The network for 'positive regulation of axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of axon guidance

Any process that activates or increases the frequency, rate or extent of axon guidance.

Danio rerio
Name Description Probability Func Analog Organism
efnb2a ephrin B2a 0.658
cdh5 cadherin 5 0.652
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.556
sema3d semaphorin 3d 0.527
myod1 myogenic differentiation 1 0.412
egr2b early growth response 2b 0.392
sox10 SRY-box containing gene 10 0.294
nrp1a neuropilin 1a 0.167
flt4 fms-related tyrosine kinase 4 0.147
pitx2 paired-like homeodomain transcription factor 2 0.134
myf5 myogenic factor 5 0.127
osr1 odd-skipped related 1 (Drosophila) 0.125
hoxb3a homeo box B3a 0.105
fgfr3 fibroblast growth factor receptor 3 0.089
hspa12b heat shock protein 12B 0.088
mcamb melanoma cell adhesion molecule b 0.082
ntn1a netrin 1a 0.079
epha4a eph receptor A4a 0.078
bmper BMP binding endothelial regulator 0.075
otx2 orthodenticle homolog 2 0.073
olig2 oligodendrocyte lineage transcription factor 2 0.070
kdrl kinase insert domain receptor like 0.070
lmo2 LIM domain only 2 (rhombotin-like 1) 0.066
foxd3 forkhead box D3 0.066
fezf2 FEZ family zinc finger 2 0.062
met met proto-oncogene (hepatocyte growth factor receptor) 0.061
nrp2b neuropilin 2b 0.057
gata2a GATA-binding protein 2a 0.057
hoxd4a homeo box D4a 0.057
pcdh8 protocadherin 8 0.049
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.048
foxa2 forkhead box A2 0.046
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.045
foxa3 forkhead box A3 0.042
nrp2a neuropilin 2a 0.041
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.041
vegfc vascular endothelial growth factor c 0.040
skia nuclear oncoprotein skia 0.037
foxc1b forkhead box C1b 0.037
dusp5 dual specificity phosphatase 5 0.036
si:dkey-261h17.1 si:dkey-261h17.1 0.035
etv2 ets variant gene 2 0.035
fsta follistatin a 0.035
fgf3 fibroblast growth factor 3 0.034
tfec transcription factor EC 0.034
mef2d myocyte enhancer factor 2d 0.033
aplnrb apelin receptor b 0.032
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.031
hoxb1a homeo box B1a 0.031
crestin crestin 0.030
irx1b iroquois homeobox protein 1, b 0.030
hhex hematopoietically expressed homeobox 0.029
hoxb2a homeo box B2a 0.029
runx1 runt-related transcription factor 1 0.028
nkx2.5 NK2 transcription factor related 5 0.028
irx3b iroquois homeobox protein 3b 0.028
pax6a paired box gene 6a 0.027
nog1 noggin 1 0.027
isl2a islet2a 0.027
six3b sine oculis homeobox homolog 3b 0.026
nrarpa notch-regulated ankyrin repeat protein a 0.026
foxa1 forkhead box A1 0.025
nrp1b neuropilin 1b 0.024
podxl podocalyxin-like 0.024
f2r coagulation factor II (thrombin) receptor 0.024
clec14a C-type lectin domain family 14, member A 0.024
crx cone-rod homeobox 0.024
cadm3 cell adhesion molecule 3 0.023
csf1ra colony stimulating factor 1 receptor, a 0.022
mecom MDS1 and EVI1 complex locus 0.022
dbx1a developing brain homeobox 1a 0.022
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.021
gbx2 gastrulation brain homeo box 2 0.020
six3a sine oculis homeobox homolog 3a 0.020
raraa retinoic acid receptor, alpha a 0.020
crh corticotropin releasing hormone 0.020
mnx1 motor neuron and pancreas homeobox 1 0.019
cxcr4a chemokine (C-X-C motif) receptor 4a 0.019
hand2 heart and neural crest derivatives expressed transcript 2 0.019
LOC100002342 carboxypeptidase A6-like 0.018
dlc deltaC 0.018
chrna4 cholinergic receptor, nicotinic, alpha 4 0.018
mapk3 mitogen-activated protein kinase 3 0.018
ntn2 netrin 2 0.018
twist2 twist2 0.018
pcdh18a protocadherin 18a 0.018
cdx1b caudal type homeobox 1 b 0.017
meis1 myeloid ecotropic viral integration 1 0.016
pax3b paired box gene 3b 0.016
meis3 myeloid ecotropic viral integration site 3 0.016
cntn2 contactin 2 0.016
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.016
her1 hairy-related 1 0.016
sumo2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.015
otx5 orthodenticle homolog 5 0.015
tal1 T-cell acute lymphocytic leukemia 1 0.015
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.015
foxc1a forkhead box C1a 0.014
gata1a GATA binding protein 1a 0.014
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
futsch CG34387 gene product from transcript CG34387-RC 0.838
robo roundabout 0.817
trio CG18214 gene product from transcript CG18214-RA 0.794
Caps Calcium activated protein for secretion 0.780
LIMK1 LIM-kinase1 0.635
comm commissureless 0.500
stan starry night 0.441
spas spastin 0.409
Sema-1a CG18405 gene product from transcript CG18405-RD 0.399
robo3 CG5423 gene product from transcript CG5423-RA 0.363
retn retained 0.339
milt milton 0.248
Pak PAK-kinase 0.244
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.231
ena enabled 0.216
katanin-60 katanin 60 0.211
tutl turtle 0.199
Trim9 CG31721 gene product from transcript CG31721-RB 0.195
hiw highwire 0.193
endoA endophilin A 0.189
Fas2 Fasciclin 2 0.188
lea leak 0.183
ems empty spiracles 0.179
rut rutabaga 0.176
grim CG4345 gene product from transcript CG4345-RA 0.175
Ank2 Ankyrin 2 0.167
drl derailed 0.161
CaMKII Calcium/calmodulin-dependent protein kinase II 0.155
Mical Molecule interacting with CasL 0.151
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.149
wnd wallenda 0.146
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.143
sli slit 0.135
sqz squeeze 0.131
Nrg Neuroglian 0.130
brp bruchpilot 0.128
tll tailless 0.125
unc-104 CG8566 gene product from transcript CG8566-RB 0.122
Dscam Down syndrome cell adhesion molecule 0.122
jeb jelly belly 0.121
ey eyeless 0.119
dome domeless 0.118
Ten-a Tenascin accessory 0.114
Abl Abl tyrosine kinase 0.114
gcm glial cells missing 0.112
TBPH CG10327 gene product from transcript CG10327-RC 0.110
Alk CG8250 gene product from transcript CG8250-RA 0.106
Hr51 Hormone receptor 51 0.105
Ork1 Open rectifier K[+] channel 1 0.105
babo baboon 0.104
cnk connector enhancer of ksr 0.088
shn schnurri 0.088
drpr draper 0.087
dock dreadlocks 0.074
lab labial 0.074
rap retina aberrant in pattern 0.073
lap like-AP180 0.068
neuroligin CG13772 gene product from transcript CG13772-RA 0.067
Hsc70-3 Heat shock protein cognate 3 0.067
dac dachshund 0.062
ab abrupt 0.059
Fak56D Focal Adhesion Kinase 0.056
baz bazooka 0.052
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.052
myoglianin CG1838 gene product from transcript CG1838-RD 0.052
unc-5 CG8166 gene product from transcript CG8166-RA 0.049
TrpA1 Transient receptor potential A1 0.046
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.045
CadN Cadherin-N 0.044
amn amnesiac 0.044
beta-Spec beta Spectrin 0.042
CG11093 CG11093 gene product from transcript CG11093-RB 0.041
WASp CG1520 gene product from transcript CG1520-RA 0.041
Ephrin CG1862 gene product from transcript CG1862-RA 0.040
Nrx-1 Neurexin 1 0.040
ato atonal 0.038
rictor rapamycin-insensitive companion of Tor 0.038
amos absent MD neurons and olfactory sensilla 0.037
tai taiman 0.037
wdb widerborst 0.037
run runt 0.036
stai stathmin 0.035
spdo sanpodo 0.033
lola longitudinals lacking 0.033
pdm3 pou domain motif 3 0.032
Nf1 Neurofibromin 1 0.031
fra frazzled 0.030
SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit 0.030
Hip14 Huntingtin-interacting protein 14 0.030
sw short wing 0.029
Tbh Tyramine beta hydroxylase 0.029
Fmr1 CG6203 gene product from transcript CG6203-RC 0.029
Wnt5 Wnt oncogene analog 5 0.028
toy twin of eyeless 0.028
repo reversed polarity 0.027
NFAT NFAT homolog 0.027
disco disconnected 0.027
stj straightjacket 0.026
CG31146 CG31146 gene product from transcript CG31146-RD 0.025
vvl ventral veins lacking 0.025
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Homo sapiens
Name Description Probability Func Analog Organism
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.940
NRP1 neuropilin 1 0.273
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.242
VEGFA vascular endothelial growth factor A 0.230
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.122
PGF placental growth factor 0.031
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.028
MYBBP1A MYB binding protein (P160) 1a 0.023
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Mus musculus
Name Description Probability Func Analog Organism
Tgfbr2 transforming growth factor, beta receptor II 0.952
Ednra endothelin receptor type A 0.684
Apc adenomatosis polyposis coli 0.617
Tgfbr1 transforming growth factor, beta receptor I 0.590
Nos3 nitric oxide synthase 3, endothelial cell 0.583
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.460
Acvr1 activin A receptor, type 1 0.437
Pten phosphatase and tensin homolog 0.414
Ctnnb1 catenin (cadherin associated protein), beta 1 0.325
Foxc1 forkhead box C1 0.316
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.310
Vegfa vascular endothelial growth factor A 0.244
Fgfr2 fibroblast growth factor receptor 2 0.222
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.207
Tgfb2 transforming growth factor, beta 2 0.153
Bmp4 bone morphogenetic protein 4 0.112
Eng endoglin 0.106
Jag1 jagged 1 0.101
Fgf8 fibroblast growth factor 8 0.087
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.084
Rxra retinoid X receptor alpha 0.080
Smad4 MAD homolog 4 (Drosophila) 0.072
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.068
Smad3 MAD homolog 3 (Drosophila) 0.067
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.057
Cdh5 cadherin 5 0.057
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.057
Esr1 estrogen receptor 1 (alpha) 0.049
Shh sonic hedgehog 0.048
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.047
Nf1 neurofibromatosis 1 0.047
Csf1 colony stimulating factor 1 (macrophage) 0.046
Pitx2 paired-like homeodomain transcription factor 2 0.046
Meox2 mesenchyme homeobox 2 0.046
Notch2 Notch gene homolog 2 (Drosophila) 0.045
Plxna1 plexin A1 0.040
Efnb2 ephrin B2 0.040
Braf Braf transforming gene 0.038
Fbn1 fibrillin 1 0.037
Bmpr1a bone morphogenetic protein receptor, type 1A 0.036
Gli3 GLI-Kruppel family member GLI3 0.034
Xiap X-linked inhibitor of apoptosis 0.030
Sox9 SRY-box containing gene 9 0.029
Ar androgen receptor 0.028
Tbx1 T-box 1 0.028
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.027
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.026
Kdr kinase insert domain protein receptor 0.025
Pax3 paired box gene 3 0.025
Foxc2 forkhead box C2 0.025
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.024
Flt4 FMS-like tyrosine kinase 4 0.024
Ptch1 patched homolog 1 0.024
Flt1 FMS-like tyrosine kinase 1 0.024
Egfr epidermal growth factor receptor 0.023
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.019
Plxnd1 plexin D1 0.018
Pkd1 polycystic kidney disease 1 homolog 0.017
Gaa glucosidase, alpha, acid 0.016
Fzd4 frizzled homolog 4 (Drosophila) 0.016
Wnt5a wingless-related MMTV integration site 5A 0.016
Lep leptin 0.016
Ece1 endothelin converting enzyme 1 0.016
Trp53 transformation related protein 53 0.015
Pgr progesterone receptor 0.014
Tgfbr3 transforming growth factor, beta receptor III 0.014
Ptf1a pancreas specific transcription factor, 1a 0.014
Bmp2 bone morphogenetic protein 2 0.014
Hoxa1 homeobox A1 0.013
Rarg retinoic acid receptor, gamma 0.013
Wwc2 WW, C2 and coiled-coil domain containing 2 0.013
Gata4 GATA binding protein 4 0.012
Pax2 paired box gene 2 0.012
Pdgfb platelet derived growth factor, B polypeptide 0.012
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.011
Gja1 gap junction protein, alpha 1 0.011
Smad6 MAD homolog 6 (Drosophila) 0.011
Adam17 a disintegrin and metallopeptidase domain 17 0.011
Kit kit oncogene 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nfib nuclear factor I/B 0.928
Pxdn peroxidasin homolog (Drosophila) 0.530
Ppap2b phosphatidic acid phosphatase type 2B 0.169
Tcf4 transcription factor 4 0.120
Igf1 insulin-like growth factor 1 0.098
Nfia nuclear factor I/A 0.094
Zbtb20 zinc finger and BTB domain containing 20 0.087
Dpt dermatopontin 0.077
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.068
Tnrc6b trinucleotide repeat containing 6B 0.059
Glg1 golgi apparatus protein 1 0.057
Mgll monoglyceride lipase 0.046
Ogn osteoglycin 0.033
Elk3 ELK3, ETS-domain protein 0.028
Ccnd2 cyclin D2 0.027
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.027
Fkbp9 FK506 binding protein 9 0.026
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.023
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.021
Ccdc80 coiled-coil domain containing 80 0.019
Cyyr1 cysteine/tyrosine-rich 1 0.019
Sh3bp5 SH3-domain binding protein 5 (BTK-associated) 0.018
Sdpr serum deprivation response 0.016
Ddr2 discoidin domain receptor tyrosine kinase 2 0.016
Mylk myosin light chain kinase 0.015
Rbm9 RNA binding motif protein 9 0.015
Col1a2 collagen, type I, alpha 2 0.014
Kdr kinase insert domain receptor 0.013
Zcchc24 zinc finger, CCHC domain containing 24 0.012
Col4a5 collagen, type IV, alpha 5 0.011
Asam adipocyte-specific adhesion molecule 0.011
Sdc2 syndecan 2 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism