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Danio rerio

15 genes annotated in zebrafish

bmp signaling pathway involved in heart development

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "bmp signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bmp signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	1.000	Human Zebrafish
shha	sonic hedgehog a	0.999
chd	chordin	0.998
tbx16	T-box gene 16	0.995
bmp4	bone morphogenetic protein 4	0.984
ndr2	nodal-related 2	0.972
ntla	no tail a	0.953
flh	floating head	0.938
gli1	GLI-Kruppel family member 1	0.900
ptch2	patched 2	0.887
ptch1	patched 1	0.887
has2	hyaluronan synthase 2	0.883
sox32	SRY-box containing gene 32	0.827
oep	one-eyed pinhead	0.796
tbx1	T-box 1	0.732	Zebrafish
lft1	lefty1	0.689
fgf8a	fibroblast growth factor 8 a	0.673
foxh1	forkhead box H1	0.664
her7	hairy and enhancer of split related-7	0.646
tbx18	T-box 18	0.637	Zebrafish
tbx2b	T-box 2b	0.603	Zebrafish
fn1	fibronectin 1	0.597
wnt5b	wingless-type MMTV integration site family, member 5b	0.578
tbx20	T-box 20	0.573	Zebrafish
foxi1	forkhead box I1	0.530
bmp7a	bone morphogenetic protein 7a	0.444
foxd5	forkhead box D5	0.433
sox17	SRY-box containing gene 17	0.422
wnt11	wingless-type MMTV integration site family, member 11	0.387
gsc	goosecoid	0.383	Zebrafish
nkx1.2la	NK1 transcription factor related 2-like,a	0.364
lft2	lefty2	0.364
sox9a	SRY-box containing gene 9a	0.336
twist3	twist3	0.326
dlx2a	distal-less homeobox gene 2a	0.316
smo	smoothened homolog (Drosophila)	0.313
snai1b	snail homolog 1b (Drosophila)	0.291
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.288
hand2	heart and neural crest derivatives expressed transcript 2	0.275
msxe	muscle segment homeobox E	0.274	Mouse
vent	ventral expressed homeobox	0.269
pax9	paired box gene 9	0.268
nkx3.2	NK3 homeobox 2	0.238
smad9	MAD homolog 9 (Drosophila)	0.230	Zebrafish
pou5f1	POU domain, class 5, transcription factor 1	0.186
mib	mind bomb	0.179
ephb4b	eph receptor B4b	0.148
bon	bonnie and clyde	0.147
tbx2a	T-box gene 2a	0.141	Zebrafish
gli2a	GLI-Kruppel family member GLI2a	0.141
nkx2.5	NK2 transcription factor related 5	0.135
dharma	dharma	0.134
tll1	tolloid-like 1	0.130
fgf10a	fibroblast growth factor 10a	0.130
ihha	Indian hedgehog homolog a	0.125	Zebrafish
pcdh8	protocadherin 8	0.122
myf5	myogenic factor 5	0.116
gbx2	gastrulation brain homeo box 2	0.115
eve1	even-skipped-like1	0.107
vangl2	vang-like 2 (van gogh, Drosophila)	0.104
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.104
mespa	mesoderm posterior a	0.100
hoxa13b	homeo box A13b	0.099
six4a	sine oculis homeobox homolog 4a	0.099
msxc	muscle segment homeobox C	0.096
her5	hairy-related 5	0.096
bmp2a	bone morphogenetic protein 2a	0.093	Human Zebrafish
gdf6a	growth differentiation factor 6a	0.092	Zebrafish
runx2b	runt-related transcription factor 2b	0.091
sp7	Sp7 transcription factor	0.091
spaw	southpaw	0.088
foxa2	forkhead box A2	0.082
cdh2	cadherin 2, neuronal	0.081
sim2	single-minded homolog 2 (Drosophila)	0.080
axin1	axin 1	0.079
ndr1	nodal-related 1	0.078	Zebrafish
cdx4	caudal type homeo box transcription factor 4	0.072
fgf4	fibroblast growth factor 4	0.071
fezf2	FEZ family zinc finger 2	0.071
lhx1b	LIM homeobox 1b	0.070
fzd5	frizzled homolog 5	0.068
rxrbb	retinoid x receptor, beta b	0.068
hapln1a	hyaluronan and proteoglycan link protein 1a	0.066
chsy1	chondroitin sulfate synthase 1	0.063
snai1a	snail homolog 1a (Drosophila)	0.062
col8a1a	collagen, type VIII, alpha 1a	0.060
lmo4a	LIM domain only 4a	0.060
fbn2b	fibrillin 2b	0.059
rarab	retinoic acid receptor, alpha b	0.057
mespb	mesoderm posterior b	0.057
per3	period homolog 3 (Drosophila)	0.056
vox	ventral homeobox	0.056
brd4	bromodomain containing 4	0.055
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.055
nkx2.3	NK2 transcription factor related 3	0.053
msxb	muscle segment homeobox B	0.053
gro1	groucho 1	0.052
grem2	gremlin 2, cysteine knot superfamily	0.051
hmx4	H6 family homeobox 4	0.050
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.050
plagl2	pleiomorphic adenoma gene-like 2	0.049
barx1	BarH-like homeobox 1	0.048
gpr126	G protein-coupled receptor 126	0.047
hoxa11b	homeo box A11b	0.047
gpc4	glypican 4	0.046
lrrc6	leucine rich repeat containing 6	0.045
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.044
rx3	retinal homeobox gene 3	0.044
dlx4b	distal-less homeobox gene 4b	0.043
gata4	GATA-binding protein 4	0.043
myod1	myogenic differentiation 1	0.042
her1	hairy-related 1	0.041
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.041
twist1a	twist1a	0.041
hoxd11a	homeo box D11a	0.039
wnt10a	wingless-type MMTV integration site family, member 10a	0.039
spon2a	spondin 2a, extracellular matrix protein	0.038
msxd	muscle segment homeobox D	0.037
s1pr2	sphingosine-1-phosphate receptor 2	0.036
ved	ventrally expressed dharma/bozozok antagonist	0.035
edn1	endothelin 1	0.034
hoxd13a	homeo box D13a	0.034
cldng	claudin g	0.034
spns2	spinster homolog 2 (Drosophila)	0.034
brd2a	bromodomain-containing 2a	0.033
siah2l	seven in absentia homolog 2 (Drosophila)-like	0.033
dlx6a	distal-less homeobox gene 6a	0.033
tgfb2	transforming growth factor, beta 2	0.032
igf1rb	insulin-like growth factor 1b receptor	0.031
plcg1	phospholipase C, gamma 1	0.031
hoxa1a	homeo box A1a	0.031
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.030
shhb	sonic hedgehog b	0.030	Zebrafish
nanos3	nanos homolog 3	0.030
wnt9a	wingless-type MMTV integration site family, member 9A	0.029
hoxa11a	homeo box A11a	0.029
rxrab	retinoid x receptor, alpha b	0.029
epha4b	eph receptor A4b	0.028
sall4	sal-like 4 (Drosophila)	0.028
sp5l	Sp5 transcription factor-like	0.028
smad1	MAD homolog 1 (Drosophila)	0.027	Zebrafish
atoh7	atonal homolog 7	0.027
im:7165141	im:7165141	0.026
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.026
vmhcl	ventricular myosin heavy chain-like	0.026
hoxd12a	homeo box D12a	0.025
emx3	empty spiracles homeobox 3	0.025
pkd2	polycystic kidney disease 2	0.025
dkk1b	dickkopf 1b	0.025
pax2a	paired box gene 2a	0.025
admp	anti-dorsalizing morphogenic protein	0.024	Zebrafish
efna5a	ephrin A5a	0.024
six4.3	sine oculis homeobox homolog 4.3	0.023
prickle1a	prickle-like 1 (Drosophila) a	0.023
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.023
hoxa9b	homeo box A9b	0.023
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.022
and1	actinodin1	0.022
fbln1	fibulin 1	0.022
piwil2	piwi-like 2 (Drosophila)	0.022
tbx24	T-box 24	0.021	Zebrafish
otx1a	orthodenticle homolog 1a	0.021
hoxa2b	homeo box A2b	0.021
hmx1	H6 homeo box 1	0.021
vax2	ventral anterior homeobox 2	0.021
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.021
top2a	topoisomerase (DNA) II alpha	0.020
szl	sizzled	0.020
gro2	groucho 2	0.020
tcf21	transcription factor 21	0.019
si:ch211-173o4.2	si:ch211-173o4.2	0.019
six3b	sine oculis homeobox homolog 3b	0.019
prrx1b	paired related homeobox 1b	0.019
sox19b	SRY-box containing gene 19b	0.018
sox9b	SRY-box containing gene 9b	0.018
foxa1	forkhead box A1	0.018
LOC567678	avidin-like	0.018
lmna	lamin A	0.018
lhx1a	LIM homeobox 1a	0.017
prrx1a	paired related homeobox 1a	0.017
disp1	dispatched homolog 1 (Drosophila)	0.017
twist1b	twist1b	0.017
frem3	Fras1 related extracellular matrix 3	0.017
etv5b	ets variant 5b	0.017
acvr2b	activin receptor IIb	0.017
rest	RE1-silencing transcription factor	0.016
nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.016
rxrba	retinoid x receptor, beta a	0.016
zorba	Orb/CPEB-related RNA-binding protein	0.016
ephb3a	eph receptor B3a	0.016
satb2	SATB homeobox 2	0.015
msgn1	mesogenin 1	0.015
pcdh18b	protocadherin 18b	0.015
rxrga	retinoid x receptor, gamma a	0.015
runx1	runt-related transcription factor 1	0.015
vasa	vasa homolog	0.015
ripply1	ripply1	0.015
hoxa13a	homeo box A13a	0.015
evx1	even-skipped homeobox 1	0.014
rxraa	retinoid X receptor, alpha a	0.014
runx2a	runt-related transcription factor 2a	0.014
b3gnt7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.014
tbx5b	T-box 5b	0.014
barx2	BarH-like homeobox 2	0.014
osr2	odd-skipped related 2 (Drosophila)	0.014
neo1	neogenin 1	0.014
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.014
hoxa10b	homeo box A10b	0.014
dlx5a	distal-less homeobox gene 5a	0.014
fzd8b	frizzled homolog 8b	0.013
vsx1	visual system homeobox 1 homolog, chx10-like	0.013
npy8ar	neuropeptide Y receptor Y8a	0.013
rargb	retinoic acid receptor, gamma b	0.013
enc1	ectodermal-neural cortex (with BTB-like domain)	0.013
dlx1a	distal-less homeobox gene 1a	0.013
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.013
notch1b	notch homolog 1b	0.013
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.013
foxn4	forkhead box N4	0.012
dusp6	dual specificity phosphatase 6	0.012
mab21l2	mab-21-like 2	0.012
drl	draculin	0.012
lhx6	LIM homeobox 6	0.012
si:dkey-97i18.2	si:dkey-97i18.2	0.012
map2k4a	mitogen-activated protein kinase kinase 4a	0.011
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.011
lrrc50	leucine rich repeat containing 50	0.011
cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
hoxc8a	homeo box C8a	0.011
efnb1	ephrin B1	0.011
fas	Fas (TNF receptor superfamily, member 6)	0.011
lhx3	LIM homeobox 3	0.011
col10a1	collagen, type X, alpha 1	0.011
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.011
eomesa	eomesodermin homolog a	0.011	Zebrafish
pitx2	paired-like homeodomain transcription factor 2	0.011
prtga	protogenin homolog a (Gallus gallus)	0.011
acvr1b	activin A receptor, type IB	0.011
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.011
fzd10	frizzled homolog 10	0.010
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.010
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.010