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Process View

Danio rerio

2 genes annotated in zebrafish

limb bud formation

The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "limb bud formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "limb bud formation" (in gray)

Name	Description	Probability	Func Analog Organism
shha	sonic hedgehog a	1.000	Mouse
dlx2a	distal-less homeobox gene 2a	0.975
ptch1	patched 1	0.951
bmp4	bone morphogenetic protein 4	0.939
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.925
tbx1	T-box 1	0.911	Zebrafish
gsc	goosecoid	0.893
fgf8a	fibroblast growth factor 8 a	0.847	Zebrafish
tbx2a	T-box gene 2a	0.807	Zebrafish
dlx5a	distal-less homeobox gene 5a	0.802
tbx18	T-box 18	0.787	Zebrafish
pcdh10b	protocadherin 10b	0.765
chd	chordin	0.748
fgf10a	fibroblast growth factor 10a	0.746	Mouse
hand2	heart and neural crest derivatives expressed transcript 2	0.693
fgf3	fibroblast growth factor 3	0.658
bmp2b	bone morphogenetic protein 2b	0.588
prdm1a	PR domain containing 1a, with ZNF domain	0.582
eomesa	eomesodermin homolog a	0.570	Zebrafish
tbx5a	T-box 5a	0.518
msxc	muscle segment homeobox C	0.512
her1	hairy-related 1	0.451
otx2	orthodenticle homolog 2	0.398
col2a1a	collagen type II, alpha-1a	0.358	Mouse
has2	hyaluronan synthase 2	0.356
tbx16	T-box gene 16	0.347	Zebrafish
her7	hairy and enhancer of split related-7	0.330
lect1	leukocyte cell derived chemotaxin 1	0.328
sox9a	SRY-box containing gene 9a	0.309	Mouse
barhl2	BarH-like 2	0.275
fezf2	FEZ family zinc finger 2	0.272
cdh2	cadherin 2, neuronal	0.272
rx3	retinal homeobox gene 3	0.265
dcc	deleted in colorectal carcinoma	0.235
osr2	odd-skipped related 2 (Drosophila)	0.233
flh	floating head	0.229
dld	deltaD	0.218
lama5	laminin, alpha 5	0.212
tgfb3	transforming growth factor, beta 3	0.211
ptch2	patched 2	0.188
fgf17	fibroblast growth factor 17	0.181	Zebrafish
lft2	lefty2	0.176
flot2a	flotillin 2a	0.171
foxg1a	forkhead box G1a	0.165
nkx2.5	NK2 transcription factor related 5	0.160
tcf12	transcription factor 12	0.155
igfbp3	insulin-like growth factor binding protein 3	0.151
neurod	neurogenic differentiation	0.136
mitfa	microphthalmia-associated transcription factor a	0.136
col8a1a	collagen, type VIII, alpha 1a	0.132
nrp2b	neuropilin 2b	0.130
her5	hairy-related 5	0.119
hoxa13b	homeo box A13b	0.110
wnt9a	wingless-type MMTV integration site family, member 9A	0.110
otx1b	orthodenticle homolog 1b	0.110
ntla	no tail a	0.106	Zebrafish
fam168a	family with sequence similarity 168, member A	0.105
pax9	paired box gene 9	0.101
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.100
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.098
epha4b	eph receptor A4b	0.097
foxi1	forkhead box I1	0.093
myf5	myogenic factor 5	0.091
bmp2a	bone morphogenetic protein 2a	0.089
fzd8a	frizzled homolog 8a	0.088
fli1a	friend leukemia integration 1a	0.087
tbx2b	T-box 2b	0.085	Zebrafish
six3a	sine oculis homeobox homolog 3a	0.085
gbx2	gastrulation brain homeo box 2	0.083
tbx6	T-box gene 6	0.082	Zebrafish
ctgf	connective tissue growth factor	0.081
coro1b	coronin, actin binding protein, 1B	0.079
sesn1	sestrin 1	0.077
msxd	muscle segment homeobox D	0.074
prrx1a	paired related homeobox 1a	0.074
bmper	BMP binding endothelial regulator	0.073
tgfb2	transforming growth factor, beta 2	0.072
hoxd11a	homeo box D11a	0.072
gpr126	G protein-coupled receptor 126	0.071
lhx1a	LIM homeobox 1a	0.071
col9a2	procollagen, type IX, alpha 2	0.069
barx1	BarH-like homeobox 1	0.068
robo3	roundabout homolog 3	0.068
lft1	lefty1	0.065
nkx3.2	NK3 homeobox 2	0.065
traf4a	tnf receptor-associated factor 4a	0.064
foxa1	forkhead box A1	0.063
tuba1l	tubulin, alpha 1, like	0.062
dlx6a	distal-less homeobox gene 6a	0.061
ndr2	nodal-related 2	0.061
wnt11	wingless-type MMTV integration site family, member 11	0.060
jag2	jagged 2	0.059
og9x	OG9 homeobox gene	0.058
oprd1b	opioid receptor, delta 1b	0.056
sema3aa	semaphorin 3aa	0.056
gli3	GLI-Kruppel family member GLI3	0.055
myl7	myosin, light polypeptide 7, regulatory	0.054
nadl1.1	neural adhesion molecule L1.1	0.053
pax2a	paired box gene 2a	0.052
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.051
grem2	gremlin 2, cysteine knot superfamily	0.050
dct	dopachrome tautomerase	0.049
prrx1b	paired related homeobox 1b	0.049
myod1	myogenic differentiation 1	0.049
gli1	GLI-Kruppel family member 1	0.048
hoxc8a	homeo box C8a	0.046
pcdh8	protocadherin 8	0.046
sox9b	SRY-box containing gene 9b	0.046
irx7	iroquois homeobox protein 7	0.046
ephb3a	eph receptor B3a	0.045
wnt5b	wingless-type MMTV integration site family, member 5b	0.043
wu:fv91b12	wu:fv91b12	0.043
im:7137555	im:7137555	0.043
eve1	even-skipped-like1	0.043
trpv4	transient receptor potential cation channel, subfamily V, member 4	0.041
sparc	secreted acidic cysteine rich glycoprotein	0.040
twist3	twist3	0.040
pmp22a	peripheral myelin protein 22a	0.039
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	0.039
bon	bonnie and clyde	0.039
rxrab	retinoid x receptor, alpha b	0.039
gngt2b	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b	0.037
hoxd13a	homeo box D13a	0.037
emx3	empty spiracles homeobox 3	0.037
matn4	matrilin 4	0.037
ttnb	titin b	0.036
hoxa11b	homeo box A11b	0.036
tmsb	thymosin, beta	0.036
col1a1a	collagen, type I, alpha 1a	0.036
ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.035
fgfr1a	fibroblast growth factor receptor 1a	0.034
dlx4b	distal-less homeobox gene 4b	0.034
auts2	autism susceptibility candidate 2	0.034
msgn1	mesogenin 1	0.033
otx5	orthodenticle homolog 5	0.033
cdx4	caudal type homeo box transcription factor 4	0.033
six2a	sine oculis-related homeobox 2a	0.032
syne1a	spectrin repeat containing, nuclear envelope 1a	0.031
hnf1ba	HNF1 homeobox Ba	0.030
bmp3	bone morphogenetic protein 3	0.030
runx1	runt-related transcription factor 1	0.030
hoxc6a	homeo box C6a	0.030
foxd5	forkhead box D5	0.030
meis3	myeloid ecotropic viral integration site 3	0.029
notch1a	notch homolog 1a	0.029
gatsl2	GATS protein-like 2	0.029
zgc:163008	zgc:163008	0.028
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.028
hoxa9a	homeo box A9a	0.028
nkx2.3	NK2 transcription factor related 3	0.027
col1a2	collagen, type I, alpha 2	0.027
pcdh10a	protocadherin 10a	0.027
osr1	odd-skipped related 1 (Drosophila)	0.026
sall1a	sal-like 1a (Drosophila)	0.026
crip2	cysteine-rich protein 2	0.026
pax6a	paired box gene 6a	0.026
mbtps1	membrane-bound transcription factor protease, site 1	0.026
zgc:175214	zgc:175214	0.025
lmo4a	LIM domain only 4a	0.025
bmp7b	bone morphogenetic protein 7b	0.025
macf1	microtubule-actin crosslinking factor 1	0.025
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.024
tbx15	T-box 15	0.024	Zebrafish
nkx1.2la	NK1 transcription factor related 2-like,a	0.024
dlx3b	distal-less homeobox gene 3b	0.023
hes6	hairy and enhancer of split 6 (Drosophila)	0.023
kita	kit receptor a	0.023
mib2	mind bomb 2	0.023
neo1	neogenin 1	0.023
hapln3	hyaluronan and proteoglycan link protein 3	0.023
pax3a	paired box gene 3a	0.023
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.023
col9a3	collagen, type IX, alpha 3	0.023
foxa2	forkhead box A2	0.022
hoxd10a	homeo box D10a	0.022
si:dkey-188i13.1	si:dkey-188i13.1	0.022
sox32	SRY-box containing gene 32	0.022
LOC100537793	hypothetical protein LOC100537793	0.022
has3	hyaluronan synthase 3	0.022
rxraa	retinoid X receptor, alpha a	0.021
hint2	histidine triad nucleotide binding protein 2	0.021
dlx1a	distal-less homeobox gene 1a	0.021
creb3l3l	cAMP responsive element binding protein 3-like 3 like	0.021
pcdh19	protocadherin 19	0.021
fn1	fibronectin 1	0.021
mef2ca	myocyte enhancer factor 2ca	0.021
tbx3	T-box 3	0.021	Zebrafish
isl2a	islet2a	0.021
spon1b	spondin 1b	0.021
hoxd12a	homeo box D12a	0.020
ptbp2	polypyrimidine tract binding protein 2	0.020
vcanb	versican b	0.020
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.020
h3f3c	H3 histone, family 3C	0.020
notch1b	notch homolog 1b	0.020
LOC100334210	growth/differentiation factor 5-like	0.020
six4a	sine oculis homeobox homolog 4a	0.020
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.019
wwp2	WW domain containing E3 ubiquitin protein ligase 2	0.019
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.019
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.019
gngt2a	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a	0.019
cx30.3	connexin 30.3	0.019
cdh1	cadherin 1, epithelial	0.019
mbd3b	methyl-CpG binding domain protein 3b	0.019
frzb	frizzled-related protein	0.019
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.019
hoxa10b	homeo box A10b	0.019
rarga	retinoic acid receptor gamma a	0.019
zgc:91860	zgc:91860	0.019
prkcbp1l	protein kinase C binding protein 1, like	0.018
cox4i2	cytochrome c oxidase subunit IV isoform 2	0.018
pdcd4b	programmed cell death 4b	0.018
dlx4a	distal-less homeobox gene 4a	0.018
sp5l	Sp5 transcription factor-like	0.018
oep	one-eyed pinhead	0.018
tubb5	tubulin, beta 5	0.018
otomp	otolith matrix protein	0.018
alas2	aminolevulinate, delta-, synthetase 2	0.018
ripply2	ripply2	0.018
her15.1	hairy and enhancer of split-related 15.1	0.018
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.018
cnot1	CCR4-NOT transcription complex, subunit 1	0.018
tcf21	transcription factor 21	0.018
hmgn3	high mobility group nucleosomal binding domain 3	0.018
and1	actinodin1	0.017
isl1	islet1	0.017
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.017
ep300b	E1A binding protein p300 b	0.017
col11a2	collagen type XI alpha-2	0.017
raraa	retinoic acid receptor, alpha a	0.017
pax6b	paired box gene 6b	0.017
fgfrl1a	fibroblast growth factor receptor-like 1a	0.017
barx2	BarH-like homeobox 2	0.017
mespa	mesoderm posterior a	0.017
col14a1	collagen, type XIV, alpha 1	0.016
hmx4	H6 family homeobox 4	0.016
ctbp2	C-terminal binding protein 2	0.016
rybpa	RING1 and YY1 binding protein a	0.016
cart1	cartilage paired-class homeoprotein 1	0.016
zgc:73311	zgc:73311	0.016
rp42-pen	rp42 homolog (pending) and rp42 homolog	0.016
tmem198b	transmembrane protein 198b	0.016
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.016
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.016
h1m	linker histone H1M	0.016
cdh5	cadherin 5	0.016
snx6	sorting nexin 6	0.016
mib	mind bomb	0.016
tial1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	0.016
zeb1	zinc finger E-box binding homeobox 1	0.016
slit3	slit (Drosophila) homolog 3	0.016
cadm1b	cell adhesion molecule 1b	0.016
tcea2	transcription elongation factor A (SII), 2	0.016
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.016
neurod6b	neurogenic differentiation 6b	0.016
hoxd9a	homeo box D9a	0.016
msxe	muscle segment homeobox E	0.016
emx2	empty spiracles homeobox 2	0.015
sema3h	semaphorin 3h	0.015
si:dkey-24g18.2	si:dkey-24g18.2	0.015
hoxa13a	homeo box A13a	0.015
satb2	SATB homeobox 2	0.015
sox17	SRY-box containing gene 17	0.015
hoxb10a	homeo box B10a	0.015
pvrl1b	poliovirus receptor-related 1b	0.015
zgc:66433	zgc:66433	0.015
pitx2	paired-like homeodomain transcription factor 2	0.015
ints6	integrator complex subunit 6	0.015
her6	hairy-related 6	0.015
spry1	sprouty homolog 1 (Drosophila)	0.015
tbx5b	T-box 5b	0.015
nr2f1b	nuclear receptor subfamily 2, group F, member 1b	0.015
celf3	cugbp, Elav-like family member 3	0.015
fgf8b	fibroblast growth factor 8 b	0.015	Zebrafish
tshz1	teashirt family zinc finger 1	0.015
olfm2	olfactomedin 2	0.015
fstl1a	follistatin-like 1a	0.015
six3b	sine oculis homeobox homolog 3b	0.014
jam2b	junctional adhesion molecule 2b	0.014
hnrpr	heterogeneous nuclear ribonucleoprotein R	0.014
xirp2a	xin actin-binding repeat containing 2a	0.014
si:ch211-285f17.1	si:ch211-285f17.1	0.014
col9a1	collagen, type IX, alpha 1	0.014
dixdc1a	DIX domain containing 1a	0.014
taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.014
grcc10	gene rich cluster, C10 gene	0.014
klhl31	kelch-like 31 (Drosophila)	0.014
shhb	sonic hedgehog b	0.014	Mouse
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.014
rargb	retinoic acid receptor, gamma b	0.014
eng1a	engrailed 1a	0.014
col27a1a	collagen, type XXVII, alpha 1a	0.014
ahr2	aryl hydrocarbon receptor 2	0.014
gng13b	guanine nucleotide binding protein (G protein), gamma 13b	0.014
eya2	eyes absent homolog 2 (Drosophila)	0.014
ptpn2b	protein tyrosine phosphatase, non-receptor type 2, b	0.014
zmym2	zinc finger, MYM-type 2	0.014
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.013
spry4	sprouty (Drosophila) homolog 4	0.013
zgc:66326	zgc:66326	0.013
zc4h2	zinc finger, C4H2 domain containing	0.013
znf503	zinc finger protein 503	0.013
dlx2b	distal-less homeobox gene 2b	0.013
mybpc3	myosin binding protein C, cardiac	0.013
dachb	dachshund b	0.013
tnrc6b	trinucleotide repeat containing 6B	0.013
kif23	kinesin family member 23	0.013
metap2	methionyl aminopeptidase 2	0.013
flot1b	flotillin 1b	0.013
smpd4	sphingomyelin phosphodiesterase 4	0.013
lhx6	LIM homeobox 6	0.013
apc	adenomatosis polyposis coli	0.013
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.013
sim2	single-minded homolog 2 (Drosophila)	0.013
calm2a	calmodulin 2a (phosphorylase kinase, delta)	0.013
hoxa9b	homeo box A9b	0.012
atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.012
dfna5	deafness, autosomal dominant 5	0.012
atp1b2b	ATPase, Na+/K+ transporting, beta 2b polypeptide	0.012
lmo4b	LIM domain only 4b	0.012
lhx1b	LIM homeobox 1b	0.012
LOC556647	GDNF family receptor alpha-4-like	0.012
pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.012
ube2e3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.012
lnpa	limb and neural patterns a	0.012
kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.012
fzd10	frizzled homolog 10	0.012
dcn	decorin	0.012
irx5a	iroquois homeobox protein 5a	0.012
mepce	methylphosphate capping enzyme	0.012
pea3	ETS-domain transcription factor pea3	0.012
ldlrap1a	low density lipoprotein receptor adaptor protein 1a	0.012
zgc:172136	zgc:172136	0.012
hgfa	hepatocyte growth factor a	0.012
notch2	notch homolog 2	0.012
nkx2.2b	NK2 transcription factor related 2b	0.012
pkp1	plakophilin 1	0.012
hist2h2l	histone 2, H2, like	0.012
actn3b	actinin alpha 3b	0.012
vcana	versican a	0.011
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.011
hmga2	high mobility group AT-hook 2	0.011
zgc:92467	zgc:92467	0.011
irx1a	iroquois homeobox protein 1, a	0.011
cldnf	claudin f	0.011
emx1	empty spiracles homeobox 1	0.011
dpp3	dipeptidylpeptidase 3	0.011
si:ch211-255l12.1	si:ch211-255l12.1	0.011
nexn	nexilin (F actin binding protein)	0.011
sass6	spindle assembly 6 homolog (C. elegans)	0.011
zgc:56685	zgc:56685	0.011
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.011
six4b	sine oculis homeobox homolog 4b	0.011
kdm5bb	lysine (K)-specific demethylase 5Bb	0.011
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.011
desma	desmin a	0.011
tiam2	T-cell lymphoma invasion and metastasis 2	0.011
defbl1	defensin, beta-like 1	0.011
myca	myelocytomatosis oncogene a	0.011
jhdm1da	jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)	0.011
gtpbp1	GTP binding protein 1	0.011
mmp2	matrix metalloproteinase 2	0.011
drl	draculin	0.011
tfe3b	transcription factor binding to IGHM enhancer 3b	0.011
sp5	Sp5 transcription factor	0.011
foxh1	forkhead box H1	0.011
nrf1	nuclear respiratory factor 1	0.011
zgc:63663	zgc:63663	0.011
mkxa	mohawk homeobox a	0.011
foxd3	forkhead box D3	0.011
vsx1	visual system homeobox 1 homolog, chx10-like	0.011
mab21l2	mab-21-like 2	0.011
wu:fb01h12	wu:fb01h12	0.011
sema3fb	semaphorin 3fb	0.011
cadm2b	cell adhesion molecule 2b	0.010
supt6h	suppressor of Ty 6 homolog	0.010
zgc:110586	zgc:110586	0.010
rorab	RAR-related orphan receptor A, paralog b	0.010
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.010
fzd8b	frizzled homolog 8b	0.010
slc25a37	solute carrier family 25, member 37	0.010
senp6a	SUMO1/sentrin specific peptidase 6a	0.010
tac1	tachykinin 1	0.010
wu:fq41a10	wu:fq41a10	0.010
pabpc4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.010
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.010
dram2	DNA-damage regulated autophagy modulator 2	0.010
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.010
im:7163548	im:7163548	0.010
col5a1	procollagen, type V, alpha 1	0.010
med25	mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)	0.010
crsp6	cofactor required for Sp1 transcriptional activation, subunit 6	0.010
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.010
hmgb1a	high-mobility group box 1a	0.010
zgc:92321	zgc:92321	0.010
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.010
illr1	immune-related, lectin-like receptor 1	0.010