The network for 'embryonic heart tube morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic heart tube morphogenesis

The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.990
tbx1 T-box 1 0.990
tbx5a T-box 5a 0.989
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.985
fn1 fibronectin 1 0.975
shha sonic hedgehog a 0.973
hnf1ba HNF1 homeobox Ba 0.970
tbx2a T-box gene 2a 0.956
foxh1 forkhead box H1 0.954
wnt11r wingless-type MMTV integration site family, member 11, related 0.952
plcg1 phospholipase C, gamma 1 0.935
gata5 GATA-binding protein 5 0.935
gata3 GATA-binding protein 3 0.934
foxn4 forkhead box N4 0.924
smad9 MAD homolog 9 (Drosophila) 0.924
gro1 groucho 1 0.908
foxa2 forkhead box A2 0.898
pkd2 polycystic kidney disease 2 0.895
smo smoothened homolog (Drosophila) 0.891
chd chordin 0.885
gpc4 glypican 4 0.879
vmhc ventricular myosin heavy chain 0.864
tp53 tumor protein p53 0.853
tbx20 T-box 20 0.843
ndr2 nodal-related 2 0.831
kdrl kinase insert domain receptor like 0.817
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.781
wnt11 wingless-type MMTV integration site family, member 11 0.781
lamb1a laminin, beta 1a 0.770
notch1b notch homolog 1b 0.746
bmp2a bone morphogenetic protein 2a 0.743
irx1a iroquois homeobox protein 1, a 0.742
lrrc50 leucine rich repeat containing 50 0.741
bmp4 bone morphogenetic protein 4 0.736
hand2 heart and neural crest derivatives expressed transcript 2 0.723
myca myelocytomatosis oncogene a 0.712
fzd10 frizzled homolog 10 0.700
pax2a paired box gene 2a 0.696
tbx16 T-box gene 16 0.686
grem2 gremlin 2, cysteine knot superfamily 0.681
tnnt2a troponin T2a, cardiac 0.668
gli2a GLI-Kruppel family member GLI2a 0.666
dld deltaD 0.665
tmem2 transmembrane protein 2 0.663
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.662
foxp1b forkhead box P1b 0.661
fbn2b fibrillin 2b 0.658
myod1 myogenic differentiation 1 0.657
tbx2b T-box 2b 0.657
ntla no tail a 0.654
spry4 sprouty (Drosophila) homolog 4 0.647
tnnc1a troponin C type 1a (slow) 0.638
twist3 twist3 0.619
synpo2lb synaptopodin 2-like b 0.615
ncor1 nuclear receptor co-repressor 1 0.612
sox9b SRY-box containing gene 9b 0.600
lrrc6 leucine rich repeat containing 6 0.595
flh floating head 0.567
pcdh8 protocadherin 8 0.566
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.562
six4b sine oculis homeobox homolog 4b 0.557
ttna titin a 0.555
sox32 SRY-box containing gene 32 0.550
nkx2.5 NK2 transcription factor related 5 0.546
oep one-eyed pinhead 0.541
pdlim7 PDZ and LIM domain 7 0.540
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.538
myl7 myosin, light polypeptide 7, regulatory 0.523
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.515
sox11a SRY-box containing gene 11a 0.515
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.512
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.511
ift88 intraflagellar transport 88 homolog 0.501
acta2 actin, alpha 2, smooth muscle, aorta 0.497
cacnb4b calcium channel, voltage-dependent, beta 4b subunit 0.492
isl1 islet1 0.491
aplnrb apelin receptor b 0.489
tbx5b T-box 5b 0.488
dlc deltaC 0.485
tcf21 transcription factor 21 0.484
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.482
mbnl2 muscleblind-like 2 (Drosophila) 0.476
eya4 eyes absent homolog 4 (Drosophila) 0.471
fgf10a fibroblast growth factor 10a 0.464
lamc1 laminin, gamma 1 0.464
snai1a snail homolog 1a (Drosophila) 0.463
lhx1a LIM homeobox 1a 0.462
acvr1l activin A receptor, type I like 0.458
tcf12 transcription factor 12 0.456
fhla four and a half LIM domains a 0.451
tnni1b troponin I, skeletal, slow b 0.451
cx27.5 connexin 27.5 0.447
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.438
znfl2a zinc finger-like gene 2a 0.438
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.430
vim vimentin 0.425
tal1 T-cell acute lymphocytic leukemia 1 0.422
smad5 MAD homolog 5 (Drosophila) 0.417
ogg1 8-oxoguanine DNA glycosylase 0.416
cav1 caveolin 1 0.405
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.981
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.955
TGFB1 transforming growth factor, beta 1 0.953
JAG1 jagged 1 0.935
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.875
TBX5 T-box 5 0.874
SMAD7 SMAD family member 7 0.809
SMAD1 SMAD family member 1 0.789
FKBP1A FK506 binding protein 1A, 12kDa 0.769
BMP2 bone morphogenetic protein 2 0.748
NOTCH1 notch 1 0.669
SMAD2 SMAD family member 2 0.659
GATA4 GATA binding protein 4 0.550
PBX1 pre-B-cell leukemia homeobox 1 0.525
SMAD3 SMAD family member 3 0.472
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.435
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.422
GSK3B glycogen synthase kinase 3 beta 0.421
FSTL1 follistatin-like 1 0.385
BMPR1A bone morphogenetic protein receptor, type IA 0.336
ENG endoglin 0.330
TGFBR1 transforming growth factor, beta receptor 1 0.277
SMAD4 SMAD family member 4 0.271
PTCH1 patched 1 0.262
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.235
EP300 E1A binding protein p300 0.216
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.184
NOTCH3 notch 3 0.167
HDAC4 histone deacetylase 4 0.163
SASS6 spindle assembly 6 homolog (C. elegans) 0.153
YAP1 Yes-associated protein 1 0.143
LRP6 low density lipoprotein receptor-related protein 6 0.133
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.115
DSP desmoplakin 0.104
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.101
FZD1 frizzled homolog 1 (Drosophila) 0.101
ACVR1 activin A receptor, type I 0.100
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.099
TJP1 tight junction protein 1 (zona occludens 1) 0.097
GDF5 growth differentiation factor 5 0.096
CAV1 caveolin 1, caveolae protein, 22kDa 0.091
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.086
KAT2B K(lysine) acetyltransferase 2B 0.086
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.070
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.067
HIPK2 homeodomain interacting protein kinase 2 0.064
EPAS1 endothelial PAS domain protein 1 0.063
SP1 Sp1 transcription factor 0.060
BMP1 bone morphogenetic protein 1 0.059
MARK3 MAP/microtubule affinity-regulating kinase 3 0.057
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.055
DLL1 delta-like 1 (Drosophila) 0.053
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.053
MEIS2 Meis homeobox 2 0.051
PRKG1 protein kinase, cGMP-dependent, type I 0.050
NOTCH2 notch 2 0.049
GLI1 GLI family zinc finger 1 0.046
PDGFC platelet derived growth factor C 0.046
BBS2 Bardet-Biedl syndrome 2 0.037
MYOCD myocardin 0.036
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.036
NRP1 neuropilin 1 0.035
TBK1 TANK-binding kinase 1 0.033
PEX26 peroxisomal biogenesis factor 26 0.033
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.031
MEF2A myocyte enhancer factor 2A 0.031
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.031
NOG noggin 0.030
AMOTL1 angiomotin like 1 0.030
TP53BP2 tumor protein p53 binding protein, 2 0.029
NCSTN nicastrin 0.029
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.029
WNT3A wingless-type MMTV integration site family, member 3A 0.027
SMAD9 SMAD family member 9 0.026
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.026
ZFYVE9 zinc finger, FYVE domain containing 9 0.026
MYOD1 myogenic differentiation 1 0.026
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.024
XIAP X-linked inhibitor of apoptosis 0.023
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.023
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.022
TP73 tumor protein p73 0.022
JAG2 jagged 2 0.022
PKP4 plakophilin 4 0.022
TRAM1 translocation associated membrane protein 1 0.022
HDAC9 histone deacetylase 9 0.021
BCL2 B-cell CLL/lymphoma 2 0.021
MAML1 mastermind-like 1 (Drosophila) 0.021
YY1 YY1 transcription factor 0.021
BBS9 Bardet-Biedl syndrome 9 0.019
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.018
SMAD5 SMAD family member 5 0.018
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.017
MKL2 MKL/myocardin-like 2 0.017
BMP4 bone morphogenetic protein 4 0.017
TGFB3 transforming growth factor, beta 3 0.017
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.016
BBS10 Bardet-Biedl syndrome 10 0.016
LMAN1 lectin, mannose-binding, 1 0.016
SNX5 sorting nexin 5 0.016
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Tbx3 T-box 3 1.000
Fgfr1 fibroblast growth factor receptor 1 1.000
Foxc1 forkhead box C1 0.999
Gata4 GATA binding protein 4 0.999
Pax3 paired box gene 3 0.999
Nodal nodal 0.999
Fgf8 fibroblast growth factor 8 0.999
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.998
Pax2 paired box gene 2 0.997
Foxh1 forkhead box H1 0.997
Meox2 mesenchyme homeobox 2 0.996
Bmp4 bone morphogenetic protein 4 0.996
Zic3 zinc finger protein of the cerebellum 3 0.996
Nog noggin 0.995
Gata6 GATA binding protein 6 0.995
Foxc2 forkhead box C2 0.994
Vangl2 vang-like 2 (van gogh, Drosophila) 0.993
Tbx1 T-box 1 0.993
Tgfb2 transforming growth factor, beta 2 0.992
Hoxa1 homeobox A1 0.991
Hoxa13 homeobox A13 0.985
Hand2 heart and neural crest derivatives expressed transcript 2 0.980
Invs inversin 0.975
Notch1 Notch gene homolog 1 (Drosophila) 0.974
Pten phosphatase and tensin homolog 0.972
Ctnnb1 catenin (cadherin associated protein), beta 1 0.969
Wnt3a wingless-related MMTV integration site 3A 0.968
Notch2 Notch gene homolog 2 (Drosophila) 0.968
Smad6 MAD homolog 6 (Drosophila) 0.966
Scn5a sodium channel, voltage-gated, type V, alpha 0.964
Lrp6 low density lipoprotein receptor-related protein 6 0.955
Nos3 nitric oxide synthase 3, endothelial cell 0.954
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.949
Hoxd13 homeobox D13 0.946
Jag1 jagged 1 0.945
Vegfa vascular endothelial growth factor A 0.944
Sox2 SRY-box containing gene 2 0.944
Psen1 presenilin 1 0.942
Sox9 SRY-box containing gene 9 0.942
Lhx1 LIM homeobox protein 1 0.933
Pitx1 paired-like homeodomain transcription factor 1 0.931
En1 engrailed 1 0.917
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.904
Gsc goosecoid homeobox 0.898
Hand1 heart and neural crest derivatives expressed transcript 1 0.894
Smo smoothened homolog (Drosophila) 0.893
Bmp7 bone morphogenetic protein 7 0.893
Mks1 Meckel syndrome, type 1 0.881
Neurog2 neurogenin 2 0.851
Msx1 homeobox, msh-like 1 0.841
Amhr2 anti-Mullerian hormone type 2 receptor 0.839
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.838
Rarg retinoic acid receptor, gamma 0.838
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.836
Hoxa2 homeobox A2 0.813
Tcfap2a transcription factor AP-2, alpha 0.801
Smad4 MAD homolog 4 (Drosophila) 0.796
Prrx2 paired related homeobox 2 0.788
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.778
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.773
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.770
Lmx1a LIM homeobox transcription factor 1 alpha 0.769
Tbx6 T-box 6 0.762
Yap1 yes-associated protein 1 0.754
Pkd1 polycystic kidney disease 1 homolog 0.753
Zeb1 zinc finger E-box binding homeobox 1 0.753
She src homology 2 domain-containing transforming protein E 0.752
Apc adenomatosis polyposis coli 0.749
Fgf10 fibroblast growth factor 10 0.721
Acvr1 activin A receptor, type 1 0.715
Uncx UNC homeobox 0.711
Tbx5 T-box 5 0.693
Twist2 twist homolog 2 (Drosophila) 0.688
Rarb retinoic acid receptor, beta 0.687
Hoxa5 homeobox A5 0.671
Wnt6 wingless-related MMTV integration site 6 0.665
Hes1 hairy and enhancer of split 1 (Drosophila) 0.664
Foxg1 forkhead box G1 0.661
Rxra retinoid X receptor alpha 0.644
Msx2 homeobox, msh-like 2 0.643
Lmx1b LIM homeobox transcription factor 1 beta 0.635
Gli1 GLI-Kruppel family member GLI1 0.633
Smad3 MAD homolog 3 (Drosophila) 0.633
Wt1 Wilms tumor 1 homolog 0.633
Ptk7 PTK7 protein tyrosine kinase 7 0.627
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.625
Lhx5 LIM homeobox protein 5 0.608
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.599
Fgfr3 fibroblast growth factor receptor 3 0.590
Sox7 SRY-box containing gene 7 0.590
Hmx1 H6 homeobox 1 0.582
Chrd chordin 0.577
Gdnf glial cell line derived neurotrophic factor 0.570
Bmpr1a bone morphogenetic protein receptor, type 1A 0.559
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism