IMP
Process View
The network for 't helper 1 type immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
t helper 1 type immune response
An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.855 | |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 0.844 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.809 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.809 | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.783 | |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.707 | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.679 | |
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.637 | |
| IL4R | interleukin 4 receptor | 0.623 | |
| BCL3 | B-cell CLL/lymphoma 3 | 0.579 | |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.544 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.496 | |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.228 | |
| IL2RG | interleukin 2 receptor, gamma | 0.204 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.133 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.129 | |
| IL4 | interleukin 4 | 0.107 | |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.088 | |
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.088 | |
| NRP1 | neuropilin 1 | 0.083 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.081 | |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | 0.065 | |
| HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | 0.064 | |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.059 | |
| TRAF3 | TNF receptor-associated factor 3 | 0.052 | |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.050 | |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 0.040 | |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.037 | |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.033 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.029 | |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.028 | |
| PLXND1 | plexin D1 | 0.027 | |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.024 | |
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.019 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.015 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.012 | |
| SOCS3 | suppressor of cytokine signaling 3 | 0.012 | |
| IL12A | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 0.011 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.010 | |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 0.010 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.998 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.946 | |
| Tnf | tumor necrosis factor | 0.942 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.907 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.894 | |
| Cd44 | CD44 antigen | 0.842 | |
| Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 0.824 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.824 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.809 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.801 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.791 | |
| Lyz2 | lysozyme 2 | 0.775 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.751 | |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.742 | |
| Ciita | class II transactivator | 0.711 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.705 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.693 | |
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.690 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.630 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.606 | |
| Lepr | leptin receptor | 0.595 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.568 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.551 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.530 | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.528 | |
| Il1b | interleukin 1 beta | 0.520 | |
| Il6st | interleukin 6 signal transducer | 0.509 | |
| Foxp3 | forkhead box P3 | 0.486 | |
| Aire | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 0.455 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.433 | |
| Cd40 | CD40 antigen | 0.422 | |
| Ifng | interferon gamma | 0.394 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.392 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.368 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.348 | |
| Irf9 | interferon regulatory factor 9 | 0.344 | |
| Il4ra | interleukin 4 receptor, alpha | 0.342 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.335 | |
| Icam1 | intercellular adhesion molecule 1 | 0.329 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.316 | |
| Il4 | interleukin 4 | 0.305 | |
| Jak2 | Janus kinase 2 | 0.294 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.284 | |
| Il10 | interleukin 10 | 0.242 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.241 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.241 | |
| Il6 | interleukin 6 | 0.238 | |
| Ctsw | cathepsin W | 0.225 | |
| Itgax | integrin alpha X | 0.223 | |
| Cd7 | CD7 antigen | 0.223 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.219 | |
| Sh2d2a | SH2 domain protein 2A | 0.202 | |
| Pdcd1 | programmed cell death 1 | 0.202 | |
| Tcf7 | transcription factor 7, T-cell specific | 0.199 | |
| Irf1 | interferon regulatory factor 1 | 0.198 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.195 | |
| Cd6 | CD6 antigen | 0.191 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.188 | |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.181 | |
| Itgal | integrin alpha L | 0.178 | |
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.177 | |
| Jak3 | Janus kinase 3 | 0.176 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.174 | |
| Il12rb2 | interleukin 12 receptor, beta 2 | 0.172 | |
| Selp | selectin, platelet | 0.170 | |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.169 | |
| Il10ra | interleukin 10 receptor, alpha | 0.168 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.162 | |
| Traf1 | TNF receptor-associated factor 1 | 0.161 | |
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.153 | |
| Stat5a | signal transducer and activator of transcription 5A | 0.150 | |
| Il1r1 | interleukin 1 receptor, type I | 0.147 | |
| Lag3 | lymphocyte-activation gene 3 | 0.144 | |
| Adam8 | a disintegrin and metallopeptidase domain 8 | 0.143 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.142 | |
| Mefv | Mediterranean fever | 0.139 | |
| Cish | cytokine inducible SH2-containing protein | 0.135 | |
| Cd86 | CD86 antigen | 0.132 | |
| Gzmb | granzyme B | 0.130 | |
| Itk | IL2-inducible T-cell kinase | 0.129 | |
| Bdkrb1 | bradykinin receptor, beta 1 | 0.127 | |
| Ccl12 | chemokine (C-C motif) ligand 12 | 0.119 | |
| Stat5b | signal transducer and activator of transcription 5B | 0.116 | |
| Il18r1 | interleukin 18 receptor 1 | 0.115 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.114 | |
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.111 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.110 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.108 | |
| Pdcd1lg2 | programmed cell death 1 ligand 2 | 0.100 | |
| Il23a | interleukin 23, alpha subunit p19 | 0.097 | |
| Il1rn | interleukin 1 receptor antagonist | 0.096 | |
| Ptgir | prostaglandin I receptor (IP) | 0.091 | |
| Serpina3g | serine (or cysteine) peptidase inhibitor, clade A, member 3G | 0.090 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.090 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.087 | |
| Mmp3 | matrix metallopeptidase 3 | 0.087 | |
| Il27ra | interleukin 27 receptor, alpha | 0.085 | |
| Rel | reticuloendotheliosis oncogene | 0.084 | |
| Cd160 | CD160 antigen | 0.081 | |
| Irf5 | interferon regulatory factor 5 | 0.078 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| RT1-Ba | RT1 class II, locus Ba | 0.761 | |
| RT1-Db1 | RT1 class II, locus Db1 | 0.261 | |
| Il6 | interleukin 6 | 0.089 | |
| Rxra | retinoid X receptor alpha | 0.071 | |
| Cd4 | Cd4 molecule | 0.065 | |
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.063 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.057 | |
| Ptafr | platelet-activating factor receptor | 0.056 | |
| Serpine1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.055 | |
| Ptpn12 | protein tyrosine phosphatase, non-receptor type 12 | 0.048 | |
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.046 | |
| F13a1 | coagulation factor XIII, A1 polypeptide | 0.041 | |
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.040 | |
| Hdac1l | histone deacetylase 1-like | 0.038 | |
| Bmp6 | bone morphogenetic protein 6 | 0.038 | |
| Cd37 | CD37 molecule | 0.037 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.036 | |
| C3ar1 | complement component 3a receptor 1 | 0.034 | |
| Cd74 | Cd74 molecule, major histocompatibility complex, class II invariant chain | 0.033 | |
| Gja4 | gap junction protein, alpha 4 | 0.033 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.033 | |
| Smad7 | SMAD family member 7 | 0.032 | |
| Anpep | alanyl (membrane) aminopeptidase | 0.030 | |
| A2m | alpha-2-macroglobulin | 0.030 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.029 | |
| Itgam | integrin, alpha M | 0.029 | |
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.028 | |
| Has2 | hyaluronan synthase 2 | 0.028 | |
| Flt1 | FMS-related tyrosine kinase 1 | 0.028 | |
| Bcl2l1 | Bcl2-like 1 | 0.027 | |
| Cysltr1 | cysteinyl leukotriene receptor 1 | 0.026 | |
| Pcyt1a | phosphate cytidylyltransferase 1, choline, alpha | 0.026 | |
| Edn1 | endothelin 1 | 0.025 | |
| Dchs1 | dachsous 1 (Drosophila) | 0.025 | |
| Alox5 | arachidonate 5-lipoxygenase | 0.025 | |
| Eng | endoglin | 0.025 | |
| Col8a1 | collagen, type VIII, alpha 1 | 0.024 | |
| Mos | Moloney sarcoma oncogene | 0.024 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.023 | |
| Mmp2 | matrix metallopeptidase 2 | 0.023 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.022 | |
| Nek9 | NIMA (never in mitosis gene a)- related kinase 9 | 0.022 | |
| Sqstm1 | sequestosome 1 | 0.022 | |
| Thbs4 | thrombospondin 4 | 0.021 | |
| Mov10 | Moloney leukemia virus 10 | 0.021 | |
| Cdc42bpb | CDC42 binding protein kinase beta (DMPK-like) | 0.021 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.020 | |
| Acvr1b | activin A receptor, type IB | 0.019 | |
| Lst1 | leukocyte specific transcript 1 | 0.019 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.019 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.018 | |
| Cd38 | CD38 molecule | 0.018 | |
| Lilrb4 | leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 0.018 | |
| Cdv3 | carnitine deficiency-associated gene expressed in ventricle 3 homolog (mouse) | 0.017 | |
| Lilrb3l | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like | 0.017 | |
| Cd2 | Cd2 molecule | 0.017 | |
| Il2 | interleukin 2 | 0.017 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.017 | |
| Timp3 | TIMP metallopeptidase inhibitor 3 | 0.016 | |
| Plau | plasminogen activator, urokinase | 0.016 | |
| Psgb1 | pregnancy-specific beta 1-glycoprotein | 0.016 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.015 | |
| Thbd | thrombomodulin | 0.015 | |
| Il4ra | interleukin 4 receptor, alpha | 0.015 | |
| Arhgap4 | Rho GTPase activating protein 4 | 0.015 | |
| Aldh1a2 | aldehyde dehydrogenase 1 family, member A2 | 0.014 | |
| Hmha1 | histocompatibility (minor) HA-1 | 0.014 | |
| Slc18a2 | solute carrier family 18 (vesicular monoamine), member 2 | 0.014 | |
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.014 | |
| Cd80 | Cd80 molecule | 0.014 | |
| Gpsm3 | G-protein signaling modulator 3 (AGS3-like, C. elegans) | 0.014 | |
| Ppp3r1 | protein phosphatase 3, regulatory subunit B, alpha isoform | 0.014 | |
| Fap | fibroblast activation protein, alpha | 0.014 | |
| Notch2 | Notch homolog 2 (Drosophila) | 0.014 | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.013 | |
| Prkch | protein kinase C, eta | 0.013 | |
| Expi | extracellular proteinase inhibitor | 0.013 | |
| Erg | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 0.013 | |
| Serpina3k | serine (or cysteine) peptidase inhibitor, clade A, member 3K | 0.013 | |
| Mmp12 | matrix metallopeptidase 12 | 0.013 | |
| Ltbp2 | latent transforming growth factor beta binding protein 2 | 0.013 | |
| Map3k3 | mitogen activated protein kinase kinase kinase 3 | 0.013 | |
| Smad1 | SMAD family member 1 | 0.013 | |
| Napsa | napsin A aspartic peptidase | 0.013 | |
| Pld1 | phospholipase D1 | 0.013 | |
| Cd86 | CD86 molecule | 0.013 | |
| Cd5 | Cd5 molecule | 0.013 | |
| RGD1311307 | similar to 1300014I06Rik protein | 0.012 | |
| Il2rg | interleukin 2 receptor, gamma | 0.012 | |
| Stxbp2 | syntaxin binding protein 2 | 0.012 | |
| Vav1 | vav 1 guanine nucleotide exchange factor | 0.012 | |
| Tgfb1 | transforming growth factor, beta 1 | 0.012 | |
| Cebpg | CCAAT/enhancer binding protein (C/EBP), gamma | 0.012 | |
| Enpep | glutamyl aminopeptidase | 0.012 | |
| LOC100360403 | ATP-binding cassette, sub-family C, member 9-like | 0.012 | |
| Gmip | Gem-interacting protein | 0.012 | |
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.012 | |
| Calcr | calcitonin receptor | 0.012 | |
| Col12a1 | collagen, type XII, alpha 1 | 0.012 | |
| Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 0.012 |