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Danio rerio

18 genes annotated in zebrafish

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endodermal cell fate commitment

GO:0001711

The cell differentiation process that results in commitment of a cell to become part of the endoderm.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endodermal cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endodermal cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
chd	chordin	0.998
flh	floating head	0.745
tbx1	T-box 1	0.605	Zebrafish
emx3	empty spiracles homeobox 3	0.589
col2a1a	collagen type II, alpha-1a	0.565
dlc	deltaC	0.551
fgf8a	fibroblast growth factor 8 a	0.528
tbx20	T-box 20	0.513	Zebrafish
tbx2b	T-box 2b	0.498	Zebrafish
pcdh8	protocadherin 8	0.478
fgf3	fibroblast growth factor 3	0.476
tbx16	T-box gene 16	0.465	Zebrafish
fli1a	friend leukemia integration 1a	0.458
cdh1	cadherin 1, epithelial	0.447
notch3	notch homolog 3	0.434	Zebrafish
pax2a	paired box gene 2a	0.426
ntla	no tail a	0.414	Zebrafish
jag2	jagged 2	0.395
gata3	GATA-binding protein 3	0.378
bmp2b	bone morphogenetic protein 2b	0.354
rarab	retinoic acid receptor, alpha b	0.331
bmp4	bone morphogenetic protein 4	0.315
mespa	mesoderm posterior a	0.294	Mouse
mib	mind bomb	0.287
gbx2	gastrulation brain homeo box 2	0.282
cdh2	cadherin 2, neuronal	0.254
foxg1a	forkhead box G1a	0.248
her1	hairy-related 1	0.236
spry2	sprouty homolog 2	0.230
ndr1	nodal-related 1	0.208
fgfr4	fibroblast growth factor receptor 4	0.207	Zebrafish Fly
sox3	SRY-box containing gene 3	0.195	Zebrafish
fgf17	fibroblast growth factor 17	0.191
her7	hairy and enhancer of split related-7	0.186
spry4	sprouty (Drosophila) homolog 4	0.181
hand2	heart and neural crest derivatives expressed transcript 2	0.180
mmp2	matrix metalloproteinase 2	0.174
fgfr2	fibroblast growth factor receptor 2	0.174	Zebrafish Fly
bmpr2b	bone morphogenetic protein receptor, type II b (serine/threonine kinase)	0.173	Zebrafish
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.164
tll1	tolloid-like 1	0.155
efnb2a	ephrin B2a	0.154
oep	one-eyed pinhead	0.143
lhx1a	LIM homeobox 1a	0.143
osr2	odd-skipped related 2 (Drosophila)	0.139
kdrl	kinase insert domain receptor like	0.139
vent	ventral expressed homeobox	0.133
tbx5a	T-box 5a	0.111	Zebrafish
msxb	muscle segment homeobox B	0.110
wnt5b	wingless-type MMTV integration site family, member 5b	0.108
gro2	groucho 2	0.105
notch2	notch homolog 2	0.103	Zebrafish
sall4	sal-like 4 (Drosophila)	0.102
sox19b	SRY-box containing gene 19b	0.099	Zebrafish
six4b	sine oculis homeobox homolog 4b	0.097
meis3	myeloid ecotropic viral integration site 3	0.097
egr2a	early growth response 2a	0.097
eomesa	eomesodermin homolog a	0.096
spns2	spinster homolog 2 (Drosophila)	0.096
snai1a	snail homolog 1a (Drosophila)	0.091
bmp7a	bone morphogenetic protein 7a	0.091
cdx4	caudal type homeo box transcription factor 4	0.090
traf4a	tnf receptor-associated factor 4a	0.089
six3b	sine oculis homeobox homolog 3b	0.087
dusp6	dual specificity phosphatase 6	0.085
isl1	islet1	0.083
foxi1	forkhead box I1	0.082
pitx2	paired-like homeodomain transcription factor 2	0.082
igfbp3	insulin-like growth factor binding protein 3	0.080
ephb4b	eph receptor B4b	0.080
ndr2	nodal-related 2	0.079
lft1	lefty1	0.078
dharma	dharma	0.078
bon	bonnie and clyde	0.077
lhx1b	LIM homeobox 1b	0.074
igf1rb	insulin-like growth factor 1b receptor	0.073
hmx4	H6 family homeobox 4	0.072
prl	prolactin	0.071
btg2	B-cell translocation gene 2	0.071
hoxd11a	homeo box D11a	0.070
fn1	fibronectin 1	0.068
rx3	retinal homeobox gene 3	0.067
dcc	deleted in colorectal carcinoma	0.066
pdgfaa	platelet-derived growth factor alpha a	0.064
pcdh10b	protocadherin 10b	0.064
gata2a	GATA-binding protein 2a	0.063
boc	brother of CDO	0.062
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.061
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.060
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.060
dlb	deltaB	0.058
pou5f1	POU domain, class 5, transcription factor 1	0.056
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.056	Zebrafish
twist1a	twist1a	0.056
tbx6	T-box gene 6	0.055	Zebrafish
hoxa11a	homeo box A11a	0.055
ccm2	cerebral cavernous malformation 2	0.053
hoxa10b	homeo box A10b	0.053
eya1	eyes absent homolog 1	0.053
nanos3	nanos homolog 3	0.053
mmp15b	matrix metallopeptidase 15b	0.052
otpb	orthopedia homolog b	0.052
hnf1ba	HNF1 homeobox Ba	0.051	Mouse
six3a	sine oculis homeobox homolog 3a	0.050
slc25a37	solute carrier family 25, member 37	0.050
otx1b	orthodenticle homolog 1b	0.048
etv2	ets variant gene 2	0.047
hapln3	hyaluronan and proteoglycan link protein 3	0.047
mespb	mesoderm posterior b	0.047	Mouse
mecom	MDS1 and EVI1 complex locus	0.047
foxd3	forkhead box D3	0.046
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.046
ved	ventrally expressed dharma/bozozok antagonist	0.046
eve1	even-skipped-like1	0.045
kitb	kit receptor b	0.045
dkk1b	dickkopf 1b	0.045
pax6b	paired box gene 6b	0.044
has2	hyaluronan synthase 2	0.043
fzd5	frizzled homolog 5	0.043
smad5	MAD homolog 5 (Drosophila)	0.043	Fly
hhip	hedgehog interacting protein	0.042
og9x	OG9 homeobox gene	0.042
irx4b	iroquois homeobox protein 4b	0.042
hspa12b	heat shock protein 12B	0.042
lef1	lymphocyte enhancer binding factor 1	0.041
gdf6a	growth differentiation factor 6a	0.041	Zebrafish
sox32	SRY-box containing gene 32	0.041
nrarpa	notch-regulated ankyrin repeat protein a	0.040
vasa	vasa homolog	0.040
arntl1b	aryl hydrocarbon receptor nuclear translocator-like 1b	0.039
hoxd10a	homeo box D10a	0.039
runx1	runt-related transcription factor 1	0.039
nkx2.5	NK2 transcription factor related 5	0.038
hoxa9b	homeo box A9b	0.038
fzd8b	frizzled homolog 8b	0.038
foxd5	forkhead box D5	0.038
dld	deltaD	0.038
gata5	GATA-binding protein 5	0.037
emx1	empty spiracles homeobox 1	0.037
cdh5	cadherin 5	0.036
fgfr3	fibroblast growth factor receptor 3	0.036	Zebrafish Fly
fzd2	frizzled homolog 2	0.036
hoxd9a	homeo box D9a	0.035
hcst	hematopoietic cell signal transducer	0.035
her5	hairy-related 5	0.035
tbx2a	T-box gene 2a	0.035	Zebrafish
cdx1a	caudal type homeo box transcription factor 1 a	0.034
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.034
runx3	runt-related transcription factor 3	0.034
six4a	sine oculis homeobox homolog 4a	0.033
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.033
tp63	tumor protein p63	0.033
emp2	epithelial membrane protein 2	0.033
bmp2a	bone morphogenetic protein 2a	0.033	Zebrafish
mab21l2	mab-21-like 2	0.033
klf4	Kruppel-like factor 4	0.033
si:ch211-235f6.2	si:ch211-235f6.2	0.033
junbl	jun B proto-oncogene, like	0.033
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.033
wnt10a	wingless-type MMTV integration site family, member 10a	0.032
gli2a	GLI-Kruppel family member GLI2a	0.030
msgn1	mesogenin 1	0.030
hoxc11a	homeo box C11a	0.030
dlx5a	distal-less homeobox gene 5a	0.030
rag1	recombination activating gene 1	0.030
sox1a	SRY-box containing gene 1a	0.029	Zebrafish
evx1	even-skipped homeobox 1	0.029
rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.029
zbtb16a	zinc finger and BTB domain containing 16a	0.029
nkx2.1b	NK2 homeobox 1b	0.029
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.029
axin1	axin 1	0.029
fgfr1a	fibroblast growth factor receptor 1a	0.029
cd8a	CD8 antigen, alpha polypeptide	0.029
tgfb2	transforming growth factor, beta 2	0.028
fgfrl1b	fibroblast growth factor receptor-like 1b	0.028
hoxd12a	homeo box D12a	0.028
otx1a	orthodenticle homolog 1a	0.028
pitx3	paired-like homeodomain transcription factor 3	0.027
insm1b	insulinoma-associated 1b	0.027
foxh1	forkhead box H1	0.027
etv5a	ets variant 5a	0.027
gro1	groucho 1	0.027
cnn2	calponin 2	0.027
vsx1	visual system homeobox 1 homolog, chx10-like	0.027
mcamb	melanoma cell adhesion molecule b	0.027
waca	WW domain containing adaptor with coiled-coil a	0.026
tbx18	T-box 18	0.026	Zebrafish
pou3f3b	POU class 3 homeobox 3b	0.026
wnt11r	wingless-type MMTV integration site family, member 11, related	0.026	Worm
irx1b	iroquois homeobox protein 1, b	0.026
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.025
hmx1	H6 homeo box 1	0.025
tagln2	transgelin 2	0.025
egr2b	early growth response 2b	0.025
dbx1a	developing brain homeobox 1a	0.025
emx2	empty spiracles homeobox 2	0.025
hoxa2b	homeo box A2b	0.024
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.024
flt4	fms-related tyrosine kinase 4	0.024
fzd7a	frizzled homolog 7a	0.024
myod1	myogenic differentiation 1	0.024
foxn4	forkhead box N4	0.024
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.024
sox19a	SRY-box containing gene 19a	0.024	Zebrafish
hoxc8a	homeo box C8a	0.024
jag1a	jagged 1a	0.024
fezf2	FEZ family zinc finger 2	0.023
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.023
scinla	scinderin like a	0.023
stab2	stabilin 2	0.023
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.023
spaw	southpaw	0.023
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.023
msxc	muscle segment homeobox C	0.022
clec14a	C-type lectin domain family 14, member A	0.022
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.022
klf2a	Kruppel-like factor 2a	0.022
pcdh18b	protocadherin 18b	0.022
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.021
myf5	myogenic factor 5	0.021
neurod6b	neurogenic differentiation 6b	0.021
fbln1	fibulin 1	0.021
tmem2	transmembrane protein 2	0.021
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.021
atoh7	atonal homolog 7	0.021
junb	jun B proto-oncogene	0.021
msxe	muscle segment homeobox E	0.021
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.020
pnx	posterior neuron-specific homeobox	0.020
hoxb2a	homeo box B2a	0.020
epb4.1l4	erythrocyte protein band 4.1-like 4	0.020
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.020
etv5b	ets variant 5b	0.020
dusp5	dual specificity phosphatase 5	0.019	Zebrafish
rargb	retinoic acid receptor, gamma b	0.019
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.019
gsc	goosecoid	0.019
hoxd13a	homeo box D13a	0.019
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.019
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.019
hoxa11b	homeo box A11b	0.019
jag1b	jagged 1b	0.019
acvr1b	activin A receptor, type IB	0.019
fgf24	fibroblast growth factor 24	0.019
lhx2b	LIM homeobox 2b	0.019
mxtx2	mix-type homeobox gene 2	0.019
zic4	zic family member 4	0.019
prickle1a	prickle-like 1 (Drosophila) a	0.018
irx3b	iroquois homeobox protein 3b	0.018
egr1	early growth response 1	0.018
notum3	notum 3	0.018
rx2	retinal homeobox gene 2	0.018
vsx2	visual system homeobox 2	0.018
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.017
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.017
hmx3	homeo box (H6 family) 3	0.017
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.017
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.017
cx36.7	connexin 36.7	0.017
dlx2a	distal-less homeobox gene 2a	0.017
tnnt2a	troponin T2a, cardiac	0.017
desma	desmin a	0.017
foxc1a	forkhead box C1a	0.017
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.016
tal1	T-cell acute lymphocytic leukemia 1	0.016
nkx2.2a	NK2 transcription factor related 2a	0.016
cd247	CD247 antigen	0.016
sox11b	SRY-box containing gene 11b	0.016
fgf10a	fibroblast growth factor 10a	0.016
fzd10	frizzled homolog 10	0.016
tsc22d3	TSC22 domain family, member 3	0.016
fgf8b	fibroblast growth factor 8 b	0.016	Zebrafish
sox21a	SRY-box containing gene 21a	0.016
dbx1b	developing brain homeobox 1b	0.016
wnt9b	wingless-type MMTV integration site family, member 9B	0.016
pid1	phosphotyrosine interaction domain containing 1	0.016
fibin	fin bud initiation factor	0.016
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.016
si:ch211-1n9.7	si:ch211-1n9.7	0.016
her12	hairy-related 12	0.016
igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	0.015
lfng	lunatic fringe homolog	0.015
per3	period homolog 3 (Drosophila)	0.015
aida	axin interaction partner and dorsalization antagonist	0.015
tbpl2	TATA box binding protein like 2	0.015
ccl25b	chemokine (C-C motif) ligand 25b	0.015
nkx2.1a	NK2 homeobox 1a	0.015
shdb	Src homology 2 domain containing transforming protein D, b	0.015
cd247l	CD247 antigen like	0.015
runx2b	runt-related transcription factor 2b	0.015
nkx1.2la	NK1 transcription factor related 2-like,a	0.015
gpr126	G protein-coupled receptor 126	0.015
wu:fd56d05	wu:fd56d05	0.015
prkci	protein kinase C, iota	0.015
meis1	myeloid ecotropic viral integration 1	0.015
hoxc6a	homeo box C6a	0.014
ephb3a	eph receptor B3a	0.014
ier2	immediate early response 2	0.014
dzip1	DAZ interacting protein 1	0.014
wnt8b	wingless-type MMTV integration site family, member 8b	0.014
evx2	even-skipped homeobox 2	0.014
pou3f2	POU class 3 homeobox 2	0.014
bmp3	bone morphogenetic protein 3	0.014	Zebrafish
mib2	mind bomb 2	0.014
fsta	follistatin a	0.014
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.014
twist3	twist3	0.014
fli1b	friend leukemia integration 1b	0.014
nkx2.2b	NK2 transcription factor related 2b	0.014
emilin1a	elastin microfibril interfacer 1a	0.014
vcana	versican a	0.013
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.013
gdf6b	growth differentiation factor 6b	0.013	Zebrafish
cart1	cartilage paired-class homeoprotein 1	0.013
neo1	neogenin 1	0.013
nkx2.7	NK2 transcription factor related 7	0.013
isl2a	islet2a	0.013
rest	RE1-silencing transcription factor	0.013
sox10	SRY-box containing gene 10	0.013
hmx2	H6 family homeobox 2	0.013
snai1b	snail homolog 1b (Drosophila)	0.013
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.013
gpr182	G protein-coupled receptor 182	0.013
pax2b	paired box gene 2b	0.013
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.013
ek1	eph-like kinase 1	0.013
sfrp1a	secreted frizzled-related protein 1a	0.013
szl	sizzled	0.013
si:rp71-40n14.1	si:rp71-40n14.1	0.012
efnb3b	ephrin B3b	0.012
pax7a	paired box gene 7a	0.012
sox9a	SRY-box containing gene 9a	0.012	Zebrafish
im:7137555	im:7137555	0.012
lft2	lefty2	0.012
foxc1b	forkhead box C1b	0.012
pou3f3a	POU class 3 homeobox 3a	0.012	Zebrafish
pou2f1a	POU class 2 homeobox 1a	0.012	Zebrafish
zgc:92360	zgc:92360	0.012
zgc:86759	zgc:86759	0.012
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.012
cltca	clathrin, heavy polypeptide a (Hc)	0.012
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.012
ism1	isthmin 1	0.012
dfna5	deafness, autosomal dominant 5	0.012
nkx3.2	NK3 homeobox 2	0.012
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.012
gata1a	GATA binding protein 1a	0.012
aplnra	apelin receptor a	0.012
hoxa9a	homeo box A9a	0.012
admp	anti-dorsalizing morphogenic protein	0.012	Zebrafish
crygm4	crystallin, gamma M4	0.012
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.012
cdk8	cyclin-dependent kinase 8	0.011
sox11a	SRY-box containing gene 11a	0.011
zic6	zic family member 6	0.011
wls	wntless homolog (Drosophila)	0.011	Worm
raraa	retinoic acid receptor, alpha a	0.011
eif4g2b	eukaryotic translation initiation factor 4, gamma 2b	0.011
pbx4	pre-B-cell leukemia transcription factor 4	0.011
arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.011
frem3	Fras1 related extracellular matrix 3	0.011
pax8	paired box gene 8	0.011
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.011
eng2b	engrailed 2b	0.011
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.011
celf1	cugbp, Elav-like family member 1	0.011
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.011
ptgs1	prostaglandin-endoperoxide synthase 1	0.011
bokb	BCL2-related ovarian killer b	0.011
si:dkey-8l13.4	si:dkey-8l13.4	0.011
sp5l	Sp5 transcription factor-like	0.011
sema3fb	semaphorin 3fb	0.011
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.011
hoxc9a	homeo box C9a	0.011
acvr2a	activin receptor IIa	0.011
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.011
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.011
ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.011
tead3a	TEA domain family member 3 a	0.010
klf2b	Kruppel-like factor 2b	0.010
zgc:153154	zgc:153154	0.010
LOC569234	hypothetical LOC569234	0.010
nppa	natriuretic peptide precursor A	0.010
fcer1gl	Fc receptor, IgE, high affinity I, gamma polypeptide like	0.010
zgc:101847	zgc:101847	0.010
ugdh	UDP-glucose dehydrogenase	0.010
trim33	tripartite motif-containing 33	0.010
b4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.010
wif1	wnt inhibitory factor 1	0.010
LOC100004296	novel protein similar to murine T brachyury (T)	0.010
gli1	GLI-Kruppel family member 1	0.010
metrn	meteorin, glial cell differentiation regulator	0.010