IMP
Process View
The network for 'granzyme mediated apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
granzyme mediated apoptotic signaling pathway
A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Xcl1 | chemokine (C motif) ligand 1 | 0.896 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.847 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.845 | |
| Gzmb | granzyme B | 0.825 | |
| Ctsw | cathepsin W | 0.765 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.755 | |
| Cpa3 | carboxypeptidase A3, mast cell | 0.716 | |
| Gzma | granzyme A | 0.691 | |
| Gzmc | granzyme C | 0.689 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.670 | |
| Mcpt4 | mast cell protease 4 | 0.609 | |
| Cst7 | cystatin F (leukocystatin) | 0.589 | |
| Cma1 | chymase 1, mast cell | 0.562 | |
| Ctsg | cathepsin G | 0.557 | |
| Cd96 | CD96 antigen | 0.536 | |
| Gzmf | granzyme F | 0.478 | |
| Gzmd | granzyme D | 0.466 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.452 | |
| Fcer1a | Fc receptor, IgE, high affinity I, alpha polypeptide | 0.443 | |
| Plbd2 | phospholipase B domain containing 2 | 0.428 | |
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.426 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.424 | |
| Sh2d2a | SH2 domain protein 2A | 0.415 | |
| Mmp10 | matrix metallopeptidase 10 | 0.409 | |
| Ctsb | cathepsin B | 0.359 | |
| Prl7a1 | prolactin family 7, subfamily a, member 1 | 0.359 | |
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.350 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.327 | |
| Sh2d1a | SH2 domain protein 1A | 0.313 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.303 | |
| Gzmg | granzyme G | 0.301 | |
| Vcp | valosin containing protein | 0.285 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.264 | |
| Cd7 | CD7 antigen | 0.250 | |
| Itk | IL2-inducible T-cell kinase | 0.218 | |
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.217 | |
| Prl2b1 | prolactin family 2, subfamily b, member 1 | 0.217 | |
| Cd8a | CD8 antigen, alpha chain | 0.215 | |
| Mpo | myeloperoxidase | 0.192 | |
| Ngp | neutrophilic granule protein | 0.190 | |
| Sva | seminal vesicle antigen | 0.188 | |
| Cidec | cell death-inducing DFFA-like effector c | 0.188 | |
| Ctsd | cathepsin D | 0.185 | |
| Lamp2 | lysosomal-associated membrane protein 2 | 0.178 | |
| Retn | resistin | 0.164 | |
| Nkg7 | natural killer cell group 7 sequence | 0.160 | |
| Ear2 | eosinophil-associated, ribonuclease A family, member 2 | 0.149 | |
| Adipoq | adiponectin, C1Q and collagen domain containing | 0.145 | |
| Aqp7 | aquaporin 7 | 0.140 | |
| Gcet2 | germinal center expressed transcript 2 | 0.138 | |
| Aoah | acyloxyacyl hydrolase | 0.134 | |
| Gzme | granzyme E | 0.125 | |
| Icos | inducible T-cell co-stimulator | 0.115 | |
| Ido1 | indoleamine 2,3-dioxygenase 1 | 0.107 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.104 | |
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.100 | |
| Klk1b26 | kallikrein 1-related petidase b26 | 0.099 | |
| Mcpt1 | mast cell protease 1 | 0.096 | |
| Gp1ba | glycoprotein 1b, alpha polypeptide | 0.095 | |
| Il12rb2 | interleukin 12 receptor, beta 2 | 0.094 | |
| Myf6 | myogenic factor 6 | 0.089 | |
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.088 | |
| Elane | elastase, neutrophil expressed | 0.088 | |
| Mcpt2 | mast cell protease 2 | 0.087 | |
| Prss2 | protease, serine, 2 | 0.085 | |
| Cma2 | chymase 2, mast cell | 0.085 | |
| Cd3d | CD3 antigen, delta polypeptide | 0.082 | |
| Sprr2h | small proline-rich protein 2H | 0.082 | |
| Cd2 | CD2 antigen | 0.080 | |
| Mcpt8 | mast cell protease 8 | 0.080 | |
| Pgk2 | phosphoglycerate kinase 2 | 0.080 | |
| Ccl1 | chemokine (C-C motif) ligand 1 | 0.079 | |
| Gzmk | granzyme K | 0.078 | |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.075 | |
| Enam | enamelin | 0.070 | |
| S100a9 | S100 calcium binding protein A9 (calgranulin B) | 0.070 | |
| Mup4 | major urinary protein 4 | 0.068 | |
| Prg2 | proteoglycan 2, bone marrow | 0.064 | |
| Prol1 | proline rich, lacrimal 1 | 0.064 | |
| Gbp1 | guanylate binding protein 1 | 0.064 | |
| Klra7 | killer cell lectin-like receptor, subfamily A, member 7 | 0.062 | |
| Ccl8 | chemokine (C-C motif) ligand 8 | 0.056 | |
| Cd3g | CD3 antigen, gamma polypeptide | 0.056 | |
| Tg | thyroglobulin | 0.056 | |
| Ccl24 | chemokine (C-C motif) ligand 24 | 0.056 | |
| Akap4 | A kinase (PRKA) anchor protein 4 | 0.055 | |
| Mmp8 | matrix metallopeptidase 8 | 0.055 | |
| Klrb1a | killer cell lectin-like receptor subfamily B member 1A | 0.052 | |
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.052 | |
| Ms4a2 | membrane-spanning 4-domains, subfamily A, member 2 | 0.052 | |
| Rhag | Rhesus blood group-associated A glycoprotein | 0.051 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.050 | |
| Rfpl4 | ret finger protein-like 4 | 0.049 | |
| Prl3d1 | prolactin family 3, subfamily d, member 1 | 0.049 | |
| Try5 | trypsin 5 | 0.048 | |
| Tnfsf8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.048 | |
| Lcn4 | lipocalin 4 | 0.048 | |
| Rragc | Ras-related GTP binding C | 0.047 | |
| Tssk2 | testis-specific serine kinase 2 | 0.046 | |
| F2rl2 | coagulation factor II (thrombin) receptor-like 2 | 0.046 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.946 | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.808 | |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.549 | |
| CTSA | cathepsin A | 0.413 | |
| ITM2B | integral membrane protein 2B | 0.113 | |
| GBA | glucosidase, beta, acid | 0.089 | |
| GNS | glucosamine (N-acetyl)-6-sulfatase | 0.060 | |
| YPEL5 | yippee-like 5 (Drosophila) | 0.034 | |
| TMEM11 | transmembrane protein 11 | 0.030 | |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.030 | |
| NCSTN | nicastrin | 0.027 | |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.026 | |
| RNF13 | ring finger protein 13 | 0.022 | |
| HEXB | hexosaminidase B (beta polypeptide) | 0.020 | |
| LEPROT | leptin receptor overlapping transcript | 0.020 | |
| OPA1 | optic atrophy 1 (autosomal dominant) | 0.019 | |
| VCAN | versican | 0.018 | |
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.014 | |
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | 0.013 | |
| SDCBP | syndecan binding protein (syntenin) | 0.012 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.011 | |
| PRF1 | perforin 1 (pore forming protein) | 0.011 |