IMP
Process View
The network for 'epidermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
epidermal cell fate specification
The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| eng2a | engrailed 2a | 0.943 | |
| foxi1 | forkhead box I1 | 0.934 | |
| dlc | deltaC | 0.902 | |
| ascl1a | achaete-scute complex-like 1a (Drosophila) | 0.901 | |
| sox19a | SRY-box containing gene 19a | 0.823 | |
| foxi3a | forkhead box I3a | 0.768 | |
| hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.697 | |
| foxa2 | forkhead box A2 | 0.673 | |
| nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.641 | |
| lhx5 | LIM homeobox 5 | 0.630 | |
| tfe3b | transcription factor binding to IGHM enhancer 3b | 0.627 | |
| foxc1a | forkhead box C1a | 0.562 | |
| dlx2a | distal-less homeobox gene 2a | 0.554 | |
| ascl1b | achaete-scute complex-like 1b (Drosophila) | 0.516 | |
| gata3 | GATA-binding protein 3 | 0.507 | |
| otx2 | orthodenticle homolog 2 | 0.503 | |
| hoxb2a | homeo box B2a | 0.496 | |
| otx1b | orthodenticle homolog 1b | 0.459 | |
| six4b | sine oculis homeobox homolog 4b | 0.445 | |
| flh | floating head | 0.422 | |
| nr2f5 | nuclear receptor subfamily 2, group F, member 5 | 0.413 | |
| rfx2 | regulatory factor X, 2 (influences HLA class II expression) | 0.387 | |
| her3 | hairy-related 3 | 0.374 | |
| dlx4b | distal-less homeobox gene 4b | 0.365 | |
| tp63 | tumor protein p63 | 0.364 | |
| fzd8a | frizzled homolog 8a | 0.361 | |
| mab21l2 | mab-21-like 2 | 0.351 | |
| olig2 | oligodendrocyte lineage transcription factor 2 | 0.351 | |
| tfap2c | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.340 | |
| her8a | hairy-related 8a | 0.340 | |
| pax6b | paired box gene 6b | 0.328 | |
| hoxa2b | homeo box A2b | 0.293 | |
| foxb1.1 | forkhead box B1.1 | 0.287 | |
| dao.2 | D-amino-acid oxidase 2 | 0.285 | |
| hoxb1b | homeo box B1b | 0.274 | |
| otpb | orthopedia homolog b | 0.245 | |
| dnmt4 | DNA (cytosine-5-)-methyltransferase 4 | 0.233 | |
| fzd10 | frizzled homolog 10 | 0.232 | |
| nkx2.3 | NK2 transcription factor related 3 | 0.228 | |
| znf503 | zinc finger protein 503 | 0.222 | |
| six3a | sine oculis homeobox homolog 3a | 0.222 | |
| col2a1a | collagen type II, alpha-1a | 0.218 | |
| lhx1a | LIM homeobox 1a | 0.218 | |
| sox1a | SRY-box containing gene 1a | 0.213 | |
| pitx2 | paired-like homeodomain transcription factor 2 | 0.210 | |
| eya1 | eyes absent homolog 1 | 0.205 | |
| irx1b | iroquois homeobox protein 1, b | 0.200 | |
| nkx2.2b | NK2 transcription factor related 2b | 0.198 | |
| foxi3b | forkhead box I3b | 0.190 | |
| gbx2 | gastrulation brain homeo box 2 | 0.188 | |
| tbx6 | T-box gene 6 | 0.185 | |
| lhx1b | LIM homeobox 1b | 0.185 | |
| notch1a | notch homolog 1a | 0.183 | |
| sox2 | SRY-box containing gene 2 | 0.181 | |
| dla | deltaA | 0.176 | |
| hoxb8a | homeo box B8a | 0.174 | |
| insm1b | insulinoma-associated 1b | 0.171 | |
| pdgfaa | platelet-derived growth factor alpha a | 0.167 | |
| her2 | hairy-related 2 | 0.161 | |
| hoxb5a | homeo box B5a | 0.159 | |
| slc4a1b | solute carrier family 4, anion exchanger, member 1b | 0.159 | |
| msgn1 | mesogenin 1 | 0.158 | |
| foxa3 | forkhead box A3 | 0.156 | |
| jag1b | jagged 1b | 0.154 | |
| six2a | sine oculis-related homeobox 2a | 0.150 | |
| notch3 | notch homolog 3 | 0.149 | |
| atp1a1a.2 | ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide | 0.149 | |
| her1 | hairy-related 1 | 0.144 | |
| sp5l | Sp5 transcription factor-like | 0.142 | |
| myod1 | myogenic differentiation 1 | 0.142 | |
| dld | deltaD | 0.141 | |
| irx7 | iroquois homeobox protein 7 | 0.132 | |
| cdx4 | caudal type homeo box transcription factor 4 | 0.128 | |
| hoxa4a | homeo box A4a | 0.124 | |
| edn1 | endothelin 1 | 0.122 | |
| hoxb3a | homeo box B3a | 0.121 | |
| pax6a | paired box gene 6a | 0.117 | |
| olig3 | oligodendrocyte transcription factor 3 | 0.114 | |
| six3b | sine oculis homeobox homolog 3b | 0.114 | |
| zic6 | zic family member 6 | 0.111 | |
| itga5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.110 | |
| nkx2.1b | NK2 homeobox 1b | 0.110 | |
| sox3 | SRY-box containing gene 3 | 0.109 | |
| bmper | BMP binding endothelial regulator | 0.109 | |
| lmo2 | LIM domain only 2 (rhombotin-like 1) | 0.109 | |
| nkx2.2a | NK2 transcription factor related 2a | 0.108 | |
| vwf | von Willebrand factor | 0.108 | |
| gbx1 | gastrulation brain homeobox 1 | 0.107 | |
| vsx2 | visual system homeobox 2 | 0.107 | |
| fgf8b | fibroblast growth factor 8 b | 0.107 | |
| foxj1a | forkhead box J1a | 0.107 | |
| hesx1 | homeo box (expressed in ES cells) 1 | 0.107 | |
| zgc:194131 | zgc:194131 | 0.105 | |
| dbx1b | developing brain homeobox 1b | 0.102 | |
| foxa1 | forkhead box A1 | 0.097 | |
| tfap2a | transcription factor AP-2 alpha | 0.095 | |
| fgf3 | fibroblast growth factor 3 | 0.094 | |
| ctnnd2b | catenin (cadherin-associated protein), delta 2b | 0.094 | |
| ripply2 | ripply2 | 0.092 | |
| hs6st2 | heparan sulfate 6-O-sulfotransferase 2 | 0.089 |
Loading network...
Caenorhabditis elegans
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| egl-18 | Protein EGL-18 | 0.990 | |
| elt-6 | Protein ELT-6 | 0.959 | |
| cnd-1 | Protein CND-1 | 0.924 | |
| flt-1 | Protein FLT-1 | 0.692 | |
| hlh-2 | Protein HLH-2 | 0.658 | |
| ten-1 | Protein TEN-1 | 0.506 | |
| pha-4 | Protein PHA-4 | 0.491 | |
| pes-1 | Protein PES-1 | 0.217 | |
| hbl-1 | Protein HBL-1 | 0.204 | |
| inx-3 | Protein INX-3 | 0.145 | |
| lin-12 | Protein LIN-12 | 0.108 | |
| cam-1 | Protein CAM-1 | 0.105 | |
| nhr-25 | Protein NHR-25 | 0.103 | |
| edc-3 | Protein EDC-3 | 0.102 | |
| ceh-16 | Protein CEH-16 | 0.098 | |
| nhr-67 | Protein NHR-67 | 0.096 | |
| hnd-1 | Protein HND-1 | 0.087 | |
| hlh-14 | Protein HLH-14 | 0.073 | |
| egl-46 | Protein EGL-46 | 0.072 | |
| unc-130 | Protein UNC-130 | 0.062 | |
| mls-2 | Protein MLS-2 | 0.059 | |
| T28B11.1 | Protein T28B11.1 | 0.058 | |
| ama-1 | Protein AMA-1 | 0.050 | |
| npp-7 | Protein NPP-7 | 0.050 | |
| K10C3.4 | Protein K10C3.4 | 0.044 | |
| fkh-2 | Protein FKH-2 | 0.039 | |
| xpo-1 | Protein XPO-1 | 0.038 | |
| ceh-13 | Protein CEH-13 | 0.035 | |
| rnt-1 | Protein RNT-1 | 0.032 | |
| fzr-1 | Protein FZR-1 | 0.030 | |
| nhr-2 | Protein NHR-2 | 0.030 | |
| ref-2 | Protein REF-2 | 0.028 | |
| vab-1 | Protein VAB-1 | 0.028 | |
| lag-2 | Protein LAG-2 | 0.027 | |
| flh-2 | Protein FLH-2 | 0.026 | |
| ptc-1 | Protein PTC-1 | 0.025 | |
| hlh-1 | Protein HLH-1 | 0.022 | |
| nkcc-1 | Protein NKCC-1 | 0.022 | |
| clr-1 | Protein CLR-1 | 0.020 | |
| mab-5 | Protein MAB-5 | 0.020 | |
| ref-1 | Protein REF-1 | 0.019 | |
| tbx-8 | Protein TBX-8 | 0.019 | |
| cye-1 | Protein CYE-1 | 0.018 | |
| pop-1 | Protein POP-1 | 0.017 | |
| lin-1 | Protein LIN-1 | 0.017 | |
| ceh-43 | Protein CEH-43 | 0.017 | |
| hsf-1 | Protein HSF-1 | 0.016 | |
| C36E8.1 | Protein C36E8.1 | 0.016 | |
| npp-8 | Protein NPP-8 | 0.014 | |
| F43D9.1 | Protein F43D9.1 | 0.014 | |
| F39B2.1 | Protein F39B2.1 | 0.014 | |
| cfz-2 | Protein CFZ-2 | 0.014 | |
| E01B7.1 | Protein E01B7.1 | 0.013 | |
| tag-256 | Protein TAG-256 | 0.013 | |
| CELE_T04H1.2 | Protein T04H1.2 | 0.013 | |
| mbk-2 | Protein MBK-2 | 0.012 | |
| mpk-1 | Protein MPK-1 | 0.011 | |
| apc-17 | Protein APC-17 | 0.011 | |
| rpn-1 | Protein RPN-1 | 0.011 | |
| mep-1 | Protein MEP-1 | 0.011 | |
| sel-8 | Protein SEL-8 | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Gbx2 | gastrulation brain homeobox 2 | 0.999 | |
| Pax2 | paired box gene 2 | 0.998 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.989 | |
| Shh | sonic hedgehog | 0.986 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.972 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.955 | |
| Sox2 | SRY-box containing gene 2 | 0.939 | |
| Foxg1 | forkhead box G1 | 0.904 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.890 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.889 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.857 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.804 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.799 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.797 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.757 | |
| Nog | noggin | 0.690 | |
| Fgf8 | fibroblast growth factor 8 | 0.685 | |
| Jag1 | jagged 1 | 0.667 | |
| En1 | engrailed 1 | 0.644 | |
| Dll1 | delta-like 1 (Drosophila) | 0.411 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.375 | |
| Pax3 | paired box gene 3 | 0.370 | |
| Wnt1 | wingless-related MMTV integration site 1 | 0.355 | |
| Fgf3 | fibroblast growth factor 3 | 0.346 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.329 | |
| Tbx1 | T-box 1 | 0.271 | |
| Hoxa1 | homeobox A1 | 0.229 | |
| Pax6 | paired box gene 6 | 0.224 | |
| Pou4f3 | POU domain, class 4, transcription factor 3 | 0.209 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.195 | |
| Foxc1 | forkhead box C1 | 0.178 | |
| Msx2 | homeobox, msh-like 2 | 0.134 | |
| Efnb2 | ephrin B2 | 0.125 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.124 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.109 | |
| Hoxa2 | homeobox A2 | 0.108 | |
| Hmx3 | H6 homeobox 3 | 0.103 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.102 | |
| Tbx10 | T-box 10 | 0.093 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.089 | |
| Neurod1 | neurogenic differentiation 1 | 0.085 | |
| Rarg | retinoic acid receptor, gamma | 0.083 | |
| Pten | phosphatase and tensin homolog | 0.082 | |
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.076 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.074 | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.070 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.068 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.068 | |
| Gata3 | GATA binding protein 3 | 0.065 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.065 | |
| Rb1 | retinoblastoma 1 | 0.063 | |
| Fgf10 | fibroblast growth factor 10 | 0.057 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.056 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.049 | |
| Lhx5 | LIM homeobox protein 5 | 0.048 | |
| Hesx1 | homeobox gene expressed in ES cells | 0.047 | |
| Msx1 | homeobox, msh-like 1 | 0.046 | |
| Psen1 | presenilin 1 | 0.046 | |
| Smo | smoothened homolog (Drosophila) | 0.043 | |
| Gsc | goosecoid homeobox | 0.043 | |
| Dlx5 | distal-less homeobox 5 | 0.043 | |
| Lhx3 | LIM homeobox protein 3 | 0.040 | |
| Lhx1 | LIM homeobox protein 1 | 0.040 | |
| Kcne1 | potassium voltage-gated channel, Isk-related subfamily, member 1 | 0.039 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.038 | |
| Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | 0.037 | |
| Fgf17 | fibroblast growth factor 17 | 0.037 | |
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.037 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.036 | |
| Hmx2 | H6 homeobox 2 | 0.034 | |
| Foxc2 | forkhead box C2 | 0.034 | |
| Dll4 | delta-like 4 (Drosophila) | 0.032 | |
| Bmp4 | bone morphogenetic protein 4 | 0.032 | |
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.031 | |
| Six2 | sine oculis-related homeobox 2 homolog (Drosophila) | 0.029 | |
| Fgf4 | fibroblast growth factor 4 | 0.029 | |
| Fgf15 | fibroblast growth factor 15 | 0.029 | |
| Neurod4 | neurogenic differentiation 4 | 0.028 | |
| Nkx1-2 | NK1 transcription factor related, locus 2 (Drosophila) | 0.028 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.027 | |
| Foxn1 | forkhead box N1 | 0.026 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.026 | |
| Neurog2 | neurogenin 2 | 0.026 | |
| Hoxd3 | homeobox D3 | 0.025 | |
| Pax8 | paired box gene 8 | 0.025 | |
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 | 0.025 | |
| Vax1 | ventral anterior homeobox containing gene 1 | 0.024 | |
| Sox3 | SRY-box containing gene 3 | 0.023 | |
| Bdnf | brain derived neurotrophic factor | 0.023 | |
| Slc26a4 | solute carrier family 26, member 4 | 0.023 | |
| Myo6 | myosin VI | 0.022 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.022 | |
| Hoxd11 | homeobox D11 | 0.021 | |
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.021 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.020 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.020 | |
| Gfi1b | growth factor independent 1B | 0.020 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.020 | |
| Alx3 | aristaless-like homeobox 3 | 0.019 | |
| Neurog1 | neurogenin 1 | 0.019 |