The network for 'lens morphogenesis in camera type eye' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lens morphogenesis in camera type eye

The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

Danio rerio
Name Description Probability Func Analog Organism
crygmxl2 crystallin, gamma MX, like 2 0.891
sox2 SRY-box containing gene 2 0.850
dlc deltaC 0.833
zgc:153846 zgc:153846 0.717
foxa2 forkhead box A2 0.619
pax6a paired box gene 6a 0.551
crygm6 crystallin, gamma M6 0.533
crygm3 crystallin, gamma M3 0.504
pea3 ETS-domain transcription factor pea3 0.372
ascl1a achaete-scute complex-like 1a (Drosophila) 0.372
mab21l2 mab-21-like 2 0.342
crygm1 crystallin, gamma M1 0.337
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.321
otx2 orthodenticle homolog 2 0.297
sox10 SRY-box containing gene 10 0.263
pax6b paired box gene 6b 0.262
otx1b orthodenticle homolog 1b 0.207
crygmxl1 crystallin, gamma MX, like 1 0.204
foxa3 forkhead box A3 0.190
cryba4 crystallin, beta A4 0.186
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.184
crygm2f crystallin, gamma M2f 0.183
cdh2 cadherin 2, neuronal 0.177
crygmx crystallin, gamma MX 0.168
zgc:103750 zgc:103750 0.168
crybb1 crystallin, beta B1 0.165
crygm2a crystallin, gamma M2a 0.153
bmper BMP binding endothelial regulator 0.152
crygm2d16 crystallin, gamma M2d16 0.143
crygn2 crystallin, gamma N2 0.139
foxi3b forkhead box I3b 0.137
crygn1 crystallin, gamma N1 0.117
crygm2d11 crystallin, gamma M2d11 0.111
zgc:171792 zgc:171792 0.111
tp63 tumor protein p63 0.104
crygs4 crystallin, gamma S4 0.103
crygm2d8 crystallin, gamma M2d8 0.101
zdhhc8b zinc finger, DHHC-type containing 8b 0.100
foxi1 forkhead box I1 0.094
crygm2d15 crystallin, gamma M2d15 0.093
crygm2b crystallin, gamma M2b 0.091
pxn paxillin 0.090
six3b sine oculis homeobox homolog 3b 0.082
rx3 retinal homeobox gene 3 0.078
rx2 retinal homeobox gene 2 0.076
crygm7 crystallin, gamma M7 0.073
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.071
crygm2d13 crystallin, gamma M2d13 0.068
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.068
nrarpa notch-regulated ankyrin repeat protein a 0.068
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.066
crygm2d6 crystallin, gamma M2d6 0.064
her1 hairy-related 1 0.063
rarga retinoic acid receptor gamma a 0.062
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.059
pitx2 paired-like homeodomain transcription factor 2 0.059
six2a sine oculis-related homeobox 2a 0.057
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.055
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.055
pax2a paired box gene 2a 0.054
myod1 myogenic differentiation 1 0.050
crygs1 crystallin, gamma S1 0.050
rbp4 retinol binding protein 4, plasma 0.049
tfe3b transcription factor binding to IGHM enhancer 3b 0.048
rx1 retinal homeobox gene 1 0.047
efnb2a ephrin B2a 0.046
crygm2d12 crystallin, gamma M2d12 0.045
her6 hairy-related 6 0.044
bmp2b bone morphogenetic protein 2b 0.044
vcana versican a 0.043
vsx2 visual system homeobox 2 0.043
fgfrl1b fibroblast growth factor receptor-like 1b 0.041
hmx4 H6 family homeobox 4 0.038
coe2 coe2 0.036
vwf von Willebrand factor 0.034
cryba2a crystallin, beta A2a 0.034
gbx2 gastrulation brain homeo box 2 0.034
boc brother of CDO 0.034
crygm4 crystallin, gamma M4 0.033
emx2 empty spiracles homeobox 2 0.033
pdgfaa platelet-derived growth factor alpha a 0.032
crygm5 crystallin, gamma M5 0.031
crygm2d2 crystallin, gamma M2d2 0.031
sfrp1b secreted frizzled-related protein 1b 0.031
foxe3 forkhead box E3 0.030
six3a sine oculis homeobox homolog 3a 0.029
foxa1 forkhead box A1 0.029
foxg1a forkhead box G1a 0.029
fgf3 fibroblast growth factor 3 0.029
tnc tenascin C 0.029
rad21 RAD21 homolog (S. pombe) 0.028
foxi3a forkhead box I3a 0.028
bhlhe22 basic helix-loop-helix family, member e22 0.028
emx3 empty spiracles homeobox 3 0.028
pknox2 pbx/knotted 1 homeobox 2 0.027
crygm2d10 crystallin, gamma M2d10 0.027
fgfr2 fibroblast growth factor receptor 2 0.027
sox1a SRY-box containing gene 1a 0.026
dmrt2a doublesex and mab-3 related transcription factor 2a 0.025
crygm2c crystallin, gamma M2c 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.988
SP1 Sp1 transcription factor 0.985
SMAD4 SMAD family member 4 0.974
SMAD3 SMAD family member 3 0.934
CREBBP CREB binding protein 0.889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.888
EP300 E1A binding protein p300 0.877
ENG endoglin 0.835
PBX1 pre-B-cell leukemia homeobox 1 0.800
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.742
PVRL4 poliovirus receptor-related 4 0.567
SKIL SKI-like oncogene 0.551
HNF4A hepatocyte nuclear factor 4, alpha 0.524
PXN paxillin 0.514
CTGF connective tissue growth factor 0.507
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.467
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.451
DCAF7 DDB1 and CUL4 associated factor 7 0.420
RUNX1 runt-related transcription factor 1 0.396
HCFC1 host cell factor C1 (VP16-accessory protein) 0.381
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.357
EFNA1 ephrin-A1 0.333
SMAD2 SMAD family member 2 0.333
SMAD1 SMAD family member 1 0.249
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.231
TACC1 transforming, acidic coiled-coil containing protein 1 0.194
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.160
ZFYVE9 zinc finger, FYVE domain containing 9 0.159
BTRC beta-transducin repeat containing 0.159
FBLN1 fibulin 1 0.150
FGF1 fibroblast growth factor 1 (acidic) 0.147
POU5F1 POU class 5 homeobox 1 0.140
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.122
MEIS2 Meis homeobox 2 0.122
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.118
SREBF2 sterol regulatory element binding transcription factor 2 0.116
SH3BP4 SH3-domain binding protein 4 0.108
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.107
TCF4 transcription factor 4 0.107
HTT huntingtin 0.100
KCTD1 potassium channel tetramerisation domain containing 1 0.098
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.096
PVRL3 poliovirus receptor-related 3 0.093
APC adenomatous polyposis coli 0.088
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.088
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.085
VCL vinculin 0.081
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.079
PDLIM5 PDZ and LIM domain 5 0.077
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.074
HIPK2 homeodomain interacting protein kinase 2 0.074
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.073
FHL2 four and a half LIM domains 2 0.066
BCAR1 breast cancer anti-estrogen resistance 1 0.066
TRIM33 tripartite motif containing 33 0.064
PML promyelocytic leukemia 0.063
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.062
ZYX zyxin 0.061
SALL2 sal-like 2 (Drosophila) 0.060
ACTN1 actinin, alpha 1 0.059
FGFR2 fibroblast growth factor receptor 2 0.059
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.052
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.050
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.050
IGFBP3 insulin-like growth factor binding protein 3 0.048
EPAS1 endothelial PAS domain protein 1 0.048
FOXD3 forkhead box D3 0.043
FLNA filamin A, alpha 0.041
IPO13 importin 13 0.040
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.038
FERMT2 fermitin family member 2 0.038
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.037
TGFB1 transforming growth factor, beta 1 0.036
BCR breakpoint cluster region 0.034
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.034
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.034
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.034
TP53 tumor protein p53 0.033
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.032
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.032
CSNK1D casein kinase 1, delta 0.031
CYR61 cysteine-rich, angiogenic inducer, 61 0.028
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.028
GLIS2 GLIS family zinc finger 2 0.028
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.027
LHX2 LIM homeobox 2 0.027
EPHB3 EPH receptor B3 0.027
YY1 YY1 transcription factor 0.027
PAX6 paired box 6 0.026
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.026
HSPG2 heparan sulfate proteoglycan 2 0.026
PTK2 PTK2 protein tyrosine kinase 2 0.026
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.025
SOX2 SRY (sex determining region Y)-box 2 0.025
FBXW11 F-box and WD repeat domain containing 11 0.025
TJP1 tight junction protein 1 (zona occludens 1) 0.024
THBS1 thrombospondin 1 0.023
EPHB2 EPH receptor B2 0.023
MYH10 myosin, heavy chain 10, non-muscle 0.023
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.023
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pax6 paired box gene 6 1.000
Tcfap2a transcription factor AP-2, alpha 0.999
Pax3 paired box gene 3 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Sox2 SRY-box containing gene 2 0.996
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.995
Pitx2 paired-like homeodomain transcription factor 2 0.993
Ephb2 Eph receptor B2 0.992
Pbx1 pre B-cell leukemia transcription factor 1 0.991
Isl1 ISL1 transcription factor, LIM/homeodomain 0.991
Alx4 aristaless-like homeobox 4 0.988
Gata4 GATA binding protein 4 0.987
Bmp4 bone morphogenetic protein 4 0.986
Sox9 SRY-box containing gene 9 0.986
Nodal nodal 0.985
Fgf8 fibroblast growth factor 8 0.981
Hand1 heart and neural crest derivatives expressed transcript 1 0.967
Hand2 heart and neural crest derivatives expressed transcript 2 0.962
Hoxa13 homeobox A13 0.943
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.930
Klf3 Kruppel-like factor 3 (basic) 0.926
Sox11 SRY-box containing gene 11 0.914
Eya1 eyes absent 1 homolog (Drosophila) 0.913
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.912
Foxh1 forkhead box H1 0.892
Msx2 homeobox, msh-like 2 0.882
Foxc1 forkhead box C1 0.863
Col2a1 collagen, type II, alpha 1 0.853
Efnb2 ephrin B2 0.831
Hoxd13 homeobox D13 0.824
Tcfap2c transcription factor AP-2, gamma 0.819
Msx1 homeobox, msh-like 1 0.805
Zic3 zinc finger protein of the cerebellum 3 0.802
Tbx3 T-box 3 0.773
Pax2 paired box gene 2 0.771
Bmp7 bone morphogenetic protein 7 0.740
Pou3f3 POU domain, class 3, transcription factor 3 0.732
Meox2 mesenchyme homeobox 2 0.694
Tgfb2 transforming growth factor, beta 2 0.671
Hmx1 H6 homeobox 1 0.652
Gata6 GATA binding protein 6 0.652
Neurog2 neurogenin 2 0.643
Efna2 ephrin A2 0.612
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.608
Neurod1 neurogenic differentiation 1 0.599
Gli2 GLI-Kruppel family member GLI2 0.596
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.595
Foxf1a forkhead box F1a 0.584
Alx3 aristaless-like homeobox 3 0.567
Nkx2-1 NK2 homeobox 1 0.565
Jag1 jagged 1 0.558
Ret ret proto-oncogene 0.554
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.543
Meis2 Meis homeobox 2 0.536
Dlx1 distal-less homeobox 1 0.509
Sema5b sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.492
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.484
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.482
Tbx2 T-box 2 0.470
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.468
Smo smoothened homolog (Drosophila) 0.442
Foxg1 forkhead box G1 0.416
Prrx1 paired related homeobox 1 0.414
Epha4 Eph receptor A4 0.406
Lmx1b LIM homeobox transcription factor 1 beta 0.402
Atoh7 atonal homolog 7 (Drosophila) 0.362
Ntf3 neurotrophin 3 0.357
Ptk7 PTK7 protein tyrosine kinase 7 0.355
Hoxb13 homeobox B13 0.350
Hoxa2 homeobox A2 0.348
Barx1 BarH-like homeobox 1 0.348
Rax retina and anterior neural fold homeobox 0.347
Hes1 hairy and enhancer of split 1 (Drosophila) 0.339
Fgf10 fibroblast growth factor 10 0.326
Dcc deleted in colorectal carcinoma 0.311
Pax8 paired box gene 8 0.301
Ephb3 Eph receptor B3 0.301
Emx2 empty spiracles homolog 2 (Drosophila) 0.297
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.292
Sall3 sal-like 3 (Drosophila) 0.292
Rarg retinoic acid receptor, gamma 0.280
Dlx5 distal-less homeobox 5 0.280
Crygd crystallin, gamma D 0.273
Trp53 transformation related protein 53 0.266
Efs embryonal Fyn-associated substrate 0.265
Alx1 ALX homeobox 1 0.264
Gbx2 gastrulation brain homeobox 2 0.249
Lef1 lymphoid enhancer binding factor 1 0.247
Pitx1 paired-like homeodomain transcription factor 1 0.243
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.243
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.242
Efnb1 ephrin B1 0.231
Acvr1 activin A receptor, type 1 0.224
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.218
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.216
Epha2 Eph receptor A2 0.215
Tead3 TEA domain family member 3 0.215
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism