The network for 'negative regulation of striated muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of striated muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.

Danio rerio
Name Description Probability Func Analog Organism
bmp4 bone morphogenetic protein 4 0.957
bmp2b bone morphogenetic protein 2b 0.481
bmp2a bone morphogenetic protein 2a 0.314
hoxc8a homeo box C8a 0.170
msxc muscle segment homeobox C 0.118
has2 hyaluronan synthase 2 0.109
nkx3.2 NK3 homeobox 2 0.107
dlx3b distal-less homeobox gene 3b 0.081
tbx2a T-box gene 2a 0.075
tgfb3 transforming growth factor, beta 3 0.075
wnt5b wingless-type MMTV integration site family, member 5b 0.074
hoxc6a homeo box C6a 0.066
lama4 laminin, alpha 4 0.066
tbx20 T-box 20 0.065
osr1 odd-skipped related 1 (Drosophila) 0.062
ephb4a eph receptor B4a 0.061
dlx5a distal-less homeobox gene 5a 0.052
efnb2a ephrin B2a 0.051
gata6 GATA-binding protein 6 0.049
hoxb1b homeo box B1b 0.049
ved ventrally expressed dharma/bozozok antagonist 0.049
desma desmin a 0.048
prdm1a PR domain containing 1a, with ZNF domain 0.044
chd chordin 0.043
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.043
fgf24 fibroblast growth factor 24 0.042
nrp1a neuropilin 1a 0.036
hhex hematopoietically expressed homeobox 0.036
six4b sine oculis homeobox homolog 4b 0.036
cdh2 cadherin 2, neuronal 0.033
mtp microsomal triglyceride transfer protein 0.033
pea3 ETS-domain transcription factor pea3 0.028
rad21 RAD21 homolog (S. pombe) 0.028
foxa3 forkhead box A3 0.027
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.026
antxr1 anthrax toxin receptor 1 0.026
dlx4b distal-less homeobox gene 4b 0.025
dlx4a distal-less homeobox gene 4a 0.025
sp7 Sp7 transcription factor 0.025
sox9a SRY-box containing gene 9a 0.024
tfec transcription factor EC 0.024
msxd muscle segment homeobox D 0.023
gata2a GATA-binding protein 2a 0.022
hoxc4a homeo box C4a 0.022
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.022
esama endothelial cell adhesion molecule a 0.020
wnt9a wingless-type MMTV integration site family, member 9A 0.020
tbx18 T-box 18 0.020
fgf3 fibroblast growth factor 3 0.020
itga3b integrin, alpha 3b 0.020
fgf10a fibroblast growth factor 10a 0.020
cdh5 cadherin 5 0.019
skia nuclear oncoprotein skia 0.019
tbx2b T-box 2b 0.018
tbx16 T-box gene 16 0.018
mef2a myocyte enhancer factor 2a 0.016
rx1 retinal homeobox gene 1 0.016
otx1a orthodenticle homolog 1a 0.015
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.015
rps3 ribosomal protein S3 0.015
vasp vasodilator-stimulated phosphoprotein 0.014
zgc:111821 zgc:111821 0.014
tp63 tumor protein p63 0.014
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.014
brd2a bromodomain-containing 2a 0.014
si:ch211-215h6.2 si:ch211-215h6.2 0.014
gli2b GLI-Kruppel family member GLI2b 0.014
rarga retinoic acid receptor gamma a 0.013
pdgfaa platelet-derived growth factor alpha a 0.013
nog3 noggin 3 0.013
cxcr4a chemokine (C-X-C motif) receptor 4a 0.013
zgc:85975 zgc:85975 0.013
six4a sine oculis homeobox homolog 4a 0.013
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.013
p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 0.013
foxi1 forkhead box I1 0.013
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.013
bmper BMP binding endothelial regulator 0.013
tpbgl trophoblast glycoprotein-like 0.013
lmo4a LIM domain only 4a 0.013
LOC100332039 ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like 0.012
vsx2 visual system homeobox 2 0.012
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.012
fn1 fibronectin 1 0.012
hoxc6b homeo box C6b 0.012
klf2a Kruppel-like factor 2a 0.012
frem3 Fras1 related extracellular matrix 3 0.012
hoxa11a homeo box A11a 0.012
tcf21 transcription factor 21 0.012
efnb3b ephrin B3b 0.012
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.011
mnx1 motor neuron and pancreas homeobox 1 0.011
tead3a TEA domain family member 3 a 0.011
per2 period homolog 2 (Drosophila) 0.011
arl4ab ADP-ribosylation factor-like 4ab 0.011
igf1rb insulin-like growth factor 1b receptor 0.011
fli1a friend leukemia integration 1a 0.011
dhrs3b dehydrogenase/reductase (SDR family) member 3b 0.011
jhdm1da jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae) 0.011
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 1.000
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.999
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.998
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.964
HDAC4 histone deacetylase 4 0.854
BMPR1A bone morphogenetic protein receptor, type IA 0.768
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.593
TBX5 T-box 5 0.561
MEF2C myocyte enhancer factor 2C 0.487
PSG4 pregnancy specific beta-1-glycoprotein 4 0.382
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.282
JAG1 jagged 1 0.218
PSG9 pregnancy specific beta-1-glycoprotein 9 0.217
PRKD2 protein kinase D2 0.200
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.166
PSG6 pregnancy specific beta-1-glycoprotein 6 0.152
FAS Fas (TNF receptor superfamily, member 6) 0.143
PSG5 pregnancy specific beta-1-glycoprotein 5 0.132
PML promyelocytic leukemia 0.132
PSG3 pregnancy specific beta-1-glycoprotein 3 0.125
MEF2A myocyte enhancer factor 2A 0.099
FSTL1 follistatin-like 1 0.079
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.077
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.075
BCL6 B-cell CLL/lymphoma 6 0.069
PSG1 pregnancy specific beta-1-glycoprotein 1 0.062
NOTCH3 notch 3 0.050
XIAP X-linked inhibitor of apoptosis 0.040
FADD Fas (TNFRSF6)-associated via death domain 0.037
PAX8 paired box 8 0.033
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.032
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.031
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.026
CXCL11 chemokine (C-X-C motif) ligand 11 0.025
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.020
HDAC7 histone deacetylase 7 0.020
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.020
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.019
FOXP3 forkhead box P3 0.019
LRP6 low density lipoprotein receptor-related protein 6 0.018
FASLG Fas ligand (TNF superfamily, member 6) 0.018
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.018
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.017
MAML1 mastermind-like 1 (Drosophila) 0.016
GATA4 GATA binding protein 4 0.016
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.016
EED embryonic ectoderm development 0.014
PSG2 pregnancy specific beta-1-glycoprotein 2 0.013
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.013
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.012
NOG noggin 0.012
EWSR1 Ewing sarcoma breakpoint region 1 0.012
NCOR2 nuclear receptor corepressor 2 0.011
MSX2 msh homeobox 2 0.010
CARTPT CART prepropeptide 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Mef2d myocyte enhancer factor 2D 0.874
Prrx1 paired related homeobox 1 0.834
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.722
Runx2 runt related transcription factor 2 0.713
Pitx2 paired-like homeodomain transcription factor 2 0.698
Jarid2 jumonji, AT rich interactive domain 2 0.669
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.622
Msx1 homeobox, msh-like 1 0.617
Psen1 presenilin 1 0.547
Dll1 delta-like 1 (Drosophila) 0.541
Foxc1 forkhead box C1 0.517
Hand2 heart and neural crest derivatives expressed transcript 2 0.483
Hand1 heart and neural crest derivatives expressed transcript 1 0.466
Gja1 gap junction protein, alpha 1 0.383
Jag1 jagged 1 0.373
Tcfap2a transcription factor AP-2, alpha 0.365
Shh sonic hedgehog 0.332
Tgfb2 transforming growth factor, beta 2 0.329
Pax3 paired box gene 3 0.315
Tbx1 T-box 1 0.310
Notch1 Notch gene homolog 1 (Drosophila) 0.300
Eed embryonic ectoderm development 0.268
Bmp7 bone morphogenetic protein 7 0.240
Stk38 serine/threonine kinase 38 0.234
Rbbp4 retinoblastoma binding protein 4 0.229
Prrx2 paired related homeobox 2 0.208
Lrp6 low density lipoprotein receptor-related protein 6 0.172
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.170
Dlx5 distal-less homeobox 5 0.154
Pax9 paired box gene 9 0.146
Alx4 aristaless-like homeobox 4 0.133
Ednra endothelin receptor type A 0.132
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.131
Cxcl1 chemokine (C-X-C motif) ligand 1 0.111
Ptch1 patched homolog 1 0.111
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 0.110
Sp6 trans-acting transcription factor 6 0.102
Ccl7 chemokine (C-C motif) ligand 7 0.095
Fgfr2 fibroblast growth factor receptor 2 0.095
Il1rn interleukin 1 receptor antagonist 0.091
Notch2 Notch gene homolog 2 (Drosophila) 0.088
Bmp4 bone morphogenetic protein 4 0.088
Sox9 SRY-box containing gene 9 0.085
Cxcl2 chemokine (C-X-C motif) ligand 2 0.082
Mtf2 metal response element binding transcription factor 2 0.081
Fgfr1 fibroblast growth factor receptor 1 0.078
Ctnnb1 catenin (cadherin associated protein), beta 1 0.077
Hdac4 histone deacetylase 4 0.077
Ceacam2 carcinoembryonic antigen-related cell adhesion molecule 2 0.075
Lef1 lymphoid enhancer binding factor 1 0.073
Otx2 orthodenticle homolog 2 (Drosophila) 0.069
Fgf8 fibroblast growth factor 8 0.068
Smo smoothened homolog (Drosophila) 0.066
Psen2 presenilin 2 0.063
Alx1 ALX homeobox 1 0.063
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.060
Aebp2 AE binding protein 2 0.059
Msx2 homeobox, msh-like 2 0.059
Tbx15 T-box 15 0.056
Foxg1 forkhead box G1 0.053
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.047
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.046
Ccl2 chemokine (C-C motif) ligand 2 0.044
Mmp3 matrix metallopeptidase 3 0.043
Chd7 chromodomain helicase DNA binding protein 7 0.041
Ier3 immediate early response 3 0.040
Eya1 eyes absent 1 homolog (Drosophila) 0.040
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.040
En1 engrailed 1 0.039
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.039
Egfr epidermal growth factor receptor 0.035
Gli3 GLI-Kruppel family member GLI3 0.035
Heyl hairy/enhancer-of-split related with YRPW motif-like 0.034
Irg1 immunoresponsive gene 1 0.033
Axin1 axin 1 0.032
Il1b interleukin 1 beta 0.031
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 0.031
Egfl7 EGF-like domain 7 0.030
Gsc goosecoid homeobox 0.030
Saa3 serum amyloid A 3 0.030
Bmp2 bone morphogenetic protein 2 0.029
Jag2 jagged 2 0.028
Zeb1 zinc finger E-box binding homeobox 1 0.027
Mef2c myocyte enhancer factor 2C 0.026
Tbx5 T-box 5 0.026
Foxc2 forkhead box C2 0.025
Atf3 activating transcription factor 3 0.024
Hes1 hairy and enhancer of split 1 (Drosophila) 0.024
Ccl12 chemokine (C-C motif) ligand 12 0.023
Cxcl5 chemokine (C-X-C motif) ligand 5 0.023
Clec4d C-type lectin domain family 4, member d 0.023
Tbx20 T-box 20 0.023
Tbx3 T-box 3 0.022
Dll4 delta-like 4 (Drosophila) 0.022
Irx4 Iroquois related homeobox 4 (Drosophila) 0.021
Ncor2 nuclear receptor co-repressor 2 0.021
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.021
Niacr1 niacin receptor 1 0.021
Il6 interleukin 6 0.020
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ctsa cathepsin A 0.018
Rps5 ribosomal protein S5 0.016
Pfn1 profilin 1 0.015
LOC499782 similar to 60S ribosomal protein L12 0.012
Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism