| Kit | kit oncogene | 0.079 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.077 | |
| Myo6 | myosin VI | 0.073 | |
| Cyld | cylindromatosis (turban tumor syndrome) | 0.065 | |
| Csf1r | colony stimulating factor 1 receptor | 0.065 | |
| Rb1 | retinoblastoma 1 | 0.063 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.059 | |
| Gja1 | gap junction protein, alpha 1 | 0.055 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.047 | |
| Tcf4 | transcription factor 4 | 0.044 | |
| Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | 0.041 | |
| Mapk14 | mitogen-activated protein kinase 14 | 0.036 | |
| Itgb2 | integrin beta 2 | 0.035 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.033 | |
| Kitl | kit ligand | 0.032 | |
| Sox11 | SRY-box containing gene 11 | 0.031 | |
| Pkdcc | protein kinase domain containing, cytoplasmic | 0.031 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.031 | |
| Fyb | FYN binding protein | 0.030 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.029 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.026 | |
| Id2 | inhibitor of DNA binding 2 | 0.026 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.026 | |
| Psen1 | presenilin 1 | 0.026 | |
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.025 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.025 | |
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.024 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.023 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.023 | |
| Wls | wntless homolog (Drosophila) | 0.022 | |
| Sgpl1 | sphingosine phosphate lyase 1 | 0.022 | |
| Casp3 | caspase 3 | 0.021 | |
| Dbnl | drebrin-like | 0.021 | |
| Cav1 | caveolin 1, caveolae protein | 0.021 | |
| Igf1 | insulin-like growth factor 1 | 0.021 | |
| Prkce | protein kinase C, epsilon | 0.020 | |
| Shank3 | SH3/ankyrin domain gene 3 | 0.019 | |
| Id3 | inhibitor of DNA binding 3 | 0.019 | |
| Il2rg | interleukin 2 receptor, gamma chain | 0.019 | |
| Arhgdib | Rho, GDP dissociation inhibitor (GDI) beta | 0.019 | |
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.018 | |
| Sirpa | signal-regulatory protein alpha | 0.018 | |
| Fermt3 | fermitin family homolog 3 (Drosophila) | 0.017 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.017 | |
| Foxc1 | forkhead box C1 | 0.017 | |
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.017 | |
| Sox2 | SRY-box containing gene 2 | 0.016 | |
| Spnb2 | spectrin beta 2 | 0.016 | |
| Cacnb3 | calcium channel, voltage-dependent, beta 3 subunit | 0.016 | |
| Cd44 | CD44 antigen | 0.016 | |
| Ifngr1 | interferon gamma receptor 1 | 0.016 | |
| Mmp9 | matrix metallopeptidase 9 | 0.015 | |
| Traf6 | TNF receptor-associated factor 6 | 0.015 | |
| Thbs1 | thrombospondin 1 | 0.015 | |
| Hs1bp3 | HCLS1 binding protein 3 | 0.015 | |
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.014 | |
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.014 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.014 | |
| Actb | actin, beta | 0.014 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.013 | |
| Prkcb | protein kinase C, beta | 0.013 | |
| Ikbkg | inhibitor of kappaB kinase gamma | 0.013 | |
| Clock | circadian locomotor output cycles kaput | 0.013 | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.013 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.013 | |
| Dlg1 | discs, large homolog 1 (Drosophila) | 0.012 | |
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.012 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.012 | |
| Sox4 | SRY-box containing gene 4 | 0.012 | |
| Igh | immunoglobulin heavy chain complex | 0.012 | |
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.012 | |
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.011 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.011 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.011 | |
| Plcd1 | phospholipase C, delta 1 | 0.011 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.011 | |
| Efnb2 | ephrin B2 | 0.011 | |
| Dnm1 | dynamin 1 | 0.011 | |
| Ahr | aryl-hydrocarbon receptor | 0.011 | |
| E2f1 | E2F transcription factor 1 | 0.011 | |
| Actn2 | actinin alpha 2 | 0.010 |