Danio rerio

190 known processes

bmp4

bone morphogenetic protein 4

(Aliases: zgc:100779,bmp-4,zbmp-4,MGC100779)

bmp4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
pathway restricted smad protein phosphorylation GO:0060389 1 1.000
Human
determination of dorsal ventral asymmetry GO:0048262 34 1.000
bmp signaling pathway involved in heart jogging GO:0003303 14 0.999
heart jogging GO:0003146 40 0.999
ear morphogenesis GO:0042471 64 0.999
Zebrafish
embryonic organ development GO:0048568 381 0.998
heart field specification GO:0003128 1 0.998
Human
mesodermal cell differentiation GO:0048333 21 0.998
digestive tract development GO:0048565 265 0.998
sensory organ morphogenesis GO:0090596 200 0.998
Zebrafish Mouse Rat Fly
digestive system development GO:0055123 289 0.997
digestive tract morphogenesis GO:0048546 231 0.997
cardiac muscle cell differentiation GO:0055007 30 0.997
Human Zebrafish
regulation of organ morphogenesis GO:2000027 35 0.996
Human Mouse Rat
regulation of multicellular organismal development GO:2000026 223 0.996
appendage morphogenesis GO:0035107 56 0.996
cellular biosynthetic process GO:0044249 286 0.996
inner ear development GO:0048839 126 0.996
Zebrafish Mouse
eye morphogenesis GO:0048592 144 0.996
Mouse Fly
heart development GO:0007507 313 0.996
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.996
regulation of nitrogen compound metabolic process GO:0051171 251 0.995
stem cell maintenance GO:0019827 4 0.995
Fly
otic vesicle morphogenesis GO:0071600 34 0.994
ventricular cardiac muscle cell differentiation GO:0055012 6 0.994
Zebrafish
cellular aromatic compound metabolic process GO:0006725 295 0.994
pituitary gland development GO:0021983 16 0.994
Mouse
anterior posterior pattern specification GO:0009952 152 0.992
Human Mouse Fly
single organism localization GO:1902578 225 0.992
Human Rat
camera type eye morphogenesis GO:0048593 108 0.991
Mouse
cardiac cell development GO:0055006 21 0.991
Human Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.989
kupffer s vesicle development GO:0070121 50 0.989
mesendoderm development GO:0048382 10 0.988
embryonic pattern specification GO:0009880 44 0.987
Fly
germ line stem cell division GO:0042078 1 0.987
Fly
regulation of endothelial cell proliferation GO:0001936 1 0.986
Human Mouse
inner ear morphogenesis GO:0042472 63 0.986
Zebrafish
regulation of biomineral tissue development GO:0070167 2 0.986
Human Rat
diencephalon development GO:0021536 58 0.986
Mouse
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.986
bmp signaling pathway involved in heart development GO:0061312 15 0.984
appendage development GO:0048736 80 0.984
muscle cell differentiation GO:0042692 139 0.984
Human Zebrafish Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.984
immune system development GO:0002520 191 0.983
locomotion GO:0040011 313 0.983
Human Zebrafish Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.982
fin morphogenesis GO:0033334 53 0.982
mesoderm development GO:0007498 88 0.982
positive regulation of muscle organ development GO:0048636 1 0.980
Human Fly
regulation of cellular metabolic process GO:0031323 320 0.980
cellular macromolecule metabolic process GO:0044260 391 0.980
regulation of epithelial cell proliferation GO:0050678 3 0.980
Human Mouse
pericardium development GO:0060039 1 0.980
photoreceptor cell differentiation GO:0046530 55 0.979
striated muscle cell differentiation GO:0051146 129 0.979
Human Zebrafish
regulation of cardiac muscle cell differentiation GO:2000725 1 0.978
Human
sensory organ development GO:0007423 393 0.977
Zebrafish Mouse Rat Fly
nucleic acid templated transcription GO:0097659 181 0.977
neuron fate commitment GO:0048663 26 0.975
Mouse
endocardial cushion development GO:0003197 6 0.974
macromolecule biosynthetic process GO:0009059 227 0.970
determination of bilateral symmetry GO:0009855 204 0.969
determination of left right symmetry GO:0007368 179 0.968
semicircular canal formation GO:0060876 4 0.967
Zebrafish
cardiac muscle cell development GO:0055013 20 0.966
Human Zebrafish
biosynthetic process GO:0009058 294 0.966
dorsal convergence GO:0060030 14 0.966
Zebrafish
heart morphogenesis GO:0003007 156 0.966
regulation of bmp signaling pathway GO:0030510 39 0.965
Mouse
regulation of embryonic development GO:0045995 47 0.965
head development GO:0060322 303 0.964
Human Mouse Rat
regulation of transcription involved in cell fate commitment GO:0060850 1 0.964
regulation of nucleic acid templated transcription GO:1903506 213 0.962
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.961
Human
somitogenesis GO:0001756 87 0.961
proepicardium development GO:0003342 4 0.961
cardiac muscle tissue development GO:0048738 48 0.959
Human Zebrafish
mesoderm morphogenesis GO:0048332 51 0.959
negative regulation of striated muscle cell differentiation GO:0051154 1 0.957
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.957
specification of organ identity GO:0010092 2 0.956
Human Mouse
heart valve formation GO:0003188 4 0.953
regionalization GO:0003002 274 0.952
embryonic pectoral fin morphogenesis GO:0035118 24 0.951
determination of dorsal identity GO:0048263 13 0.950
nephron epithelium morphogenesis GO:0072088 1 0.949
Human Mouse Rat
response to growth factor GO:0070848 39 0.948
Mouse Rat
organic cyclic compound biosynthetic process GO:1901362 223 0.948
cellular component morphogenesis GO:0032989 336 0.948
Human Fly
otic placode formation GO:0043049 23 0.945
formation of primary germ layer GO:0001704 62 0.944
regulation of metabolic process GO:0019222 359 0.944
hair cell differentiation GO:0035315 32 0.943
otic vesicle formation GO:0030916 27 0.942
ameboidal type cell migration GO:0001667 143 0.940
Human Zebrafish Fly
negative regulation of cellular process GO:0048523 283 0.940
limb bud formation GO:0060174 2 0.939
embryonic skeletal system morphogenesis GO:0048704 93 0.938
Mouse
atrial ventricular junction remodeling GO:0003294 2 0.936
regulation of cell communication GO:0010646 232 0.935
Human Mouse Rat
cell migration GO:0016477 237 0.933
Human Zebrafish Fly
cell fate specification GO:0001708 68 0.932
cell projection organization GO:0030030 284 0.932
Rat
endocardial cushion formation GO:0003272 2 0.930
endoderm development GO:0007492 49 0.930
heart looping GO:0001947 94 0.930
regulation of transcription dna templated GO:0006355 213 0.929
anal fin morphogenesis GO:0035144 1 0.925
regulation of multicellular organismal process GO:0051239 277 0.925
endocardial cushion morphogenesis GO:0003203 3 0.923
regulation of macromolecule biosynthetic process GO:0010556 225 0.922
regulation of signaling GO:0023051 235 0.922
Human Mouse Rat
otolith development GO:0048840 32 0.917
morphogenesis of an epithelial fold GO:0060571 1 0.915
Mouse
epithelial cell morphogenesis GO:0003382 2 0.914
Human
protein localization to nucleus GO:0034504 3 0.906
Human
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.906
embryonic appendage morphogenesis GO:0035113 30 0.905
positive regulation of striated muscle tissue development GO:0045844 1 0.903
Human
positive regulation of endothelial cell proliferation GO:0001938 1 0.903
Human Mouse
p38mapk cascade GO:0038066 1 0.902
regulation of response to stimulus GO:0048583 269 0.900
Human Mouse Rat
regulation of heart morphogenesis GO:2000826 17 0.899
Human
endodermal cell fate specification GO:0001714 17 0.898
regulation of bone mineralization GO:0030500 2 0.898
Human Rat
regulation of rna metabolic process GO:0051252 224 0.897
atrioventricular valve morphogenesis GO:0003181 6 0.897
negative regulation of muscle cell differentiation GO:0051148 1 0.896
Human
semicircular canal development GO:0060872 24 0.895
Zebrafish
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016338 1 0.894
atrioventricular valve formation GO:0003190 3 0.894
head morphogenesis GO:0060323 8 0.889
enzyme linked receptor protein signaling pathway GO:0007167 106 0.888
somatic stem cell maintenance GO:0035019 1 0.888
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.888
convergent extension involved in gastrulation GO:0060027 71 0.886
Zebrafish
regulation of primary metabolic process GO:0080090 311 0.886
epithalamus development GO:0021538 10 0.885
mesenchyme development GO:0060485 127 0.884
regulation of muscle organ development GO:0048634 9 0.881
Human Fly
phosphate containing compound metabolic process GO:0006796 108 0.881
Human Mouse Rat
organ formation GO:0048645 17 0.880
Human Mouse
embryonic anal fin morphogenesis GO:0035125 1 0.879
localization of cell GO:0051674 244 0.877
Human Zebrafish Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.877
rhombomere development GO:0021546 19 0.875
regulation of wnt signaling pathway GO:0030111 53 0.875
odontogenesis of dentin containing tooth GO:0042475 1 0.870
Mouse
negative regulation of muscle tissue development GO:1901862 2 0.867
Human
pericardium morphogenesis GO:0003344 1 0.867
embryonic limb morphogenesis GO:0030326 2 0.865
Mouse
photoreceptor cell development GO:0042461 40 0.863
tube morphogenesis GO:0035239 349 0.862
mesodermal cell fate commitment GO:0001710 14 0.859
heterocycle biosynthetic process GO:0018130 215 0.858
negative regulation of cardiac muscle cell differentiation GO:2000726 1 0.856
somite development GO:0061053 96 0.853
embryonic camera type eye development GO:0031076 29 0.851
muscle structure development GO:0061061 196 0.849
Human Zebrafish Mouse Fly
cell projection morphogenesis GO:0048858 244 0.846
nephron development GO:0072006 31 0.845
Human Mouse Rat
gastrulation with mouth forming second GO:0001702 44 0.843
brain development GO:0007420 293 0.842
Human Mouse Rat
nitrogen compound metabolic process GO:0006807 319 0.840
cell migration involved in gastrulation GO:0042074 79 0.839
Zebrafish
positive regulation of gene expression GO:0010628 71 0.839
Human Mouse Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.837
Human Mouse Rat
semicircular canal morphogenesis GO:0048752 18 0.837
Zebrafish
eye photoreceptor cell development GO:0042462 30 0.833
heterocycle metabolic process GO:0046483 290 0.832
skeletal system development GO:0001501 181 0.831
Human Mouse
embryonic camera type eye formation GO:0060900 10 0.822
endocrine system development GO:0035270 65 0.821
Human Mouse
determination of heart left right asymmetry GO:0061371 117 0.819
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.817
Human Fly
cell morphogenesis GO:0000902 289 0.817
Human
nephric duct development GO:0072176 13 0.817
Human
muscle tissue development GO:0060537 110 0.814
Human Zebrafish Mouse
multi organism reproductive process GO:0044703 36 0.811
Mouse Fly
transcription from rna polymerase ii promoter GO:0006366 80 0.811
morphogenesis of a branching epithelium GO:0061138 16 0.811
Human Mouse Rat
kidney epithelium development GO:0072073 23 0.811
Human Mouse Rat
cerebellum formation GO:0021588 2 0.810
pharyngeal muscle development GO:0043282 4 0.808
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.807
otic vesicle development GO:0071599 42 0.806
single organism cell adhesion GO:0098602 29 0.804
ectodermal placode formation GO:0060788 26 0.803
cell motility GO:0048870 244 0.802
Human Zebrafish Fly
regulation of stem cell differentiation GO:2000736 4 0.802
organic substance biosynthetic process GO:1901576 289 0.800
negative regulation of biological process GO:0048519 304 0.800
positive regulation of stem cell proliferation GO:2000648 1 0.800
Rat
bmp signaling pathway GO:0030509 52 0.798
taxis GO:0042330 109 0.798
Human Fly
muscle organ morphogenesis GO:0048644 8 0.794
pectoral fin development GO:0033339 50 0.794
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.793
Human Mouse
response to organic substance GO:0010033 153 0.792
Human Mouse Rat
eye development GO:0001654 277 0.791
Mouse Rat Fly
negative regulation of muscle organ development GO:0048635 5 0.786
Human
skeletal system morphogenesis GO:0048705 102 0.781
Mouse
intermediate mesoderm development GO:0048389 2 0.780
Human
protein destabilization GO:0031648 1 0.780
regulation of cell differentiation GO:0045595 142 0.780
cardiac muscle tissue morphogenesis GO:0055008 7 0.779
epithelial cell proliferation GO:0050673 17 0.779
Human Mouse
medial fin morphogenesis GO:0035141 14 0.776
photoreceptor cell fate commitment GO:0046552 1 0.776
kidney development GO:0001822 92 0.775
positive regulation of skeletal muscle tissue development GO:0048643 1 0.775
retina morphogenesis in camera type eye GO:0060042 79 0.775
single organism reproductive process GO:0044702 40 0.774
Mouse Rat Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.773
dorsal ventral pattern formation GO:0009953 125 0.768
renal system development GO:0072001 94 0.768
regulation of anatomical structure morphogenesis GO:0022603 130 0.768
mesenchymal cell differentiation GO:0048762 87 0.767
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.763
Human Mouse Rat
glucocorticoid metabolic process GO:0008211 2 0.762
ventricular cardiac muscle cell development GO:0055015 5 0.760
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.760
Human Mouse Rat
nucleobase containing compound biosynthetic process GO:0034654 205 0.756
nephron epithelium development GO:0072009 16 0.754
Human Mouse Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.754
regulation of cardiac muscle tissue development GO:0055024 1 0.754
Human
regulation of cell division GO:0051302 12 0.750
Human
organic cyclic compound metabolic process GO:1901360 301 0.748
gastrulation GO:0007369 208 0.748
rhombomere 5 development GO:0021571 4 0.745
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.741
sensory system development GO:0048880 76 0.737
embryonic heart tube morphogenesis GO:0003143 108 0.736
epidermal cell differentiation GO:0009913 36 0.735
Human
embryonic hemopoiesis GO:0035162 53 0.734
mesenchymal cell proliferation GO:0010463 1 0.733
Human Mouse
optic placode formation involved in camera type eye formation GO:0046619 3 0.732
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.729
cardiocyte differentiation GO:0035051 44 0.728
Human Zebrafish Fly
mesodermal cell fate specification GO:0007501 12 0.726
regulation of mesodermal cell fate specification GO:0042661 9 0.724
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.722
protein modification process GO:0036211 100 0.720
Human Mouse
heart valve morphogenesis GO:0003179 8 0.719
endodermal cell differentiation GO:0035987 19 0.717
glomerulus vasculature development GO:0072012 2 0.712
Human Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.711
Human Mouse
tissue remodeling GO:0048771 4 0.709
regulation of chemotaxis GO:0050920 18 0.708
positive regulation of biosynthetic process GO:0009891 68 0.705
Human Mouse Rat
nephron tubule morphogenesis GO:0072078 1 0.705
Human Mouse Rat
positive regulation of epithelial cell proliferation GO:0050679 1 0.703
Human Mouse
regulation of developmental process GO:0050793 247 0.698
negative regulation of cardiac muscle tissue development GO:0055026 1 0.695
regulation of p38mapk cascade GO:1900744 1 0.694
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.694
pronephros development GO:0048793 69 0.694
fin development GO:0033333 77 0.692
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.690
negative regulation of bmp signaling pathway GO:0030514 13 0.690
negative regulation of endodermal cell differentiation GO:1903225 8 0.689
regeneration GO:0031099 91 0.687
apoptotic process involved in morphogenesis GO:0060561 2 0.686
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.686
Mouse
rostrocaudal neural tube patterning GO:0021903 29 0.675
embryonic skeletal joint development GO:0072498 3 0.673
Mouse
regulation of signal transduction GO:0009966 225 0.667
Human Mouse Rat
intestinal epithelial cell differentiation GO:0060575 3 0.666
ear development GO:0043583 127 0.658
Zebrafish Mouse
adenohypophysis development GO:0021984 15 0.650
cardiac conduction system development GO:0003161 1 0.650
bone development GO:0060348 14 0.649
Mouse
hematopoietic or lymphoid organ development GO:0048534 191 0.649
regulation of cell fate specification GO:0042659 20 0.648
regulation of epithelial to mesenchymal transition GO:0010717 3 0.646
mesenchyme morphogenesis GO:0072132 5 0.645
neural crest cell differentiation GO:0014033 72 0.643
regulation of canonical wnt signaling pathway GO:0060828 34 0.642
negative regulation of striated muscle tissue development GO:0045843 2 0.642
Human
single organism nuclear import GO:1902593 3 0.639
Human
regulation of endodermal cell differentiation GO:1903224 15 0.638
protein targeting to nucleus GO:0044744 3 0.638
Human
nephron morphogenesis GO:0072028 2 0.635
Human Mouse Rat
regulation of gene expression GO:0010468 265 0.633
segmentation GO:0035282 97 0.630
Mouse
axis elongation GO:0003401 31 0.625
Human Mouse
ectoderm development GO:0007398 9 0.621
positive regulation of metabolic process GO:0009893 108 0.618
Human Mouse Rat
regulation of mesenchymal cell proliferation GO:0010464 1 0.610
Human
heart formation GO:0060914 13 0.603
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.602
cell part morphogenesis GO:0032990 246 0.602
notochord cell differentiation GO:0060034 18 0.601
cellular response to lipopolysaccharide GO:0071222 3 0.599
death GO:0016265 121 0.598
Human Mouse Rat
atrioventricular valve development GO:0003171 11 0.595
c21 steroid hormone biosynthetic process GO:0006700 1 0.594
meiotic nuclear division GO:0007126 4 0.593
specification of organ position GO:0010159 3 0.591
Mouse
auditory receptor cell differentiation GO:0042491 15 0.589
embryonic eye morphogenesis GO:0048048 30 0.580
regulation of mesoderm development GO:2000380 11 0.579
morphogenesis of an epithelium GO:0002009 333 0.573
embryonic organ morphogenesis GO:0048562 274 0.568
apoptotic process GO:0006915 116 0.562
Human Mouse Rat
germ line stem cell maintenance GO:0030718 2 0.561
Fly
cell death GO:0008219 121 0.560
Human Mouse Rat
embryonic camera type eye morphogenesis GO:0048596 19 0.558
mesoderm formation GO:0001707 43 0.554
heart valve development GO:0003170 14 0.551
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.548
camera type eye development GO:0043010 222 0.545
Mouse Rat
regulation of cellular protein metabolic process GO:0032268 52 0.543
Human Mouse
forebrain regionalization GO:0021871 4 0.540
Mouse
forebrain development GO:0030900 96 0.540
Human Mouse
multicellular organism reproduction GO:0032504 35 0.539
Mouse Rat Fly
embryonic heart tube development GO:0035050 133 0.539
generation of neurons GO:0048699 385 0.538
Mouse Rat
neural crest cell development GO:0014032 62 0.533
cellular response to organic substance GO:0071310 105 0.533
Human Mouse Rat
inner ear receptor cell differentiation GO:0060113 29 0.532
Mouse
regulation of alcohol biosynthetic process GO:1902930 1 0.531
vasculature development GO:0001944 278 0.528
Human Mouse
bone morphogenesis GO:0060349 11 0.524
Mouse
negative regulation of signaling GO:0023057 96 0.523
Human
nucleocytoplasmic transport GO:0006913 4 0.522
Human
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.518
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.518
Human Mouse Rat
negative regulation of cell communication GO:0010648 96 0.517
Human
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.516
cortisol biosynthetic process GO:0034651 1 0.510
response to stress GO:0006950 263 0.509
Rat
specification of symmetry GO:0009799 204 0.509
cell surface receptor signaling pathway GO:0007166 325 0.503
protein metabolic process GO:0019538 183 0.498
Human Mouse
retina development in camera type eye GO:0060041 146 0.496
Rat
protein import into nucleus GO:0006606 3 0.496
Human
regulation of localization GO:0032879 104 0.495
Human Rat
tissue migration GO:0090130 37 0.493
Human Fly
regulation of biosynthetic process GO:0009889 250 0.492
cellular response to growth factor stimulus GO:0071363 39 0.483
Mouse Rat
regulation of endodermal cell fate specification GO:0042663 15 0.482
neuron fate specification GO:0048665 20 0.482
pronephros morphogenesis GO:0072114 14 0.481
single organism transport GO:0044765 206 0.473
Human Rat
larval development GO:0002164 2 0.472
Fly
muscle cell fate determination GO:0007521 1 0.471
cell proliferation involved in heart morphogenesis GO:0061323 2 0.470
Human
signal transduction GO:0007165 455 0.469
biomineral tissue development GO:0031214 13 0.469
Human Rat
stem cell differentiation GO:0048863 117 0.464
Mouse Fly
regulation of notch signaling pathway GO:0008593 16 0.461
rna biosynthetic process GO:0032774 181 0.460
dorsal ventral axis specification GO:0009950 14 0.460
Zebrafish Fly
nucleic acid metabolic process GO:0090304 244 0.460
eye photoreceptor cell differentiation GO:0001754 45 0.458
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.452
embryonic neurocranium morphogenesis GO:0048702 15 0.449
wnt signaling pathway GO:0016055 80 0.449
cellular protein metabolic process GO:0044267 129 0.447
Human Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.443
Human
regulation of muscle tissue development GO:1901861 6 0.442
Human
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.440
regulation of protein localization to nucleus GO:1900180 2 0.438
Human
regulation of binding GO:0051098 3 0.438
Human
notochord development GO:0030903 54 0.438
gamete generation GO:0007276 33 0.437
Mouse Fly
negative regulation of cell fate commitment GO:0010454 13 0.435
determination of left right asymmetry in nervous system GO:0035545 4 0.433
cellular localization GO:0051641 97 0.431
Human Rat
cellular protein modification process GO:0006464 100 0.429
Human Mouse
body morphogenesis GO:0010171 16 0.428
branching morphogenesis of an epithelial tube GO:0048754 15 0.424
Human Mouse Rat
reproduction GO:0000003 40 0.419
Mouse Rat Fly
striated muscle tissue development GO:0014706 110 0.419
Human Zebrafish
establishment of protein localization to organelle GO:0072594 4 0.418
Human
pectoral fin morphogenesis GO:0035138 29 0.417
retinal cone cell development GO:0046549 8 0.416
fin regeneration GO:0031101 51 0.415
cartilage development GO:0051216 96 0.413
Human Mouse
apoptotic process involved in development GO:1902742 2 0.413
embryo development ending in birth or egg hatching GO:0009792 271 0.410
Mouse Fly
tongue development GO:0043586 3 0.410
Rat
ectodermal placode morphogenesis GO:0071697 32 0.408
bone mineralization GO:0030282 9 0.407
Human Rat
transcription dna templated GO:0006351 181 0.406
positive regulation of biological process GO:0048518 253 0.402
cardiac atrium morphogenesis GO:0003209 2 0.401
central nervous system development GO:0007417 387 0.398
Human Mouse Rat
negative regulation of wnt signaling pathway GO:0030178 30 0.398
gene expression GO:0010467 252 0.394
positive regulation of muscle tissue development GO:1901863 1 0.393
Human
face development GO:0060324 8 0.387
positive regulation of muscle cell differentiation GO:0051149 1 0.385
Human
outflow tract morphogenesis GO:0003151 1 0.384
regulation of protein transport GO:0051223 3 0.380
Human
regulation of cell motility GO:2000145 46 0.380
Human
cellular component maintenance GO:0043954 3 0.380
post anal tail morphogenesis GO:0036342 19 0.380
neuron development GO:0048666 262 0.376
Rat
cellular component movement GO:0006928 335 0.372
Human Zebrafish Fly
blood vessel morphogenesis GO:0048514 216 0.366
Human Mouse
limb morphogenesis GO:0035108 7 0.366
Mouse
cellular response to nutrient levels GO:0031669 2 0.366
blood vessel development GO:0001568 246 0.364
Human Mouse
endothelial cell proliferation GO:0001935 11 0.364
Human Mouse
wound healing GO:0042060 90 0.362
Rat
neural tube patterning GO:0021532 33 0.361
Mouse
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.361
myeloid cell differentiation GO:0030099 86 0.358
Human Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.352
Human
pharyngeal system development GO:0060037 18 0.352
gliogenesis GO:0042063 45 0.351
Rat
developmental induction GO:0031128 10 0.349
Human Mouse
regulation of rna biosynthetic process GO:2001141 213 0.348
positive regulation of response to stimulus GO:0048584 80 0.347
Human Mouse
cellular component biogenesis GO:0044085 178 0.346
Zebrafish
renal tubule morphogenesis GO:0061333 1 0.344
Human Mouse Rat Fly
sequestering of calcium ion GO:0051208 3 0.343
palate development GO:0060021 8 0.342
response to chemical GO:0042221 320 0.342
Human Mouse Rat Fly
regulation of cell migration GO:0030334 40 0.342
Human
cardioblast migration to the midline involved in heart rudiment formation GO:0003319 5 0.339
mechanoreceptor differentiation GO:0042490 37 0.336
Mouse
regulation of establishment of protein localization GO:0070201 4 0.334
Human
regulation of organ growth GO:0046620 3 0.333
Fly
positive regulation of cell proliferation GO:0008284 15 0.328
regulation of heart growth GO:0060420 2 0.327
cortisol metabolic process GO:0034650 2 0.325
cloaca development GO:0035844 9 0.324
cell cell signaling involved in cell fate commitment GO:0045168 12 0.323
Human Zebrafish Mouse
negative regulation of signal transduction GO:0009968 94 0.321
Human
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.321
photoreceptor cell fate specification GO:0043704 1 0.320
nucleobase containing compound metabolic process GO:0006139 274 0.319
multi organism process GO:0051704 134 0.317
Mouse Fly
connective tissue development GO:0061448 99 0.316
Human Mouse
endodermal cell fate commitment GO:0001711 18 0.315
cellular component assembly GO:0022607 170 0.315
Zebrafish
axon guidance GO:0007411 86 0.314
epidermis development GO:0008544 48 0.313
Human
determination of pancreatic left right asymmetry GO:0035469 11 0.311
peripheral nervous system development GO:0007422 55 0.309
mesenchymal cell development GO:0014031 78 0.307
cartilage condensation GO:0001502 3 0.307
morphogenesis of a branching structure GO:0001763 21 0.300
Human Mouse Rat
glial cell migration GO:0008347 3 0.300
rna metabolic process GO:0016070 219 0.299
cytoskeleton organization GO:0007010 96 0.299
cellular response to chemical stimulus GO:0070887 157 0.298
Human Mouse Rat Fly
regulation of skeletal muscle tissue development GO:0048641 4 0.295
Human
mesodermal cell migration GO:0008078 12 0.291
regulation of cytoplasmic transport GO:1903649 4 0.290
Human Rat
striated muscle cell development GO:0055002 108 0.290
Human Zebrafish
nephric duct morphogenesis GO:0072178 7 0.286
Human
positive regulation of transport GO:0051050 2 0.286
Human Rat
macromolecular complex subunit organization GO:0043933 74 0.284
Zebrafish
bone remodeling GO:0046849 2 0.276
negative regulation of nucleic acid templated transcription GO:1903507 45 0.276
Human Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.272
negative regulation of response to stimulus GO:0048585 104 0.269
Human
kidney vasculature development GO:0061440 2 0.267
Human Mouse
septum transversum development GO:0003343 4 0.266
immune system process GO:0002376 241 0.266
morphogenesis of an epithelial sheet GO:0002011 49 0.266
protein import GO:0017038 3 0.263
Human
regulation of locomotion GO:0040012 55 0.263
Human
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 9 0.262
negative regulation of cellular biosynthetic process GO:0031327 55 0.261
Human Mouse
spemann organizer formation GO:0060061 10 0.260
regulation of phosphorus metabolic process GO:0051174 43 0.259
Human Mouse Rat
response to mechanical stimulus GO:0009612 24 0.258
Rat
patterning of blood vessels GO:0001569 15 0.252
regulation of striated muscle tissue development GO:0016202 6 0.248
Human
negative regulation of stem cell differentiation GO:2000737 2 0.245
hepaticobiliary system development GO:0061008 98 0.243
negative regulation of cell adhesion GO:0007162 6 0.240
rhombomere formation GO:0021594 12 0.239
defense response GO:0006952 47 0.239
regulation of protein metabolic process GO:0051246 56 0.238
Human Mouse
auditory receptor cell fate commitment GO:0009912 4 0.237
response to fibroblast growth factor GO:0071774 22 0.236
neural crest cell migration GO:0001755 42 0.235
anterior posterior axis specification GO:0009948 20 0.234
Mouse
oocyte axis specification GO:0007309 5 0.232
Fly
midbrain hindbrain boundary development GO:0030917 23 0.232
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.232
hepatocyte proliferation GO:0072574 2 0.231

bmp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.866
bone disease DOID:0080001 0 0.866
disease of anatomical entity DOID:7 0 0.866
Human
dysostosis DOID:1934 0 0.866
musculoskeletal system disease DOID:17 0 0.866
connective tissue disease DOID:65 0 0.866