The network for 'negative regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of i kappab kinase nf kappab signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

Danio rerio
Name Description Probability Func Analog Organism
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.160
arhgdig Rho GDP dissociation inhibitor (GDI) gamma 0.142
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.105
caspa caspase a 0.097
capns1a calpain, small subunit 1 a 0.091
s100v2 S100 calcium binding protein V2 0.067
pdcd6ip programmed cell death 6 interacting protein 0.064
mcl1a myeloid cell leukemia sequence 1a 0.056
cd63 Cd63 antigen 0.054
LOC100006361 galanin-like 0.052
phlda2 pleckstrin homology-like domain, family A, member 2 0.050
cav1 caveolin 1 0.050
gabarapa GABA(A) receptor-associated protein a 0.049
ip6k2 inositol hexaphosphate kinase 2 0.042
cnot6 CCR4-NOT transcription complex, subunit 6 0.040
nccrp1 nonspecific cytotoxic cell receptor protein 1 0.040
fuca2 fucosidase, alpha-L- 2, plasma 0.037
agr2 anterior gradient homolog 2 (Xenopus laevis) 0.037
zgc:110340 zgc:110340 0.036
grid2 glutamate receptor, ionotropic, delta 2 0.035
rel v-rel reticuloendotheliosis viral oncogene homolog 0.034
klf2a Kruppel-like factor 2a 0.034
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.033
mib mind bomb 0.033
nod1 nucleotide-binding oligomerization domain containing 1 0.033
si:ch73-60e21.1 si:ch73-60e21.1 0.032
itm2bb integral membrane protein 2Bb 0.031
serpinb1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.030
mpzl2 myelin protein zero-like 2 0.029
march6 membrane-associated ring finger (C3HC4) 6 0.027
anxa5b annexin A5b 0.027
s100a10b S100 calcium binding protein A10b 0.027
fxyd6l FXYD domain containing ion transport regulator 6 like 0.026
stxbp2 syntaxin binding protein 2 0.025
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.025
capns1b calpain, small subunit 1 b 0.025
ghsra growth hormone secretagogue receptor a 0.025
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.025
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.025
icn ictacalcin 0.024
junb jun B proto-oncogene 0.024
anxa2a annexin A2a 0.024
socs3a suppressor of cytokine signaling 3a 0.023
fkbp5 FK506 binding protein 5 0.023
jun jun proto-oncogene 0.023
acot11a acyl-CoA thioesterase 11a 0.023
hcrt hypocretin (orexin) neuropeptide precursor 0.023
stap2b signal transducing adaptor family member 2b 0.022
card9 caspase recruitment domain family, member 9 0.022
wu:fj37c10 wu:fj37c10 0.022
zgc:110717 zgc:110717 0.022
mcl1b myeloid cell leukemia sequence 1b 0.022
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.022
ahnak AHNAK nucleoprotein 0.022
brd3a bromodomain containing 3a 0.021
wnt9b wingless-type MMTV integration site family, member 9B 0.021
sc:d0144 sc:d0144 0.021
max myc-associated factor X 0.020
sb:cb252 sb:cb252 0.020
mtnr1bb melatonin receptor 1B b and melatonin receptor 1B 0.020
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.020
tert telomerase reverse transcriptase 0.019
chmp5 chromatin modifying protein 5 0.019
ift88 intraflagellar transport 88 homolog 0.019
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.019
mmp15b matrix metallopeptidase 15b 0.019
si:ch211-9d9.3 si:ch211-9d9.3 0.019
cry2a cryptochrome 2a 0.018
ube2i2 ubiquitin-conjugating enzyme E2I2 0.018
gins2 GINS complex subunit 2 0.018
usp7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.018
zgc:64114 zgc:64114 0.018
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.018
akirin2 akirin 2 0.018
aldoca aldolase C, fructose-bisphosphate, a 0.018
zgc:92380 zgc:92380 0.018
si:dkey-236e20.2 si:dkey-236e20.2 0.018
phb2 prohibitin 2 0.017
brd2b bromodomain containing 2b 0.017
irf2bp2a interferon regulatory factor 2 binding protein 2a 0.017
unc45a unc-45 homolog A (C. elegans) 0.017
zgc:73328 zgc:73328 0.017
csnk1da casein kinase 1, delta a 0.017
zgc:113210 zgc:113210 0.017
ogt.1 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1 0.017
grm5a glutamate receptor, metabotropic 5a 0.017
LOC557072 caspase recruitment domain-containing protein 11-like 0.017
papolb poly(A) polymerase beta (testis specific) 0.017
stc1l stanniocalcin 1, like 0.016
pias4a protein inhibitor of activated STAT, 4a 0.016
chn1 chimerin (chimaerin) 1 0.016
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.016
supt6h suppressor of Ty 6 homolog 0.016
ftsjd1 FtsJ methyltransferase domain containing 1 0.016
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.016
hnrpr heterogeneous nuclear ribonucleoprotein R 0.016
smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.016
polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.016
itpk1 inositol 1,3,4-triphosphate 5/6 kinase 0.016
pkz protein kinase containing Z-DNA binding domains 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
slpr slipper 0.024
Myd88 CG2078 gene product from transcript CG2078-RA 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
RIPK2 receptor-interacting serine-threonine kinase 2 0.867
BIRC3 baculoviral IAP repeat containing 3 0.722
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.628
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.628
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.613
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.607
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.589
BIRC2 baculoviral IAP repeat containing 2 0.556
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.545
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.489
C1QA complement component 1, q subcomponent, A chain 0.449
XIAP X-linked inhibitor of apoptosis 0.446
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.440
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.394
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.242
CFLAR CASP8 and FADD-like apoptosis regulator 0.239
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.213
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.195
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.178
TNIP2 TNFAIP3 interacting protein 2 0.160
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.156
NLRC4 NLR family, CARD domain containing 4 0.154
TRAF1 TNF receptor-associated factor 1 0.149
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.141
IL4R interleukin 4 receptor 0.127
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.114
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.114
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.103
HIPK3 homeodomain interacting protein kinase 3 0.102
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.096
FAS Fas (TNF receptor superfamily, member 6) 0.090
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.089
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.079
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.079
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.064
GFM1 G elongation factor, mitochondrial 1 0.058
C1QC complement component 1, q subcomponent, C chain 0.055
CUL1 cullin 1 0.050
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.050
TNIP1 TNFAIP3 interacting protein 1 0.049
APAF1 apoptotic peptidase activating factor 1 0.047
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.047
TRAF6 TNF receptor-associated factor 6 0.046
EP300 E1A binding protein p300 0.044
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.044
TRAF3 TNF receptor-associated factor 3 0.042
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.041
BBS10 Bardet-Biedl syndrome 10 0.041
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.039
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.036
IRF1 interferon regulatory factor 1 0.034
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.034
JAK1 Janus kinase 1 0.034
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.034
IRF9 interferon regulatory factor 9 0.029
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.029
IL2RB interleukin 2 receptor, beta 0.028
MYH9 myosin, heavy chain 9, non-muscle 0.027
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.027
ZNF84 zinc finger protein 84 0.024
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.023
RANBP3 RAN binding protein 3 0.023
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.023
C1QB complement component 1, q subcomponent, B chain 0.023
BCAR1 breast cancer anti-estrogen resistance 1 0.023
ZNF260 zinc finger protein 260 0.022
OPTN optineurin 0.022
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.022
TRAF5 TNF receptor-associated factor 5 0.021
CSNK1E casein kinase 1, epsilon 0.021
IL12RB2 interleukin 12 receptor, beta 2 0.020
ZNF585A zinc finger protein 585A 0.020
NMI N-myc (and STAT) interactor 0.020
SNAI1 snail homolog 1 (Drosophila) 0.019
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.019
ZNF432 zinc finger protein 432 0.018
DIABLO diablo, IAP-binding mitochondrial protein 0.018
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.018
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.017
ACTN1 actinin, alpha 1 0.017
KAT2B K(lysine) acetyltransferase 2B 0.017
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.017
TRIM63 tripartite motif containing 63 0.017
FLNA filamin A, alpha 0.016
CCDC90B coiled-coil domain containing 90B 0.016
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.016
PFN1 profilin 1 0.016
HOXA9 homeobox A9 0.016
PYDC2 pyrin domain containing 2 0.016
USP15 ubiquitin specific peptidase 15 0.016
FLNB filamin B, beta 0.015
RIPK3 receptor-interacting serine-threonine kinase 3 0.015
STAT5A signal transducer and activator of transcription 5A 0.015
MEFV Mediterranean fever 0.015
PXN paxillin 0.014
RIPK4 receptor-interacting serine-threonine kinase 4 0.014
ZNF189 zinc finger protein 189 0.014
ZNF180 zinc finger protein 180 0.014
ARL4D ADP-ribosylation factor-like 4D 0.013
ZNF569 zinc finger protein 569 0.013
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism