IMP
Process View
The network for 'centromere complex assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
centromere complex assembly
The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ect2 | ect2 oncogene | 0.503 | |
| Haus6 | HAUS augmin-like complex, subunit 6 | 0.419 | |
| Dck | deoxycytidine kinase | 0.270 | |
| Plk4 | polo-like kinase 4 (Drosophila) | 0.199 | |
| Casp8ap2 | caspase 8 associated protein 2 | 0.183 | |
| Smc2 | structural maintenance of chromosomes 2 | 0.164 | |
| Smc4 | structural maintenance of chromosomes 4 | 0.138 | |
| C330027C09Rik | RIKEN cDNA C330027C09 gene | 0.118 | |
| Srsf7 | serine/arginine-rich splicing factor 7 | 0.111 | |
| Trim59 | tripartite motif-containing 59 | 0.091 | |
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.079 | |
| Tmpo | thymopoietin | 0.078 | |
| Cenpk | centromere protein K | 0.075 | |
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.072 | |
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.063 | |
| Ncapg2 | non-SMC condensin II complex, subunit G2 | 0.063 | |
| Srsf5 | serine/arginine-rich splicing factor 5 | 0.054 | |
| Chek1 | checkpoint kinase 1 homolog (S. pombe) | 0.052 | |
| Atad2 | ATPase family, AAA domain containing 2 | 0.044 | |
| Rfc3 | replication factor C (activator 1) 3 | 0.043 | |
| Cenpq | centromere protein Q | 0.040 | |
| Dnmt3b | DNA methyltransferase 3B | 0.036 | |
| 2610039C10Rik | RIKEN cDNA 2610039C10 gene | 0.034 | |
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.033 | |
| Eri2 | exoribonuclease 2 | 0.033 | |
| 1110004F10Rik | RIKEN cDNA 1110004F10 gene | 0.030 | |
| Siah1b | seven in absentia 1B | 0.030 | |
| 5830433M19Rik | RIKEN cDNA 5830433M19 gene | 0.030 | |
| Hmgb2 | high mobility group box 2 | 0.030 | |
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.027 | |
| Slbp | stem-loop binding protein | 0.027 | |
| Caprin1 | cell cycle associated protein 1 | 0.026 | |
| Lin9 | lin-9 homolog (C. elegans) | 0.026 | |
| Pacrgl | PARK2 co-regulated-like | 0.026 | |
| Terf1 | telomeric repeat binding factor 1 | 0.025 | |
| Dsn1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.025 | |
| Stag1 | stromal antigen 1 | 0.025 | |
| Eri1 | exoribonuclease 1 | 0.025 | |
| Wsb1 | WD repeat and SOCS box-containing 1 | 0.024 | |
| G2e3 | G2/M-phase specific E3 ubiquitin ligase | 0.023 | |
| Stil | Scl/Tal1 interrupting locus | 0.023 | |
| Adss | adenylosuccinate synthetase, non muscle | 0.022 | |
| Dhx15 | DEAH (Asp-Glu-Ala-His) box polypeptide 15 | 0.021 | |
| Rrm2 | ribonucleotide reductase M2 | 0.021 | |
| Myef2 | myelin basic protein expression factor 2, repressor | 0.021 | |
| Cklf | chemokine-like factor | 0.020 | |
| Rbm26 | RNA binding motif protein 26 | 0.020 | |
| Rad51ap1 | RAD51 associated protein 1 | 0.020 | |
| Fmr1 | fragile X mental retardation syndrome 1 homolog | 0.019 | |
| Racgap1 | Rac GTPase-activating protein 1 | 0.018 | |
| Msh6 | mutS homolog 6 (E. coli) | 0.018 | |
| Top2a | topoisomerase (DNA) II alpha | 0.017 | |
| Zwilch | Zwilch, kinetochore associated, homolog (Drosophila) | 0.017 | |
| Lrrc40 | leucine rich repeat containing 40 | 0.017 | |
| BC016423 | cDNA sequence BC016423 | 0.017 | |
| Ncaph | non-SMC condensin I complex, subunit H | 0.017 | |
| Shcbp1 | Shc SH2-domain binding protein 1 | 0.016 | |
| Ccne2 | cyclin E2 | 0.016 | |
| Dr1 | down-regulator of transcription 1 | 0.016 | |
| Cirbp | cold inducible RNA binding protein | 0.016 | |
| Mki67 | antigen identified by monoclonal antibody Ki 67 | 0.016 | |
| Rnf138 | ring finger protein 138 | 0.016 | |
| Ccna2 | cyclin A2 | 0.015 | |
| Pold3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.015 | |
| Cnot6 | CCR4-NOT transcription complex, subunit 6 | 0.015 | |
| Depdc1a | DEP domain containing 1a | 0.015 | |
| D030056L22Rik | RIKEN cDNA D030056L22 gene | 0.015 | |
| Rad51 | RAD51 homolog (S. cerevisiae) | 0.014 | |
| Ccnb2 | cyclin B2 | 0.014 | |
| Cdc7 | cell division cycle 7 (S. cerevisiae) | 0.014 | |
| Cenpl | centromere protein L | 0.013 | |
| Etaa1 | Ewing's tumor-associated antigen 1 | 0.013 | |
| Ythdc2 | YTH domain containing 2 | 0.013 | |
| Trip13 | thyroid hormone receptor interactor 13 | 0.012 | |
| Melk | maternal embryonic leucine zipper kinase | 0.012 | |
| Cbx1 | chromobox homolog 1 (Drosophila HP1 beta) | 0.012 | |
| Cdca7 | cell division cycle associated 7 | 0.012 | |
| Actr3 | ARP3 actin-related protein 3 homolog (yeast) | 0.012 | |
| Efcab7 | EF-hand calcium binding domain 7 | 0.012 | |
| Pola1 | polymerase (DNA directed), alpha 1 | 0.012 | |
| Ube2c | ubiquitin-conjugating enzyme E2C | 0.012 | |
| Nup205 | nucleoporin 205 | 0.012 | |
| Cenpa | centromere protein A | 0.012 | |
| Pafah1b2 | platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 | 0.011 | |
| Dnmt3a | DNA methyltransferase 3A | 0.011 | |
| Morc3 | microrchidia 3 | 0.011 | |
| Dna2 | DNA replication helicase 2 homolog (yeast) | 0.011 | |
| Cenpc1 | centromere protein C1 | 0.011 | |
| Rbl1 | retinoblastoma-like 1 (p107) | 0.011 | |
| Suz12 | suppressor of zeste 12 homolog (Drosophila) | 0.011 | |
| Hnrnpa2b1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.011 | |
| Nek2 | NIMA (never in mitosis gene a)-related expressed kinase 2 | 0.011 | |
| Nup50 | nucleoporin 50 | 0.011 | |
| Rbbp8 | retinoblastoma binding protein 8 | 0.011 | |
| Pnrc2 | proline-rich nuclear receptor coactivator 2 | 0.010 | |
| Pdk3 | pyruvate dehydrogenase kinase, isoenzyme 3 | 0.010 | |
| Srsf1 | serine/arginine-rich splicing factor 1 | 0.010 | |
| Ino80c | INO80 complex subunit C | 0.010 |
Loading network...
Caenorhabditis elegans
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| hcp-1 | Protein HCP-1 | 0.541 | |
| bub-1 | Protein BUB-1 | 0.521 | |
| aspm-1 | Protein ASPM-1 | 0.352 | |
| CELE_Y53F4B.9 | Protein Y53F4B.9 | 0.323 | |
| klp-19 | Protein KLP-19 | 0.225 | |
| cyk-4 | Protein CYK-4 | 0.179 | |
| mel-28 | Protein MEL-28 | 0.173 | |
| hcp-6 | Protein HCP-6 | 0.169 | |
| him-10 | Protein HIM-10 | 0.165 | |
| tac-1 | Protein TAC-1 | 0.119 | |
| rpl-11.1 | Protein RPL-11.1 | 0.116 | |
| ect-2 | Protein ECT-2 | 0.096 | |
| mcm-7 | Protein MCM-7 | 0.094 | |
| mcm-2 | Protein MCM-2 | 0.058 | |
| klp-10 | Protein KLP-10 | 0.052 | |
| gpr-1 | Protein GPR-1 | 0.050 | |
| icp-1 | Protein ICP-1 | 0.048 | |
| csc-1 | Protein CSC-1 | 0.044 | |
| spdl-1 | Protein SPDL-1 | 0.044 | |
| gpr-2 | Protein GPR-2 | 0.043 | |
| pri-1 | Protein PRI-1 | 0.042 | |
| set-21 | Protein SET-21 | 0.041 | |
| F25B5.2 | Protein F25B5.2 | 0.041 | |
| npp-11 | Protein NPP-11 | 0.041 | |
| T07C4.10 | Protein T07C4.10 | 0.039 | |
| knl-1 | Protein KNL-1 | 0.038 | |
| B0001.7 | Protein B0001.7 | 0.037 | |
| dna-2 | Protein DNA-2 | 0.036 | |
| iff-1 | Protein IFF-1 | 0.034 | |
| hil-4 | Protein HIL-4 | 0.031 | |
| klp-7 | Protein KLP-7 | 0.031 | |
| CELE_C39E9.12 | Protein C39E9.12 | 0.029 | |
| klp-18 | Protein KLP-18 | 0.028 | |
| hcp-2 | Protein HCP-2 | 0.025 | |
| B0261.7 | Protein B0261.7 | 0.025 | |
| cyb-1 | Protein CYB-1 | 0.024 | |
| cye-1 | Protein CYE-1 | 0.024 | |
| top-2 | Protein TOP-2 | 0.023 | |
| lin-5 | Protein LIN-5 | 0.022 | |
| pig-1 | Protein PIG-1 | 0.018 | |
| rnr-1 | Protein RNR-1 | 0.018 | |
| ndc-80 | Protein NDC-80 | 0.017 | |
| F20A1.9 | Protein F20A1.9 | 0.016 | |
| ZK430.7 | Protein ZK430.7 | 0.016 | |
| Y4C6B.1 | Protein Y4C6B.1 | 0.016 | |
| bir-1 | Protein BIR-1 | 0.016 | |
| perm-1 | Protein PERM-1 | 0.016 | |
| air-2 | Protein AIR-2 | 0.016 | |
| hcp-3 | Protein HCP-3 | 0.015 | |
| brd-1 | Protein BRD-1 | 0.015 | |
| CELE_C24H12.5 | Protein C24H12.5 | 0.014 | |
| F33H2.5 | Protein F33H2.5 | 0.014 | |
| ubxn-1 | Protein UBXN-1 | 0.013 | |
| pie-1 | Protein PIE-1 | 0.012 | |
| T20F5.7 | Protein T20F5.7 | 0.012 | |
| CELE_F23C8.9 | Protein F23C8.9 | 0.012 | |
| sas-4 | Protein SAS-4 | 0.011 | |
| CELE_F59A6.5 | Protein F59A6.5 | 0.011 | |
| dao-5 | Protein DAO-5 | 0.011 | |
| lig-1 | Protein LIG-1 | 0.011 | |
| obr-3 | Protein OBR-3 | 0.011 | |
| CELE_R09B3.2 | Protein R09B3.2 | 0.011 | |
| F54E12.2 | Protein F54E12.2 | 0.010 | |
| ani-1 | Protein ANI-1 | 0.010 |
Loading network...
Drosophila melanogaster
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ndc80 | CG9938 gene product from transcript CG9938-RA | 0.324 | |
| Nuf2 | CG8902 gene product from transcript CG8902-RA | 0.208 | |
| Cenp-C | CG31258 gene product from transcript CG31258-RA | 0.058 | |
| mars | CG17064 gene product from transcript CG17064-RB | 0.038 | |
| cmet | CENP-meta | 0.026 | |
| Kmn1 | kinetochore Mis12-Ndc80 network component 1 | 0.025 | |
| Spc25 | CG7242 gene product from transcript CG7242-RA | 0.019 | |
| Mis12 | CG18156 gene product from transcript CG18156-RA | 0.017 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CUL1 | cullin 1 | 0.376 | |
| NSL1 | NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.254 | |
| SKP2 | S-phase kinase-associated protein 2 (p45) | 0.250 | |
| CENPM | centromere protein M | 0.217 | |
| BTRC | beta-transducin repeat containing | 0.192 | |
| CENPA | centromere protein A | 0.083 | |
| CBX5 | chromobox homolog 5 | 0.082 | |
| NUP133 | nucleoporin 133kDa | 0.077 | |
| CACYBP | calcyclin binding protein | 0.071 | |
| POLE4 | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 0.048 | |
| CHRAC1 | chromatin accessibility complex 1 | 0.034 | |
| FAM83D | family with sequence similarity 83, member D | 0.033 | |
| FAM64A | family with sequence similarity 64, member A | 0.031 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.031 | |
| YBX1 | Y box binding protein 1 | 0.028 | |
| E2F3 | E2F transcription factor 3 | 0.020 | |
| CENPE | centromere protein E, 312kDa | 0.018 | |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.015 | |
| DIAPH3 | diaphanous homolog 3 (Drosophila) | 0.015 | |
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.014 | |
| HIST1H3B | histone cluster 1, H3b | 0.013 | |
| RNF111 | ring finger protein 111 | 0.013 | |
| CENPH | centromere protein H | 0.012 | |
| SPAG5 | sperm associated antigen 5 | 0.012 | |
| FBXO4 | F-box protein 4 | 0.012 | |
| GLRX3 | glutaredoxin 3 | 0.012 | |
| TRPS1 | trichorhinophalangeal syndrome I | 0.011 | |
| FBXW11 | F-box and WD repeat domain containing 11 | 0.011 | |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.011 | |
| CENPN | centromere protein N | 0.011 | |
| CBX1 | chromobox homolog 1 | 0.011 | |
| PRR14 | proline rich 14 | 0.011 | |
| MELK | maternal embryonic leucine zipper kinase | 0.011 | |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.010 | |
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.010 | |
| KIF2C | kinesin family member 2C | 0.010 |